Abstract: This application relates to a method of detecting negatively charged phosphate-containing membranes and membrane components, such as in cell membranes or artificial lipid vesicles, and its use, for example, in detecting apoptosis and bacterial infection.

Abstract: The present disclosure relates to a composition comprising a post-translationally modified Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) protein. The disclosure further relates to methods of preventing or treating Crohn's Disease and/or a condition resulting from Crohn's Disease in a subject. The disclosure further relates to methods for diagnosing and/or predicting severity of and/or treating Crohn's Disease in a subject. Also disclosed are methods for diagnosing inflammatory bowel disease in a subject and methods for diagnosing a pre-disease state of Crohn's Disease in a subject.

Abstract: According to an aspect of an embodiment, operations may include obtaining a first fixed temperature and a second fixed temperature of a replica exchange Markov Chain Monte Carlo (MCMC) process used to solve an optimization problem associated with a system, and obtaining a plurality of replicas of the system. The operations may also include obtaining a target swap acceptance probability with respect to swapping, during the replica exchange MCMC process, between replicas that correspond to adjacently ordered temperatures of a set of temperatures between the first fixed temperature and the second fixed temperature. The operations may include determining a respective average swap acceptance probability with respect to one or more respective adjacent pairs of temperatures. Further, the operations may include adjusting one or more of the variable temperatures based on a relationship between the target swap acceptance probability and each of one or more of the respective swap acceptance probabilities.

Abstract: Some embodiments of the present disclosure provide a deep-learning-based framework for designing components of a downlink precoding system. The components of such a system include downlink training pilots and channel estimation based on receipt of the downlink training pilots. Another component involves channel measurement and feedback strategy at the user equipment. The components include a precoding scheme designed at the base station based on the feedback from the user equipment.

Abstract: The invention relates to a composite multilayer carbon dioxide (CO2) reduction catalyst, comprising a catalyst layer comprising at least one metal compound, the catalyst layer having opposed first and second sides; a hydrophobic gas-diffusion layer provided on the first side of the catalyst layer; a current collection structure provided on the second side of the catalyst layer. The metal is preferably copper. The invention also relates to a method for electrochemical production of a hydrocarbon product, such as ethylene, using said catalyst.

Abstract: Cryptographic processor chips, systems and associated methods are disclosed. In one embodiment, a cryptographic processor is disclosed. The cryptographic processor includes a first cryptographic processing module to perform a first logic operation. The first cryptographic processing module includes first input circuitry to receive ciphertext input symbols. A first pipeline stage performs a first operation on the ciphertext input symbols and generates a first stage output. On-chip memory temporarily stores the first stage output and feeds the first stage output to a second pipeline stage in a pipelined manner. The second pipeline stage is configured to perform a second operation on the first stage output in a pipelined manner with respect to the first pipeline stage.

Abstract: Embodiments of the present disclosure relate to generating explanation maps for explaining convolutional neural networks through attribution-based input sampling and block-wise feature aggregation. An example of a disclosed method for generating an explanation map for a convolutional neural network (CNN) includes obtaining an input image resulting in an output determination of the CNN, selecting a plurality of feature maps extracted from a plurality of pooling layers of the CNN, generating a plurality of attribution masks based on the plurality of feature maps, applying the generated attribution masks to the input image to obtain a plurality of visualization maps, and generating an explanation map of the output determination of the CNN based on the plurality of visualization maps.

Abstract: Methods and systems for mRNA analysis and quantification of mRNA expression in cells are provided. An example method includes introducing a first capture probe and a second capture probe into the cells, the first capture probe and the second capture probe each configured to be complementary to a respective section of target mRNA within the cells, wherein binding of the first and second capture probes to the respective sections of the target mRNA results in tagging of the cells and causes the first and second capture probes to form clusters with each other. The first capture probe and the second capture probe are each bound to magnetic nanoparticles (MNPs) that, when trapped within the tagged cells, cause the tagged cells to be susceptible to magnetic forces. The method and system further include introducing the cells into a device configured to magnetically capture tagged cells.

Abstract: A storage unit stores some of a plurality of coupling coefficients stored in a storage device. A processing unit takes a plurality of first state variables among a plurality of state variables as a trial target set. The processing unit performs a process of reading a plurality of first coupling coefficients corresponding to a plurality of first pairs of the first state variables belonging to the trial target set from the storage device, storing the plurality of first coupling coefficients in the storage unit, and conducting, a plurality of times, a trial on whether to update the value of any first state variable belonging to the trial target set using the plurality of first coupling coefficients. The processing unit repeats change of the trial target set and the process, so as to target all the plurality of state variables in the trials.

Abstract: The invention describes methods and reagents useful for sequencing polypeptide molecules. The method comprises affixing a polypeptide to a substrate and contacting the polypeptide with a plurality of probes. Each probe selectively binds to an N-terminal amino acid or an N-terminal amino acid derivative. Probes bound to the polypeptide molecule are then identified before cleaving the N-terminal amino acid or N-terminal amino acid derivative of the polypeptide. Also provided are methods for the sequencing a plurality of polypeptide molecules in a sample and probes specific for N-terminal amino acids or N-terminal amino acid derivatives.

Abstract: Heptose-1-monophosphate-7-derivatives are modifiable immunomodulators that can be used to prepare clinically active conjugate compounds. Such conjugate compounds are useful in modulating an immune response in a subject.

Abstract: An electric vehicle fast charger and methods thereof are described, adapted for re-use of magnetic components of an electric vehicle having traction converters when the electric vehicle is stationary and connected to a power grid. A switching stage provided by one or more sets of switches is controlled complementarily with the switches of the traction converters to (i) provide inversion of a grid voltage and (ii) shape current of the grid current between the electric vehicle and the power grid to track a waveshape of the grid voltage. A single switching stage and a dual switching stage circuit are contemplated, along with switch controller circuits, and instruction sets for switch control. Variants provide for energy transfer to accommodate for energy imbalances between storage devices.

Abstract: Brain-targeted (BT) and ROS-activable nanoconstructs (NC) comprising a metal oxide nanoparticle embedded in a matrix of lipid and a brain targeted polymer (BTP)/platform configured to facilitate blood brain barrier (BBB) penetration and accumulation in a disease area of the central nervous system (CNS), as well as compositions having the BT and ROS-activable NC and methods of using the BT and ROS-activable NC to treat and diagnose a CNS disease or condition.

Abstract: The present invention is directed to compounds, compositions, and methods for inhibiting drug-efflux pumps. The compounds, compositions, and methods can be used for enhancing the activity of therapeutic agents that are efflux pump substrates and for the treatment of drug-resistant diseases or disorders, such as microbial infections and cancers.

Abstract: Methods and systems for data management are described, particularly for processing global queries. Each global query includes a user-defined query constraint value, such as laxity or query response time limit. The query receiving node maintains a copy of the previously updated data from all of its children node. The query receiving node first searches for the requested query data in its local data storage to minimize children node query. If any portion of the requested data in the local data storage fails to meet the query constraint value, then the child node from which the data came from is tasked with recursively executing the global query.

Abstract: Aspects included herein include an electrolytic system for electrochemical reduction of carbon dioxide, the system comprising: a cathode comprising: a porous gas-diffusion membrane permeable to CO2; an electrocatalyst layer adjacent to a second side of the gas-diffusion membrane; the electrocatalyst layer comprising: an electrically conductive catalyst; and a selectivity-determining organic material attached to at least a portion of the electrically conductive catalyst; wherein: the organic material is formed of a plurality of oligomers; each oligomer comprises a plurality of covalently bonded base units; each base unit comprises at least one heterocyclic group having at least one nitrogen in its structure; and an anion exchange membrane adjacent to the electrocatalyst layer and positioned between the anode and the cathode; wherein anion exchange membrane is characterized by anion conductivity and the cathode is in ionic communication with the anode via the anion exchange membrane.

Abstract: An energy optimized imaging system that includes a light source that has the ability to illuminate specific pixels in a scene, and a sensor that has the ability to capture light with specific pixels of its sensor matrix, temporally synchronized such that the sensor captures light only when the light source is illuminating pixels in the scene.

Abstract: The present disclosure relates to electroactive materials that are useful for secondary battery electrode materials and the secondary battery device including thereof. Further, the disclosure relates to cathode and anode materials obtained via the polymerization of triptycene-based organic molecules having one or more arylene diimide groups attached forming a crosslinked network.

Abstract: A power-hub for an electric vehicle and operating modes thereof are disclosed herein. The disclosed power-hub is designed to operate in the Vehicle-to Grid (V2G), Grid-to-Vehicle (G2V), Vehicle-to-Home (V2H), and Vehicle-to-Vehicle (V2V) operating modes. When operating in the V2V mode, the power-hub is configured to allow for sending DC power through a conventional AC power port, with all the associated ratings and constraints from the AC design, in order to achieve higher power transfer and efficiency for V2V operation. A digital Hysteretic Current Mode Control (HCMC) scheme is disclosed and the efficiency and loss distribution of four operating modes are disclosed for the power-hub: 1) DC-AC Boundary Conduction Mode (BCM), 2) DC-AC Continuous Conduction Mode (CCM)/BCM hybrid, 3) DC-DC BCM, and 4) DC-DC CCM. A low-frequency commutation scheme is also disclosed that allows for reducing the peak junction temperature.

Abstract: Electrorefining cells and methods for electrorefining ferrous molten metal (e.g. steels), that includes impurities (e.g., carbon), are described. Liquid metal is provided in ladle with a molten electrolyte on top of it to form a metal-electrolyte interface. An electrode connection is put into contact with the metal for electronic conduction therewith, while a counter electrode is put into contact with the electrolyte for forming an electrolyte-counter electrode interface. Both the electrode connection and the counter electrode remain in the solid form in, and inert to, the metal and the electrolyte, respectively. The electrode connection and the counter electrode are made of an electronically conductive material.