Patents Assigned to University of Southern California
  • Patent number: 11364035
    Abstract: A swallow exerciser device that exercises and thereby strengthens the muscles involved in swallowing includes a rigid shell, an adjustable fastener, and an inflatable pad. The rigid shell has a longitudinal dimension such that the shell extends above and below the larynx of the subject when the swallow exerciser device is positioned over the larynx of the subject. The adjustable fastener is dimensioned to secure the shell around a neck of the subject with the shell positioned over the larynx of the subject. The inflatable pad is connected to a proximal surface of the shell. The inflatable pad is dimensioned to apply resistance to force of at least one swallowing muscle of the subject when the shell positioned over the larynx of the subject and when the inflatable pad is in an inflated position. The swallow exerciser device can be used in a method for improving swallowing function in a subject.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: June 21, 2022
    Assignees: The Medical College of Wisconsin, Inc., University of Southern California
    Inventors: Reza Shaker, Anisa Shaker
  • Publication number: 20220184551
    Abstract: A system for exhaust gas remediation includes an engine, a plasma reactor, and a pulse source. The engine emits exhaust gas that includes NO molecules and NOx molecules. The plasma reactor includes an internal chamber that is fluidly connected to the engine such that the exhaust gas flows into the internal chamber. An electrode is disposed within the internal chamber of the plasma reactor. The electrode is electrically coupled to an electrical pulse source. The electrical pulse source delivers electrical pulse to the electrode to form a plasma from the exhaust gas, which removes at least a portion of the NO molecules and at least a portion of the NOx molecules.
    Type: Application
    Filed: March 11, 2020
    Publication date: June 16, 2022
    Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA, TAI CHONG CHEANG STEAMSHIP CO. (H.K.) LIMITED
    Inventors: Stephen B. CRONIN, Sriram SUBRAMANIAN, Tom HUISKAMP, Alec NYSTROM, William SCHROEDER
  • Patent number: 11359008
    Abstract: Described herein are compositions that include monoclonal antibodies that specifically bind Hsp90? and methods of using the same to treat HIF-1a-overexpressing cancer. In some embodiments, the cancers are breast cancer or lung cancer. The monoclonal antibodies bind the epitope TKPIWTRNP in Hsp90? or VKHFSVEGQ in Hsp90?.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: June 14, 2022
    Assignee: University of Southern California
    Inventors: Wei Li, David Woodley, Mei Chen, Divya Sahu, Hangming Dong, Mengchen Zou
  • Patent number: 11359227
    Abstract: Disclosed are methods and systems for determining the three-dimensional structure of chromatin in eukaryotic cells. More specifically, disclosed are methods and systems for obtaining chromatin structural information by surface immobilization that includes tethering crosslinked protein:DNA complexes and/or ligated DNA complexes to media such as beads, gels, and or matrices during the conformation capture assay.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: June 14, 2022
    Assignee: University of Southern California
    Inventor: Lin Chen
  • Publication number: 20220180518
    Abstract: Histologic classification of pathology specimens through machine learning is a nascent field which offers tremendous potential to improve cancer medicine. Its utility has been limited, in part because of differences in tissue preparation and the relative paucity of well-annotated images. We introduce tissue recognition, an unsupervised learning problem analogous to human face recognition, in which the goal is to identify individual tumors using a learned set of histologic features. This feature set is the “tissue fingerprint.” Because only specimen identities are matched to fingerprints, constructing an algorithm for producing them is a self-learning task that does not need image metadata annotations. Here, we provide an algorithm for self-learning tissue fingerprints, that, in conjunction with color normalization, can match hematoxylin and eosin stained tissues to one of 104 patients with 93% accuracy.
    Type: Application
    Filed: March 9, 2020
    Publication date: June 9, 2022
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: David AGUS, Daniel RUDERMAN, Rishi RAWAT, Fei SHA, Darryl SHIBATA
  • Patent number: 11348458
    Abstract: The disclosure presents methods and apparatus for adaptive control of one or more traffic signals. A method may include determining an offset value based on a function of a traffic flow performance metric. The method may further include determining a green time split value based on a distributed algorithm. The method may further include adaptive control of the one or more traffic signals based on the green time split value and the offset value.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: May 31, 2022
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Ketan Savla, Pouyan Hosseini
  • Publication number: 20220152553
    Abstract: This invention relates to methods and systems for reducing the concentration of SOx and/or NOx in gas streams.
    Type: Application
    Filed: March 11, 2020
    Publication date: May 19, 2022
    Applicants: University of Southern California, Tai Chong Cheang Steamship Co. (H.K.) Limited
    Inventors: Stephen B. CRONIN, Alec NYSTROM, Sriram SUBRAMANIAN, Vyaas GURURAJAN, Haotian SHI, Martin A. GUNDERSEN, William SCHROEDER, Sisi YANG, Christi SCHROEDER, Fokion EGOLFOPOULOS, Tom HUISKAMP
  • Patent number: 11331391
    Abstract: This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and/or inner ear. Methods of treating diseases or disorders of the middle ear and/or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: May 17, 2022
    Assignees: Massachusetts Eye and Ear Infirmary, University of Southern California
    Inventors: Charles E. McKenna, Boris A. Kashemirov, Shuting Sun, Kim Nguyen, David Jung, Michael J. McKenna, William Sewell, Judith Kempfle, Woo Seok Kang, Albert Edge
  • Publication number: 20220145387
    Abstract: Described herein is a method to create dendritic biocompatible polymers from pairs of complementary dendritic nucleic acid monomers in a controlled manner, using polymerization triggers. The dendritic monomers are constituted of nucleic acids and an organic polymer capable of self-assembly. A variety of additional improvements are described herein, including processes not requiring snap cooling, “wobble clamp” designs to confer a transitory measure of hairpin stability prior to branch migration, and multiple assemblies of amplifying systems. Depending on the context this technology could be used to reveal the presence of a large variety of analytes such as specific nucleic acid molecules, small molecules, proteins, and peptides.
    Type: Application
    Filed: December 20, 2019
    Publication date: May 12, 2022
    Applicant: University of Southern California
    Inventors: Scott E. Fraser, Simon Restrepo, Joseph P. Dunham
  • Publication number: 20220148708
    Abstract: A method for monitoring and understanding interpersonal relationships includes a step of monitoring interpersonal relations of a couple or group of interpersonally connected users with a plurality of smart devices by collecting data streams from the smart devices. Representations of interpersonal relationships are formed for increasing knowledge about relationship functioning and detecting interpersonally-relevant mood states and events. Feedback and/or goals are provided to one or more users to increase awareness about relationship functioning.
    Type: Application
    Filed: December 27, 2021
    Publication date: May 12, 2022
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Shrikanth Sambasivan NARAYANAN, Gayla MARGOLIN, Adela C. AHLE, Theodora CHASPARI
  • Patent number: 11318225
    Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 ?m to 5 ?m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: May 3, 2022
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Bo Lu, Mark Humayun
  • Patent number: 11313696
    Abstract: A vehicle is described, and includes an on-board controller, an extra-vehicle communication system, a GPS sensor, a spatial monitoring system, and a navigation system that employs an on-vehicle navigation map. Operation includes capturing a 3D sensor representation of a field of view and an associated GPS location, executing a feature extraction routine, executing a semantic segmentation of the extracted features, executing a simultaneous location and mapping (SLAM) of the extracted features, executing a context extraction from the simultaneous location and mapping of the extracted features, and updating the on-vehicle navigation map based thereon. A parsimonious map representation is generated based upon the updated on-vehicle navigation map, and is communicated to a second, off-board controller. The second controller executes a sparse map stitching to update a base navigation map based upon the parsimonious map representation. The on-vehicle navigation map is updated based upon the off-board navigation map.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: April 26, 2022
    Assignees: GM Global Technology Operations LLC, University of Southern California
    Inventors: Fawad Ahmad, Hang Qiu, Ramesh Govindan, Donald K. Grimm, Fan Bai
  • Patent number: 11307205
    Abstract: Described herein are methods for assessing cytotoxicity of an agent. The methods include providing a target cell that has been engineered to express intracellularly a reporter that is not expressed endogenously by the target cell, exposing the target cell to an agent capable of modulating cytotoxicity and assaying the activity of the reporter, wherein a change in reporter activity relative to a reference value is indicative of the agent being able to modulate cytotoxicity of the target cell.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: April 19, 2022
    Assignee: University of Southern California
    Inventor: Preet M. Chaudhary
  • Patent number: 11308400
    Abstract: An optimally stopped heuristic optimizer includes a processor. The processor heuristically generates a sequence of proposed solutions for solving a discrete optimization problem associated with an objective function, and for each additional proposed solution of the sequence, derives an estimate of a quality distribution that is based on the sequence including the additional proposed solution. The quality distribution assigns a probability to each of the proposed solutions according to quality of the proposed solution. The processor further, responsive to a most recent additional proposed solution of the sequence having quality better than a quality threshold that is defined by the estimate corresponding to the sequence including the most recent additional proposed solution, commands a stop such that further proposed solutions to the discrete optimization problem are no longer generated, and identifies and outputs a selected one of the sequence having best quality.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: April 19, 2022
    Assignee: University of Southern California
    Inventors: Daniel A. Lidar, Walter Vinci
  • Patent number: 11303281
    Abstract: An SFQ circuit system includes at least one SFQ block having a plurality of SFQ logic gates. Characteristically, at least a portion of the SFQ logic gates are arranged in series. The SFQ circuit system includes a timing system configured to provide a first set of inputs and collect a first set of outputs of the at least one SFQ block at a rate defined by a slow clock frequency while the SFQ logic gates are clocked at a fast clock frequency. Advantageously, the rate is sufficiently slow to allow the first set of inputs to propagate through all levels of the SFQ logic gates to produce the first set of outputs of the at least one SFQ block without colliding with a second set of inputs to the at least one SFQ block.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: April 12, 2022
    Assignee: University of Southern California
    Inventors: Ghasem Pasandi, Massoud Pedram
  • Publication number: 20220098739
    Abstract: In various embodiments of the present disclosure, an oxygen-generating bioelectrical reactor comprises two chambers, a first oxidative chamber configured for the abiotic oxidation of water to generate molecular oxygen, and a second reductive chamber configured for the biotic reduction of an insoluble metal(loid) oxide or hydroxide. In various embodiments, the biotic reduction comprises microbially-catalyzed metal(loid) ion reduction of the insoluble metal(loid) oxide or hydroxide, wherein a dissimilatory metal(loid) reducing microorganism transfers electrons obtained from the oxidation of the water extracellularly to the metal(loid) ions.
    Type: Application
    Filed: September 22, 2021
    Publication date: March 31, 2022
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Martin Van Den Berghe, Kenneth H. Nealson, A. Joshua West
  • Patent number: 11284640
    Abstract: A fasting mimicking diet package providing daily meal portions for a predetermined number of days is provided. The fasting mimicking diet package includes a kale cracker composition, a first vegetable broth composition, a mushroom soup composition, a tomato soup composition, a quinoa-containing minestrone soup composition, a bean-containing minestrone soup composition, and a pumpkin soup composition. Characteristically, the daily meal portions are packaged into meal servings or into a total daily serving to be divided into meals.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: March 29, 2022
    Assignee: University of Southern California
    Inventors: Sebastian Brandhorst, Valter D. Longo, Min Wei, Fabrizio Schirano
  • Publication number: 20220088112
    Abstract: Novel antibody-drug conjugates (ADCs) and methods of using such ADCs to treat proliferative disorders are described herein. The ADCs may comprise a PARP protein automodified with a plurality of poly-ADP-ribose polymers functionalized with novel NAD+ analogues. The automodified PARP with functionalized poly-ADP-ribose polymers provide a novel type of drug carrier, which allows facile conjugation of monoclonal antibodies and cytotoxic drug in high ratios.
    Type: Application
    Filed: March 27, 2020
    Publication date: March 24, 2022
    Applicant: University of Southern California
    Inventor: Yong Zhang
  • Patent number: 11278226
    Abstract: A fully-implantable brain-computer interface cyber-physical system capable of acquiring and analyzing electrocorticogram (“ECoG”) signals, recorded directly from the subdural space of the brain, to enable direct brain control of a prosthetic (e.g., a robotic gait exoskeleton or a functional electrical stimulation (“FES”) system) is disclosed. The present system comprises a plurality of electrodes, for acquiring the ECoG signals, and a digital signal processor (“DSP”) for deriving a plurality of real-time commands from the ECoG signals. These real-time commands may then be wirelessly transmitted to the prosthetic for execution. Further, to avoid wireless data transmission of the ECoG signals from the plurality of electrodes to the DSP, which would expose the brain, skull, and scalp tissue to potentially harmful radio frequencies, a subcutaneous tunneling cable operatively couples the plurality of electrodes and the DSP.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: March 22, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Payam Heydari, Zoran Nenadic, An Do, Charles Liu
  • Publication number: 20220079559
    Abstract: A modular array includes modular array includes one or more array modules. Each array module includes one or more transducer arrays, where each of the one or more transducer arrays includes a plurality of piezoelectric elements; a conducting interposer arranged and configured to provide acoustic absorbing backing for the one or more transducer arrays; and one or more Application Specific Integrated Circuits (ASICs). The conducting interposer and the one or more ASICs are in electrical contact with each other at a first direct electrical interface. Additionally, the conducting interposer and the one or more transducer arrays are in electrical contact with each other at a second direct electrical interface.
    Type: Application
    Filed: August 31, 2021
    Publication date: March 17, 2022
    Applicants: University of Southern California, The Regents of the University of California
    Inventors: Robert G. Wodnicki, Qifa Zhou, Thomas Matthew Cummins, Douglas N. Stephens, Katherine W. Ferrara