Patents Assigned to University of Southern California
  • Patent number: 10261168
    Abstract: The present disclosure generally relates to localization and, more particularly, to remote localization and radio-frequency identification using a combination of structural and antenna mode scattering responses. A method and system include receiving location data of an object from a plurality of transmitter-reader pairs (TRPs); generating a plurality of first ellipses representing the received location data; determining blocking likelihoods at points of intersection between the plurality of first ellipses; generating additional ellipses representing additional location data received from additional TRPs; and updating the blocking likelihoods at points of intersection between the plurality of first ellipses and the additional ellipses.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: April 16, 2019
    Assignees: KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Sundar Aditya, Hatim M. Behairy, Andreas F. Molisch
  • Patent number: 10260045
    Abstract: This invention provides methods of inducing and maintaining osteogenic potential in mesenchymal stem cells and compositions for doing the same. The compositions this invention comprise collagen 7 (C7), the NC1 domain of C7, or the 27 kD fragment of C7. Also provided are methods for treating bone diseases and correcting bone defects by applying compositions of this invention or by first priming ex vivo mesenchymal stem cells with compositions of this invention and then applying the primed mesenchymal stem cells to the patient. The invention further provides a mesenchymal stem cell osteogenesis induction kit.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: April 16, 2019
    Assignee: University of Southern California
    Inventors: Mei Chen, David Woodley
  • Patent number: 10256421
    Abstract: A compound that can be used as a donor material in organic photovoltaic devices comprising a non-activated porphyrin fused with one or more non-activated polycyclic aromatic rings or one or more non-activated heterocyclic rings can be obtained by a thermal fusion process. The compounds include those having the following structure By heating the reaction mixture of non-activated porphyrins with non-activated polycyclic aromatic rings or heterocyclic rings to a fusion temperature and holding for a predetermined time, fusion of one or more polycyclic rings or heterocyclic rings to the non-activated porphyrin core in meso,? fashion is achieved resulting in hybrid structures containing a distorted porphyrin ring with annulated aromatic rings. The porphyrin core can be olygoporphyrins.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: April 9, 2019
    Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Mark E. Thompson, Viacheslav Diev, Kenneth Hanson, Stephen R. Forrest
  • Publication number: 20190101539
    Abstract: A method of identifying subjects with colorectal cancer (CRC) is provided. The method includes obtaining a sample from a subject, determining a level of one or more folate one carbon metabolism (FOCM) metabolites in the sample of the subject, and comparing the level of the FOCM metabolites in the sample of the subject to a level in a non CRC control.
    Type: Application
    Filed: January 22, 2016
    Publication date: April 4, 2019
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: David CONTI, Fredrick SCHUMACHER, Stan LOUIE, Isaac ASANTE
  • Patent number: 10246446
    Abstract: Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human GH, GHR, STAT5, SOCS, IGF-1, insulin are provided. Monoclonal antibodies for treating diseases or conditions related to growth hormone and growth hormone receptor activity are also provided.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: April 2, 2019
    Assignee: University of Southern California
    Inventors: Valter D. Longo, Priya Balasubramanian, Nouri Neamati, Min Wei
  • Patent number: 10249834
    Abstract: An organic light emitting device having an anode, a cathode and an organic layer disposed between the anode and the cathode is provided.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: April 2, 2019
    Assignees: The University of Southern California, Universal Display Corporation
    Inventors: Peter Djurovich, Jui-Yi Tsai, Chun Lin, Jason Brooks, Bert Alleyne, Mark E. Thompson, Peter B. MacKenzie, Bin Ma
  • Patent number: 10247719
    Abstract: Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging of cell-seeded substrates implanted in target tissues in the context of stem cell therapy.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: April 2, 2019
    Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, DOHENY EYE INSTITUTE
    Inventors: Mark Humayun, Ashish Ahuja, Charles Le Pere
  • Patent number: 10241173
    Abstract: Systems and methods for acquiring magnetic resonance fingerprinting (MRF) imaging data from a subject using a magnetic resonance imaging (MRI) system are provided. The method includes receiving an indication of an MRF imaging process to be performed by the MRI system and receiving a desired design objective for the MRF imaging process and a configuration metric associated with the MRF imaging process. The method further includes using the configuration metric to bound a variance of tissue parameter estimates associated with the MRF imaging process and determine imaging parameters that achieve the desired design objective. The method also includes performing the MRF imaging process using the determined imaging parameters to acquire MRF data using the MRI system.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: March 26, 2019
    Assignees: The General Hospital Corporation, The University of Southern California
    Inventors: Bo Zhao, Justin P. Haldar, Lawrence Wald
  • Patent number: 10232080
    Abstract: A method for reconstructing a functional tooth by using a carrier loaded with a plurality of mesenchymal stem cells including at least one of a stem cell derived from Apical Papilla (SCAP), Periodontal Ligament Stem Cells (PDLSC), and Dental Pulp Stem Cells (DPSC). The mesenchymal stem cell loaded carrier is planted into a site within a subject's oral cavity to form a bio-root upon which a crown may be affixed, The mesenchymal stem cells will develop new periodontal tissues to stabilize the bio-root. Methods disclosed herein are particularly beneficial for subjects lacking good bone structures for conventional crown treatments.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: March 19, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Songtao Shi, Wataru Sonoyama, Takayoshi Yamaza, Songlin Wang
  • Patent number: 10227326
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: March 12, 2019
    Assignee: University of Southern California
    Inventors: Robert D. Ladner, Bruno Giethlen
  • Patent number: 10227394
    Abstract: Disclosed are compositions and methods for accelerating wound closure and preventing inhibiting or reducing scarring or fibrosis. The methods of the present invention include administering to a person in need thereof an effective amount of a pharmaceutical composition comprising collagen 7 and/or one or more functional fragments or variants thereof. The functional fragments generally comprise at least one of the nine Fibronectin Type III-like Region of the NC1 region of collagen 7.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: March 12, 2019
    Assignee: University of Southern California
    Inventors: Mei Chen, David T. Woodley
  • Patent number: 10226312
    Abstract: An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: March 12, 2019
    Assignee: University of Southern California
    Inventors: Behrokh Khoshnevis, Hongsheng Tong, Yong Chen, Philong John Pham, Robert Lee
  • Patent number: 10219877
    Abstract: An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: March 5, 2019
    Assignee: University of Southern California
    Inventors: Behrokh Khoshnevis, Hongsheng Tong, Yong Chen, Philong John Pham, Robert Lee
  • Patent number: 10215775
    Abstract: Some embodiments of the invention are directed to electrochemical fabrication methods for forming structures or devices (e.g. microprobes for use in die level testing of semiconductor devices) from a core material and a shell or coating material that partially coats the surface of the structure. Other embodiments are directed to electrochemical fabrication methods for producing structures or devices (e.g. microprobes) from a core material and a shell or coating material that completely coats the surface of each layer from which the probe is formed including interlayer regions. Additional embodiments of the invention are directed to electrochemical fabrication methods for forming structures or devices (e.g. microprobes) from a core material and a shell or coating material wherein the coating material is located around each layer of the structure without locating the coating material in inter-layer regions.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: February 26, 2019
    Assignee: University of Southern California
    Inventors: Ming Ting Wu, Rulon J. Larsen, III, Young Kim, Kieun Kim, Adam L. Cohen, Ananda H. Kumar, Michael S. Lockard, Dennis R. Smalley
  • Publication number: 20190048334
    Abstract: The disclosure provides for single amplification and double amplification methods for preparing nucleic acid samples for sequencing.
    Type: Application
    Filed: June 12, 2018
    Publication date: February 14, 2019
    Applicants: University of Southern California, SeqOnce Biosciences Inc.
    Inventor: Joseph Dunham
  • Patent number: 10203392
    Abstract: A magnetic resonance imaging system may include: a magnet; gradient coils; an RF pulse transmitter; an RF receiver that receives MR signals from tissue that has been exposed to RF pulses from the RF pulse generator, gradient fields from the gradient coils, and a magnetic field from the magnet; a system controller that controls the magnet, gradient coils, RF pulse transmitter, and RF receiver so as to generate data representative of at least a portion of the composition of an object, including controlling the gradient coils and RF receiver so as to cause MRI data to be acquired that includes information about at least one attribute of the object at different points in time and that represents an incomplete sample of a portion of k-space that is a Fourier transform of the object; and a data processing system that generates one or more images of at least a portion of the object based on the MRI data.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: February 12, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Yinghua Zhu, Yi Guo, Krishna S. Nayak, Robert Marc Lebel
  • Patent number: 10202327
    Abstract: A catalyst system includes a complex having formula I which advantageously has a sterically protecting N-heterocyclic carbene (NHC) carbene-pyridine ligand to handle harsh reactions conditions than many prior art catalysts: wherein M is a transition metal; o is 0, 1, 2, 3, or 4; R1 is a C1-6 alkyl, a C6-18 aryl, or an optionally substituted C5-18 heteroaryl. In a refinement, R1 is methyl, ethyl, butyl, n-propyl, isopropyl, n-butyl, sec-butyl, or t-butyl; R2, R3, R3? are independently an optionally substituted C1-6 alkyl, halo (e.g., Cl, F, Br, etc), NO2, an optionally substituted C6-18 aryl, or an optionally substituted C5-18 heteroaryl; R4, R4? are independently an optionally substituted C1-6 alkyl, halo, NO2, an optionally substituted C6-18 aryl, or an optionally substituted C5-18 heteroaryl; and X? is a negatively charge counter ion and L1, L2 are each independently a neutral ligand.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: February 12, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Travis J. Williams, Zhiyao Lu, Ivan Demianets
  • Patent number: 10199582
    Abstract: A compound comprising a ligand LA according to formula (I) as well as, a first device and a formulation including the same are disclosed. In the structure of formula (I): ring A is a 5- or 6-membered heteroaryl ring; X1 is C or N; RA is mono-, bi-, tri-, tetradentate, or unsubstituted; RA, R10, R11, R12, R13, R14, R15, R16, and R17 are independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof, any adjacent substituents of RA, R10, R11, R12, R13, R14, R15, R16, and R17 are optionally joined to form a fused ring; the dashed lines represent bonds to a metal M; and metal M has an atomic number greater than 40.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: February 5, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mark E. Thompson, John W. Facendola, Peter I. Djurovich
  • Patent number: 10195282
    Abstract: Described herein are compositions of alginate formulations that include water, divalent ions, and alginate cross-linked by the divalent ions, and their use for treating incisional wounds, such as intra-incisional application.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: February 5, 2019
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Kevin J. Gaffney, Gere S. Dizerega
  • Patent number: 10196435
    Abstract: Provided is an isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide fragment or a biological equivalent thereof and compositions comprising: an isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide fragment; and a pharmaceutically acceptable carrier. Also provided are methods for treating or ameliorating the symptoms of cancer in a canine comprising administering an effective amount of the isolated recombinant polypeptide of the disclosure and/or a composition of the disclosure to a canine in need thereof.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: February 5, 2019
    Assignee: University of Southern California
    Inventors: Alan L. Epstein, Peisheng Hu