Abstract: A system for monitoring tissue lesion development during a medical ablation process applied to a patient, the system comprising a catheter ablation device having at least one catheter electrode, the device connectable via an electrical feedline to a source of electrical energy and configured to apply ablation energy to ablate tissue in a target region, a plurality of external electrodes for application to the body of the patient, measurement circuitry for determining an electrical characteristic of a current path between the at least one catheter electrode and the external electrodes in the absence of said application of ablation energy, and an electrical controller.

Abstract: An isolated nucleic acid encoding a nucleotide-binding and leucine-rich repeat (NLR) polypeptide including a zinc-finger BED domain, wherein expression of the NLR polypeptide in a plant confers or enhances resistance of the plant to a fungus.

Abstract: The present application describes fib-reinforced dental composites (FRCs), processes for producing and uses of, the fibre-reinforced dental composites. More particularly, the fibre-reinforced dental 5 composites described herein comprise a polymerisable resin and from about 0.5% to about 25% w/w of fibres having a diameter of from about 3 ?m to about 9 ?m and a length of from about 60 ?m to about 2 mm.

Abstract: A pump-out tube for evacuating a space between two sheets of glass, the pump out tube being receivable in a hole formed in at least one of the sheets of glass, the pump out tube formed as a separate element comprising a tubular member and a seal formed around the tube.

Abstract: This disclosure relates to quantum electronic devices for storing qubits. In particular, this disclosure relates to a quantum electronic device comprising a carbon nanosphere adapted to store a qubit represented by an electron spin and a control and readout device to set the qubit and read the qubit stored on the carbon nanosphere. Qubits stored on carbon nanospheres have a long electron spin lifetime at room temperature. This disclosure further relates to a method for quantum computing. The method comprises storing a qubit represented by an electron spin on a carbon nanosphere, performing a quantum operation on the qubit to generate a resulting qubit and reading the resulting qubit from the nanosphere. There is further provided a spintronic device comprising multiple carbon nanospheres adapted to provide a qubit represented by an electron spin in that carbon nanosphere and a control device to facilitate interaction between the qubits to perform a quantum operation.

Abstract: The treatment of stroke related diseases are described herein. In addition, fibrin clot formation and related activity is proposed for the disclosed compounds, in particular, peptides for inhibiting or modifying the cleavages of fibrinogen by thrombin. Methods for producing such compounds are also disclosed.

Abstract: The present invention is directed to novel vaccine compositions and methods for immunising subjects against Mycobacterium avium subspecies paratuberculosis. The invention involves the use of mineral oil adjuvants, or white mineral oil adjuvants, more specifically those having CAS 8042-47-5, CAS 1335203-18-3, CAS 1174522-45-2, CAS 1335203-17-2 (or EC equivalents 232-455-8, 932-078-5, 934-954-2 and 934-956-3, respectively) to reduce lesions or adverse reactions.

Abstract: The present disclosure is drawn to methods of treating diseases or disorders, and uses of preparing medicaments. The methods of administering and/or preparation of medicaments can include the use of a compound of Formula (I) disclosed herein, or a geometric isomer, stereoisomer, and/or pharmaceutically acceptable salt or solvate thereof.

Abstract: The invention relates to a catheter ablation device for delivery of energy to a selected region of tissue, the device having an antenna portion including a radiating antenna electrically connectable via an electrical feedline to a source of energy, the antenna configured to generate an electromagnetic field able to ablate tissue in said selected region of tissue, the device including a thermocouple having a hot junction formed by electrical connection between a thermocouple conductor and a conducting part of the electrical feedline. This avoids the need for a dedicated thermocouple conductor pair, as the second conductor of the thermocouple is provided by the feedline used to supply the ablation energy to the device antenna.

Abstract: The invention relates to a catheter ablation device for delivery of energy (such as microwave energy) via a radiating antenna to a selected region of tissue, the device having an elongated catheter with an outer sheath, configured to allow flow of fluid along the catheter to exit through one or more orifices adjacent to the antenna. The device includes an impedance monitoring system having two electrodes arranged respectively inside and outside said catheter sheath, the impedance monitoring system including an electric circuit incorporating an ionic conductivity path through said fluid. The device is introduced into a blood vessel and the invention allows monitoring of changes in the size of the blood vessel during an ablation procedure, as it can be used to measure the impedance of an electrical circuit including a blood path in the blood vessel in the region of the ablation, the measured impedance providing a measure of vascular calibre.

Abstract: The invention relates to an ablation device for delivery of microwave energy to a selected region of tissue, in particular for producing deep endocardial or epicardial ventricular lesions, such as for the treatment or prevention of arrhythmias.

Abstract: A microwave ablation device (10) comprises a feed line (22), a microwave radiator and a device outer sheath (46) in which at least part of the feed line (22) is contained. The sheath (46) in use, allows an irrigation liquid to flow therethrough, wherein the feed line has a junction (38) with the radiator (22) has an outer conducting shield (28) terminating and insulated at the junction (38). The feed line (22) has a conductive core (32) that extends to the radiator (24). The conductive core forms a radiating element (34) electrically insulated from its surrounding environment. The radiator (24) is unbalanced.

Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.

Abstract: A method of fabricating a casting, the method including applying a substrate to a sacrificial mold, the sacrificial mold including a shaped non-planar receiving surface to receive the substrate and provide a casting of the substrate having a shaped structure corresponding to the receiving surface; and subjecting the sacrificial mold and casting to freeze drying conditions and sublimating the sacrificial mold from the casting to form a cast article including the shaped non-planar structure.

Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).

Abstract: The specification relates generally to the post-genomic identification of therapeutic targets and agents. In particular the specification relates to PSMD9 inhibitors and methods for preventing or treating metabolic disorders such as fatty liver disease that are associated with dysregulation of lipid homeostasis.

Abstract: The present disclosure provides a composition comprising isolated T cells, wherein the T cells have specificity against a range of clinical fungal pathogens.

Abstract: This invention relates to molecular diagnostics and, more specifically DNA-based tests for the prognosis and/or monitoring of fibrotic disease progression in humans, and processes for stratifying patients based on their likely rates of fibrotic disease progression. The invention also relates to the field of therapy for fibrotic disease, based on such prognoses, monitoring and stratification results, such as in monitoring and/or stratifying and/or treating patients having a higher likelihood of rapid fibrotic disease progression.

Abstract: This disclosure relates to optical RF spectrum analysers and methods for analysing an input RF signal. An optical modulator modulates an input RF signal onto a carrier frequency and an optical spectral weight with a spectral weight function modifies the modulated optical signal. The spectral weight defines a frequency relationship between the spectral weight function and the carrier frequency. A frequency control module modifies the frequency relationship between the spectral weight function and the carrier frequency over time. An optical sensor senses the modified optical signal over time and to generates an RF signal over time. A signal recovery module calculates the RF spectrum based on the RF signal over time. Shifting the spectral weight against the carrier frequency over time results in a high spectral resolution even if the spectral weight is relatively broad band. The result is an increased spectral resolution at a reduced price/complexity and increased robustness.

Abstract: The invention relates to terpenes and uses thereof.