Patents Assigned to University of Southern California
  • Patent number: 10147892
    Abstract: Compounds that act as capture agents to sequester unsaturated metal complexes are provided. In particular, the compounds may be host materials, dopant materials, or dopant materials containing functional groups, such as an isocyanide or a phosphine group, which are suitable for trapping an unsaturated coordination complex. These compounds may be used in organic light emitting devices, particularly blue devices, to provide improved device lifetime.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: December 4, 2018
    Assignee: THE UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mark E. Thompson, Alberto Bossi, Peter Djurovich
  • Patent number: 10132807
    Abstract: Provided are methods for aiding in diagnosing autoimmune diseases in a mammal, comprising contacting a biological sample that is not a tear sample from the mammal with an antibody that specifically binds to a first polypeptide selected from the group Ctss, Ctsh, Ctsr, Ctsw, Ctsz, Ifng, IL-6ra, IL-10, IL-10ra, IL-15, Tnfa, Apo-F, or Lcn-2 or a second polypeptide selected from the group lactoperoxidase, lactoferrin or lysozyme under conditions favoring the formation of an antibody-polypeptide complex, and determining the amount of complex formed, wherein an increased formation of antibody-first-polypeptide complex or a decreased formation of antibody-second-polypeptide complex as compared to a suitable control, indicates a likely positive diagnosis of an autoimmune disease for the mammal, thereby aiding in the diagnosis. Methods of treating the autoimmune diseases are also provided.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: November 20, 2018
    Assignee: University of Southern California
    Inventor: Sarah Hamm-Alvarez
  • Patent number: 10131599
    Abstract: A method of producing methanol from shale gas and CO2 by the exclusive dry CO2 fracking of shale rock by injection of gaseous CO2 at a pressure between 10 and 100 atm to extract shale gas and recover it together with used CO2; combining and admixing produced shale gas containing CO2 and steam to produce a mixture of methane:carbon dioxide:water having a molar ratio of 3:1:2 for conducting the bi-reforming reaction to form a mixture of hydrogen and carbon monoxide having a molar ratio of 2:1 to 2.1:1; and converting the hydrogen and carbon monoxide under conditions sufficient to exclusively form methanol.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: November 20, 2018
    Assignee: University of Southern California
    Inventors: George A. Olah, G. K. Surya Prakash
  • Patent number: 10124333
    Abstract: A module may be provided with at least one opening, the opening being an endpoint of a microfluidic channel that passes through at least part of the module. A set of multiple such modules may be arranged into an arrangement of modules, which may be coupled together using one or more coupling mechanisms included on each module. The arrangement of modules may fit within a regular polyhedral grid, and each module within the arrangement of modules may have a form suitable for arrangement of the modules within the regular polyhedral grid. Fluid may then flow through at least a subset of the arrangement of modules via the microfluidic channel of each module of the subset of the arrangement of modules. Some modules may include sensors, actuators, or inner microfluidic channel surface coatings. The arrangement of modules may form a microfluidic circuit that can perform a microfluidic circuit function.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: November 13, 2018
    Assignees: REOLAB INC., UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Krisna Chandra Bhargava, Bryant Thompson, Noah Malmstadt
  • Patent number: 10125099
    Abstract: A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: November 13, 2018
    Assignee: University of Southern California
    Inventors: Jean C. Shih, Florence M. Hoffman, Thomas C. Chen
  • Patent number: 10128450
    Abstract: A compound having a structure according to formula (I) is disclosed. In formula (I), Cu is a monovalent copper atom; *C is a carbene carbon; X1 and X2 are selected from alkyl, cycloalkyl, alkoxy, amino, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, heteroalkynyl, arylalkyl, aryloxy, aryl, heteroalkyl, heteroaryl, and combinations thereof; X1 is bonded to *C by a C atom, and X2 is bonded to *C by an N atom; X1 and X2 are optionally joined to form a ring; and Y is selected halide, alkyl, cycloalkyl, alkoxy, amino, phosphine, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, heteroalkynyl, arylalkyl, aryloxy, aryl, heteroalkyl, heteroaryl, and combinations thereof. A formulation containing compound having a structure according to formula (I), and a device with an organic layer comprising disposed between an anode and a cathode, that includes a compound having a structure according to formula (I) are also described.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: November 13, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mark E. Thompson, Peter I. Djurovich, Valentina Krylova
  • Publication number: 20180318355
    Abstract: The present invention discloses methods, compositions and devices for improving tissue regeneration by suppressing the effects of several proinflammatory cytokines such as TNF-? and IFN-?. Compositions and devices of this invention will generally include one or more anti-inflammatory agent(s) capable of reducing the level of TNF-?, IFN-?, or both. Methods for improving tissue regeneration in accordance with this invention will generally have the step of applying a composition or device of the invention to a site in need of the composition or device. Also disclosed are methods for forming composition and devices of the invention and pharmaceutical compositions comprising one or more anti-inflammatory agent(s) effective of inhibiting or reducing the levels of TNF-?, IFN-?, or both.
    Type: Application
    Filed: December 7, 2017
    Publication date: November 8, 2018
    Applicant: Alfred E. Mann Institute for Biomedical Eng. at the University of Southern California
    Inventors: Songtao Shi, Yi Liu, Lei Wang
  • Patent number: 10118945
    Abstract: Modified fungal strains having deleted gene clusters are provided. The modified fungal strains include A. nidulans. The deleted gene clusters are selected from the group of gene clusters responsible for the biosynthesis of sterigmatocystin, emericellamides, asperfuranone, monodictyphenone, terrequinone, F9775A, F9775B, asperthecin, and both portions of the split cluster that makes austinol and dehydroaustinol. Methods for making compounds by culturing the fungus in a growth media and separating the compound from the fungus and/or separating the compound from the growth media are included, as are the compounds and compositions comprising them.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: November 6, 2018
    Assignees: University of Kansas, University of Southern California
    Inventors: Berl Oakley, Manmeet Ahuja, Ruth Entwistle, Christine Oakley, Yi-Ming Chiang, Clay Wang
  • Patent number: 10117774
    Abstract: In various embodiments, a drug-delivery device includes one or more reservoirs that may each contain a therapeutic agent for delivery to a patient.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: November 6, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mark S. Humayun, Sean Caffey
  • Publication number: 20180316158
    Abstract: A vertical cavity surface emitting laser (VCSEL) composite assembly includes a VCSEL, a substrate spaced from the VCSEL, and at least one metal layer disposed between the VCSEL and the substrate to facilitate efficient thermal management of the assembly.
    Type: Application
    Filed: January 29, 2016
    Publication date: November 1, 2018
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Jongseung YOON, Dongseok KANG
  • Patent number: 10111597
    Abstract: Aspects of the present disclosure are directed to electrochemical approaches for synthesis of platinum-iridium alloys with selected platinum-iridium ratio content and subsequently predetermined mechanical properties and electrochemical impedance properties. Such can provide a simple and cost-effective process for preparing these electrodes, as compared to conventional thin film processing techniques. A three-electrode electrochemical electrodeposition system is described including an electrochemical cell with a working electrode on which the electrodeposited film is deposited, a counter electrode to complete the electrochemical circuit and a reference electrode to measure and control surface potential. Mixed layers of platinum atoms and iridium atoms can be deposited from electrolyte solution onto the working electrode surface to create an electrically conductive surface with material properties related to the composition of the as-deposited film.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: October 30, 2018
    Assignee: University of Southern California
    Inventors: Artin Petrossians, Artak Arakelian, James D. Weiland, Florian B. Mansfeld, John J. Whalen, III
  • Patent number: 10106397
    Abstract: In some aspects of the disclosure, an apparatus includes an XYZ control stage and an acoustic transducer coupled with the XYZ control stage. The acoustic transducer includes a multi-foci Fresnel lens having multiple focal spots.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: October 23, 2018
    Assignee: University of Southern California
    Inventors: Eun Sok Kim, Youngki Choe, Jonathan W. Kim, K. Kirk Shung
  • Publication number: 20180300401
    Abstract: A computer implemented method of matching ontologies is disclosed. The method includes, for each pair of entities of a first ontology and a second ontology, wherein each pair of entities includes a first entity from a first plurality of entities of the first ontology and a second entity from a second plurality of entities of the second ontology, and wherein the first entity and the second entity of each pair of entities is of a same data type: (1) determining a vector of similarities for the pair of entities; (2) determining a confidence score for the vector of similarities; (3) determining a relation score for each relation type based on the vector of similarities to measure relatedness between the first entity of the pair of entities and the second entity of the pair of entities; and (4) generating a mapping ontology based on the relation type, the relation score, and the confidence score of each pair of entities.
    Type: Application
    Filed: March 8, 2018
    Publication date: October 18, 2018
    Applicants: Chevron U.S.A. Inc., University of Southern California
    Inventors: Yinuo ZHANG, Anand V. PANANGADAN, Randall G. MCKEE, Mauritz THERON, Benjamin D. GAMBLE, Viktor K. PRASANNA
  • Patent number: 10098333
    Abstract: This invention discloses a stem cell modified animal model useful as a research tool for investigating aging-related degeneration processes and treatments. The animal model is preferably a rodent subcutaneously transplanted with a mesenchymal stem cell capable of generating a functional bone or marrow element. Also provided are a method for extending the lifespan and improving the quality of life of a subject by subcutaneously transplanting a plurality of mesenchymal stem cells to the subject, wherein the mesenchymal stem cells are capable of generating a functional bone or marrow element. Compositions and source of stem cells suitable for use with the methods of this invention, including stem cells from human exfoliated deciduous teeth (SHED), are also disclosed. Further disclosed is a method for identifying progenitor bone marrow mesenchymal stem cells, and a method for treating SLE-like autoimmune diseases by infusion of mesenchymal stem cells.
    Type: Grant
    Filed: December 9, 2009
    Date of Patent: October 16, 2018
    Assignee: University Of Southern California
    Inventors: Songtao Shi, Takayoshi Yamaza, Kentaro Akiyama
  • Patent number: 10099644
    Abstract: A facial image capture system may capture images of a face of a person while the person is moving. A video camera may capture sequential images of a scene to which the video camera is directed. A marker-based location detection system may determine and generate information about the location of a marker worn on or close to the face of the person. A camera control system may automatically adjusts both the horizontal and vertical direction to which the video camera is directed so as to cause the sequential images of the camera to each be of the face of the person while the person is moving, based on the information about the location of the marker from the marker-based location detection system.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: October 16, 2018
    Assignee: University of Southern California
    Inventors: Paul E. Debevec, Mark Bolas, Graham L. Fyffe
  • Patent number: 10098913
    Abstract: This disclosure relates in general to a stem cell treatment. This disclosure further relates to a stem cell treatment using a composition comprising stem cells having highly expressed Fas-L. This disclosure further relates to a stem cell treatment of multiple myeloma. This disclosure also relates to a composition comprising stem cells having highly expressed Fas-L. This disclosure also relates to preparation of a composition comprising stem cell having highly expressed Fas-L. This disclosure also relates to preparation of a composition comprising stem cells having highly expressed Fas-L by using a salicylate. An example of salicylate may be aspirin. This disclosure further relates to a stem cell treatment of multiple myeloma. This disclosure also relates to a stem cell treatment of an inflammatory disease and/or autoimmune disease.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: October 16, 2018
    Assignee: University Of Southern California
    Inventors: Songtao Shi, Shiyu Liu, Fa-ming Chen
  • Patent number: 10098790
    Abstract: This disclosure relates generally to adhesive articles and particularly to adhesive articles comprising a reversible adhesive layer and a non-reversible adhesive layer. The adhesive article may further comprise a backing material. The adhesive article may further comprise a dressing material. Such adhesive articles may be particularly suitable for treatment of damaged sensitive tissue, for example wounds formed on a fragile skin.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: October 16, 2018
    Assignee: University of Southern California
    Inventors: Cesar Blanco, Jonathan Gregory Lasch
  • Patent number: 10092568
    Abstract: Provided are: methods for treating aging or an age-related condition, symptom or disease; methods for stimulating hair growth, regrowth or pigmentation (or preventing hair loss); methods for increasing the expression of an adenosine receptor in dermal cells (in combination with hair growth); methods for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrance). The methods comprise administering a sufficient amount of a CBP/catenin (e.g., CBP/?-catenin) antagonist as disclosed, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: October 9, 2018
    Assignee: University of Southern California
    Inventors: Michael Kahn, Jia-Ling Teo, Michael McMillan, Yi Zhao, Yongfeng Wu
  • Publication number: 20180282397
    Abstract: The invention provides for polypeptides that bind to Ras proteins and methods of using the same, as described herein. For example, the disclosure provides an isolated polypeptide comprising a fibronectin domain, and a first peptide domain at least 90% identical to an amino acid sequence selected from a group consisting of (SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, and SEQ ID NO: 10), and a second peptide domain at least 90% identical to an amino acid sequence selected from a group consisting of (SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, and SEQ ID NO: 15) that specifically binds to an activated Ras protein.
    Type: Application
    Filed: December 15, 2017
    Publication date: October 4, 2018
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mehmet CETIN, Garrett Gross, Richard Roberts
  • Patent number: 10076242
    Abstract: Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment epithelial detachments (PEDs) based on characteristics of their internal reflectivity, size and shape. The classification can be based on selected subsets of the data located within or surrounding the abnormalities. Training data can be used to generate the classification scheme and the classification can be weighted to highlight specific classes of particular clinical interest.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: September 18, 2018
    Assignees: DOHENY EYE INSTITUTE, UNIVERSITY OF SOUTHERN CALIFORNIA, CARL ZEISS MEDITEC, INC.
    Inventors: SriniVas R. Sadda, Paul F. Stetson