Abstract: The present disclosure provides a textile coating composition comprising a primer bonding to at least one surface of a textile and a polymer brush bonding to the primer. The primer is of general formula (I) and the polymer brush is of general formula (II). A coated textile comprising a textile coated with the textile coating composition and a method of forming the coated textile are also provided.

Abstract: Methods and devices for analyzing and updating intermediate representations containing pointers includes compiling one or more source files into intermediate representations (IRs) having pointers, analyzing the IRs, producing transformed IRs comprising updated pointers, and producing object code from the transformed IRs. The device may include one or more non-transitory computer-readable storage devices having computer-executable instructions, when executed, cause a processing structure to perform the actions described relating to pointers. The analysis and updating of pointers may relate to types of bounds to enhance security of the systems in question by preventing erroneous references to memory space by pointers.

Abstract: The present application relates to hyaluronic acid (HA) hydrogels comprising divalent cations and hyaluronic acid molecules cross-lined with the divalent cations, and uses thereof. The present application also relates to methods of preparing the HA hydrogels of the present application.

Abstract: A linear double stranded deoxyribonucleic acid (dsDNA) molecule comprising operatively linked in 5? to 3? direction: a) one or more Ter sites at 5? terminus (“5? Ter”); b) a segment comprising a DNA sequence of interest; and c) one or more Ter sites at 3? terminus (“3? Ter). Also methods of protecting DNA sequences of interest from exonuclease degradation using the DNA constructs of the present disclosure, cells transformed with the DNA construct of the present disclosure and cell-free synthetic biology system comprising a linear dsDNA molecule of the present disclosure.

Abstract: Provided are antibodies or fragments thereof having binding specificity to anti-IL-18 receptor alpha or beta. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and inflammatory and autoimmune diseases are also provided.

Abstract: A fusion protein comprises a nanocage monomer; and an antibody or fragment thereof linked to the nanocage monomer, the antibody or fragment thereof comprising a first member of a binding pair; wherein a plurality of the fusion proteins self-assemble to form a nanocage in which a plurality of the antibodies or fragments thereof decorate the exterior surface of the nanocage, whereby the first member of the binding pair is exposed for interacting with a second member of a binding pair.

Abstract: Described are methods for generating a reporter molecule in response to a target analyte in a cell-free system. A synthetic biological circuit is used to modify the level of the reporter molecule in response to the presence of the target analyte. The reporter molecule may be glucose or another molecule readily detected using a device such as glucose monitor or other portable sensor. Also provided are kits comprising a cell-free system with a synthetic biological circuit that generates or consumes a reporter molecule in response to a target analyte.

Abstract: An azide-containing cross-linker and method of preparing the same are provided. Such cross-linker can be used as an intermediate in a scalable production of a cross-linked hemoglobin protein having its beta subunits covalently linked to the azide-containing cross-linker. The present disclosure also pertains to a hemoglobin-based oxygen carrier (HBOC) comprising a pair of azide cross-linked hemoglobin proteins coupled by a copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) and a method for preparing the same. The HBOC may be used in a method for increasing oxygen transport or for use in transfusions or perfusions.

Abstract: The present application relates to compounds (e.g. Formulae III, V, VII, IX, and XII) having a negative singlet-triplet gap and a positive oscillator strength. The present application also relates to use of the compounds of the present application in photocatalysis and in OLEDs as emitters and/or dopants.

Abstract: The present application relates to the treatment of nematode infections. For example, the application relates to the use of compounds of Formula (III) as defined herein for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection.

Abstract: A compound of formula (I): as described herein and methods and uses thereof as for mass tagging a biosensor or biologically active material.

Abstract: The present application provides an inhibitory compound, such as a peptide, and methods for using the inhibitory compound in the treatment, diagnosis or monitoring of cognitive and mood disorders that are typically associated with memory loss and/or loss of executive function. In one example, the inhibitory compound is a peptide that mimics the N-terminal sequence of the intracellular loop of ?5 subunit of ?5GABAA receptors. Also provided are compositions and methods for treating a disorder associated with memory loss or loss of executive function. The therapeutic method comprises the step of inhibiting binding of radixin to ?5GABAA receptors, for example, by administration of the presently described inhibitory compound or peptide.

Abstract: Phosphorylated heptose compounds are useful in modulating an immune response in a subject. Also, the compounds are useful as adjuvants.

Abstract: The invention describes methods and reagents useful for sequencing polypeptide molecules. The method comprises affixing a polypeptide to a substrate and contacting the polypeptide with a plurality of probes that selectively bind to a terminal amino acid or a terminal amino acid derivative. Probes bound to the polypeptide molecule are then identified before cleaving the terminal amino acid or terminal amino acid derivative of the polypeptide. Also provided are probe compositions comprising (a) a ClpS variant comprising at least 80% sequence identity to SEQ ID NO: 1, wherein the ClpS variant binds to an N-terminal amino acid or a N-terminal amino acid derivative with a different selectivity than a wild-type ClpS; and (b) a detectable label.

Abstract: Disclosed are optical devices suitable as security devices for document authentication, which comprise at least one array of patterns such as laser-fabricated patterns, or other structures, optionally formed for example from elongate laser-modified tracks extending within a document substrate. The patterns are combined with at least one array of microlenses to cause certain optical effects. Also disclosed are the use of such devices for document authentication, and methods for their production.

Abstract: The disclosure provides antibodies that bind human ITGAv/B1 and methods of use thereof. In some aspects, the disclosure is directed to methods of treating a cancer in a subject, comprising administering to the subject an anti-ITGAv/B1 antibody.

Abstract: A method to obtain a cache miss ratio curve where a memory blocks of a cache have variable block sizes. By stacking sets of counters, each set being for a different block size, a stack distance for variable block sizes can be obtained and used to determine a miss ratio curve. Such curve can then be used to select a cache size that is appropriate for an application without requiring excessive memory. Methods can be used for batches of request, can apply limits to block sizes, and rounding for intermediary block sizes, they can be used with pruning, and their space complexity can be held constant.

Abstract: For a given application, increasing the size of a cache is beneficial up to a certain point and the number of hits does not increase significantly with a greater cache size. This disclosure provides a method to determine a miss ratio curve, for a cache having data blocks with a time-to-live. A hashed value of a data block's key address can be used to generate a 2D HLL counter for storing expiry times of the data blocks. The 2D HLL counter can be converted to a 1D array, from which a stack distance can be calculated. A frequency distribution of stack distances can then be converted into a miss ratio curve, from which an appropriate cache size can be selected.

Abstract: The present disclosure relates to controlling drug release in cross-linked poly(valerolactone) based matrices. In one aspect, the compounds or pharmaceutically acceptable salts thereof include a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol (PEG) copolymer. In some embodiments, at least a portion of allylvalerolactone residues within the copolymer are crosslinked with a crosslinker. In some embodiments, the compound has a polydispersity index of less than or equal to 1.5. In one aspect, a method is described herein, comprising: (a) polymerizing valerolactone residues, allylvalerolactone, and polyethylene glycol residues in the presence of a non-metal catalyst via a ring opening polymerization to produce a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer; (b) crosslinking the poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer with a crosslinker; and (c) loading a drug into the crosslinked copolymer.

Abstract: Disclosed are optical devices suitable as security devices for document authentication, which comprise at least one two-dimensional array of elongate laser-modified tracks extending within a document substrate that have a distinct optical refractive index compared to the unmodified substrate, which can exhibit excellent diffractive effects. Also disclosed are the use of such devices for document authentication and methods for their production.