Abstract: Antimicrobial catheters and medical devices are provided. In some aspects, a low durometer aliphatic polyether polyurethane may be impregnated with a first antimicrobial agent (e.g., minocycline and rifampin) and coated with a second antimicrobial agent (e.g., chlorhexidine, gendine, or gardine). The antimicrobial catheters may display improved flexibility and resistance to kinking. Methods of producing the antimicrobial catheters are also provided.

Abstract: The present invention discloses a live attenuated strain of Zika virus (ZIKV) having a deletion in the 3? untranslated region (3?UTR) of the viral genome, which may affect viral RNA synthesis and sensitivity to type I interferon inhibition, but may not affect viral RNA translation. The present invention also discloses the use of these live attenuated ZIKV strains in the preparation of ZIKV vaccines and for providing immunoprotection against ZIKV infection and congenital ZIKV syndrome, particularly in pregnant females.

Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.

Abstract: A method includes obtaining a first imaging scan and a second imaging scan of a single subject brain. The first imaging scan is converted to a first dataset, and the second imaging scan is converted to a second dataset. A sequence-adaptive multimodal segmentation algorithm is applied to the first dataset and the second dataset. The sequence-adaptive multimodal segmentation algorithm performs automatic intensity-based tissue classification to generate a first labelled dataset and a second labeled dataset. The first labeled dataset and the second labeled dataset are automatically co-registered to each other to generate a transformation matrix based on the first labeled dataset and the second labeled dataset. The transformation matrix is applied to align the first dataset and the second dataset.

Abstract: Apparatus and methods for providing three-dimensional printed oral stents are provided for head and neck radiotherapy. Movement of the jaw of the patient is simulated via a computer processor. Simulating movement of the jaw of the patient comprises rotating and translating a mandible of the jaw. A digital negative impression is transformed into a digital oral stent by adding support structures to the digital negative impression. The support structures facilitate three-dimensional (3D) printing of the patient-specific oral stent.

Abstract: Provided herein are methods for determining a subtype of a small cell lung cancer in a patient based on the express status of ASCL1, NEUROD1, and POU2F3, which are expressed in a mutually exclusive fashion. The subtype of the cancer can be used to determine the sensitivity of the cancer to certain anti-cancer therapies. As such, also provided are methods of treating patients having small cell lung cancer based on the subtyping results.

Abstract: A protonated dimeric ionic liquid that enhances and improves the performance of a fuel cell catalyst. The protonated dimeric ionic liquid comprises 9?9?-(butane-1,4-diyl)bis(3,4,6,7,8,9-hexahydro-2H-pyrimido[1,2-a]pyrimidin-1-ium) 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate. Membrane electrode assemblies (MEAs) and polymer electrolyte membrane fuel cells (PEMFCs) employing the protonated dimeric ionic liquid are also disclosed.

Abstract: Various embodiments provide for deep learning-based architectures and design methodologies for an orthogonal frequency division multiplexing (OFDM) receiver under the constraint of one-bit complex quantization. Single bit quantization greatly reduces complexity and power consumption in the receivers, but makes accurate channel estimation and data detection difficult. This is particularly true for OFDM waveforms, which have high peak-to average (signal power) ratio in the time domain and fragile subcarrier orthogonality in the frequency domain. The severe distortion for one-bit quantization typically results in an error floor even at moderately low signal-to-noise-ratio (SNR) such as 5 dB. For channel estimation (using pilots), various embodiments use novel generative supervised deep neural networks (DNNs) that can be trained with a reasonable number of pilots. After channel estimation, a neural network-based receiver specifically, an autoencoder jointly learns a precoder and decoder for data symbol detection.

Abstract: Aspects of the disclosure relate to a method of treating glioblastoma in a subject comprising administering to the subject a KDM6B inhibitor. In some aspects, the methods are performed in combination with an immunoterhapy. Further aspects relate to a composition comprising a KDM6B inhibitor and an immunotherapy.

Abstract: Disclosed are systems and techniques for increasing heat transfer from a substrate to a working fluid. The systems may include a substrate comprising a plurality of grooves or cavities on at least one external surface. The system may also include an infusing liquid filling at least a majority of the plurality of grooves. The system may also include a working fluid configured to flow parallel to the external surface.

Abstract: A shunt operable to be implanted on an eye is provided. The shunt includes a vein fluidic channel operable to be in fluid communication with an interior of the eye and operable to receive aqueous fluid from the interior of the eye. A body is fluidly coupled with the vein fluidic channel. A valve is disposed within the body and is operable to regulate intraocular pressure in the eye by opening and closing based on pressure from the aqueous fluid. A plurality of outlets are in fluid communication with the body opposite the vein fluidic channel in relation to the valve. The outlets are operable to release the aqueous fluid to the sclera of the eye.

Abstract: We disclose a method, comprising administering, to a patient suffering from a cancer, a composition comprising a compound containing a gold atom; and administering, to a portion of the patient's body in which the cancer is present, radiation. We also disclose a kit comprising a composition comprising a compound containing a gold atom; and instructions to perform the method.

Abstract: The claimed invention is directed to the use of a composition for use as an antimicrobial comprising an antimicrobial agent. In certain embodiments, the composition is used for treating or ameliorating inflammation in a subject and comprises an anti-inflammatory agent. The anti-inflammatory agent may include an NSAID, such as ibuprofen or diclofenac. The composition may further include solvents, anti-bacterial agents, anti-fungal agents, anti-parasitic agents, anti-viral agents, and buffers. The composition may include particles that have been processed via jet milling to reduce a diameter of the particles and to improve a flowability of the particles.

Abstract: The present invention relates to ethanediamine-heterocycle compounds that are able to act as inhibitors of PRMTs (protein arginine methyltransferases) for treating cancer and other diseases mediated by PRMTs.

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

Abstract: Methods, apparatuses, systems, and implementations for creating 3-dimensional (3D) representations exhibiting geometric and surface characteristics of brain lesions are disclosed. 2D and/or 3D MM images of the brain may be acquired. Brain lesions and other abnormalities may be identified and isolated with each lesion serving as a region of interest (ROI). Saved ROI may be converted into stereolithography format, maximum intensity projection (MIP) images, and/or orthographic projection images. Data corresponding to these resulting 3D brain lesion images may be used to create 3D printed models of the isolated brain lesions using 3D printing technology. Analysis of the 3D brain lesion images and the 3D printed brain lesion models may enable a more efficient and accurate way of determining brain lesion etiologies.

Abstract: Disclosed herein are methods preparing a purified, carrier-free 68Ga solution. Tire present disclosure also provides systems for preparing a purified, carrier-free 68Ga solution. The present disclosure also provides compositions comprising the purified, carrier-free 68Ga solutions disclosed herein. Also provided are methods of administering compositions of the present disclosure to a patient in need thereof, for example, for imaging a disease or disorder, such as cancer.

Abstract: A microfluidic device capable of trapping contents in a manner suitable for high-throughput imaging is described herein. The microfluidic device may include one or more trapping devices, with each trapping device having a plurality of trapping channels. The trapping channels may be configured to receive contents via an inlet channel that connects a sample reservoir to the trapping channels via fluid communication. The trapping channels are shaped such that contents within the trapping channels are positioned for optimal imaging purposes. The trapping channels are also connect to at least one exit channel via fluid communication. The fluid, and contents within the fluid, may be controlled via hydraulic pressure.

Abstract: Devices and methods for extraction and processing of substantiagelatineafuniculi umbilicalis (Wharton's Jelly) from an umbilical cord.

Abstract: The disclosure provides methods and compositions for treating subject having cancers with abnormal WNT signaling, such as APC-deficient cancers. Accordingly, aspects of the disclosure relate to methods for treating APC-deficient cancers comprising administering an inhibitor of TDO2 or of a cytokine activated by TDO2. Additional aspects relate to methods for identifying a cancer as being sensitive to TDO2 inhibition comprising detecting a deficiency in an APC gene and/or measuring an expression level of TDO2.