Patents Assigned to University of Southern California
  • Patent number: 10660932
    Abstract: Stem cell-based therapies can potentially reverse organ dysfunction and diseases but the removal of impaired tissue and reactivation of the program leading to organ regeneration pose major challenges. In mice, a four-day fasting mimicking diet (FMD) induces a step-wise expression of Sox17 and Pdx-1, resembling that observed during pancreatic development and followed by Ngn3-driven generation of insulin-producing ?-cells. FMD cycles restore insulin secretion and glucose homeostasis in both a type 2 and type 1 diabetes mouse models. In human type 1 diabetes pancreatic islets, fasting conditions reduce PKA and mTOR activity and induce Sox2 and Ngn3 expression and insulin production. The effects of the FMD are reversed by IGF-1 treatment and recapitulated by PKA and mTOR inhibition. These results indicate that a FMD promotes the reprogramming of pancreatic cells to restore insulin generation in islets from T1D patients and reverse both T1D and T2D phenotypes in mouse models.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: May 26, 2020
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Valter D. Longo, Roberta Buono
  • Patent number: 10656496
    Abstract: An optical device includes a row of optical units, each of the optical units comprising an antenna element and an associated phase shifting element, a first optical power splitter optically coupled to a first optical input/output element, and a first plurality of boundary adjustment elements. In the optical phased array, each of the first plurality of boundary adjustment units optically couples the first optical power splitter to different sub-rows of the row of optical units, and each of the plurality of boundary adjustment elements include a sub-row amplitude adjustment element and a sub-row phase adjustment element.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: May 19, 2020
    Assignee: University of Southern California
    Inventors: Hossein Hashemi, SungWon Chung, Hooman Abediasl
  • Patent number: 10654879
    Abstract: A compound having formula I that is useful for C?O reduction is provided: wherein: M is a transition metal; X1, X2 are each independently a counterion; and R1, R2, R3 are each independently H, C1-6 alkyl, C6-15 aryl, or C6-15 heteroaryl.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: May 19, 2020
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Sri Narayan, Travis J. Williams, Zhiyao Lu, Debanjan Mitra
  • Patent number: 10654785
    Abstract: Conversion of vegetable-derived triglycerides to fatty acid methyl esters (FAMEs) is a popular approach to the generation of biodiesel fuels and the basis of a growing industry. Drawbacks of the strategy are that (a) the glycerol backbone of the triglyceride is discarded as waste in this synthesis, and (2) many natural triglycerides are multiply-unsaturated or fully saturated, giving inferior performance and causing engine problems with long-term use. Here, we show that catalysis by iridium complex 1 can address both of these problems through selective reduction of triglycerides high in polyunsaturated fatty esters to FAMEs with high oleate concentration. This is realized using hydrogen imbedded in the triglyceride backbone, concurrently generating lactate as a value-added C3 product. Additional methanol or glycerol as a hydrogen source enables reduction of corn and soybean oils to >80% oleate.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: May 19, 2020
    Assignee: University of Southern California
    Inventors: Travis J. Williams, Zhiyao Lu, Valery Cherepakhin
  • Patent number: 10648959
    Abstract: The inventors experimentally demonstrated NO2 gas sensing performance of multilayer black phosphorous (BP) field effect transistors. The BP sensors were sensitive to NO2 concentration down to 5 ppb making them comparable in sensitivity to the best 2D material based sensors. Raman spectroscopy comparison revealed no apparent change in the spectra before and after exposure to NO2, which shows that thick BP flakes can maintain their relative stability after sensing. Moreover, the BP device sensing performance fitted well with the Langmuir Isotherm for molecules adsorbed on a surface, which confirms charge transfer as the dominant mechanism for sensing. The systematic increase in conductance with increasing NO2 concentrations suggests NO2 molecules withdraw electrons and dope BP flakes with holes. These results lay the ground work for BP to be applied to various sensing applications including chemical, gas, and bio-sensors.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: May 12, 2020
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Chongwu Zhou, Ahmad Abbas
  • Patent number: 10646598
    Abstract: Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula where A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC/targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: May 12, 2020
    Assignee: University of Southern California
    Inventors: Peter S. Conti, Hancheng Cai, Zibo Li, Shuanglong Liu
  • Patent number: 10646518
    Abstract: This disclosure relates to apoptotic bodies. The disclosure particularly relates to a composition comprising the apoptotic bodies. The disclosure further relates to preparation of apoptotic bodies from stem cells. The disclosure also relates to medical treatments comprising the use of the composition comprising the apoptotic bodies. The apoptotic bodies may comprise apoptotic stem cells. The apoptosis of a cell may be induced by a starvation method, an ultra-violet irradiation method, a thermal stress method, a staurosporine method, or a combination thereof.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: May 12, 2020
    Assignees: ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Songtao Shi, Dawei Liu, Cunye Qu
  • Publication number: 20200140921
    Abstract: Described herein is a method to create dendritic biocompatible polymers from pairs of complementary dendritic nucleic acid monomers in a controlled manner, using polymerization triggers. The dendritic monomers are constituted of nucleic acids and an organic polymer capable of self-assembly. Each polymer contains approximately 200 dendrites that can be used to attach labels and constitute a biologically compatible signal amplification technology. Depending on the context this technology could be used to reveal the presence of a large variety of analytes such as specific nucleic acid molecules, small molecules, proteins, and peptides.
    Type: Application
    Filed: February 28, 2018
    Publication date: May 7, 2020
    Applicant: University of Southern California
    Inventors: Scott E. Fraser, Simon Restrepo, Joseph P. Dunham
  • Patent number: 10641792
    Abstract: Some embodiments of the invention are directed to electrochemical fabrication methods for forming structures or devices (e.g. microprobes for use in die level testing of semiconductor devices) from a core material and a shell or coating material that partially coats the surface of the structure. Other embodiments are directed to electrochemical fabrication methods for producing structures or devices (e.g. microprobes) from a core material and a shell or coating material that completely coats the surface of each layer from which the probe is formed including interlayer regions. Additional embodiments of the invention are directed to electrochemical fabrication methods for forming structures or devices (e.g. microprobes) from a core material and a shell or coating material wherein the coating material is located around each layer of the structure without locating the coating material in inter-layer regions.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: May 5, 2020
    Assignee: University of Southern California
    Inventors: Ming Ting Wu, Rulon J. Larsen, III, Young Kim, Kieun Kim, Adam L. Cohen, Ananda H. Kumar, Michael S. Lockard, Dennis R. Smalley
  • Patent number: 10631564
    Abstract: This disclosure provides a microencapsulated capsule or microparticle comprising a nutrient-filled core encapsulated in an enteric coating. The microparticles are useful in the treatment of a variety of disorders when ingested or administered to a subject in need thereof. Alternate non-encapsulated methods and compositions for providing the desired intestinal release are provided included modified nutrient composition and matrix embedded nutrient.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: April 28, 2020
    Assignee: University of Southern California
    Inventors: Elizabeth Demetriades, Travis Williams
  • Patent number: 10634973
    Abstract: An optical device includes an array of unit optical elements. Each of the unit optical elements includes a plurality of amplitude adjustment (AA) elements, each of the plurality of AA elements configured for processing one of different phases of an optical signal; an optical antenna, and a combining mechanism for optically coupling the plurality of AA elements to the optical antenna. The optical device also includes a controller coupled to the plurality of AA elements, the controller configured for generating control signals for the plurality of AA elements according to a target optical beam pattern.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: April 28, 2020
    Assignee: University of Southern California
    Inventors: Hossein Hashemi, SungWon Chung, Hooman Abediasl
  • Publication number: 20200124717
    Abstract: A method may include receiving radar data from a plurality of TX-RX pairs (TRPs); generating a plurality of first ellipses representing a first portion of the received radar data; determining a blocking likelihood at a point of intersection between the plurality of first ellipses; generating a new or additional ellipse representing a second portion of the received radar data; and updating, based on generating the new or additional ellipse, the blocking likelihood at the point of intersection between the first plurality of ellipses.
    Type: Application
    Filed: October 18, 2018
    Publication date: April 23, 2020
    Applicant: University of Southern California
    Inventors: Hatim M. Behairy, Sundar Aditya, Andreas F. Molisch
  • Patent number: 10626511
    Abstract: In various embodiments, the invention teaches a method for water splitting with much higher efficiency than previous methods. By decreasing the distance between two electrodes to nanometer scale, even shorter than the electric field screening length, the external power required for water splitting is significantly reduced.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: April 21, 2020
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Wei Wu, Yifei Wang
  • Patent number: 10623902
    Abstract: A method for localizing a mobile device in a physical space based on radio signals received from transmitters in the physical space includes a step of transforming a received signal strength vector to produce a transformed received signal strength vector. Sequence based localization is performed on the transformed RSS vector with a different ideal sequence centroid table.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: April 14, 2020
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Suvil Singh Deora, Bhaskar Krishnamachari
  • Patent number: 10622785
    Abstract: A vertical cavity surface emitting laser (VCSEL) composite assembly includes a VCSEL, a substrate spaced from the VCSEL, and at least one metal layer disposed between the VCSEL and the substrate to facilitate efficient thermal management of the assembly.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: April 14, 2020
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Jongseung Yoon, Dongseok Kang
  • Patent number: 10610685
    Abstract: Methods, systems, and apparatus for electrically stimulating a smooth muscle. The method includes generating a continuous pulse train signal having pulses and pulse intervals between the pulses, the pulses and the pulse intervals being generated at a pulse frequency. The method also includes modulating the continuous pulse train signal at a modulation frequency to match dynamics of intracellular calcium ion oscillations in the smooth muscle. The method also includes entraining a group of cells of the smooth muscle by applying the modulated continuous pulse train signal to the group of cells of the smooth muscle to increase an oscillation frequency of the calcium ion oscillations.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: April 7, 2020
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventor: Stan Yamashiro
  • Patent number: 10615949
    Abstract: A multi-port hybrid-based cancellation network may include a first and second hybrid coupler, and a first and second two-port network. The second hybrid coupler may be distinct from the first hybrid coupler. The first two-port network may include a first filter connected between the first and the second hybrid couplers. The second two-port network may include a second filter that is distinct from but essentially the same as the first filter connected between the first and the second hybrid couplers. Other circuitry components may be connected to one of the ports of multi-port hybrid-based cancellation network. These other circuitry components may have a configuration that increases or maximizes signal isolation between at least two of the ports of the multi-port hybrid-based cancellation network.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: April 7, 2020
    Assignee: University of Southern California
    Inventors: Ankush Goel, Behnam Analui, Hossein Hashemi
  • Publication number: 20200106815
    Abstract: Aspects of the subject disclosure may include, for example, allocating, by a processing system including a processor, a first subset of resources to a first plurality of applications and a second subset of the resources to a second plurality of applications, wherein the allocating is based on respective statuses associated with the first plurality of applications and the second plurality of applications, and assigning, by the processing system, a respective bitrate to each application of the first plurality of applications, wherein the assigning of the respective bitrate to each application of the first plurality of applications is based on: a first threshold associated with a re-buffering of content, and a second threshold associated with the statuses. Other embodiments are disclosed.
    Type: Application
    Filed: October 1, 2018
    Publication date: April 2, 2020
    Applicants: AT&T Intellectual Property I, L.P., University of Southern California
    Inventors: Jia Wang, Nemmara Shankaranarayanan, Ajay Mahimkar, Xing Xu, Ramesh Govindan
  • Patent number: 10604771
    Abstract: Disclosed herein are methods and compositions for delivery of engineered nucleases and donor molecules into the genome of a cell.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: March 31, 2020
    Assignees: Sangamo Therapeutics, Inc., University of Southern California
    Inventors: Paula M. Cannon, Colin Michael Exline, Michael C. Holmes
  • Patent number: 10595530
    Abstract: Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more HMG-box domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: March 24, 2020
    Assignees: Nationwide Children's Hospital, Inc., University of Southern California
    Inventors: Steven D. Goodman, Lauren O. Bakaletz