Abstract: A system for identification of a biological structure present in a liquid biopsy sample is provided. The system identifies common biological structures and rare biological structures based on their fluorescence characteristics and morphology. The identified biological structures may be used in diagnosis and treatment of a human afflicted with a disease. Examples described in this disclosure also relate to methods and assays that may be used together with the systems of this disclosure for diagnosis and treatment of a human afflicted with a disease.

Abstract: An optimized protein-free tripartite vaccine that protects against lethal blood and lung infections caused by a variety of nosocomial pathogens across taxonomic kingdoms, including Gram-positive bacteria, Gram-negative bacteria, and fungi.

Abstract: The invention relates to antiviral compounds, compositions comprising antiviral compounds, and methods of use. In particular, the antiviral compounds are cytidine triphosphate synthetase 1 (CTPS1) inhibitors that are effective in treating and/or preventing viral infection and in particular, SARS-CoV-2 infection and/or COVID-19 disease.

Abstract: Given developing resistance of tumor cells to current chemotherapeutic and targeted therapeutic agents, novel cancer therapies with enhanced potency and specificity are substantially required. Applicant has provided herein extracellular nanoparticle vesicles that redirect immune effector cells towards cancer cells for killing. Relative to conventional immunotherapeutic antibodies with defined orientation and geometry for their distinct antigen-binding arms, antibodies displayed on spherical exosomes can promote formation of immunological synapses as well as enhanced efficacy to activate immune cells.

Abstract: A method of aerobic depolymerization of fiber-reinforced polymer (FRP) composites using sustainable reagents and conditions. A cured matrix is digested into soluble monomers and oligomers by catalytic aerobic oxidation. Carbon fibers are removed for re-use, then the remaining material is treated and valuable monomers are isolated. The isolated monomers can be converted back into resin precursors for re-use. The method solves the problem created because the typically irreversible cure reaction impedes recycling and re-use of FRP composites.

Abstract: A redirecting rotating mirror arrangement includes a directional antenna subcomponent having a direction of maximum received or transmitted beam intensity. The redirecting rotating mirror arrangement also includes a rotatable mirror that reflects an electromagnetic beam to or from the directional antenna subcomponent. The rotatable mirror is inclined at an inclination angle with respect to a horizontal plane. The arrangement also includes a motor that rotates the rotatable mirror about the direction of maximum received or transmitted beam intensity such that the electromagnetic beam is either received from or transmitted to a range of angles as the rotatable mirror rotates.

Abstract: Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

Abstract: A method of making an ink for use in additive manufacturing of a self-healing product includes providing a thiol material. The method further includes oxidizing the thiol material to form a thiol-disulfide oligomer. The method further includes applying an alkene material to the thiol-disulfide oligomer to allow a thiol-ene reaction and form a self-healing ink embedded with a disulfide bond.

Abstract: Methods, systems, and robots for multi-layer prepreg composite sheet layup. The robotic system may include a memory for storing a dataset including start and end point pairs of a mold of a 3D part that defines a layup sequence, a first robot or a first robot arm that is configured to conform a prepreg layer or sheet onto the mold of the 3D part, and a second robot or a second robot arm that is configured to hold or grasp the prepreg layer or sheet above the mold of the 3D part and stretch or relax the prepreg layer or sheet when the first robot or the first robot arm conforms the prepreg layer or sheet onto the mold. The robotic system may also include one or more processors connected to the first robot or the first robot arm and the second robot or the second robot arm.

Abstract: In various embodiments of the present disclosure, an oxygen-generating bioelectrical reactor comprises two chambers, a first oxidative chamber configured for the abiotic oxidation of water to generate molecular oxygen, and a second reductive chamber configured for the biotic reduction of an insoluble metal(loid) oxide or hydroxide. In various embodiments, the biotic reduction comprises microbially-catalyzed metal(loid) ion reduction of the insoluble metal(loid) oxide or hydroxide, wherein a dissimilatory metal(loid) reducing microorganism transfers electrons obtained from the oxidation of the water extracellularly to the metal(loid) ions.

Abstract: A method assessing tissue morphology using machine learning includes a step of training a machine learnable device to predict the status of a diagnostic feature in stained tissue samples. The machine learnable device is trained with a characterized set of digital images of stained tissue samples. Each digital image of the characterized set has a known status for the diagnostic feature and an extracted feature map provides values for a extracted feature over an associated 2-dimensional grid of spatial locations. A step of inputting the set of extracted feature maps is inputted into the machine learnable device to form associations therein between the set of extracted feature maps to and the known status for the diagnostic feature to form a trained machine learnable device. The status for the diagnostic feature of a stained tissue sample of unknown status for the diagnostic feature is predicted from the trained machine learnable device.

Abstract: Systems and methods for mapping brain perivascular spaces. A system may include a memory to store one or more images of a brain of a patient. The system may further include a processor coupled to the memory. The processor may be configured to obtain a first and a second image of the brain. The processor may be further configured to combine the first image and the second image to preserve and magnify structures including the brain perivascular spaces within the image of the brain. The processor may be further configured to determine the brain perivascular spaces within the combined image of the brain of the patient. The processor may be further configured to generate a three-dimensional (3-D) map of the perivascular spaces. The system may further include a display configured to display the perivascular spaces to an operator.

Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.

Abstract: This invention relates to alkali metal (Li, Na, K) ion batteries, electrodes for alkali metal ion batteries, and methods for manufacturing electrodes for alkali metal ion batteries.

Abstract: Systems and methods of image reconstruction are provided. A system may have a memory and a processor to receive data corresponding to magnetic resonance imaging coils and data corresponding to a region of interest within a field of view of the magnetic resonance imaging machine. By determining different weights to associate with virtualized magnetic resonance imaging coils, images may be reconstructed to favor signals associated with a region of interest and to disfavor interference associated with areas outside the region of interest.

Abstract: A method for detecting and/or localizing keyboard accessibility failures (KAFs) in a web page is disclosed. A web page is rendered in a browser on a display portion of a computing system. A keyboard navigation flow graph based on based on keyboard-based navigation of a user with the web page. A second point-click navigation flow graph based on mouse-based navigation of the user with the web page. One or more KAFs are determined based on a comparison of the first graphical model with the second graphical model.

Abstract: Methods, systems, and apparatus for treating wastewater and generating electricity. The system includes layers of sediment containing microorganisms for treating the wastewater. The system includes layers of granular activated carbon or granular activated carbon with graphene oxide or sand with graphene oxide disposed on top of the sediment layers for enhancing electron transfer, current generation rate, and wastewater treatment. The system also includes one or more anodes and one or more cathodes located on top of the layers of granular activated carbon or granular activated carbon with graphene oxide or sand with graphene oxide. The one or more anodes and the one or more cathodes are configured to generate electrical voltage. The system also includes a battery connected to the one or more anodes and the one or more cathodes and configured to store the electrical voltage generated by the one or more anodes and the one or more cathodes.

Abstract: Disclosed herein are recombinant proteins and/or polypeptides comprising a Beclin 2 polypeptide and/or a targeting moiety and methods relating to treating, preventing, reducing, and/or inhibiting a cancer, metastasis, and/or a neurodegenerative disease comprising administering said recombinant protein or polypeptides.

Abstract: Described herein is a novel, mitochondrial encoded, open reading frame, that leads to the production of a new mitochondrial peptide. Residing within the ND-Two subunit, a specific small nucleotide polymorphism disrupts expression of this mitochondrial peptide, and is correlated with an increase in obesity and diabetes, particularly in certain ethnic populations. In vitro administration of the peptide increases insulin secretion, decreases fat accumulation and improves glucose uptake in muscle cell. Antibodies generated against the peptide can be used for detecting peptide deficiency, in addition to SNP detection, supporting diagnostic approaches. In vivo studies further revealed that administration of the peptide improves glucose tolerance, thereby providing a new therapeutic avenue for a novel diabetes therapy and decreases bodyweight, thus serving as a novel obesity therapy. Generation of synthetic analogs further enhance or abrogated activity relative to the natural peptide.

Abstract: A method for processing a surface, comprising obtaining a substrate comprising an epitaxially grown semiconductor; reacting a surface of the semiconductor and/or a surface of a dielectric layer on the semiconductor, with a reactant comprising a gas or a plasma, to form a reactive layer on the dielectric layer and/or the semiconductor, wherein the reactive layer comprises a chemical compound including the reactant and elements of the dielectric layer or the semiconductor; and processing (e.g.