Abstract: A sound reproduction system and filter set comprising an array of loudspeakers, comprises a plurality of delay-gain filter elements, and further wherein the filter set comprises a plurality of loudspeaker-specific filter elements (12) which are each associated with different respective speakers of the loudspeaker array, and further comprising a plurality of loudspeaker-independent filter elements (10) which are each common to a plurality of the loudspeakers of the array.

Abstract: The present invention provides a method for detecting events in an input signal. The method volatile resistive switching component to detect the events in the input signal. The method comprising identifying the events based on sampling an output from the resistive switching component.

Abstract: An audio signal processing apparatus for processing an input audio signal is provided, the apparatus comprising a plurality of filters, each filter configured to filter the input audio signal to obtain a plurality of filtered audio signals, each filter designed according to an extended mode matching beamforming applied to a surface of a half revolution, the surface partially characterizing a loudspeaker enclosure shape, a plurality of scaling units, each scaling unit configured to scale the plurality of filtered audio signals using a plurality of gain coefficients to obtain a plurality of scaled filtered audio signals, and a plurality of adders, each adder configured to combine the plurality of scaled filtered audio signals, thereby providing an output audio signal for producing a sound field having a beam directivity pattern defined by the plurality of gain coefficients.

Abstract: A super-resolution scanning confocal polarization contrast microscope is provided. The microscope has a laser light source (1), sample stage (10) for mounting a sample 6 and detector (8). A polarization controller (3) is used to set the polarization state of the light beam to any one of a defined set of different polarization states. A spatial light modulator (5) modulates the light beam in amplitude and/or phase to focus a sub-diffraction-limit central spot on the sample together with unwanted sidebands. A scanning confocal scheme is used with a pin hole 9 in front of the detector (8) so that only that portion of the light is detected which has comes from the central spot, while rejecting light that has been scattered by the sample from the sidebands. Polarization contrast images with sub-diffraction limit resolution can thus be acquired.

Abstract: The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.

Abstract: The present invention provides a method and system for processing data from an event, such as a neurological event. When a neurological event occurs, a spike in a neural waveform is generated. The spike can be detected and used to determine information about the neurological event. The method uses data values from a resistive switching component capable of undergoing a resistive state change when a voltage is applied to it. The data values represent a sequence of resistive state changes of the resistive switching component which correspond to the neurological event. The method further comprises processing the received data values to identify a resistive state change corresponding to the neurological event and to obtain information about the neurological event. Thus, a method and system for processing neural spikes is provided.

Abstract: The disclosure relates to an apparatus for generating a sound field on the basis of an input audio signal. The apparatus comprises a plurality of transducers, wherein each transducer is configured to be driven by a transducer driving signal ql of the respective transducer; a plurality of filters configured to generate for each transducer the transducer driving signal ql of the respective transducer; and a control unit configured to provide or receive a first transducer driving signal vector q0 of dimension L such that the gradient of J(q;?) with respect to q is zero in (q0;?0), the control unit is further configured to provide a second transducer driving signal vector {tilde over (q)} of dimension L such that the gradient of the cost function J(q;?) with respect to q is [approximately] zero in ({tilde over (q)}; {tilde over (?)}), the control unit is configured to provide the second transducer driving signal vector {tilde over (q)}.

Abstract: A method of electrically measuring the electrical properties of individual particles flowing in a liquid, which method comprises: (i) providing apparatus (3) which is for electrically measuring the individual particles and which has: (a) a fluidic channel (5) for receiving a liquid (6) having the individual particles (4) in suspension in the liquid (6); (b) a first electrode arrangement (8) having at least one measurement electrode (16) and at least one signal electrode (11); and (c) at least one other electrode arrangement (9) having at least one measurement electrode (18) and at least one signal electrode (13); (ii) providing a flow of the liquid (6) through the fluidic channel (5); (iii) applying a first electrical signal through the liquid (6) and along a first conduction path between the measurement electrode (16) and the signal electrode (11) of the first electrode arrangement (8); (iv) applying an electrical signal through the liquid (6) and along at least one other conduction path; (v) comparing the e

Abstract: Techniques for making fluid flow devices are described. The technique is based on radiation-induced conversion of a radiation-sensitive substance from a first state to a second state. With adjustment of the radiation parameters such as power and scan speed we can control the depths of barriers that are formed within a substrate which can produce 3D flow paths. We have used this depth-variable patterning protocol for stacking and sealing of multilayer substrates, for assembly of backing layers for two-dimensional (2D) lateral flow devices and for fabrication of 3D devices. Since the 3D flow paths can be formed via a single laser-writing process by controlling the patterning parameters, this is a distinct improvement over other methods that require multiple complicated and repetitive assembly procedures.

Abstract: Apparatus (3) for electrically measuring individual particles (4) flowing in a liquid (6), which apparatus (3) comprises: (i) a fluidic channel (5) for receiving a liquid (6) having the individual particles (4) in suspension in the liquid (6); (ii) a first electrode arrangement (8) having at least one measurement electrode (16) and at least one signal electrode (11); (iii) at least one other electrode arrangement (9) having at least one measurement electrode and at least one signal electrode (13); (iv) at least one signal conditioning electrode (10, 12, 14, 15, 17, 19) positioned adjacent to at least one of the measurement electrodes (16, 18) or at least one of the signal electrode (9); and (v) measuring means (20, 21) for measuring electrical signal changes; and the apparatus (3) being such that: (vi) the first and the other electrode arrangements (8, 9) are connected to the measuring means (20, 21) whereby individual particles passing between the first and other electrode arrangements (8, 9) cause a change

Abstract: Methods and apparatus for generating droplets are disclosed. In one arrangement a peristaltic screw pump is configured to drive pulsatile flows of fluids in different conduits which are phased relative to each other such that a sequence of droplets are formed at a junction downstream from the pump.

Abstract: The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.

Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.

Abstract: The present invention relates to inhibitors of HIF-1 and HIF-2 and uses thereof. The present invention further relates to the inhibitors for use in treatment of diseases. An isolated polypeptide is provided, that prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and/or inhibits the activity of HIF-1 and HIF-2, wherein the polypeptide comprises the amino acid sequence C-X1-X2-X3-Z-X4 (SEQ ID NO 1) and wherein X1, X2, X3 and X4 are any amino acid and wherein Z is leucine, valine of isoleucine or a non-natural derivative or leucine, valine or isoleucine. The isolated polypeptide prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and inhibits the activity of HIF-1 and HIF-2 by binding to HIF-1? or HIF-1? and/or HIF-2? or HIF-1?.

Abstract: This patent describes an optical element, which converts incident linearly or circularly polarized visible light into radially or azimuthally polarized light beam. The polarization converter is a single optical element, produced by direct laser writing technique in an optically transparent substrate. Direct laser writing based on ultra-short pulsed laser radiation forms form birefringence self-assembled nanogratings in optically transparent material, such as fused silica. The period of gratings is smaller than wavelengths of a visible light.

Abstract: Apparatus for providing information on at least one muscle in a patient, which apparatus comprises: (i) signal providing means for providing measurement-enabling signals for the muscle; (ii) first contact electrodes for enabling the measurement-enabling signals from the signal providing means to be received by the patient; (iii) measurement means for measuring a parameter of the muscle, the parameter being such that it is affected by the measurement-enabling signals, and the parameter being such that it relates to at least one electrical property that is indicative of changes in tissue impedance caused by movement of the muscle; and (iv) a garment which is for being worn over the muscle in the patient and which comprises an array of separate electrically conducting areas. The apparatus optionally includes neuromuscular stimulator means for providing neuromuscular stimulation signals for the muscle.

Abstract: A modular structural member (100) comprising: at least two connection portions (102), and a structural portion (101), the connection portions arranged to provide electrical and mechanical connection to other structural members, and wherein, electronic componentry (125) is provided on the structural portion, and/or the connection portions are arranged to receive a fastener (240; 260), to connect multiple connection portions together, which is provided with electronic componentry, and further wherein, a plurality of the structural members arranged to be connected together to form a structure.

Abstract: An anti-resonant hollow-core fiber comprising a first tubular, cladding element which defines an internal cladding surface, a plurality of second tubular elements which are attached to the cladding surface and together define a core with an effective radius, the second tubular elements being arranged in spaced relation and adjacent ones of the second tubular elements having a spacing therebetween, and a plurality of third tubular elements, each nested within a respective one of the second tubular elements.

Abstract: The present invention relates to Surfactant Protein D (SP-D) or nucleic acids encoding SP-D or variants thereof such as surfactant protein A or mannan binding lectin for use in the treatment and/or prevention of a parasitic infection. Methods for determining the presence of a parasitic infection by determining levels of SP-D in a sample are also disclosed. Also disclosed are helminths for treating allergy, inflammation or infection.

Abstract: Protein conjugate comprising a protein antigen for generating an immune response against the HER2/neu protein and an immunogenic carrier covalently bonded to said protein antigen, wherein said protein antigen (i) has a sequence segment of 300 or more contiguous amino acids of the amino acid sequence of SEQ ID NO: 1; or (ii) has a variant sequence segment of 300 or more amino acid residues, wherein the amino acid sequence of said variant sequence segment has at least 85% sequence identity to a sequence portion from SEQ ID: 1; or (iii) has a variant sequence segment of 300 or more amino acid residues and has from 1 to 10 substitutions, deletions or additions in said variant sequence segment compared to a sequence segment of 300 or more amino acid residues of the amino acid sequence of SEQ ID NO: 1 or 2.