Patents Assigned to University of Texas Systems
  • Patent number: 11542229
    Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: January 3, 2023
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Daniel J. Siegwart, Jason B. Miller
  • Patent number: 11539365
    Abstract: A skyrmion logic gate is provided. The logic gate comprises a first track configured for propagation of magnetic skyrmions and a second track configured for propagation of magnetic skyrmions. A junction links the first and second tracks. A continuous current flows through the logic gate, wherein skyrmions propagate due to the current.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: December 27, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Joseph S. Friedman, Xuan Hu, Maverick Alisier Mathis Chauwin
  • Patent number: 11534757
    Abstract: An electrowetting-on-dielectric (EWOD) microfluidic device comprises at least one integrated electrochemical sensor, the electrochemical sensor comprising: a reference electrode; a sensing electrode; and an analyte-selective layer positioned over the sensing electrode. In some embodiments, the electrochemical sensor measures a concentration of an analyte in a fluid sample exposed to the electrochemical sensor based on a potential difference between the reference electrode and the sensing electrode. The first analyte and the second analyte can be selected from a group consisting of K+, Na+, Ca2+, Cl?, HCO3?, Mg2+, H+, Ba2+, Pb2+, Cu2+, I?, NH4+, (SO4)2?.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: December 27, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Hyejin Moon, Ali Farzbod
  • Publication number: 20220403474
    Abstract: Provided herein are methods of determining tumoral sensitivity to hormonal (endocrine) therapy based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index), and may have additional consideration for the proportion of ER gene (ESR1) RNA transcripts that contain a mutation relative to the value of the SETER/PR index. Further provided are methods of treating breast cancer patients determined to be sensitive to an endocrine therapy by the SETER/PR index.
    Type: Application
    Filed: August 25, 2022
    Publication date: December 22, 2022
    Applicants: Board of Regents, The University of Texas System, Yale University
    Inventors: William Fraser SYMMANS, Bruno SINN, Christos HATZIS, Chunxiao FU, Rosanna LAU
  • Patent number: 11529314
    Abstract: Disclosed herein are nanoparticles comprising a lipid core comprising a sterol; and a complex comprising a cationic agent and a therapeutic agent, wherein the complex is encapsulated within the lipid core. Methods to produce the nanoparticle comprise: combining a cationic agent, a therapeutic agent, and a first water-immiscible solvent with a first aqueous solution, thereby forming a mixture comprising a complex comprising the cationic agent and the therapeutic agent; combining the mixture with a second waterim-miscible solvent, thereby forming an aqueous phase and an organic phase, and separating the organic phase comprising the complex; combining the organic phase comprising the complex with a sterol and a first water-miscible organic solvent; and dispersing the complex in a second aqueous solution to form a herein disclosed nanoparticle. Methods for treating a disease and for reducing nanoparticle burst rate are also disclosed.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: December 20, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Zhengrong Cui, Abdulaziz Aldayel, Hannah O'Mary
  • Patent number: 11529055
    Abstract: In one embodiment, a device for in vivo tissue evaluation includes an elongated manipulator including an elongated proximal tube and an articulable distal portion, and a sensor provided at a distal end of the articulable distal portion, the sensor including a sensor head configured to be pressed against tissue and measure a reaction force of the tissue.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: December 20, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Panayiotis S. Shiakolas, Shashank Kumat, Samson Abimbola Adejokun
  • Publication number: 20220396601
    Abstract: The disclosure relates to engineered heme sequestering peptides and their use in treating cancer and inhibiting microbial infections and colonization.
    Type: Application
    Filed: May 13, 2022
    Publication date: December 15, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventor: Li ZHANG
  • Publication number: 20220395217
    Abstract: Systems and methods to detect seizures using analog circuitry. One example method generally includes obtaining, at a seizure detection system, one or more electroencephalogram (EEG) signals, detecting a plurality of features associated with each of the one or more EEG signals, generating a bitstream indicating a seizure probability associated with each feature of the plurality of features to yield a plurality of bitstreams indicating a plurality of seizure probabilities, and generating a seizure detection output based on the plurality of bitstreams indicating the plurality of seizure probabilities of the plurality of features.
    Type: Application
    Filed: June 10, 2022
    Publication date: December 15, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Joseph S. Friedman, Mehrdad Nourani, Hina Dave, Alexander J. Edwards, Xuan Hu, Abbas A. Zaki, Noah C. Parker, Jay H. Harvey, TaeYoon Kim
  • Patent number: 11525214
    Abstract: Cellulose materials and methods of making the cellulose materials are described herein. The method can include contacting a cotton fabric with an oxidizing system to obtain an oxidized cotton material and processing the oxidized cotton material to form the cellulose material. The oxidizing system can include an aqueous mixture of a N-oxyl compound and a hypochlorite compound. During oxidation, the pH of the aqueous mixture can be maintained at from 8.5 to 11. Cellulose products can be formed from the cellulose materials. For example, the cellulose products can be used to form a packaging material, a biomedical device or implant, a drug delivery material, a fiber, a textile material, a template for electronic components, or a separation membrane. Methods of making the cellulose product include dissolving or suspending an active ingredient in a medium comprising the cellulose material.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: December 13, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventor: Jonathan Y. Chen
  • Patent number: 11525002
    Abstract: The present disclosure is directed to antibodies binding to PD-L1 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: December 13, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael A. Curran, Carlo Toniatti, Ashvin R. Jaiswal, Dongxing Zha, Kui Voo, Bianka Prinz, Nadthakarn Boland
  • Patent number: 11525740
    Abstract: A method of measuring a junction temperature of a SiC MOSFET can be provided by applying a gate-source voltage to an external gate loop coupled to a gate of the SiC MOSFET, detecting a first time when the gate-source voltage exceeds a first value configured to disable conduction of a current in a drain of the SiC MOSFET, detecting, after the first time, a second time when a voltage across a common source inductance in a package of the SiC MOSFET indicates that the current in the drain is greater than a reference value, defining a time interval from the first time to the second time as a turn on delay time of the SiC MOSFET and determining the junction temperature for the SiC MOSFET using the turn on delay time.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: December 13, 2022
    Assignee: Boards of Regents, The University of Texas System
    Inventors: Bilal Akin, Fei Yang, Shi Pu, Chi Xu, Bhanu Vankayalapati
  • Patent number: 11525834
    Abstract: The present invention includes methods and kits for the diagnosing a neurological disease within primary care settings comprising: obtaining a blood test sample from a subject, measuring IL-7 and TNF? biomarkers in the blood sample, comparing the level of the one or a combination of biomarkers and neurocognitive screening tests with the level of a corresponding one or combination of biomarkers in a normal blood sample and neurocognitive screening tests, and predicting that an increase in the level of the blood test sample in relation to that of the normal blood sample indicates that the subject is likely to have a neurological disease.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: December 13, 2022
    Assignees: University of North Texas Health Science Center at Fort Worth, Board of Regents, The University of Texas System
    Inventors: Sid E. O'Bryant, Robert C. Barber, Guanghua Xiao, Dwight German
  • Patent number: 11525034
    Abstract: Described herein are water desalination membranes and methods of desalinating water. Sulfonated poly(arylene ether) polymers are also disclosed, including those comprising one or more sulfonate groups at various points along the polymer chain. The polymers may be used as at least a portion of a water desalination membrane. The polymers described herein are useful for preventing transport of aqueous ionic species (e.g., Na+ and Cl?) across a membrane made from the polymers while allowing water to pass. Chlorine-stable polymers are described, as well as polymers exhibiting good performance for rejecting monovalent cations in the presence of polyvalent cations.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: December 13, 2022
    Assignees: Board of Regents, The University of Texas System, Virginia Tech Intellectual Properties, Inc.
    Inventors: Judy S. Riffle, Ozma R. Lane, Amin Daryaei, Shreya Roy-Choudhury, Benny D. Freeman, Eui Soung Jang, Gurtej S. Narang, John J. Lesko, Trevor Schumacher
  • Publication number: 20220387635
    Abstract: The present disclosure provides methods of imaging cancerous cells in a subject, wherein the cancerous cells are localized to the skeletal system or central nervous system of the subject, the method comprising administering to the subject an effective amount of 18F-fluoroacetate, detecting a first signal emitted by 18F-fluoroacetate, and generating an image representative of the location and/or amount of the first signal to image the cancerous cells. In some embodiments, the methods further comprising diagnosing, prognosing, staging, and/or monitoring the progression of a disease or disorder, such as acute lymphoblastic leukemia and/or leptomeningeal disease.
    Type: Application
    Filed: November 4, 2020
    Publication date: December 8, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventor: Amer NAJJAR
  • Publication number: 20220389106
    Abstract: Provided herein are agents, such as antibodies, antibody-drug conjugates, or chimeric antigen receptors, that target EphA10. Methods of treating cancer are provided, comprising administering to a patient in need thereof an effective amount of an EphA10-targeting agent. The patient may be selected for treatment if the cancer expresses an increased level of EphA10.
    Type: Application
    Filed: September 18, 2020
    Publication date: December 8, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Mien-Chie HUNG, Jong-Ho CHA, Li-Chuan CHAN
  • Publication number: 20220387337
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Application
    Filed: June 14, 2022
    Publication date: December 8, 2022
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Qiang CHENG, Tuo WEI, Daniel J. SIEGWART
  • Publication number: 20220387380
    Abstract: The present invention provides methods and compositions for treating or preventing melanoma with S-equol. The S-equol may be administered alone or in combination with one or more cytotoxic or immunotherapeutic compound or molecule.
    Type: Application
    Filed: August 15, 2022
    Publication date: December 8, 2022
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Rong LI, Bin YUAN, Tyler CURIEL
  • Publication number: 20220390456
    Abstract: Provided herein are methods for predicting whether a cancer patient will respond to treatment with bevacizumab based on determining a level of small extracellular vesicle (sEV)-associated VEGF in the patient. Also provided are methods of treating patients with either bevacizumab or a VEGFR tyrosine kinase inhibitor, a VEGFR neutralizing antibody, or a VEGF ligand trap based on the level of small extracellular vesicle (sEV)-associated VEGF in the patient.
    Type: Application
    Filed: October 16, 2020
    Publication date: December 8, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Honami NAORA, Song Yi KO
  • Publication number: 20220387393
    Abstract: Provided herein are methods of treating a dysmyelinating/demyelinating disease or condition in a patient in need thereof. The methods comprise restoring Qki-PPAR?-RXR?-dependent lipid metabolism in myelin. For example, the methods comprise administering a PPAR? agonist or an RXR agonist to the patient.
    Type: Application
    Filed: November 6, 2020
    Publication date: December 8, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jian HU, Xin ZHOU
  • Patent number: 11517877
    Abstract: Disclosed are air-stable small-molecule adsorbents trimeric [Cu—Br]3 and [Cu—H]3 that undergo a reversible solid-state molecular rearrangements to [Cu—Br.(alkene)]2 and [Cu—H.(alkene)]2 dimers. The reversible solid-state rearrangement allows one to break adsorbent design trade-offs and achieve low heat of adsorption while retaining high selectivity and uptake.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: December 6, 2022
    Assignees: Board of Regents, The University of Texas System, University of Canterbury
    Inventors: Rasika Dias, Matthew Greig Cowan, Devaborniny Parasar