Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
Type:
Application
Filed:
June 15, 2023
Publication date:
February 8, 2024
Applicant:
The Board of Regents of The University of Texas System
Abstract: A pyrogenicity test method and assay of endotoxins allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay monitored with a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by detecting shifts in the resonant condition of an open microcavity affected by the changes in the refractive index of the analyte solutions used.
Type:
Grant
Filed:
May 10, 2021
Date of Patent:
February 6, 2024
Assignee:
Board of Regents, The University of Texas System
Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to MeCP2 loss and/or misfunction, including RETT syndrome. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a MeCP2 polypeptide.
Type:
Grant
Filed:
December 4, 2020
Date of Patent:
February 6, 2024
Assignee:
Board of Regents of the University of Texas System
Abstract: The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.
Type:
Grant
Filed:
February 11, 2022
Date of Patent:
February 6, 2024
Assignee:
Board of Regents, The University of Texas System
Abstract: A diagnostic imaging device includes a probe that uses both an ultrasound transducer and frequency-domain diffuse optical imaging (FD-DOI) to assist with locating and diagnosing sub-tissue anomalies. According to one aspect, the diagnostic imaging device relates to a clip-on cap that can be utilized with existing ultrasound transducers. The diagnostic imaging device described herein can be utilized for image-guided needle biopsy to regions where prostate tissues are highly suspicious for high-grade cancer, as well as for image guided interventions, such as cryotherapy, photodynamic therapy, and brachytherapy for early-stage or localized prostate cancer.
Type:
Grant
Filed:
April 29, 2015
Date of Patent:
January 30, 2024
Assignee:
The Board of Regents of the University of Texas System
Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
Type:
Application
Filed:
June 15, 2023
Publication date:
January 25, 2024
Applicant:
The Board of Regents of The University of Texas System
Abstract: A method for fabricating a three-dimensional (3D) static random-access memory (SRAM) architecture using catalyst influenced chemical etching (CICE). Utilizing CICE, semiconductor fins can be etched with no etch taper, smooth sidewalls and no maximum height limitation. CICE enables stacking of as many nanosheet layers a desired and also enables a 3D stacked architecture for SRAM cells. Furthermore, CICE can be used to etch silicon waveguides thereby creating waveguides with smooth sidewalls to improve transmission efficiency and, for photon-based quantum circuits, to eliminate charge fluctuations that may affect photon indistinguishability.
Type:
Grant
Filed:
May 3, 2022
Date of Patent:
January 23, 2024
Assignee:
Board of Regents, The University of Texas System
Inventors:
Sidlgata V. Sreenivasan, Akhila Mallavarapu, Jaydeep Kulkarni, Michael Watts, Sanjay Banerjee
Abstract: Certain embodiments are directed to methods and compositions for treating or preventing seizures in a subject using a therapeutic agent comprising one or more Transient Receptor Potential-Canonical 4/5 channel antagonists sufficient to regulate excitability of neurons in the brain of a subject.
Type:
Grant
Filed:
February 25, 2021
Date of Patent:
January 23, 2024
Assignee:
Board of Regents, The University of Texas System
Abstract: Procedures for inhibiting hormone receptor activation include administering to a subject in need of hormone receptor inhibition a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions. Procedures for treating prostate cancer or breast cancer include administering to a subject having prostate cancer or breast cancer a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions.
Type:
Grant
Filed:
January 20, 2021
Date of Patent:
January 23, 2024
Assignees:
Board of Regents, The University of Texas System, The University of British Columbia
Abstract: A railway track defect detection system may include a mobile defect detection platform and a modal parameter analyzer. The platform may include an excitation mechanism (e.g., an excitation hammer or wheels that are in contact with a railway track) to apply multiple impact forces to the railway track while the platform travels along the railway track, and a laser Doppler vibrometer to capture, while the platform travels along the railway track, vibration data representing vibrations of the railway track caused by application of the multiple impact forces by the excitation mechanism. The modal parameter analyzer may be configured to detect, based on the vibration data captured by the laser Doppler vibrometer, a defect in the railway track. For example, changes in vibration amplitudes, mode shapes, damping ratios, or a natural frequency derived from the received vibration data may indicate the presence of a defect in the railway track.
Type:
Grant
Filed:
September 18, 2018
Date of Patent:
January 23, 2024
Assignee:
Board of Regents, The University of Texas System
Abstract: Autonomous wireless sensors in subsurface environments can be charged while present in the subsurface environment to allow the sensors to measure and wirelessly transmit measurements. The sensors rely upon a contrast agent to provide a power flow path to the sensors.
Type:
Grant
Filed:
March 2, 2020
Date of Patent:
January 16, 2024
Assignees:
National Technology & Engineering Solutions of Sandia, LLC, The Board of Regents of the University of Texas System, Wayne State University
Inventors:
Jason E. Heath, Gungor Didem Beskardes, Wallace McAliley, Chester J. Weiss, Mohsen Ahmadian-Tehrani, David T. Chapman, Leela Arava
Abstract: A method can include receiving, at a computer system, characteristic values of a pregnancy of a subject. As an example, the characteristic values can include a numerical value for a live birth order of the pregnancy for the subject. The computer system can store a machine learning model that receives a first set of input features and provides a second set of one or more output values. In some embodiments, the first set of input features can correspond to the characteristic values of the pregnancy of the subject. The second set of one or more output values can include a probability of a Cesarean delivery. The characteristic values can be input into the machine learning model to obtain the probability of the Cesarean delivery being required for the subject during an attempt of a vaginal delivery. The Cesarean delivery can be performed based on the probability.
Type:
Application
Filed:
November 4, 2021
Publication date:
January 11, 2024
Applicant:
Board of Regents, The University of Texas System
Abstract: The present disclosure provide for methods of using 6-thio-2?-deoxyguanosine (6-thio-dG) to treat telomerase-positive cancers that exhibit (a) one or more TERT promoter mutations, and/or (b) enriched telomere transcriptional signature(s). In particular, melanomas, including those who are not sensitive or have become resistant to immune checkpoint inhibition and/or MAPKi therapy are targets for this therapy.
Type:
Application
Filed:
June 5, 2023
Publication date:
January 11, 2024
Applicants:
The Board of Regents of The University of Texas System, The Wistar Institute of Anatomy and Biology
Abstract: Provided herein are methods for determining a subtype of a small cell lung cancer in a patient based on the express status of ASCL1, NEUROD1, and POU2F3, which are expressed in a mutually exclusive fashion. The subtype of the cancer can be used to determine the sensitivity of the cancer to certain anti-cancer therapies. As such, also provided are methods of treating patients having small cell lung cancer based on the subtyping results.
Type:
Application
Filed:
June 29, 2023
Publication date:
January 11, 2024
Applicant:
Board of Regents, The University of Texas System
Inventors:
Carl M. GAY, Lauren A. BYERS, John V. HEYMACH
Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
Type:
Application
Filed:
June 15, 2023
Publication date:
January 11, 2024
Applicant:
The Board of Regents of The University of Texas System
Abstract: Methods are provided for identifying tumor-specific antibodies and/or T-cell receptors by paired mRNA sequencing from individual immune cells in sentinel lymph nodes and comparison of these sequences with corresponding mass spectroscopy data from a subject having a cancer. Novel tumor-specific antibodies (e.g., NY-ESO-1-binding antibodies) are also provided.
Type:
Grant
Filed:
October 29, 2018
Date of Patent:
January 9, 2024
Assignee:
Board of Regents, The University of Texas System
Inventors:
Gregory C. Ippolito, Jonathan R. Mcdaniel, William N. Voss, George Georgiou
Abstract: A method for determining a radiotherapy treatment plan can include: receiving anatomical data for a patient; generating, via a neural network analyzing the anatomical data, a plurality of fitness values for a plurality of candidate beam orientations; determining a selected beam orientation based on the plurality of fitness values; performing a fluence map optimization (FMO) process on the selected beam orientation; and determining a dose distribution for the patient based on the FMO process.
Type:
Grant
Filed:
April 30, 2020
Date of Patent:
January 9, 2024
Assignee:
The Board of Regents of University
of Texas System
Inventors:
Dan Nguyen, Azar Sadeghnejad Barkousaraie, Steve Jiang
Abstract: In one embodiment, a system for evacuating subdural hematomas includes an inlet configured to be placed in fluid communication with a subdural space, an irrigation reservoir in fluid communication with the inlet and configured to supply irrigation fluid to the inlet and the subdural space, an outlet separate from the inlet and also configured to be placed in fluid communication with the subdural space, and a pump in fluid communication with the outlet and configured to create negative pressure within the subdural space and evacuate fluid from the subdural space.
Type:
Grant
Filed:
December 14, 2018
Date of Patent:
January 9, 2024
Assignee:
The Board of Regents, The University of Texas System
Abstract: The disclosure provides for eRNA-targeted transcriptional reprogramming through targeted reduction of eRNAs for a clinically relevant gene, TNFSF10, resulting in a selective control of interferon-induced apoptosis. A method of inhibiting a TNFSF10 gene expression in a human cell is disclosed. The methods described herein comprise contacting the human cell with a single-stranded antisense compound consisting of the sequence selected from a set of SEQ ID NOs: disclosed herein, wherein the antisense compound targets an enhancer RNA (eRNA) transcribed from a genomic enhancer sequence or region. The eRNA is an TNFSF10 eRNA sequence comprising the nucleic acid sequence selected from the SEQ ID NOs disclosed herein which inhibits expression of the TNFSF10 gene in the human cell.
Type:
Grant
Filed:
October 21, 2020
Date of Patent:
January 9, 2024
Assignee:
Board of Regents, The University of Texas System