Patents Assigned to University of Southern California
  • FLUIDIC DEVICE FOR LONG-TERM EXPLANT CULTURE AND IMAGING
    Publication number: 20230250379
    Abstract: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts.
    Type: Application
    Filed: March 22, 2023
    Publication date: August 10, 2023
    Applicants: University of Southern California, Children's Hospital Los Angeles
    Inventors: MEGAN McCAIN, JOYCELYN YIP, CHING-LING LIEN, MICHAEL HARRISON
  • AUTOMATED MODEL BUILDING AND UPDATING ENVIRONMENT
    Publication number: 20230252348
    Abstract: Methods and systems for building and maintaining model(s) of a physical process are disclosed. One method includes receiving training data associated with a plurality of different data sources, and performing a clustering process to form one or more clusters. For each of the one or more clusters, the method includes building a data model based on the training data associated with the data sources in the cluster, automatically performing a data cleansing process on operational data based on the data model, and automatically updating the data model based on updated training data that is received as operational data. For data sources excluded from the clusters, automatic building, data cleansing, and updating of models can also be applied.
    Type: Application
    Filed: October 24, 2022
    Publication date: August 10, 2023
    Applicants: Chevron U.S.A. Inc., University of Southern California
    Inventors: Yining DONG, Alisha DESHPANDE, Yingying ZHENG, Lisa Ann BRENSKELLE, Si-Zhao QIN
  • EFFICIENT CONVERSION OF METHANE TO METHANESULFONIC ACID VIA TRIFLUOROACETYLSULFURIC ACID
    Publication number: 20230242477
    Abstract: For methane activation, various sulfonation systems using SO3 or H2SO4 have been well studied, however, sulfur dioxide (SO2), a preliminary source of SO3 and H2SO4, has not been used successfully. Herein, we report a novel methane sulfonation method to produce methanesulfonic acid (MSA) utilizing sulfur dioxide by a free radical mechanism. In the presence of H2O2 as a radical initiator, the reaction of SO2 and O2 in trifluoroacetic acid (TFAOH) furnished trifluoroacetylsulfuric acid (TFAOSO3H), which served as the radical propagator to facilitate H-abstraction of methane at low temperatures. In typical reactions, sulfur dioxide was incorporated into MSA in 75% with high selectivity at 60° C.
    Type: Application
    Filed: January 26, 2023
    Publication date: August 3, 2023
    Applicant: University of Southern California
    Inventors: Kyung Woon JUNG, Sungah KIM, Jen-Chieh WANG, Joo Ho LEE
  • Latent space model for road networks to predict time-varying traffic
    Patent number: 11715369
    Abstract: A method for traffic prediction of a road network includes receiving past traffic information corresponding to multiple locations on the road network. The method further includes determining, by a processor and based on the past traffic information, temporal characteristics of the past traffic information corresponding to changes of characteristics over time and spatial characteristics of the past traffic information corresponding to interactions between locations on the road network. The method further includes predicting predicted traffic information corresponding to a later time based on the determined temporal and spatial characteristics of the past traffic information. The method further includes receiving detected additional traffic information corresponding to the later time.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: August 1, 2023
    Assignee: University of Southern California
    Inventors: Ugur Demiryurek, Dingxiong Deng, Cyrus Shahabi, Linhong Zhu, Rose Yu, Yan Liu
  • Sub-nanosecond RF synchronization for MIMO software defined radio sensor networks
    Patent number: 11711254
    Abstract: This disclosure presents distributed and decentralized synchronization for wireless transceivers. The disclosed system, device, and method achieve sub-nanosecond synchronization using low-cost commercial off the shelf software defined radios. By providing a decentralized mechanism that does not rely on a hierarchical master-slave structure, networks constructed as disclosed are robust to sensor drop-out in contested or harsh environments. Such networks may be used to create phased array radars and communication systems without requiring wired connections to distribute a common clock or local oscillator reference.
    Type: Grant
    Filed: January 14, 2022
    Date of Patent: July 25, 2023
    Assignee: University of Southern California
    Inventors: Mahta Moghaddam, Samuel M. Prager, Mark S. Haynes
  • Scan-specific recurrent neural network for image reconstruction
    Patent number: 11710261
    Abstract: Methods, systems, devices and apparatuses for generating a high-quality MRI image from under-sampled or corrupted data The image reconstruction system includes a memory. The memory is configured to store multiple samples of biological, physiological, neurological or anatomical data that has missing or corrupted k-space data and a deep learning model or neural network. The image reconstruction system includes a processor coupled to the memory. The processor is configured to obtain the multiple samples. The processor is configured to determine the missing or corrupted k-space data using the multiple samples and the deep learning model or neural network. The processor is configured to reconstruct an MRI image using the determined missing or corrupted k-space data and the multiple samples.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: July 25, 2023
    Assignee: University of Southern California
    Inventors: Tae Hyung Kim, Justin Haldar
  • Sliding window screen for reducing resin refilling time in stereolithography
    Patent number: 11707884
    Abstract: A sliding window is used in a projection-based stereolithographic process to more quickly deliver uncured resin after each curing pass. The sliding window may be configured in different patterns, and includes features for delivering resin and exposing resin to curing radiation. The window screen divides the stereolithographic building area divided into two portions, a light exposure portion for resin curing and a liquid resin refilling portion. The light exposure portion is used to selectively solidify liquid resin, while the liquid resin refilling portion is used to quickly refill liquid resin in order to build additional layers. During the layer fabrication process, a mask image is projected to the tank; however, the projection light only passes through the light exposure portion of the window screen.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: July 25, 2023
    Assignee: University of Southern California
    Inventors: Yong Chen, Huachao Mao
  • Rifabutin for the treatment of acinetobacter baumannii
    Patent number: 11701346
    Abstract: To identify novel agents to treat carbapenem-resistant Acinetobacter baumannii. the Inventors used a nutrient-depleted medium with serum to mimic the in vivo environment. In RPMI with serum, the screen identified rifabutin (RBT) as being 133-fold more potent than rifampin (RIF) against A. baumannii, with MICs of 0.031 ?g/ml and 4 ?g/ml respectively. No difference in RBT vs. RIF activity was observed when MHII was used as the culture media. RBT possesses markedly superior in efficacy to RIF in murine models of lethal iv and pneumonia models of infection with a hyper-virulent, clinical lung and blood isolate of extreme-drug resistant (XDR) A. baumannii. In both models, RBT significantly improved survival and lowered bacterial burden compared to RIF. RBT is a promising, novel therapeutic option for A. baumannii infections.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: July 18, 2023
    Assignee: University of Southern California
    Inventors: Brad Spellberg, Brian Luna
  • Method and apparatus for encoding/decoding video signal by using edge-adaptive graph-based transform
    Patent number: 11695958
    Abstract: The present invention provides a method for encoding a video signal based on an Edge Adaptive Graph-Based Transform (EA-GBT) including detecting a step edge or a ramp edge from a residual signal; generating a graph signal based on at least one of the step edge or the ramp edge; obtaining an EA-GBT coefficient by performing the EA-GBT for the graph signal; quantizing the EA-GBT coefficient; and entropy-encoding the quantized EA-GBT coefficient.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: July 4, 2023
    Assignees: LG ELECTRONICS INC., UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Yung-Hsuan Chao, Hilmi E. Egilmez, Antonio Ortega, Sehoon Yea, Bumshik Lee
  • OPTIMIZED GENE EDITING UTILIZING A RECOMBINANT ENDONUCLEASE SYSTEM
    Publication number: 20230203541
    Abstract: Described herein are methods and compositions for genomic editing. Endonucleases for genomic editing involve inducing breaks in double stranded DNA, for which knock-ins are notoriously inefficient for relying on random integration of homologous DNA sequences into the break site by repair proteins. To address these issues, described herein are novel recombinant fusion proteins that actively recruit linear DNA inserts in closer proximity to the genomic cleavage site, increasing integration efficiency of large DNA fragments into the genome. Such improvements to genomic editing technology allow one to use lower linear DNA concentrations without sacrificing efficiency and can be further combined with other features, such as fluorescent protein reporting systems.
    Type: Application
    Filed: December 23, 2022
    Publication date: June 29, 2023
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Jason Junge, Timothy Hunt, Scott E. Fraser
  • Closed-loop multi-channel asynchronous neurostimulator to mimic neural code for cognitive prosthesis
    Patent number: 11684780
    Abstract: A method for providing stimulation of living tissue may include generating electrical pulses onto multiple output channels to a plurality of electrodes each corresponding to one of the multiple output channels. The method may also include disconnecting the plurality of electrodes from recording amplifiers during a stimulation. Additionally, the method may include shorting, after each stimulation before recording is resumed, inputs of the recording amplifiers to ground to suppress ringing in the recording system.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: June 27, 2023
    Assignee: University of Southern California
    Inventors: Dong Song, Theodore W. Berger, Sahar Elyahoodayan
  • Very-long-chain polyunsaturated fatty acids, elovanoid hydroxylated derivatives, and methods of use
    Patent number: 11684599
    Abstract: Provided are compounds, pharmaceutical compositions, cosmetic and dermatological compositions or nutritional supplement compositions, comprising omega-3 very-long-chain polyunsaturated fatty acids (n-3 VLC-PUFAs) and/or their endogenous hydroxylated derivatives thereof, known as elovanoids. This disclosure provides methods for neuroprotection, organ and tissue protection or restoration, prevention or slowing down of aging-related diseases and conditions, and sustainment of function during the aging process.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: June 27, 2023
    Assignees: Board of Supervisors of Lousiana State University and Agricultural and Mechanical College, University of Southern California
    Inventors: Nicolas G. Bazan, Nicos A. Petasis
  • Site-specific antibody-drug conjugates by ADP-ribosyl cyclases
    Patent number: 11684676
    Abstract: Antibody-drug conjugates, compositions thereof, and methods use. The antibody-drug conjugates include a fusion protein comprising an antibody covalently linked to an ADP-ribosyl cyclase protein via a peptide linker moiety at one or more of a C-terminus or N-terminus of a heavy or light chain of the antibody, a NAD or NMN analogue, and a payload such that the NAD or NMN analogue is conjugated to both the payload and the ADP-ribosyl cyclase protein.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: June 27, 2023
    Assignee: University of Southern California
    Inventors: Yong Zhang, Zhefu Dai, Xiao-Nan Zhang
  • METHOD TO GENERATE BIOCOMPATIBLE DENDRITIC POLYMERS FOR ANALYTE DETECTION WITH MULTIMODAL LABELING Ahttps://dav.uspto.gov/prex/index.html#domesticContinuityND SIGNAL AMPLIFICATION
    Publication number: 20230193363
    Abstract: Described herein is a method to create dendritic biocompatible polymers from pairs of complementary dendritic nucleic acid monomers in a controlled manner, using polymerization triggers. The dendritic monomers are constituted of nucleic acids and an organic polymer capable of self-assembly. Each polymer contains approximately 200 dendrites that can be used to attach labels and constitute a biologically compatible signal amplification technology. Depending on the context this technology could be used to reveal the presence of a large variety of analytes such as specific nucleic acid molecules, small molecules, proteins, and peptides.
    Type: Application
    Filed: October 17, 2022
    Publication date: June 22, 2023
    Applicant: University of Southern California
    Inventors: Scott E. Fraser, Simon Restrepo, Joseph P. Dunham
  • Low-cost surface-protected iron-based substrates for the nickel hydroxide electrode in alkaline batteries
    Patent number: 11682768
    Abstract: An electrode for a battery includes an iron-containing substrate and a cobalt ferrite layer disposed over the iron-containing substrate. Advantageously, the cobalt ferrite layer inhibits corrosion of the iron-containing substrate. A nickel hydroxide layer is disposed over the cobalt ferrite layer. A battery incorporating the electrode is also provided.
    Type: Grant
    Filed: November 9, 2021
    Date of Patent: June 20, 2023
    Assignee: University of Southern California
    Inventors: Sri Narayan, Debanjan Mitra, Phong Thanh Trinh, Ahamed Irshad Maniyanganam
  • DESIGN OF HIGH-PERFORMANCE AND SCALABLE MONTGOMERY MODULAR MULTIPLIER CIRCUITS
    Publication number: 20230185537
    Abstract: This patent discloses novel design and implementations of high-performance and scalable Montgomery modular multiplier circuits by utilizing and developing a combination of optimization techniques and dataflow transformations including use of carry-save compressions, multiplier decomposition using a radix of 2m, multiplicand decomposition using a radix of 2w, parallelization of computations of the quotient and intermediate results in each iteration of the Montgomery modular multiplication, replacement of multiplications and additions in each iteration with simple encoding and compression operations, and correction of potential overflows in intermediate results by doing a simple 2-bit addition.
    Type: Application
    Filed: April 23, 2021
    Publication date: June 15, 2023
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Bo ZHANG, Zeming CHENG, Massoud PEDRAM
  • Compositions and methods for a multi-adjuvant only approach to immunoprophylaxis for preventing infections
    Patent number: 11672857
    Abstract: This disclosure provides a new vaccine composition and methods for its use. The composition contains an effective amount of each of: an aluminum hydroxide, a mono-phosphoryl lipid (MPL), and a whole glucan particles (WGP) but no an antigen that raises an immune response against a bacterial or fungal infection.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: June 13, 2023
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Brad Spellberg, Travis Nielsen, Brian Luna
  • A DIET COMPOSITION FOR ENHANCING LEAN BODY MASS AND MUSCLE MASS
    Publication number: 20230172251
    Abstract: The use of and a method using a diet composition for enhancing lean body mass/muscle mass is provided. The diet composition includes a fasting-mimicking diet (FMD) component to be administered for a first time period of reduced calorie intake of 24 to 190 hours. The fasting-mimicking diet component provides less than 50% of the normal calorie intake of the subject with both protein restriction and sugar restriction. The diet composition can also include a re-feeding diet component to be administered for a second time period. Characteristically, the re-feeding diet component providing 60-100% of the normal calorie intake of the subject. Advantageously, the fasting-mimicking diet component and the re-feeding diet component are administered for multiple cycles.
    Type: Application
    Filed: April 22, 2021
    Publication date: June 8, 2023
    Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA, UNIVERSITA DEGLI STUDI DE GENOVA
    Inventors: Valter LONGO, Alessio NENCIONI, Irene CAFFA
  • MAGNETO-ELECTRIC SENSOR FOR HARDWARE TROJAN DETECTION
    Publication number: 20230176111
    Abstract: A sensing circuit for detecting hardware trojans in a target integrated circuit is provided. The sensing circuit includes an array of magnetic tunnel junction circuits where each magnetic tunnel junction circuit including one or more magnetic tunnel junctions. Characteristically, each magnetic tunnel junction circuit configured to provide data for and/or determine a temperature map or a current map of the target integrated circuit.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 8, 2023
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Ajey JACOB, Akhilesh JAISWAL
  • SCALABLE TRIO GUIDE RNA APPROACH FOR INTEGRATION OF LARGE DONOR DNA
    Publication number: 20230175019
    Abstract: A new DNA knock-in approach is provided based on the usage of three single guide RNA (sgRNA) to increase the integration efficiency of donor DNA based on the CRISRP-Cas system. The approach uses a pair of universal sgRNAs complementary to the donor DNA and a single sgRNA that targets the locus of interest. In various embodiments, targeting is achieved by pre-forming a DNA:RNA:protein (DNA:RNP) complex in vitro and introducing the complex into the embryo or cells of interest either by microinjection or transfection.
    Type: Application
    Filed: May 28, 2021
    Publication date: June 8, 2023
    Applicant: University of Southern California
    Inventors: Scott E. Fraser, Le Trinh