Patents Assigned to University of Texas System
  • Collection probe and methods for the use thereof
    Patent number: 12087566
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Grant
    Filed: July 28, 2023
    Date of Patent: September 10, 2024
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Livia Schiavinato Eberlin, Thomas Milner, Jialing Zhang, John Lin, John Rector, Nitesh Katta, Aydin Zahedivash
  • PEPTIDES AND ENGINEERED T CELL RECEPTORS TARGETING SARS-COV-2 ANTIGENS AND METHODS OF USE
    Publication number: 20240293459
    Abstract: This disclosure provides for peptides useful for vaccination and other applications, engineered T cell Receptors (TCRs), cells comprising the peptides and TCRs, and methods of making and using the peptides and TCRs. The current disclosure relates to TCRs that specifically recognize SARS-Cov-2 HLA-A2 restricted peptide from membrane glycol-protein (MGP), MGP-65: FVLAAVYRI (SEQ ID NO:22).
    Type: Application
    Filed: March 29, 2022
    Publication date: September 5, 2024
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Cassian YEE, Ke PAN, Yulun CHIU
  • LIPID NANOPARTICLE (LNP) DELIVERY SYSTEMS AND USES THEREOF
    Publication number: 20240293317
    Abstract: Lipid nanoparticles (LNPs) comprising biologically active poly nucleotides (e.g., RNAs) are provided. In some aspects, the LNP complexes are provided as aerosols and/or dry powders, such as for delivery to the lungs. Method of making and using such compositions are provided.
    Type: Application
    Filed: April 20, 2021
    Publication date: September 5, 2024
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hugh D.C. SMYTH, Hairui ZHANG, Debadyuti GHOSH, Jasmim LEAL, Melissa SOTO, Robert O. WILLIAMS, III
  • ANTIBODIES TO CHITINASE 3-LIKE-1 AND METHODS OF USE THEREFOR
    Publication number: 20240294670
    Abstract: Provided herein are antibodies binding to CHI3L1 and the uses of the antibodies in detecting and treating cancer and for treating hepatotoxicity.
    Type: Application
    Filed: April 21, 2021
    Publication date: September 5, 2024
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Cynthia JU, Jongmin JEONG, Zhao SHAN, Leike LI, Ningyan AN, Zhiqiang AN
  • IMMUNOGENIC COMPOSITIONS AND USES THEREOF
    Publication number: 20240293529
    Abstract: Immunogenic compositions comprising viral vectors and surfactants are provided. Methods for administration and preparation of such compositions are also provided.
    Type: Application
    Filed: May 17, 2024
    Publication date: September 5, 2024
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Maria A. CROYLE, Stephen Clay SCHAFER
  • Substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione analogues
    Patent number: 12077540
    Abstract: A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3?-indoline]-2?,5(3H)-dione analogues, the use thereof and the preparation thereof.
    Type: Grant
    Filed: July 1, 2022
    Date of Patent: September 3, 2024
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Jia Zhou, Pei-Yong Shi, Jimin Xu, Xuping Xie
  • Compounds for the selective solid-liquid extraction and liquid-liquid extraction of lithium chloride
    Patent number: 12077520
    Abstract: The present disclosure relates to calixpyrrole compounds and compositions thereof. The calixpyrrole compounds are chemical groups which are located in such a manner so as to be useful for the selective extraction of specific salts. Also provided herein are compositions and methods of use thereof.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: September 3, 2024
    Assignees: Board of Regents, The University of Texas System, GYEONGSANG NATIONAL UNIVERSITY
    Inventors: Jonathan L. Sessler, Qing He, Sung Kuk Kim
  • Pharmaceutical compositions of niclosamide
    Patent number: 12076328
    Abstract: The present disclosure provides pharmaceutical compositions of niclosamide that may be administered either orally or by inhalation. These compositions may allow the achievement of a therapeutically effective dose of niclosamide to the lungs or the gastrointestinal tract. These compositions may be used to treat one or more diseases or disorders such as a viral infection or cancer.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: September 3, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Robert O. Williams, III, Hugh D. C. Smyth, Zachary N. Warnken, Miguel Orlando Jara Gonzalez, Hyo-Jong Seo, Ashlee D. Brunaugh, Matthew Herpin
  • Transgene cassettes, AAV vectors and AAV viral vectors for the expression of human codon-optimized SLC6A1
    Patent number: 12077772
    Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SLC6A1 loss and/or misfunction. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a GAT1 polypeptide.
    Type: Grant
    Filed: November 7, 2020
    Date of Patent: September 3, 2024
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Steven J. Gray, Frances C. Shaffo
  • Wearable biosensors with room temperature ionic liquid buffer
    Patent number: 12076143
    Abstract: A biosensor device includes a porous substrate, where the substrate comprises semiconductor elements functionalized to conjugate with a particular analyte, the semiconductor elements are embedded within at least a portion of the substrate, and the substrate is to absorb fluid capable of carrying the particular analyte. The device further includes two or more electrodes attached to the substrate to correspond to the portion of the substrate, where the portion of the substrate further comprises Room-Temperature Ionic Liquid (RTIL).
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: September 3, 2024
    Assignees: EnLiSense, LLC, Board of Regents, The University of Texas System
    Inventors: Shalini Prasad, Sriram Muthukumar
  • Ultrasound-guided optoacoustic monitoring of oxygen saturation
    Patent number: 12076138
    Abstract: Apparatus and methods are described for ultrasound guided optoacoustic monitoring to provide diagnostic information for many clinical applications blood oxygenation in blood vessels and in tissues including for early diagnosis and management of circulatory shock (including that induced by hemorrhage). In certain embodiments provided herein, methods and apparatus for optoacoustics for measurement of blood oxygenation in the innominate vein are provided.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: September 3, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Donald S. Prough, Michael P Kinsky, Rinat O. Esenaliev, Irene Y. Petrov, Yuriy Petrov
  • DNA aptamers and use thereof for the treatment of cancer
    Patent number: 12077760
    Abstract: Provided herein are DNA aptamers targeting AXL receptor kinase. The DNA aptamers may comprise a thiophosphate backbone and be chemically modified. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: September 3, 2024
    Assignees: Board of Regents, The University of Texas System, Consiglio Nazionale delle Ricerche
    Inventors: Gabriel Lopez-Berestein, Paola Amero, Cristian Rodriguez-Aguayo, Rahul Mitra, Anil K. Sood, Vittorio De Franciscis, David Volk, Lokesh Ganesh L. Rao
  • Hiccup relieving apparatus
    Patent number: 12076484
    Abstract: The hiccup relieving apparatus includes a body with a first end having a mouthpiece, a second end having a restriction in the body between the first end and the second end. The restriction makes it difficult to draw fluid through the body to the user's mouth. The fluid can be air or the body can be immersed in water or other potable liquid in a container. The restriction requires an adult user, using the mouthpiece, to produce a threshold suction of for example water before water can flow from the water in the water container, through the body, through the mouthpiece, and to the user.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: September 3, 2024
    Assignee: The Board of Regents of the University of Texas System
    Inventor: Ali Seifi
  • Prefusion-stabilized hMPV F proteins
    Patent number: 12077563
    Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.
    Type: Grant
    Filed: January 12, 2024
    Date of Patent: September 3, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jason McLellan, Ching-Lin Hsieh, Scott Rush, Nianshuang Wang
  • Nanofabrication and design techniques for 3D ICs and configurable ASICs
    Patent number: 12079557
    Abstract: Various embodiments of the present technology provide for the ultra-high density heterogenous integration, enabled by nano-precise pick-and-place assembly. For example, some embodiments provide for the integration of modular assembly techniques with the use of prefabricated blocks (PFBs). These PFBs can be created on one or more sources wafers. Then using pick-and-place technologies, the PFBs can be selectively arranged on a destination wafer thereby allowing Nanoscale-aligned 3D Stacked Integrated Circuit (N3-SI) and the Microscale Modular Assembled ASIC (M2A2) to be efficiently created. Some embodiments include systems and techniques for the construction of construct semiconductor devices which are arbitrarily larger than the standard photolithography field size of 26×33 mm, using pick-and-place assembly.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: September 3, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Sidlgata V. Sreenivasan, Paras Ajay, Aseem Sayal, Mark McDermott, Jaydeep Kulkarni
  • SYSTEMS AND METHODS FOR STRESS DETECTION USING KINEMATIC DATA
    Publication number: 20240289626
    Abstract: Devices, systems and methods to detect stress using kinematic data are disclosed herein. In certain embodiments a spatial attention mechanism is used to describe the contribution of each kinematic feature to the classification of normal/stressed movements. Some embodiments comprise determining if the kinematic data from a user belong to a class of sub-movements associated with known signatures found to highly correlate with when the user is experiencing motor degradation due to high psychological stress versus a normal class of movements where the user is unaffected by stress.
    Type: Application
    Filed: February 8, 2024
    Publication date: August 29, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventors: Ann MAJEWICZ FEY, Yi ZHENG
  • METHODS OF USE OF MODULATORS TO IMPROVE NERVE REGENERATION
    Publication number: 20240285831
    Abstract: The present disclosure describes the use of immune modulators to promote nerve growth and regeneration, particularly in the context of nerve deficit stemming from trauma and disease. In particular, the disclosure provides for the use of CXCR4 antagonists, STAT3 activators, and an agent that increases levels of nitric oxide, either alone or in any combination of these drugs, in surgery performed to treat nerve deficit conditions, especially peripheral nerve deficit conditions caused by cut injury or tear injury, the method especially useful in bridging nerve gaps of 3 cm or longer.
    Type: Application
    Filed: April 29, 2024
    Publication date: August 29, 2024
    Applicants: The Board of Regents of The University of Texas System
    Inventors: Jonathan CHENG, Edward KEEFER, Srikanth VASUDEVAN
  • INDIUM BASED SOL-GEL OXIDE PRECURSOR FILMS AS EXTREME ULTRAVIOLET AND LOW-ENERGY ELECTRON BEAM RESISTS
    Publication number: 20240288766
    Abstract: A method for lithography includes preparing an indium-based precursor solution. The precursor solution is not limited to indium and may include other metals such as, but not limited to, zinc, tin, aluminum, or gallium, in addition to indium. Additionally, the precursor solution may include a nitrate, an acetate, a chloride, an acetylacetonate, an iodide, and other organic or inorganic groups. The method further includes spin-coating the precursor solution on a substrate at a predetermined rate to form a resist film with a predetermined thickness. The method further includes exposing the resist film to one of a low-energy electron beam and an extreme ultraviolet (EUV) beam to produce one or more chemical changes on the resist film to form a pattern. The resist is negative tone with the exposed regions remaining on the substrate and unexposed regions being removed from the substrate by the developer.
    Type: Application
    Filed: February 27, 2023
    Publication date: August 29, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventors: Julia W.P. Hsu, Trey B. Daunis
  • BAFF-R ANTIBODIES AND USES THEREOF
    Publication number: 20240287200
    Abstract: Provided herein are BAFF-R antibodies as well as compositions and methods of making and using the same. The antibodies provided herein are, inter alia, useful for the treatment of cancer and autoimmune diseases.
    Type: Application
    Filed: April 3, 2024
    Publication date: August 29, 2024
    Applicants: CITY OF HOPE, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hong QIN, Larry W. KWAK, Jingxing LI, Kexin HUANG
  • TCR-REPERTOIRE FRAMEWORK FOR MULTIPLE DISEASE DIAGNOSIS
    Publication number: 20240290418
    Abstract: A novel method of geometric isometry based antigen-specific TCR alignment (GIANA) is described herein. GIANA is an antigen-specific TCR clustering method that is able to efficiently handle tens of millions of sequences. GIANA achieved higher sensitivity and precision than all existing methods, and is able to retrieve TCRs specific to known antigens with high accuracy. The ultra-large-scale TCR clustering and fast query of novel samples also enabled a novel reference-based repertoire classification framework. GIANA can also analyze single cell RNA-seq data with TCR regions solved, and it is possible to query TCRs from unknown data against the large database of TCR repertoire samples in the public domain, and provide new insights over shared antigen-specificity. GIANA is applicable to cluster or query large B cell receptor sequencing data as well.
    Type: Application
    Filed: June 17, 2022
    Publication date: August 29, 2024
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Bo LI