Patents Assigned to University of Southern California
  • Patent number: 10098913
    Abstract: This disclosure relates in general to a stem cell treatment. This disclosure further relates to a stem cell treatment using a composition comprising stem cells having highly expressed Fas-L. This disclosure further relates to a stem cell treatment of multiple myeloma. This disclosure also relates to a composition comprising stem cells having highly expressed Fas-L. This disclosure also relates to preparation of a composition comprising stem cell having highly expressed Fas-L. This disclosure also relates to preparation of a composition comprising stem cells having highly expressed Fas-L by using a salicylate. An example of salicylate may be aspirin. This disclosure further relates to a stem cell treatment of multiple myeloma. This disclosure also relates to a stem cell treatment of an inflammatory disease and/or autoimmune disease.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: October 16, 2018
    Assignee: University Of Southern California
    Inventors: Songtao Shi, Shiyu Liu, Fa-ming Chen
  • Patent number: 10099644
    Abstract: A facial image capture system may capture images of a face of a person while the person is moving. A video camera may capture sequential images of a scene to which the video camera is directed. A marker-based location detection system may determine and generate information about the location of a marker worn on or close to the face of the person. A camera control system may automatically adjusts both the horizontal and vertical direction to which the video camera is directed so as to cause the sequential images of the camera to each be of the face of the person while the person is moving, based on the information about the location of the marker from the marker-based location detection system.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: October 16, 2018
    Assignee: University of Southern California
    Inventors: Paul E. Debevec, Mark Bolas, Graham L. Fyffe
  • Patent number: 10098790
    Abstract: This disclosure relates generally to adhesive articles and particularly to adhesive articles comprising a reversible adhesive layer and a non-reversible adhesive layer. The adhesive article may further comprise a backing material. The adhesive article may further comprise a dressing material. Such adhesive articles may be particularly suitable for treatment of damaged sensitive tissue, for example wounds formed on a fragile skin.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: October 16, 2018
    Assignee: University of Southern California
    Inventors: Cesar Blanco, Jonathan Gregory Lasch
  • Patent number: 10098333
    Abstract: This invention discloses a stem cell modified animal model useful as a research tool for investigating aging-related degeneration processes and treatments. The animal model is preferably a rodent subcutaneously transplanted with a mesenchymal stem cell capable of generating a functional bone or marrow element. Also provided are a method for extending the lifespan and improving the quality of life of a subject by subcutaneously transplanting a plurality of mesenchymal stem cells to the subject, wherein the mesenchymal stem cells are capable of generating a functional bone or marrow element. Compositions and source of stem cells suitable for use with the methods of this invention, including stem cells from human exfoliated deciduous teeth (SHED), are also disclosed. Further disclosed is a method for identifying progenitor bone marrow mesenchymal stem cells, and a method for treating SLE-like autoimmune diseases by infusion of mesenchymal stem cells.
    Type: Grant
    Filed: December 9, 2009
    Date of Patent: October 16, 2018
    Assignee: University Of Southern California
    Inventors: Songtao Shi, Takayoshi Yamaza, Kentaro Akiyama
  • Patent number: 10092568
    Abstract: Provided are: methods for treating aging or an age-related condition, symptom or disease; methods for stimulating hair growth, regrowth or pigmentation (or preventing hair loss); methods for increasing the expression of an adenosine receptor in dermal cells (in combination with hair growth); methods for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrance). The methods comprise administering a sufficient amount of a CBP/catenin (e.g., CBP/?-catenin) antagonist as disclosed, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: October 9, 2018
    Assignee: University of Southern California
    Inventors: Michael Kahn, Jia-Ling Teo, Michael McMillan, Yi Zhao, Yongfeng Wu
  • Publication number: 20180282397
    Abstract: The invention provides for polypeptides that bind to Ras proteins and methods of using the same, as described herein. For example, the disclosure provides an isolated polypeptide comprising a fibronectin domain, and a first peptide domain at least 90% identical to an amino acid sequence selected from a group consisting of (SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, and SEQ ID NO: 10), and a second peptide domain at least 90% identical to an amino acid sequence selected from a group consisting of (SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, and SEQ ID NO: 15) that specifically binds to an activated Ras protein.
    Type: Application
    Filed: December 15, 2017
    Publication date: October 4, 2018
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mehmet CETIN, Garrett Gross, Richard Roberts
  • Patent number: 10076242
    Abstract: Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment epithelial detachments (PEDs) based on characteristics of their internal reflectivity, size and shape. The classification can be based on selected subsets of the data located within or surrounding the abnormalities. Training data can be used to generate the classification scheme and the classification can be weighted to highlight specific classes of particular clinical interest.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: September 18, 2018
    Assignees: DOHENY EYE INSTITUTE, UNIVERSITY OF SOUTHERN CALIFORNIA, CARL ZEISS MEDITEC, INC.
    Inventors: SriniVas R. Sadda, Paul F. Stetson
  • Patent number: 10074820
    Abstract: The present disclosure relates to a photosensitive optoelectronic device comprising two electrodes, an inorganic subcell positioned between the two electrodes, wherein the inorganic subcell comprises at least one inorganic semiconductor material having a band gap energy (EG), and an organic sensitizing window layer disposed on the inorganic subcell. In one aspect, the organic sensitizing window layer comprises a singlet fission material. In another aspect, the organic sensitizing window layer comprises a singlet fission host and a phosphorescent emitter dopant, where the singlet fission host exhibits an excitation triplet energy (ET-SF) greater than or equal to an excitation triplet energy (ET-PE) exhibited by the phosphorescent emitter dopant.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: September 11, 2018
    Assignees: University of Southern California, The Regents of the University of Michigan
    Inventors: Stephen R. Forrest, Mark E. Thompson
  • Patent number: 10066413
    Abstract: A robot may extrude a tower or column. The robot may include an extrusion nozzle, a positioning system, a climbing apparatus, and a controller. The extrusion nozzle may controllably extrude uncured construction material. The positioning system may controllably cause the extrusion nozzle to traverse a perimeter layer of the tower or column. A climbing apparatus may controllably cause the robot to climb. A controller may autonomously: direct the positioning system to cause the nozzle to traverse the perimeter layer of the tower or column; direct the nozzle to extrude uncured construction material during the traverse; direct the climbing apparatus to cause the robot to climb an incremental amount; and repeat each of the foregoing positioning, extrusion, and climbing steps until the extruded tower or column attains a desired height.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: September 4, 2018
    Assignee: University of Southern California
    Inventor: Behrokh Khoshnevis
  • Patent number: 10069095
    Abstract: Disclosed herein are organic photosensitive devices including at least one exciton-blocking charge carrier filter. The filters comprise a mixture of at least one wide energy gap material and at least one electron or hole conducting material. As described herein, the novel filters simultaneously block excitons and conduct the desired charge carrier (electrons or holes).
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: September 4, 2018
    Assignees: University of Southern California, The Regents of the University of Michigan
    Inventors: Stephen R. Forrest, Xin Xiao, Jeramy D. Zimmerman, Kevin Bergemann, Anurag Panda, Brian E. Lassiter, Mark E. Thompson, Andrew N. Bartynski, Cong Trinh
  • Patent number: 10063831
    Abstract: A method for stereo image rectification includes receiving a plurality of images and determining a matrix for performing rectification on the plurality of images based on a first cost function and a second cost function. The first cost function may be associated with a distance of a corresponding pair of points from among the plurality of images. The second cost function may be associated with distortion in a converted image.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: August 28, 2018
    Assignees: Samsung Electronics Co., Ltd., University of Southern California
    Inventors: Ouk Choi, Hyunsuk Ko, C. C. Jay Kuo, Han Suk Shim
  • Patent number: 10052621
    Abstract: A formic acid decomposition catalyst system includes metal-ligand complexes having formula 1: wherein M is a transition metal; R1, R2 are independently C1-6 alkyl groups; o is 1, 2, 3, or 4; R3 are independently hydrogen, C1-6 alkyl groups, OR14, NO2, or halogen; R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, are independently hydrogen or C1-6 alkyl groups; R14 is a C1-6 alkyl group; and X? is a negatively charge counter ion.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: August 21, 2018
    Assignee: University of Southern California
    Inventors: Travis J. Williams, Jeff Joseph A. Celaje, Zhiyao Lu
  • Patent number: 10047058
    Abstract: A compound of Formula II, is provided. R1, R2 and R3 are independently either hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino or hydroxyl. X is either F, Cl, Br, I or CN. Y is either N or CH. Compositions that include Formula II can be used to inhibit vacuolar H+ ATPase.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 14, 2018
    Assignee: University of Southern California
    Inventors: Chao Zhang, Ying-Chu Chen
  • Patent number: 10031348
    Abstract: A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: July 24, 2018
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Nicholas E. Scianmarello, Charles M. T. DeBoer, Mark S. Humayun
  • Patent number: 10029000
    Abstract: Methods for enhancing or stimulating hematopoiesis including the step of administering Interleukin-12 (IL-12) to yield hematopoietic recovery in a mammal in need. Preferred methods include the step of administering IL-12 as an adjuvant therapy to alleviate the hematopoietic toxicities associated with one or more treatment regimens used to combat a disease state. Other methods include administering IL-12 to ameliorate various hematopoietic deficiencies. Still other methods are directed to uses of IL-12 for in-vivo proliferation of hematopoietic repopulating cells, hematopoietic progenitor cells and hematopoietic stem cells. Other disclosed methods are directed to uses of Il-12 for bone marrow preservation or recovery.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: July 24, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Tingchao Chen, Yi Zhao, W. French Anderson
  • Patent number: 10022097
    Abstract: A medical imaging system for reconstructing quantitative dynamic nuclear medicine images of a subject may include a three dimensional positron emission tomography (3D PET) scanner and a data processing system. The three dimensional positron emission tomography (3D PET) scanner may: perform scans of the subject at each of multiple bed positions, each scan being of only a sub-portion of the subject that is within an axial length covered by the scanner; and generate dynamic list-mode PET data that: represents a total number of photon pairs arriving at each of multiple detector pairs in the 3D PET scanner; and is organized in a list of elements, each element in the list including a detector pair index and an arrival time for each detected photon pair; and acquires PET data using a dynamic PET protocol with at least two scans at each of the multiple bed positions.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: July 17, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Richard M. Leahy, Wentao Zhu, Quanzheng Li, Bing Bai, Peter Stephen Conti
  • Patent number: 10015980
    Abstract: A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet. The first diet includes less than 30 g of sugar on the first day; less than 20 g of sugar on the second to fifth days; less than 28 g of proteins on the first day; less than 18 g of proteins on days the second to fifth days; 20 to 30 grams of monounsaturated fats on the first day; 10 to 15 grams of monounsaturated fats on the second to fifth days; and between 6 and 10 grams of polyunsaturated fats on the first day.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: July 10, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Valter D. Longo, Chia-Wei Cheng, Sebastian Brandhorst, Min Wei
  • Patent number: 10019516
    Abstract: A computer implemented method of matching ontologies is disclosed. The method includes, for each pair of entities of a first ontology and a second ontology, wherein each pair of entities includes a first entity from a first plurality of entities of the first ontology and a second entity from a second plurality of entities of the second ontology, and wherein the first entity and the second entity of each pair of entities is of a same data type: (1) determining a vector of similarities for the pair of entities; (2) determining a confidence score for the vector of similarities; (3) determining a relation score for each relation type based on the vector of similarities to measure relatedness between the first entity of the pair of entities and the second entity of the pair of entities; and (4) generating a mapping ontology based on the relation type, the relation score, and the confidence score of each pair of entities.
    Type: Grant
    Filed: April 4, 2015
    Date of Patent: July 10, 2018
    Assignees: University of Southern California, Chevron U.S.A. Inc.
    Inventors: Yinuo Zhang, Anand V. Panangadan, Randall G. McKee, Mauritz Theron, Benjamin D. Gamble, Viktor K. Prasanna
  • Publication number: 20180185303
    Abstract: A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer cells. Novel MAOs inhibitors, such as small molecules, siRNA, shRNA, antisense oligonucleotides, aptamers, decoys, and pharmaceutical compositions useful for treating cancer by disrupting the workings of MAOs are provided. In particular, a class of conjugates formed by covalently conjugating near infrared dye 783, IR-780, and MHI-148 to a MAO inhibitor, such as clorgyline, with and without encapsulation it in a nanoparticle is provided. Other aspects of the invention include methods for forming the nano-conjugates, method for monitoring treatment progress in a cancer patient by monitoring the changes in MAO activity, methods for screening patients who are at risk of cancer or differentiating different forms of cancer by assaying the level and location of MAO activity.
    Type: Application
    Filed: August 28, 2017
    Publication date: July 5, 2018
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Jean C. SHIH, Leland CHUNG, Haiyen E. ZHAU, Boyang Jason WU, Bogdan Z. OLENYUK
  • Patent number: 10009038
    Abstract: An analog-to-digital converter may convert an analog signal into digital codes representative of the changing level of the analog signal. An analog high pass filter may receive and continuously differentiate the analog signal. A voltage controlled oscillator may receive the differentiated analog signal and continuously generates an output that is an integral of the differentiated analog signal in the phase domain. A time-to-digital converter may sample the output of the voltage controlled oscillator and convert each sample into a digital code representative of the current phase of the sampled output of the voltage controlled oscillator.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: June 26, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventor: Shuo-Wei Chen