Patents Assigned to University of Texas Systems
  • Patent number: 12193786
    Abstract: A hyperspectral imaging system can include a first hyperspectral imaging camera that is configured to provide first hyperspectral image data of an object in a first field of view. A second hyperspectral imaging camera can be separated from the first hyperspectral imaging camera, where the second hyperspectral imaging camera is configured to provide second hyperspectral image data of the object in a second field of view. A processor circuit can be operatively coupled to the first and second hyperspectral imaging cameras, where the processor circuit configured to combine the first and second hyperspectral image data to generate a hypercube of data for the object comprising spectral data included in the first and second hyperspectral image data.
    Type: Grant
    Filed: November 2, 2023
    Date of Patent: January 14, 2025
    Assignee: Boards of Regents, The University of Texas System
    Inventor: Baowei Fei
  • Patent number: 12195803
    Abstract: Provided herein are methods and materials for detecting and/or treating subject (e.g. a human) having cancer. In some embodiments, methods and materials for identifying a subject as having cancer (e.g., a localized cancer) are provided in which the presence of member(s) of two or more classes of biomarkers are detected. In some embodiments, methods and materials for identifying a subject as having cancer (e.g. a localized cancer) are provided in which the presence of member(s) of at least one class of biomarkers and the presence of aneuploidy are detected. In some embodiments, methods described herein provide increased sensitivity and/or specificity in the detection of cancer in a subject (e.g. a human).
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: January 14, 2025
    Assignees: The Johns Hopkins University, Board of Regents, The University of Texas System, The Research Foundation for The State University of New York
    Inventors: Bert Vogelstein, Kenneth W. Kinzler, Joshua Cohen, Nickolas Papadopoulos, Anne Marie Lennon, Cristian Tomasetti, Yuxuan Wang, Georges Jabboure Netto, Rachel Karchin, Christopher Douville, Samir Hanash, Simeon Springer, Arthur P. Grollman, Kathleen Dickman
  • Patent number: 12193821
    Abstract: Manufacturing a neural interface device. Forming a neural interface probe of an implantable microelectrode body. PECVD a first amorphous silicon carbide insulation layer, forming a thin film metal trace and interface pad on the first layer, the pad on a portion of the trace. PECVD a second amorphous silicon carbide insulation layer on the first layer and covering the trace and the pad. Forming an opening in the second layer to expose the pad to an ambient environment. Patterning the first and second layers to define the neural interface probe. The probe has a rectangular cuboid shape, a cross-sectional area perpendicularly transverse to a long axis length of the probe and through any perpendicularly transverse cross-section along the long axis length is less than about 50 microns. The layers are the principle material of construction of the probe.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: January 14, 2025
    Assignees: Board of Regents, The University of Texas System, Trustees of Boston University
    Inventors: Timothy James Gardner, Stuart F. Cogan
  • Patent number: 12195206
    Abstract: An electrospray thruster with integrated propellant storage directly embedded into small satellite structural elements integrates the volume of the thruster into the volume of the rail.
    Type: Grant
    Filed: January 4, 2023
    Date of Patent: January 14, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventor: Amelia Diane Greig
  • Patent number: 12193770
    Abstract: An instrument cart configured to position an instrument controller at a desired location and attitude pitch with respect to an incision location of a patient includes a base, a lift member moveable with respect to the base, a first planar translation member connected to the lift member and arcuately moveable with respect thereto, a second planar translation member connected to the first planar translation member and arcuately moveable with respect thereto, a third planar translation member connected to the second planar translation member and arcuately moveable with respect thereto, an arcuate slide base connected to the third planar translation member and moveable with respect thereto and an arcuate slide coupled to the arcuate slide base, and moveable with respect thereto; and an instrument controller coupling connected to the arcuate slide member, the instrument controller connected thereto and movable with respect thereto.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: January 14, 2025
    Assignees: Board Of Regents Of The University Of Texas System, ColubrisMX, Inc
    Inventors: Daniel H. Kim, Dong Suk Shin, Taeho Jang, Yongman Park, Jeihan Lee, Kihoon Nam, Yongchul Shin
  • Publication number: 20250009656
    Abstract: Ultra pH sensitive (UPS) micelles encapsulating cytokines are provided that provide lower toxicity and higher efficacy compositions and methods for treating cancer with those compositions.
    Type: Application
    Filed: November 15, 2022
    Publication date: January 9, 2025
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Jinming GAO, Gang HUANG, Zhichen SUN, Qiang FENG, Wei LI
  • Publication number: 20250012708
    Abstract: The present disclosure is directed to characterizing the adhesion between thin films and rigid substrates. Exemplary embodiments provide systems, apparatus and methods to characterize mechanical mix-mode adhesion between thin films and rigid substrates using the blister test (BT). Exemplary embodiments provide the full triaxial displacement field obtained through Digital Image Correlation with inverse Finite Element Method simulations using Cohesive Zone Elements. Particular embodiments eliminate the need for making mechanistic or kinematic assumptions of the blister formation and allow the characterization of the full traction-separation law governing the adhesion between the film and the substrate. Exemplary embodiments can aid in the design and optimization of adhesively bonded structures by providing a comprehensive understanding of the adhesion mechanics between thin films and rigid substrates.
    Type: Application
    Filed: July 3, 2024
    Publication date: January 9, 2025
    Applicant: Board of Regents, The University of Texas System
    Inventors: Drishya DAHAL, Juan-Sebastian RINCON-TABARES, David Y. RISK-MORA, Brendy C. RINCON TROCONIS, David RESTREPO
  • Patent number: 12187799
    Abstract: The present disclosure is directed to dual specificity antibodies which may bind to PD-L1 or PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1 or PD-L2.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: January 7, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael A. Curran, Ashvin R. Jaiswal, Dongxing Zha, Kui Voo, Carlo Toniatti, Bianka Prinz, Nga Rewa Houston, Eric Krauland
  • Patent number: 12187888
    Abstract: Cardiac tissue-on-a-chip platforms aimed at mimicking human cardiac tissue structures, are valuable tools to model, and serve as preclinical platforms for drug testing or therapies for cardiac repair. We have developed three types of electrospun scaffolds including furfuryl gelatin (f-gelatin) alone, with polycaprolactone (PCL) in the ratio of f-gelatin and PCL (1:1), and coaxial scaffolds with PCL (core) and f-gelatin (sheath). Scaffolds were developed through single nozzle electrospinning and coaxial electrospinning, respectively, to serve as scaffolds for cardiac tissue-on-a-chip platforms.
    Type: Grant
    Filed: April 18, 2023
    Date of Patent: January 7, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Binata Joddar, David A. Roberson, Naveen Nagiah, Zayra N. Dorado, Ivana Hernandez
  • Patent number: 12186974
    Abstract: Provided are methods and systems for manufacturing and using heat-shrink elastomeric. An example method of manufacturing a heat-shrink elastomeric element comprises providing a thermoplastic elastomeric element having a first shape; modifying the thermoplastic elastomeric element to produce a thermoset elastomeric element having the first shape; heating the thermoset elastomeric element to a temperature of at least the glass transition temperature of the thermoset elastomeric element; adjusting the first shape of the thermoset elastomeric element to produce a second shape with at least one dimension greater than that of the first shape; and cooling the thermoset elastomeric element to a temperature below that of the glass transition temperature of the thermoset elastomeric element to produce the heat-shrink elastomeric element.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: January 7, 2025
    Assignees: Halliburton Energy Services, Inc., Board of Regents, The University of Texas System
    Inventors: Michael L. Fripp, Kejia Yang, Radu Reit, Benjamin Lund, Walter Voit
  • Patent number: 12186324
    Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: January 7, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kang Le, Michael J. Soth, Philip Jones, Jason Bryant Cross, Christopher L. Carroll, Timothy Joseph McAfoos, Pijus Kumar Mandal
  • Patent number: 12178787
    Abstract: Provided are T cell receptors (TCR) and TCR variable regions that can selectively bind SLC45A2. The TCR may be utilized in various therapies, such as autologous cell transplantation, to treat a cancer, such as a cutaneous melanoma, uveal melanoma, a mucosal melanoma, or a metastatic melanoma. Methods for expanding a population of T cells that target SLC45A2 are also provided.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: December 31, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Gregory Lizée, Cassian Yee
  • Patent number: 12178848
    Abstract: The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the treatment of EPI or pancreatitis resulting from surgical procedures.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: December 31, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: David J. Mangelsdorf, Steven A. Kliewer, Katie C. Coate, Genaro Hernandez
  • Patent number: 12180251
    Abstract: The present disclosure provides ?2?-1 C-terminal domain mimetics for the treatment of pain, epilepsy or other disorders in a subject. Further provided is an ?2?-1 C-terminal domain peptide which blocks binding of ?2?-1 to the glutamate receptors NMDAR and AMPAR.
    Type: Grant
    Filed: September 11, 2023
    Date of Patent: December 31, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventor: Hui-Lin Pan
  • Patent number: 12181421
    Abstract: A test capsule for measuring at least one property of a material exposed to nuclear radiation comprises a lattice structure configured to exhibit a change in at least one property responsive to exposure to nuclear radiation. The lattice structure comprises a first strut and a second strut connected to the first strut at a node. Related test capsules and methods are also described.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: December 31, 2024
    Assignees: Battelle Energy Alliance, LLC, Board of Regents, The University of Texas System
    Inventors: Robert A. Roach, Andrea M. Jokisaari, Michael D. McMurtrey, Geoffrey L. Beausoleil, Carolyn L. Seepersad
  • Publication number: 20240424013
    Abstract: Disclosed herein are methods of treatments with a telomerase-mediated telomere-targeting drug, 6-thio-2?-deoxyguanosine (6-thio-dG), checkpoint inhibitors and/or radiation therapy for treating cancers. eads to tumor regression in innate and adaptive immune-dependent manners in syngeneic and humanized mouse cancer models.
    Type: Application
    Filed: September 9, 2024
    Publication date: December 26, 2024
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Jerry SHAY, Yang-Xin FU, Ilgen MENDER, Anli ZHANG
  • Patent number: 12173317
    Abstract: The present disclosure provides methods for re-programming effector T cells to a central memory phenotype comprising culturing the effector T cells with a histone deacetylase inhibitor (HDACi) and IL-21. Further provided are methods of treating cancer comprising administering the central memory T cells.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: December 24, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Cassian Yee, Junmei Wang
  • Patent number: 12173061
    Abstract: Methods for treating, reducing, ameliorating or inhibiting symptoms idiopathic pulmonary fibrosis (IPF) or interstitial pneumonia, comprising administering to a subject in need of an effective amount of a) multiple EGF-like-domains-9 (MEGF9) or a biologically active fragment thereof; b) uncoordinated receptor 5A (UNC5A) or a biologically active fragment thereof; c) dolichyl-phosphate beta-glucosyltransferase (ALG5) or a biologically active fragment thereof; d) a combination of two or three of a)-c); e) an antibody specifically binding to a); f) an antibody specifically binding to b); g) an antibody specifically binding to c); h) a combination of two or three of e)-g); or i) a combination of at least one of a)-c) and at least one of e)-g). Pharmaceutical compositions and processes for making and using the compositions are also disclosed.
    Type: Grant
    Filed: October 5, 2023
    Date of Patent: December 24, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventor: Sreerama Shetty
  • Patent number: 12173087
    Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imagable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
    Type: Grant
    Filed: January 24, 2022
    Date of Patent: December 24, 2024
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., Intezyne Technologies Inc., Arizona Board of Regents on Behalf of The University of Arizona, Board of Regents, The University of Texas System
    Inventors: Robert J. Gillies, David L. Morse, Natalie M. Barkey, Kevin N. Sill, Josef Vagner, Narges K. Tafreshi, Jonathan L. Sessler, Christian Preihs, Victor J. Hruby
  • Patent number: D1056217
    Type: Grant
    Filed: December 12, 2022
    Date of Patent: December 31, 2024
    Assignee: The Board of Regents of The University of Texas System
    Inventor: Kenneth Dale Westover