Abstract: The present invention relates to Surfactant Protein D (SP-D) or nucleic acids encoding SP-D or variants thereof such as surfactant protein A or mannan binding lectin for use in the treatment and/or prevention of a parasitic infection. Methods for determining the presence of a parasitic infection by determining levels of SP-D in a sample are also disclosed. Also disclosed are helminths for treating allergy, inflammation or infection.

Abstract: Protein conjugate comprising a protein antigen for generating an immune response against the HER2/neu protein and an immunogenic carrier covalently bonded to said protein antigen, wherein said protein antigen (i) has a sequence segment of 300 or more contiguous amino acids of the amino acid sequence of SEQ ID NO: 1; or (ii) has a variant sequence segment of 300 or more amino acid residues, wherein the amino acid sequence of said variant sequence segment has at least 85% sequence identity to a sequence portion from SEQ ID: 1; or (iii) has a variant sequence segment of 300 or more amino acid residues and has from 1 to 10 substitutions, deletions or additions in said variant sequence segment compared to a sequence segment of 300 or more amino acid residues of the amino acid sequence of SEQ ID NO: 1 or 2.

Abstract: Apparatus (2) for sensing at least one parameter in water, which apparatus comprises: (i) a conductivity sensor (6) for sensing conductivity in the water; (ii) a dissolved oxygen sensor (4) for sensing dissolved oxygen in the water; (iii) a glass substrate (14); and (iv) the conductivity sensor (6) and the dissolved oxygen sensor (4) are fabricated on the glass substrate (14) using photolithography and etching.

Abstract: A single-phase flip-flop comprising: a master latch comprising: a first circuit to generate a master latch signal in response to a first master logic operation on a flip flop input signal and a first clock signal, and a second circuit to generate a master output signal in response to a second master logic operation on the first clock signal and master latch signal; a slave latch comprising: a third circuit to generate a slave output signal in response to a first slave logic operation on the first clock signal and one of the master output signal and an inverted slave output signal; and wherein the master latch is configured to capture the flip-flop input signal during a first portion of the first clock signal and the slave latch is configured to capture the master output signal during a second portion of the first clock signal.

Abstract: Methods of inducing T cell proliferation and expansion in vivo for treating conditions wherein antigen-specific T cell immune response are therapeutically desirable such as cancer, infection, inflammation, allergy and autoimmunity and for enhancing the efficacy of vaccines are provided. These methods comprise the administration of at least one CD27 agonist, preferably an agonistic CD27 antibody, alone or in association with another moiety such as immune stimulant or immune modulator such as an anti-CD40, OX-40, 4-1BB, or CTLA-4 antibody or an agent that depletes regulatory cells, or a cytokine. These mono and combination therapies may also optionally include the administration of a desired antigen such as a tumor antigen, an allergen, an autoantigen, or an antigen specific to an infectious agent or pathogen against which a T cell response (often CD8+) is desirably elicited.

Abstract: A hollow-core photonic bandgap fiber having a hollow core and a cladding which surrounds the core at a core boundary and comprises a lattice or network of struts and interstitial nodes which together define an array of cavities, wherein a ratio between a difference in a length of a longest and shortest pitch spacing of the nodes at the core boundary to an average pitch spacing at the core boundary is less than about 0.3.

Abstract: Apparatus (2) for sensing at least one parameter in water, which apparatus (2) comprises: (i) a conductivity sensor (6) for sensing conductivity in water; (ii) the conductivity sensor (6) is an electrode-based conductivity sensor having bare electrodes (12) which contact the water; (iii) there are at least four of the electrodes (12); (iv) the conductivity sensor (6) is fabricated on a substrate (14) using photolithography and etching; (v) the conductivity sensor (6) is an open cell sensor having a physically unconstrained electric field; (vi) the conductivity sensor (6) is of a dot construction comprising a dot and a surrounding formation; (vii) the conductivity sensor (6) has two electrodes which are for current stimulation and which geometrically bound and enclose another two electrodes which are for voltage sensing; and (viii) the conductivity sensor (6) is a laminar construction on the substrate (14).

Abstract: The present invention provides screening methods which may be regarded as in vitro or ex vivo methods of interrogating the immune system to understand what viral antigens are “seen” and responded to by T cells of the immune systems during viral infection. The screening methods further link in vitro or ex vivo responses to progression of infection in subjects.

Abstract: Methods for converting an alcohol, such as cyclohexanol to a ketone, such as cyclohexanone, include reacting the alcohol in the presence of a catalyst and oxygen to produce the ketone. In one exemplary embodiment, the catalyst comprises a microporous copper chloropyrophosphate framework including a plurality of noble metal nanoparticles. In one exemplary embodiment, the noble metal nanoparticles include at least one metal selected from the group consisting of platinum, palladium, and gold.

Abstract: Apparatus (2) for sensing at least one parameter in water, which apparatus (2) comprises: (i) at least one electrode based sensor (4, 6) for sensing at least one parameter in water; and which apparatus (2) is such that: (ii) the electrode based sensor (4, 6) has a self-cleaning electrode; (iii) the electrode based sensor (4, 6) has a reference electrode; (iv) the self-cleaning electrode is stable in water; (v) the apparatus (2) is configured to operate by liberating chlorine from the water using a first waveform applied to the self-cleaning electrode; (VI) the apparatus (2) is configured to operate by liberating chlorine and oxygen from the water using a second waveform applied to the self-cleaning electrode; and (VII) the apparatus (2) is configured to preserve the condition of the reference electrode by periodically regenerating the reference electrode.

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

Abstract: Apparatus (2) for sensing and measuring and/or shear components of a force at an interface between two surfaces, which apparatus (2) comprises: (i) at least one flexible means (4) for receiving the pressure and/or shear components of the force; and (ii) transducer means (6) for producing electrical signals consequent upon movement of the flexible means (4) in response to the pressure and/or shear components of the force, and the apparatus (2) being such that: (iii) the flexible means (4) comprises first and second electrode parts (18, 20) which are spaced apart by the flexible means (12); (iv) the first and second electrode parts (18, 20) move solely towards each other as a result of the pressure component of the force being applied to the flexible means (4); and (v) the first and second electrode parts (18, 20) move towards and parallel to each other as a result of the shear component of the force being applied to the flexible means (4).

Abstract: An electro-optic device, comprising a layer of light-carrying material; and a rib, projecting from the layer of light-carrying material, for guiding optical signals propagating through the device. The layer of light-carrying material comprises a first doped region of a first type extending into the rib, and a second doped region of a second, different type extending into the rib such that a pn junction is formed within the rib. The pn junction extends substantially parallel to at least two contiguous faces of the rib, resulting in a more efficient device. In addition, a self-aligned fabrication process can be used in order to simplify the fabrication process and increase reliability and yield.

Abstract: Methods for producing lactams from oximes by performing a Beckmann rearrangement using a silicoaluminophosphate catalyst are provided. These catalysts may be used in gas phase or liquid phase reactions to convert oximes into lactams. High conversion of oxime and high selectivity for the desired lactams are produced using the disclosed methods, including high conversion and selectivity for ?-caprolactam produced from cyclohexanone oxime and high conversion and selectivity for ?-laurolactam produced from cyclododecanone oxime.

Abstract: A fiber gain medium provided by a rare-earth doped fiber (10) is contained in a first resonant cavity by end reflectors (12, 18). The reflector (12) is wavelength selective to limit the frequency band of the first resonant cavity. The first resonant cavity also contains a second resonant enhancement cavity (16) with multiple transmission bands lying within the first resonant cavity's frequency band. Multiple standing wave modes of the first resonant cavity lie within both the frequency band of the first resonant cavity and the transmission bands of the second resonant cavity, and it is these standing wave modes that support laser action when the rare-earth doped fiber is suitably pumped by pump lasers (40).

Abstract: Methods for converting an alcohol, such as cyclohexanol to a ketone, such as cyclohexanone, include reacting the alcohol in the presence of a catalyst and oxygen to produce the ketone. In one exemplary embodiment, the catalyst comprises a microporous copper chloropyrophosphate framework including a plurality of noble metal nanoparticles. In one exemplary embodiment, the noble metal nanoparticles include at least one metal selected from the group consisting of platinum, palladium, and gold.

Abstract: A super-oscillatory lens (10) having a pre-defined pattern to spatially modulate the light beam in amplitude and/or phase which has a blocking element (6) formed integrally with the lens, or as a separate component adjacent to the lens, which is opaque to the light beam to cause diffraction of the light beam around the blocking element and formation of a shadow region (20). The lens and blocking element focus the light beam to form an elongate needle-shaped focus (15) in the shadow region (20). In any application in which it is necessary to scan a small spot over a surface, compared with a conventional objective lens focus the elongate shape of the focus relaxes the requirement on a feedback loop to maintain a constant separation between a scan head and a surface being scanned. The elongate shape is also ideal shape for materials processing applications.

Abstract: First and second coherent light beams of the same wavelength are propagated in opposite directions to interact on a sub-wavelength thickness metallic metamaterial layer which is structured with a periodicity such that there is a resonance matched to the wavelength of the coherent beams. The first beam is then able to modulate the intensity of the second beam by modulating the phase and/or intensity of the first beam. The interference of the counter- propagating beams can eliminate or substantially reduce Joule loss of light energy in the metamaterial layer or, on the contrary, can lead to a near total absorption of light, depending on the mutual phase and/or intensity of the interacting beams. A modulation is thus provided without using a non-linear effect.

Abstract: The present invention relates to Surfactant Protein D (SP-D) or nucleic acids encoding SP-D or variants thereof such as surfactant protein A or mannan binding lectin for use in the treatment and/or prevention of a parasitic infection. Methods for determining the presence of a parasitic infection by determining levels of SP-D in a sample are also disclosed. Also disclosed are helminths for treating allergy, inflammation or infection.