Abstract: A wearing-type movement assistance device includes a frame to be worn on an upper limb of a wearer, a drive unit provided in each of joints of the frame, a biomedical signal detection unit detecting a biological potential signal of the wearer, a joint angle detection unit detecting an angle of each joint, and a control unit controlling the drive unit based on the biological potential signal and the angle of each joint. The frame includes a vertical frame, a shoulder frame that is laterally provided in a shoulder width direction from an upper end of the vertical frame, a first arm frame having one end coupled to the shoulder frame via a shoulder joint unit, and a second arm frame having one end coupled to the other end of the first arm frame via an intermediate joint unit and the other end connected to an elbow joint unit.

Abstract: There is provided a motion reproducing system and a motion reproducing apparatus that store human motions and reproduce them. The motion reproducing system includes a data acquiring apparatus acquiring body motion data representing a motion of a subject during the motion, and transmitting the body motion data, a data managing apparatus receiving the body motion data from the data acquiring apparatus, the data managing apparatus including a memory storing the body motion data, and a motion reproducing apparatus receiving the body motion data stored in the memory from the data managing apparatus, and allowing a reproducer to reproduce the motion of the subject using the body motion data, the motion being performed at the time of acquisition of the body motion data.

Abstract: Provided is a prodrug of 2-nitro-1-imidazolepropionic acid and a therapeutically active organic compound having on the molecule an amino group, a cyclic amino group or a hydroxyl group, particularly a prodrug in which the therapeutically active organic compound is selected from among antitumor agents. The prodrug cleaves specifically under hypoxic conditions in vivo to exhibit the inherent therapeutic activity.

Abstract: A storage unit stores therein a collection of structures of biomolecules whose structure varies. A computing unit decreases a temperature set as a temperature parameter, which represents the temperature of the biomolecules, from a prescribed value in steps. When decreasing the temperature of the temperature parameter, the computing unit performs clustering on the structures included in the collection from before the decrease, detects detect outlier structures from the clustering result, and performs molecular dynamics simulations using the temperature parameter with the outlier structures as initial structures. Then, the computing unit stores structures generated by the molecular dynamics simulations in the storage unit.

Abstract: An information processing apparatus includes: a memory configured to store a plurality of structures of a substance whose structure changes and a dimension group, which is a group of index dimensions that are indices for structural analysis of the substance, out of a plurality of dimensions that express the structure of the substance; and a processor configured to perform a procedure including: performing, for each of a plurality of candidate dimensions, which are not included in the dimension group, out of the plurality of dimensions, clustering of a plurality of structures in multidimensional space that has every index dimension included in the dimension group and a candidate dimension as coordinate axes; and adding a specified candidate dimension for which it is possible to generate a largest number of clusters to the dimension group as an index dimension.

Abstract: An electrocardiogram analyzer includes a first acquiring section that acquires a body surface electrocardiogram of a subject, a second acquiring section that acquires an intracardiac electrocardiogram of a ventricle of a heart of the subject, and an analyzing section that performs a frequency analysis on the intracardiac electrocardiogram and includes a range setting section that sets an analysis time range of the frequency analysis in the intracardiac electrocardiogram based on a unit waveform of the body surface electrocardiogram, and a calculating section that, in the analysis time range, performs the frequency analysis on the intracardiac electrocardiogram, and that calculates an index value indicating a ratio of local abnormal ventricular activities in the intracardiac electrocardiogram.

Abstract: [Problem to be Solved] The problem to be solved by the present invention is to reduce the load applied to the wearer by correcting a parameter in correspondence with detectivity of biosignals. [Means to Solve Problem] The calibration controlling part 162 of the movement assisting apparatus 10 enables the power amplifying part 158 to apply a driving force of the driving source 140 as a load (input torque) from the load generating part 164 to the wearer 12 when the wearer 12 wears the movement assisting wearing device. Then, the wearer 12 applied with the driving force of the driving source 140 generates power from the skeletal muscles by performing a predetermined calibration operation. Accordingly, the physical phenomenon detecting part 142 detects joint angle along with the calibration operation, and the biosignal detecting part 144 detects myoelectric signals.

Abstract: The present invention aims to provide a novel low-molecular-weight compound having an orexin agonist activity, which is expected to be useful as a superior agent for the treatment or prophylaxis of narcolepsy. The present invention provides a compound showing superior orexin agonist activity which is represented by the formula (I) wherein each symbol is as defined in the DESCRIPTION, and a pharmaceutically acceptable acid addition salt thereof, as well as an orexin agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.

Abstract: A MgF2 system fluoride sintered body for a radiation moderator having a compact polycrystalline structure excellent in radiation moderation performance, especially neutron moderation performance, contains CaF2 of 90% by weight at the maximum and has a relative density of 95.2% or more.

Abstract: [Problem] To provide a composition capable of effectively preventing adhesion. [Solution] An adhesion-preventing preparation comprising, as an active ingredient, a composition comprising an A-B-A triblock copolymer, in which A denotes a cationically chargeable polymer block and B denotes a water-soluble block that comprises a poly(ethylene glycol) (or poly(oxyethylene)) chain, and a polyanionic polymer.

Abstract: The present invention provides a novel boron carrier compound that can be used for boron neutron capture therapy for cancer, and that can realize improvement in the efficiency of a Drug Delivery System (DDS) and an increase in the boron concentration in a tumor. The present invention provides a boron cluster-modified PEG lipid derivative represented by Formula (I): wherein, m and n are each independently an integer of 1-4, q is an integer of 1-280, and R1 and R2 are each independently a hydrocarbon group with a carbon number of 8-22, and a molecular assembly containing the same.

Abstract: Data measured by PS-OCT is corrected in a non-linear manner to enhance the quantitative analysis capability of PS-OCT and permit accurate quantitative diagnosis, including diagnosis of disease stage of lesions, as a useful means for computer diagnosis. Even when retardation per PS-OCT 1 contains error and becomes noise and its distribution is not normal or symmetrical around the true value, measured data is converted using a distribution conversion function obtained by analyzing the characteristics of noise via Monte Carlo simulation to remove the systematic error and estimate the true value otherwise buried in noise and thereby correct the PS-OCT 1 image more clearly.

Abstract: This cycloduction measurement device is provided with a blood vessel position recognition unit and a first angle calculation unit. The blood vessel position recognition unit recognizes the position of a blood vessel in a sclera region in an eye image, and acquires information pertaining to the position of the blood vessel. The first angle calculation unit calculates the angle of cycloduction on the basis of the first information pertaining to the position of a predetermined blood vessel acquired by the blood vessel position recognition unit during actual measurement of cycloduction, and a second information pertaining to the position of the predetermined blood vessel while in a reference state.

Abstract: A wearable action-assist device includes a biosignal detection unit detecting a biosignal from a wearer, an action-assist wearing tool having a drive source supplying a torque acting on the wearer around each joint of the wearer as an axis of rotation, a control unit controlling the drive source to generate the torque according to the detected biosignal, a drive torque estimation unit estimating a drive torque generated by the drive source, a joint-angle detecting unit detecting an angular displacement of the joint, and a parameter identification unit identifying kinetics parameters concerned by substituting the estimated drive torque and the detected angular displacement into an equation of motion of an entire system including kinetics parameters intrinsic to the wearer. The control unit is configured to control the drive source according to a predetermined control method based on the equation of motion into which the identified parameters are substituted.

Abstract: An information processing apparatus includes: an outlying structure detecting unit that uses a certain outlier detection method to detect, from a distribution of molecular structures in a structural space, molecular structures deviating from others; an outlying degree specifying unit that specifies outlying degrees for the respective detected molecular structures; and an MD simulation executing unit that executes molecular simulations with initial structures set to the molecular structures to which weights are assigned in such a manner that a larger weight is assigned to a molecular structure for which the higher outlying degree has been specified.

Abstract: The present invention relate to a highly efficient and novel method, using clean technologies, for obtaining a natural bioactive concentrate that is rich on polyphenols from olive mill water (OMW). The clean technologies integrate centrifugation, a drowning-out crystallization-based separation process, and vacuum evaporation. The method provides a highly-concentrated polyphenol isolate (up to 99% (mass fraction)) from other components presents in OMW, with up to half of the polyphenol content being hydroxytyrosol. The isolated polyphenols exhibit anti-oxidant, anti-microbial, anti-inflammatory, and anti-carcinogenic activities; they can be prepared as solid particles, as an aqueous solution, in an emulsion, or as lipidic-based nanoparticles. The isolated polyphenols can be used in the food industry, cosmetic industry, or pharmaceutical industry.

Abstract: A classification estimating system can include an input element group; an intermediate element group into which are input values of first intermediate variables for which a first multiple desensitization, including an accumulation of values of each input element of a first input element group and each value of a first output sensitivity and each value of a first multiplex output sensitivity, has been carried out and calculated; an output element group into which is input a value of an output variable calculated based on a value of each intermediate element of a first intermediate element group and a value of each connection weight; a classification information estimating module for estimating classification information based on pre-stored correspondence relationship information and a value of the output variable; and a classification information display.

Abstract: A steam injector including an introducing portion introducing a liquid flow of a refrigerant and a steam flow of the refrigerant; a mixing portion that has a shape with an internal cross-sectional area decreasing toward a moving direction of the liquid flow, and internally mixes the jet-like liquid flow with the steam flow to form a refrigerant flow; a throat portion formed on an outlet side of the mixing portion; and a diffuser portion that has a shape with an internal cross-sectional area increasing from the throat portion toward a moving direction of the refrigerant flow, and discharges the refrigerant flow at an increased pressure from a discharge portion. The throat portion has an internal cross-sectional area smaller than a critical cross-sectional area at which a discharge pressure of the refrigerant flow discharged from the discharge portion nonlinearly increases when the internal cross-sectional area of the throat portion is reduced.

Abstract: Biomarkers for detecting cognitive dysfunction diseases and methods for detecting cognitive dysfunction diseases using the biomarkers are provided. A method for detecting cognitive dysfunction diseases comprising measuring one or more biomarkers for detecting cognitive dysfunction diseases selected from the following (a), (b), and (c) in a biological sample simultaneously or separately: (a) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of apolipoprotein A1 comprising the amino acid sequence represented by SEQ ID NO:1 or a partial peptide thereof; (b) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of transthyretin comprising the amino acid sequence represented by SEQ ID NO:2 or a partial peptide thereof; and (c) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of complement C3 comprising the amino acid sequence represented by SEQ ID NO:3 or a partial peptide thereof.

Abstract: [Problem] To provide a physiologically active peptide-loaded stable composition for injection into living bodies. [Solution] A composition containing a triblock copolymer represented by formula (I), a polyanionic polymer and a physiologically active peptide: CNR-PEG-CNR??(I) in the formula, CNR moieties are each independently a polymer segment containing a repeating unit that contains, as a part of a pendant group, a cyclic nitroxide radical bonded to a main polymer chain via a linking group that contains at least one amino group, and PEG is a segment that contains poly(ethylene glycol).