Patents Assigned to University of Southern California
  • Patent number: 10047058
    Abstract: A compound of Formula II, is provided. R1, R2 and R3 are independently either hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino or hydroxyl. X is either F, Cl, Br, I or CN. Y is either N or CH. Compositions that include Formula II can be used to inhibit vacuolar H+ ATPase.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 14, 2018
    Assignee: University of Southern California
    Inventors: Chao Zhang, Ying-Chu Chen
  • Patent number: 10029000
    Abstract: Methods for enhancing or stimulating hematopoiesis including the step of administering Interleukin-12 (IL-12) to yield hematopoietic recovery in a mammal in need. Preferred methods include the step of administering IL-12 as an adjuvant therapy to alleviate the hematopoietic toxicities associated with one or more treatment regimens used to combat a disease state. Other methods include administering IL-12 to ameliorate various hematopoietic deficiencies. Still other methods are directed to uses of IL-12 for in-vivo proliferation of hematopoietic repopulating cells, hematopoietic progenitor cells and hematopoietic stem cells. Other disclosed methods are directed to uses of Il-12 for bone marrow preservation or recovery.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: July 24, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Tingchao Chen, Yi Zhao, W. French Anderson
  • Patent number: 10022097
    Abstract: A medical imaging system for reconstructing quantitative dynamic nuclear medicine images of a subject may include a three dimensional positron emission tomography (3D PET) scanner and a data processing system. The three dimensional positron emission tomography (3D PET) scanner may: perform scans of the subject at each of multiple bed positions, each scan being of only a sub-portion of the subject that is within an axial length covered by the scanner; and generate dynamic list-mode PET data that: represents a total number of photon pairs arriving at each of multiple detector pairs in the 3D PET scanner; and is organized in a list of elements, each element in the list including a detector pair index and an arrival time for each detected photon pair; and acquires PET data using a dynamic PET protocol with at least two scans at each of the multiple bed positions.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: July 17, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Richard M. Leahy, Wentao Zhu, Quanzheng Li, Bing Bai, Peter Stephen Conti
  • Patent number: 10019516
    Abstract: A computer implemented method of matching ontologies is disclosed. The method includes, for each pair of entities of a first ontology and a second ontology, wherein each pair of entities includes a first entity from a first plurality of entities of the first ontology and a second entity from a second plurality of entities of the second ontology, and wherein the first entity and the second entity of each pair of entities is of a same data type: (1) determining a vector of similarities for the pair of entities; (2) determining a confidence score for the vector of similarities; (3) determining a relation score for each relation type based on the vector of similarities to measure relatedness between the first entity of the pair of entities and the second entity of the pair of entities; and (4) generating a mapping ontology based on the relation type, the relation score, and the confidence score of each pair of entities.
    Type: Grant
    Filed: April 4, 2015
    Date of Patent: July 10, 2018
    Assignees: University of Southern California, Chevron U.S.A. Inc.
    Inventors: Yinuo Zhang, Anand V. Panangadan, Randall G. McKee, Mauritz Theron, Benjamin D. Gamble, Viktor K. Prasanna
  • Patent number: 10015980
    Abstract: A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet. The first diet includes less than 30 g of sugar on the first day; less than 20 g of sugar on the second to fifth days; less than 28 g of proteins on the first day; less than 18 g of proteins on days the second to fifth days; 20 to 30 grams of monounsaturated fats on the first day; 10 to 15 grams of monounsaturated fats on the second to fifth days; and between 6 and 10 grams of polyunsaturated fats on the first day.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: July 10, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Valter D. Longo, Chia-Wei Cheng, Sebastian Brandhorst, Min Wei
  • Publication number: 20180185303
    Abstract: A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer cells. Novel MAOs inhibitors, such as small molecules, siRNA, shRNA, antisense oligonucleotides, aptamers, decoys, and pharmaceutical compositions useful for treating cancer by disrupting the workings of MAOs are provided. In particular, a class of conjugates formed by covalently conjugating near infrared dye 783, IR-780, and MHI-148 to a MAO inhibitor, such as clorgyline, with and without encapsulation it in a nanoparticle is provided. Other aspects of the invention include methods for forming the nano-conjugates, method for monitoring treatment progress in a cancer patient by monitoring the changes in MAO activity, methods for screening patients who are at risk of cancer or differentiating different forms of cancer by assaying the level and location of MAO activity.
    Type: Application
    Filed: August 28, 2017
    Publication date: July 5, 2018
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Jean C. SHIH, Leland CHUNG, Haiyen E. ZHAU, Boyang Jason WU, Bogdan Z. OLENYUK
  • Patent number: 10009038
    Abstract: An analog-to-digital converter may convert an analog signal into digital codes representative of the changing level of the analog signal. An analog high pass filter may receive and continuously differentiate the analog signal. A voltage controlled oscillator may receive the differentiated analog signal and continuously generates an output that is an integral of the differentiated analog signal in the phase domain. A time-to-digital converter may sample the output of the voltage controlled oscillator and convert each sample into a digital code representative of the current phase of the sampled output of the voltage controlled oscillator.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: June 26, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventor: Shuo-Wei Chen
  • Patent number: 10002214
    Abstract: Compound libraries, systems, methods, and apparatus, including computer program apparatus, are described for implementing techniques for processing data from a combinatorial inquiry to determine materials of use in various photoelectronic devices, e.g., organic light emitting diodes. The libraries include a collection of putative compounds of use as components of OLED devices, which are cross-referenced with one or more electronic property relevant to the efficacy of the compounds in an OLED device. The techniques broadly include receiving data from a chemical experiment on a library of materials having a plurality of members and generating a queriable representation of the chemical experiment. The chemical experiment is optionally an in silico experiment.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: June 19, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mark E. Thompson, Patrick Saris, Peter I. Djurovich, Hsiao-fan Chen
  • Patent number: 9996798
    Abstract: Systems and techniques for enhancing accuracy of traffic prediction include a system of one or more computers operable to receive a request relating to traffic prediction, compare a first prediction error for a first (moving average) traffic prediction model with a second prediction error for a second (historical average) traffic prediction model, calculated using a historical data set selected from previously recorded traffic data in accordance with a day and time associated with the request, select use of the first model or the second model based on the comparison of prediction errors, and provide an output for use in traffic prediction, wherein the output comes from applying the first traffic prediction model when the first prediction error is less than the second prediction error, and the output comes from applying the second traffic prediction model when the first prediction error is not less than the second prediction error.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: June 12, 2018
    Assignee: University of Southern California
    Inventors: Bei Pan, Ugur Demiryurek, Cyrus Shahabi
  • Publication number: 20180159171
    Abstract: A lithium ion mixed conduction membrane includes an optional polymeric binder and a partially lithiated ion conductive material having lithium ion conductivity and electrical conductivity dispersed within the polymeric binder that is capable of improving the performance and cycle life of lithium-sulfur rechargeable batteries and other batteries exhibiting the polysulfide shuttle. One or more lithium ion conduction membranes are placed between the positive and negative electrodes, or adjacent to the negative electrode of a battery and in particular, of a lithium sulfur battery.
    Type: Application
    Filed: June 20, 2016
    Publication date: June 7, 2018
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Sri R. NARAYAN, Derek MOY
  • Patent number: 9988653
    Abstract: Processes, methods, and apparatus for carbon sequestration utilizing catalysis schemes configured to provide high concentrations of hydrated CO2 in proximity with a sequestration agent are provided. Reactants are combined with catalyst such that at least two regions of controlled catalytic activity form encompassing at least the interface between a sequestration agent and an aqueous solution containing dissolved CO2. Suitable reactants include various sequestration agents, catalyst, and carbon dioxide dissolved in an aqueous solution (seawater, for example). Possible products include bicarbonate and metal cations.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: June 5, 2018
    Assignees: California Institute of Technology, University of Southern California, Yissum Research Development Company of the Hebrew University of Jeresalem Ltd.
    Inventors: Adam Vinay Subhas, William Berelson, Nick Everett Rollins, Jess Firey Adkins, Jonathan Erez
  • Patent number: 9987380
    Abstract: A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: wherein R1-R7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: June 5, 2018
    Assignee: University of Southern California
    Inventors: Zibo Li, Francois P. Gabbai, Peter S. Conti, Todd W. Hudnall, Tzu-Pin Lin, Shuanglong Liu, Chiun-Wei Huang
  • Patent number: 9986903
    Abstract: Medical instruments, particularly structurally-adjustable speculums and retractors for obstetrical and gynecological operations, procedures, and examinations, including a minimally obstructive compact speculum or retractor. The compact speculum may comprise a first wing and a second wing; and a hinge comprising at least one hinge component. The compact speculum may further comprise a ratchet that releasably holds the wings in an open position. The hinge component may comprise the ratchet, an illumination source, a fluid handler, a light guide, a lubrication source, or a combination thereof. The compact speculum may be a vaginal speculum.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: June 5, 2018
    Assignee: ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Afshin Nadershahi, Sudeep Deshpande
  • Publication number: 20180147156
    Abstract: This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.
    Type: Application
    Filed: November 15, 2017
    Publication date: May 31, 2018
    Applicant: University of Southern California
    Inventors: Thomas C. Chen, Clovis O. da Fonseca, Thereza Quirico dos Santos, Gilberto Schwartsmann
  • Publication number: 20180148508
    Abstract: The invention is directed to a masked chimeric antigen receptor, comprising: (a) a masking peptide; (b) one or more antigen-specific targeting domains; (c) an extracellular spacer domain; (d) a transmembrane domain; (e) at least one co-stimulatory domain; and (f) an intracellular signaling domain. The mCARs are activated upon cleavage of the masking peptide.
    Type: Application
    Filed: June 27, 2016
    Publication date: May 31, 2018
    Applicant: University of Southern California
    Inventors: Pin WANG, Xiaolu HAN, Paul BRYSON
  • Publication number: 20180142213
    Abstract: This disclosure relates to pancreatic stromal progenitor cells. This disclosure also relates to isolation of pancreatic stromal progenitor cells. This disclosure further relates to a composition comprising pancreatic stromal progenitor cells and preparation of this composition. This disclosure also relates to a treatment comprising administering a composition comprising pancreatic stromal progenitor cells. This disclosure also relates to a treatment of diabetes mellitus comprising administering a composition comprising pancreatic stromal progenitor cells.
    Type: Application
    Filed: May 11, 2016
    Publication date: May 24, 2018
    Applicant: Alfred E. Mann Institute for Biomedical Engineer- ing at the University of Southern California
    Inventors: Songtao Shi, Jin Liu
  • Patent number: 9974932
    Abstract: A self-monitoring catheter system may detect an obstruction during use of a catheter. The system may include a catheter with an interior lumen that has one or more ports into the lumen; a first and a second electrode; and an impedance measurement instrument that measures changes in the impedance between the first and the second electrodes after the first electrode is exposed to fluid within the catheter lumen, thereby signaling an obstruction during use of the catheter.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: May 22, 2018
    Assignee: University of Southern California
    Inventors: Brian J. Kim, Ellis Meng
  • Publication number: 20180133336
    Abstract: There is no specific cure for chronic kidney disease (CKD), which affects one in every ten adults. The unmet medical need has created significant interest in regenerative therapeutic approaches. Described herein is a radically new and innovative therapeutic approach identified by characterizing a novel mechanism of renal tissue repair and its role in glomerular injury. By targeting this mechanism in CKD, significant therapeutic benefit supported by rapid cellular remodeling of kidney tissues, coincident with structural and functional nephron regeneration. Methods and compositions for achieving the described therapeutic approach are fundamentally different from existing strategies.
    Type: Application
    Filed: November 7, 2017
    Publication date: May 17, 2018
    Applicant: University of Southern California
    Inventor: Janos Peti-Peterdi
  • Publication number: 20180136019
    Abstract: Methods and systems for detecting a fault in a data set from an industrial process are disclosed. One method includes forming a first data matrix at a data processing framework from time-series training data, and performing a principal component pursuit on the first data matrix to form an uncorrupted, unscaled matrix and a sparse matrix in the memory, and scaling the uncorrupted, unscaled matrix to form an uncorrupted scaled matrix. The method also includes performing a dynamic principal component analysis (DPCA) on the uncorrupted scaled matrix to form a DPCA model, and determining a squared prediction error from the DPCA model. Based on the squared prediction error, faults are detected in a different data set from operation of the industrial process. At least one of (1) correcting the one or more faults in the different data set or (2) performing a repair operation on a sensor is performed.
    Type: Application
    Filed: November 13, 2017
    Publication date: May 17, 2018
    Applicants: Chevron U.S.A. Inc., University of Southern California
    Inventors: ALISHA DESHPANDE, SI-ZHAO J. QIN, LISA ANN BRENSKELLE
  • Patent number: 9968880
    Abstract: The invention relates to regenerative, solid sorbent for adsorbing carbon dioxide from a gas mixture, with the sorbent including a modified polyamine and a nano-structured solid support. The modified polyamine is the reaction product of an amine and an aldehyde. The sorbent provides structural integrity, as well as high selectivity and increased capacity for efficiently capturing carbon dioxide from gas mixtures, including the air. The sorbent is regenerative, and can be used through multiple operations of absorption-desorption cycles.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: May 15, 2018
    Assignee: University of Southern California
    Inventors: Alain Goeppert, Hang Zhang, G. K. Surya Prakash, George A. Olah