Patents Assigned to University of Southern California
  • Publication number: 20190048334
    Abstract: The disclosure provides for single amplification and double amplification methods for preparing nucleic acid samples for sequencing.
    Type: Application
    Filed: June 12, 2018
    Publication date: February 14, 2019
    Applicants: University of Southern California, SeqOnce Biosciences Inc.
    Inventor: Joseph Dunham
  • Patent number: 10202327
    Abstract: A catalyst system includes a complex having formula I which advantageously has a sterically protecting N-heterocyclic carbene (NHC) carbene-pyridine ligand to handle harsh reactions conditions than many prior art catalysts: wherein M is a transition metal; o is 0, 1, 2, 3, or 4; R1 is a C1-6 alkyl, a C6-18 aryl, or an optionally substituted C5-18 heteroaryl. In a refinement, R1 is methyl, ethyl, butyl, n-propyl, isopropyl, n-butyl, sec-butyl, or t-butyl; R2, R3, R3? are independently an optionally substituted C1-6 alkyl, halo (e.g., Cl, F, Br, etc), NO2, an optionally substituted C6-18 aryl, or an optionally substituted C5-18 heteroaryl; R4, R4? are independently an optionally substituted C1-6 alkyl, halo, NO2, an optionally substituted C6-18 aryl, or an optionally substituted C5-18 heteroaryl; and X? is a negatively charge counter ion and L1, L2 are each independently a neutral ligand.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: February 12, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Travis J. Williams, Zhiyao Lu, Ivan Demianets
  • Patent number: 10203392
    Abstract: A magnetic resonance imaging system may include: a magnet; gradient coils; an RF pulse transmitter; an RF receiver that receives MR signals from tissue that has been exposed to RF pulses from the RF pulse generator, gradient fields from the gradient coils, and a magnetic field from the magnet; a system controller that controls the magnet, gradient coils, RF pulse transmitter, and RF receiver so as to generate data representative of at least a portion of the composition of an object, including controlling the gradient coils and RF receiver so as to cause MRI data to be acquired that includes information about at least one attribute of the object at different points in time and that represents an incomplete sample of a portion of k-space that is a Fourier transform of the object; and a data processing system that generates one or more images of at least a portion of the object based on the MRI data.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: February 12, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Yinghua Zhu, Yi Guo, Krishna S. Nayak, Robert Marc Lebel
  • Patent number: 10195282
    Abstract: Described herein are compositions of alginate formulations that include water, divalent ions, and alginate cross-linked by the divalent ions, and their use for treating incisional wounds, such as intra-incisional application.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: February 5, 2019
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Kevin J. Gaffney, Gere S. Dizerega
  • Patent number: 10199582
    Abstract: A compound comprising a ligand LA according to formula (I) as well as, a first device and a formulation including the same are disclosed. In the structure of formula (I): ring A is a 5- or 6-membered heteroaryl ring; X1 is C or N; RA is mono-, bi-, tri-, tetradentate, or unsubstituted; RA, R10, R11, R12, R13, R14, R15, R16, and R17 are independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof, any adjacent substituents of RA, R10, R11, R12, R13, R14, R15, R16, and R17 are optionally joined to form a fused ring; the dashed lines represent bonds to a metal M; and metal M has an atomic number greater than 40.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: February 5, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mark E. Thompson, John W. Facendola, Peter I. Djurovich
  • Patent number: 10196435
    Abstract: Provided is an isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide fragment or a biological equivalent thereof and compositions comprising: an isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide fragment; and a pharmaceutically acceptable carrier. Also provided are methods for treating or ameliorating the symptoms of cancer in a canine comprising administering an effective amount of the isolated recombinant polypeptide of the disclosure and/or a composition of the disclosure to a canine in need thereof.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: February 5, 2019
    Assignee: University of Southern California
    Inventors: Alan L. Epstein, Peisheng Hu
  • Publication number: 20190029301
    Abstract: A method for treating a subject with multiple myeloma includes a step of identifying a patient having multiple myeloma. A fasting mimicking and enhancing diet is administered to the subject for a predetermined time period of at least 8 days. A diet package for implementing the method is also provided.
    Type: Application
    Filed: January 12, 2017
    Publication date: January 31, 2019
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Valter D. LONGO, Woodring E. WRIGHT
  • Patent number: 10188769
    Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: January 29, 2019
    Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, CALIFORNIA INSTITUTE OF TECHNOLOGY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Mark S. Humayun, Ashish Ahuja, Yu-Chong Tai, David R. Hinton, Robert H. Grubbs, Dennis O. Clegg, Lincoln Vallance Johnson, Sherry T. Hikita
  • Patent number: 10188843
    Abstract: The present disclosure described methods, systems, and techniques for applying contrast-enhanced ultrasound to locate areas of blockage within retinal vessels and to break up clots that are causing damage. In addition to identifying the damaged area, the researchers anticipate that the initial image may serve as a baseline for monitoring the effect of treatment on the vessel, which may be achieved in multiple ways. The vibration effect of the ultrasound itself may suffice to dislodge clots. The microbubbles may also be coated or filled with medication, with ultrasonic shock waves activating the coating or causing mini explosions to release the medicine. Loading the microbubbles with a therapeutic agent, visualizing their presence at the diseased site using the ultrasound diagnostic mode, and then activating the microbubbles to release their contents at the targeted lesion could be a powerful and effective way to reverse occlusion without harming other areas of the eye or body.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: January 29, 2019
    Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, DOHENY EYE INSTITUTE
    Inventors: Amani Fawzi, Hossein Ameri, Mark S. Humayun
  • Patent number: 10179798
    Abstract: A formic acid decomposition catalyst system includes organometallic complexes having formula 1: wherein: M is a transition metal; E is P, N, or C (as in imidazolium carbene); R1, R2 are independently C1-6 alkyl groups; o is 1, 2, 3, or 4; R3 are independently hydrogen, C1-6 alkyl groups, OR14, NO2, halogen; R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R15, R16 are independently hydrogen or C1-6 alkyl groups; R14 is a C1-6 alkyl group; and X? is a negatively charge counter ion.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: January 15, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Travis J. Williams, Jeff Joseph A. Celaje, Zhiyao Lu
  • Patent number: 10172839
    Abstract: A method of alleviating or treating symptoms of cancer and/or effects of chemotherapy or of kinase inhibitors includes a step of identifying a subject having cancer. A reduced caloric diet is administered to the subject for a first time period, the reduced caloric diet providing at most 1000 kcal per day. A kinase inhibitor is administered to the subject.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: January 8, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Valter D. Longo, Stefano Di Biase
  • Publication number: 20180371506
    Abstract: Processes, methods, and apparatus for carbon sequestration utilizing catalysis schemes configured to provide high concentrations of hydrated CO2 in proximity with a sequestration agent are provided. Reactants are combined with catalyst such that at least two regions of controlled catalytic activity form encompassing at least the interface between a sequestration agent and an aqueous solution containing dissolved CO2. Suitable reactants include various sequestration agents, catalyst, and carbon dioxide dissolved in an aqueous solution (seawater, for example). Possible products include bicarbonate and metal cations.
    Type: Application
    Filed: June 1, 2018
    Publication date: December 27, 2018
    Applicants: California Institute of Technology, University of Southern California, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Adam Vinay Subhas, William Max Berelson, Nick Everett Rollins, Jess Firey Adkins, Jonathan Erez
  • Publication number: 20180362559
    Abstract: A compound of Formula I has the structure: wherein G is a straight, branched or cyclic alkyl group having 2 to 50 carbon atoms or an ether group, and R is a fluorescent dye. In some embodiments, G is selected from the group consisting of —(CH2)n— and —(CH2OCH2)m—, wherein n is an integer from 2 to 18, m is an integer from 2 to 18.
    Type: Application
    Filed: September 21, 2016
    Publication date: December 20, 2018
    Applicant: University of Southern California
    Inventors: Charles E. MCKENNA, Boris A. KASHEMIROV, Kim NGUYEN
  • Patent number: 10147892
    Abstract: Compounds that act as capture agents to sequester unsaturated metal complexes are provided. In particular, the compounds may be host materials, dopant materials, or dopant materials containing functional groups, such as an isocyanide or a phosphine group, which are suitable for trapping an unsaturated coordination complex. These compounds may be used in organic light emitting devices, particularly blue devices, to provide improved device lifetime.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: December 4, 2018
    Assignee: THE UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mark E. Thompson, Alberto Bossi, Peter Djurovich
  • Patent number: 10131599
    Abstract: A method of producing methanol from shale gas and CO2 by the exclusive dry CO2 fracking of shale rock by injection of gaseous CO2 at a pressure between 10 and 100 atm to extract shale gas and recover it together with used CO2; combining and admixing produced shale gas containing CO2 and steam to produce a mixture of methane:carbon dioxide:water having a molar ratio of 3:1:2 for conducting the bi-reforming reaction to form a mixture of hydrogen and carbon monoxide having a molar ratio of 2:1 to 2.1:1; and converting the hydrogen and carbon monoxide under conditions sufficient to exclusively form methanol.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: November 20, 2018
    Assignee: University of Southern California
    Inventors: George A. Olah, G. K. Surya Prakash
  • Patent number: 10132807
    Abstract: Provided are methods for aiding in diagnosing autoimmune diseases in a mammal, comprising contacting a biological sample that is not a tear sample from the mammal with an antibody that specifically binds to a first polypeptide selected from the group Ctss, Ctsh, Ctsr, Ctsw, Ctsz, Ifng, IL-6ra, IL-10, IL-10ra, IL-15, Tnfa, Apo-F, or Lcn-2 or a second polypeptide selected from the group lactoperoxidase, lactoferrin or lysozyme under conditions favoring the formation of an antibody-polypeptide complex, and determining the amount of complex formed, wherein an increased formation of antibody-first-polypeptide complex or a decreased formation of antibody-second-polypeptide complex as compared to a suitable control, indicates a likely positive diagnosis of an autoimmune disease for the mammal, thereby aiding in the diagnosis. Methods of treating the autoimmune diseases are also provided.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: November 20, 2018
    Assignee: University of Southern California
    Inventor: Sarah Hamm-Alvarez
  • Publication number: 20180325373
    Abstract: A miniature, low power electronic pressure sensor with a first, oil-filled chamber to protect its microelectromechanical systems (MEMS) pressure sensitive membrane and a second chamber filled with saline or body fluids connected by tube into an organ in the body, such as an eyeball, that needs pressure sensing, is described. The tube carries pressure from a sensitive area within the organ to the electronic pressure sensor. The pressure sensor may communicate wirelessly with external readers and pass data to a server or other computer. Running alongside the tube is another tube for draining and pressure relief. The tubes, or cannulas, can share an opening into the organ in order to minimize the number of holes needed. The tubes may be molded into a single oval cross section, combined coaxially, or share a lumen for a portion that enters the wall of an organ so as to promote healing.
    Type: Application
    Filed: April 9, 2018
    Publication date: November 15, 2018
    Applicants: California Institute of Technology, University of Southern California
    Inventors: Damien C. Rodger, Yu-Chong Tai, Mark S. Humayun, Aubrey M. Shapero, Abhinav Agarwal, Azita Emami
  • Patent number: 10125099
    Abstract: A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: November 13, 2018
    Assignee: University of Southern California
    Inventors: Jean C. Shih, Florence M. Hoffman, Thomas C. Chen
  • Patent number: 10124333
    Abstract: A module may be provided with at least one opening, the opening being an endpoint of a microfluidic channel that passes through at least part of the module. A set of multiple such modules may be arranged into an arrangement of modules, which may be coupled together using one or more coupling mechanisms included on each module. The arrangement of modules may fit within a regular polyhedral grid, and each module within the arrangement of modules may have a form suitable for arrangement of the modules within the regular polyhedral grid. Fluid may then flow through at least a subset of the arrangement of modules via the microfluidic channel of each module of the subset of the arrangement of modules. Some modules may include sensors, actuators, or inner microfluidic channel surface coatings. The arrangement of modules may form a microfluidic circuit that can perform a microfluidic circuit function.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: November 13, 2018
    Assignees: REOLAB INC., UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Krisna Chandra Bhargava, Bryant Thompson, Noah Malmstadt
  • Patent number: 10128450
    Abstract: A compound having a structure according to formula (I) is disclosed. In formula (I), Cu is a monovalent copper atom; *C is a carbene carbon; X1 and X2 are selected from alkyl, cycloalkyl, alkoxy, amino, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, heteroalkynyl, arylalkyl, aryloxy, aryl, heteroalkyl, heteroaryl, and combinations thereof; X1 is bonded to *C by a C atom, and X2 is bonded to *C by an N atom; X1 and X2 are optionally joined to form a ring; and Y is selected halide, alkyl, cycloalkyl, alkoxy, amino, phosphine, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, heteroalkynyl, arylalkyl, aryloxy, aryl, heteroalkyl, heteroaryl, and combinations thereof. A formulation containing compound having a structure according to formula (I), and a device with an organic layer comprising disposed between an anode and a cathode, that includes a compound having a structure according to formula (I) are also described.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: November 13, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mark E. Thompson, Peter I. Djurovich, Valentina Krylova