Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
Type:
Grant
Filed:
July 25, 2022
Date of Patent:
July 2, 2024
Assignees:
AustinPx, LLC, Board of Regents, The University of Texas System
Inventors:
Chris Brough, James W. McGinity, Dave A. Miller, James C. Dinunzio, Robert O. Williams, III
Abstract: In some aspects, the present disclosure provides compositions comprising one or more of each of the following nucleic acids: (1) a mRNA; (2) a sgRNA; and (3) a DNA; and a lipid nanoparticle comprising at least one ionizable lipid; wherein the each of the nucleic acids are encapsulated within the lipid nanoparticle, and pharmaceutical compositions thereof. The present disclosure also provides methods employing said compositions and/or pharmaceutical compositions, such as methods of repairing genes, methods of performing homology directed repair on the genome, and methods of treating diseases or disorders.
Type:
Application
Filed:
April 22, 2022
Publication date:
June 27, 2024
Applicant:
The Board of Regents of The University of Texas System
Abstract: A test artifact for additive manufacturing is provided. The artifact comprises an additively manufactured singular continuous body between 100 cc and 6 cc in bounding box volume and between 50 cc and 3 cc in solid body. The body comprises at least three fiducials positioned for identification of locations in cross-section after sectioning of the artifact and at least three geometries that are unique from each other when exposed in cross section.
Type:
Grant
Filed:
July 2, 2021
Date of Patent:
June 25, 2024
Assignee:
Board of Regents, The University of Texas System
Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.
Type:
Application
Filed:
February 22, 2024
Publication date:
June 20, 2024
Applicants:
Board of Regents, The University of Texas System, CardioVol, LLC
Inventors:
Jonathan W. Valvano, John Porterfield, Clay Heighten, Anil Kottam, Marc David Feldman, Aleksandra Borisovna Gruslova, Drew R. Nolen
Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.
Type:
Application
Filed:
March 1, 2024
Publication date:
June 20, 2024
Applicants:
Board of Regents, The University of Texas System, CardioVol, LLC
Inventors:
John Porterfield, Jonathan W. Valvano, Clay Heighten, Anil Kottam, Marc David Feldman, Aleksandra Borisovna Gruslova, Drew R. Nolen
Abstract: Provided are methods, compositions and kits to detect anti-folic acid antibodies in a sample, which are useful for identifying risk of pathologies associated with increased or decreased levels of anti-folic acid antibodies including infertility, folate responsive birth defects, folate responsive blood disorders, heart and vascular diseases, neurological disorders, neurodegenerative diseases and cancers.
Type:
Grant
Filed:
March 21, 2022
Date of Patent:
June 18, 2024
Assignee:
Board of Regents, The University of Texas System
Abstract: Brain tumors remain the leading cause of cancer-related deaths in children and often are associated with long-term sequelae among survivors of current therapies. Telomerase and telomeres play important roles in cancer, representing attractive therapeutic targets to treat children with poor-prognosis brain tumors such as diffuse intrinsic pontine glioma (DIPG), high-grade glioma (HGG) and high-risk medulloblastoma (MB). It has shown that DIPG, HGG and MB frequently express telomerase activity. It is now shown that the telomerase-dependent incorporation of 6-thio-2?deoxyguanosine (6-thio-dG), a telomerase substrate precursor analog, into telomeres leads to telomere dysfunction-induced foci (TIFs) along with extensive genomic DNA damage, cell growth inhibition and cell death of primary stem-like cells derived from patients with DIPG, HGG and MB. Importantly, the effect of 6-thio-dG is persistent even after drug withdrawal.
Type:
Application
Filed:
November 16, 2023
Publication date:
June 13, 2024
Applicants:
The Board of Regents of The University of Texas System, Children's Hospital Medical Center
Abstract: Sheath-run artificial muscles (or SRAMs) are described in which the dimensional changes and/or modulus changes of a sheath on the surface of a twisted or coiled host yarn or fiber drives torsional and tensile actuation. The sheath-core artificial muscle includes a sheath on a coiled core yarn or fiber that has inserted twist, in which the sheath does not include a yarn, the coiled core yarn or fiber includes a core yarn or fiber, the sheath can change volume, modulus, or a combination thereof when actuated by an influence source to drive actuation, and the influence source is selected from a group consisting of absorption processes, desorption processes, changes in temperature, changes in external pressure, changes in a magnetic field, changes in an electric field, exposures to actinic radiation, electrochemical charge and discharge, chemical reactions, and combinations thereof.
Type:
Grant
Filed:
May 7, 2020
Date of Patent:
June 11, 2024
Assignee:
Board of Regents, The University of Texas System
Inventors:
Ray H. Baughman, Jiuke Mu, Monica Jung De Andrade, Shaoli Fang, Na Li, Carter S. Haines
Abstract: A quad-polymer composition includes monomers of (a) acrylonitrile, (a) vinylimidazole, (c) methyl acrylate and (d) either acrylic acid or itaconic acid. Such quad-polymer compositions may be used to form fibers (such as by melt spinning) that may then be annealed, stabilized, and/or carbonized to produce carbon fibers. The quad-polymer composition may be used for supercapacitors, lithium battery electrodes once carbonized, and as synthesized, it may be used for wound healing fibers, fabrics, coatings, and films, and anti-bacterial/anti-microbial fibers, fabrics, coatings and films. The carbon fibers formed from the quad-polymer composition may be used for the fiber composites for automobile, aerospace structures, marine structures, military equipment/parts, sporting goods, robotics, furniture, and electronic parts.
Type:
Grant
Filed:
July 3, 2023
Date of Patent:
June 11, 2024
Assignees:
Board of Regents, The University of Texas System, Korea Institute of Carbon Convergence Technology
Inventors:
Min Hye Jung, Hyun Kyu Shin, Kyu Soon Park, Duck Joo Yang, Benjamin Batchelor, Samsuddin Mahmood
Assignee:
Board of Regents, The University of Texas System
Inventors:
Sidlgata V. Sreenivasan, Paras Ajay, Aseem Sayal, Mark McDermott, Shrawan Singhal, Ovadia Abed, Lawrence Dunn, Vipul Goyal, Michael Cullinan
Abstract: A system for producing a three-dimensional object from a fluid medium includes image processing units. The fluid medium is configured to solidify when subjected to a prescribed light stimulation. Each image processing unit includes at least one light emitting source configured to emit light, and at least one mirror system configured to reflect the light emitted by the light emitting source. The mirror system includes a manipulating system for adjusting the direction of the emitted light, a control system for controlling the manipulating system, and at least one optical element configured to manipulate the emitted light and to project the emitted light onto an area of a surface of the fluid medium to form an image on the surface. The image processing units are configured to form corresponding images on the surface, and are configured to be movable at least in a lateral direction relative to the surface.
Type:
Application
Filed:
December 28, 2023
Publication date:
June 6, 2024
Applicants:
Adaptive 3D Technologies, LLC, Board of Regents, The University of Texas System
Inventors:
Walter VOIT, Benjamin LUND, Daniel ZAMORANO, Caleb LUND, Stephen KAY, Eric PARKER
Abstract: The present techniques may provide improved processing and functionality of performance of the 128-bit AES Algorithm, which may provide improved power consumption. For example, in an embodiment, an encryption and decryption apparatus may comprise memory storing a current state matrix of an encryption or decryption process and a plurality of multiplexers configured to receive from the memory current elements of the state matrix stored in the memory, perform a cyclic shift on the received elements of the state matrix, and transmit the shifted elements to the memory for storage as a new state matrix.
Type:
Application
Filed:
November 30, 2023
Publication date:
June 6, 2024
Applicant:
The Board of Regents of the University of Texas System
Abstract: The present disclosure relates to steroidal glucocorticoid receptor (GR) ligands and related compositions that degrade the GR and/or modulate its activity that may be utilized as pharmaceuticals for the treatment of diseases including cancer.
Type:
Grant
Filed:
April 12, 2019
Date of Patent:
June 4, 2024
Assignee:
Board of Regents, The University of Texas System
Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
Type:
Grant
Filed:
June 15, 2023
Date of Patent:
June 4, 2024
Assignee:
The Board of Regents of The University of Texas System
Abstract: The present disclosure in various aspects provides methods for making pharmaceutical compositions for treating neurodegenerative diseases (e.g., demyelinating diseases), such as but not limited to multiple sclerosis, neuromyelitis optica, and transverse myelitis. The pharmaceutical compositions impact specific antibody-mediated processes involved in the biology of neurodegenerative disease. In certain aspects, the disclosure provides pharmaceutical compositions for treating neurodegenerative disease, which are based on inhibiting the action of pathologic antibodies, or alternatively providing antibodies to stimulate neuroprotection or repair processes.
Type:
Grant
Filed:
May 12, 2017
Date of Patent:
June 4, 2024
Assignee:
The Board of Regents of The University of Texas System
Abstract: The present specification provides combinations of active agents for the improved treatment of Her2+ cancers and associated methods of treatments. The combinations comprise an RXR agonist and a Her2-targeted therapeutic agent and may optionally further comprise thyroid hormone.
Type:
Grant
Filed:
December 7, 2022
Date of Patent:
June 4, 2024
Assignees:
Io Therapeutics, Inc., Board of Regents, The University of Texas System
Inventors:
Martin E. Sanders, Powel H. Brown, Cassandra Moyer, Abhijit Mazumdar
Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
Type:
Application
Filed:
May 10, 2023
Publication date:
May 30, 2024
Applicant:
The Board of Regents of The University of Texas System
Abstract: The disclosure relates to defined solutions for organ (heart, liver, kidney, etc,) vascular composite allografts or autografts (VCA: hand, limb, face, etc.) or tissue (peripheral nerves, spinal cord, skin) storage that preserve the electrophysiological functions of axons contained therein. The disclosure also concerns the use of isolated peripheral nerve segments and solid organs preserved in the defined solutions in autograft or allograft transplantation procedures, as well as the use of isolated peripheral nerve segments and solid organs preserved in the defined solutions in autograft/allograft transplantation procedures in combination with the peripheral nerve repair techniques of neurorrhaphy and axonal fusion primarily using polyethylene glycol known as PEG-fusion.
Type:
Application
Filed:
November 20, 2023
Publication date:
May 30, 2024
Applicant:
Board of Regents, The University of Texas System
Abstract: Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.
Type:
Application
Filed:
February 8, 2024
Publication date:
May 30, 2024
Applicant:
Board of Regents, The University of Texas System
Inventors:
Jef De Brabander, Daniel Rosenbaum, Qiren Liang, Wentian Wang
Abstract: A computer-implemented method of training a neural network to improve a characteristic of a protein comprises collecting a set of amino acid sequences from a database, compiling each amino acid sequence into a three-dimensional crystallographic structure of a folded protein, training a neural network with a subset of the three-dimensional crystallographic structures, identifying, with the neural network, a candidate residue to mutate in a target protein, and identifying, with the neural network, a predicted amino acid residue to substitute for the candidate residue, to produce a mutated protein, wherein the mutated protein demonstrates an improvement in a characteristic over the target protein. A system for improving a characteristic of a protein is also described. Improved blue fluorescent proteins generated using the system are also described.
Type:
Application
Filed:
November 28, 2022
Publication date:
May 30, 2024
Applicant:
Board of Regents, The University of Texas System
Inventors:
Andrew Ellington, Austin Cole, Raghav Shroff, Ross Thyer