Abstract: Provided is a coating agent which can be stably immobilized on metal surface, and which can give blood compatibility. Provided is a copolymer which is usable as the above-mentioned coating agent that comprises PEG segment and a segment which has a phosphoric acid residue (PO(—OH)2) and a cyclic nitroxideradical randomly as a side chain or a pendant group.

Abstract: Provided is a plant such as tomato, in which plant vigor has been increased and heat resistance has further been imparted. A plant such as tomato can be obtained, which has increased the stem diameter as well as the plant height and has become heat resistant by having a mutant Della protein, in which a leucine corresponding to the leucine at position 567 in SEQ ID NO: 2 in the amino acid sequence of the Della protein has been replaced by another amino acid, preferably phenylalanine.

Abstract: The purpose of the present invention is to provide a compound useful as a prophylactic or therapeutic agent for various diseases and symptoms related to orexin receptors, and a medical usage of the same. The present invention provides a morphinan derivative represented by the general formula (I) below or a pharmaceutically acceptable acid addition salt thereof, the morphinan derivative having excellent selectivity for and antagonism against orexin receptors and excellent therapeutic and prophylactic effects on drug dependence, and an orexin receptor antagonist and a therapeutic or prophylactic agent for drug dependence each containing it as an active ingredient.

Abstract: A heat-tolerant tomato plant exhibiting a high capacity for developing seed-containing fruits under high temperature conditions is provided. The present invention relates to a method for producing a heat-tolerant tomato plant comprising introducing a genetic mutation into a tomato plant, wherein the mutation improves the pollen viability and the capacity for developing seed-containing fruits under high temperature conditions compared with wild-type plant; and a heat-tolerant tomato plant into which the mutation has been introduced.

Abstract: The present invention aims to provide a novel low-molecular-weight compound exhibiting an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.

Abstract: A super-resolution microscope includes an illuminator and a detector. The illuminator irradiates illumination beams of different wavelengths through an objective lens onto a sample while causing at least a portion of the illumination beams to overlap spatially and temporally. The detector detects a signal beam generated by the sample as a result of irradiation of the sample with the illumination beams. The illumination beams include a first illumination beam that induces a first nonlinear optical process with respect to the sample and a second illumination beam that induces a second nonlinear optical process that suppresses the first nonlinear optical process. The nonlinear susceptibility of the second nonlinear optical process is greater than the nonlinear susceptibility of the first nonlinear optical process.

Abstract: A swallowing action measurement device includes a holder, a sound detector and a posture detector. The holder is fitted to a neck region of a person being measured from behind. The sound detector is held in the holder in contact with the outer side surface of the neck region close to the epiglottis, and detects sound associated with at least a swallowing action of the person being measured and outputs a measured sound signal. The posture detector detects a posture of the person being measured.

Abstract: The present invention relates to a carotenoid-containing composition for use in exercise therapy for improving cognitive function, particularly exercise therapy for hippocampal neurogenesis.

Abstract: Problem to be Solved A traverse that is percutaneously provided and a surgical instrument for percutaneously providing the transverse are provided. Solution A rod 10 is placed in each of two rod openings 113, 123 and a transverse bar 130 is inserted in two bar holes 111, 121. Set screws 140, 150 are screwed in screw holes 114, 124. The set screws 140, 150 press the transverse bar 130, thereby restraining the transverse bar 130 in the longitudinal direction. Since portions of the bar holes 111, 121 adjoin the rod openings 113, 123, the pressed transverse bar 130 contacts the rods 10 and pushes the rods 10 against the rod openings 113, 123. A protrusion 127 engages with the rods 10 to restrain hooks 110, 120 in the longitudinal direction and circumferential direction of the rods 10.

Abstract: An information processing apparatus includes: a memory configured to store a plurality of structures of a substance whose structure changes and a dimension group, which is a group of index dimensions that are indices for structural analysis of the substance, out of a plurality of dimensions that express the structure of the substance; and a processor configured to perform a procedure including: performing, for each of a plurality of candidate dimensions, which are not included in the dimension group, out of the plurality of dimensions, clustering of a plurality of structures in multidimensional space that has every index dimension included in the dimension group and a candidate dimension as coordinate axes; and adding a specified candidate dimension for which it is possible to generate a largest number of clusters to the dimension group as an index dimension.

Abstract: A wearing-type movement assistance device includes a frame to be worn on an upper limb of a wearer, a drive unit provided in each of joints of the frame, a biomedical signal detection unit detecting a biological potential signal of the wearer, a joint angle detection unit detecting an angle of each joint, and a control unit controlling the drive unit based on the biological potential signal and the angle of each joint. The frame includes a vertical frame, a shoulder frame that is laterally provided in a shoulder width direction from an upper end of the vertical frame, a first arm frame having one end coupled to the shoulder frame via a shoulder joint unit, and a second arm frame having one end coupled to the other end of the first arm frame via an intermediate joint unit and the other end connected to an elbow joint unit.

Abstract: A method for efficiently producing a poly(ethylene glycol)-b-poly(halomethylstyrene), a novel poly(ethylene glycol)-b-poly(halomethylstyrene) produced using the method, and a derivative thereof. The target novel copolymer can be provided by introducing a functional group, which enables reversible addition-fragmentation chain transfer (RAFT) polymerization, to the ? terminal of poly(ethylene glycol) and copolymerizing the resulting poly(ethylene glycol) with a halomethylstyrene.

Abstract: Provided is a gel material for ophthalmic treatment useful as a synthetic vitreous body which is a novel intraocular tamponade material having a low swelling pressure, an appropriate elastic force, and no toxicity to ocular tissues, specifically, to retinas, and which is capable of stably maintaining a long-term stable tamponade effect. A gel material for ophthalmic treatment including a hydrogel in which a gel precursor cluster crosslinks to form a three-dimensional network. The gel precursor cluster has a structure with crosslinked monomer units or crosslinked polymer units present at concentrations less than a critical gelation concentration, and the gel precursor cluster has a relationship of G?<G? where G? represents a storage elastic modulus and G? represents a loss elastic modulus. The hydrogel has a polymer content of 50 g/L or less, a storage elastic modulus G? of 1 to 10,000 Pa at a frequency of 1 Hz, and a fractal dimension of 1.5 to 2.5.

Abstract: The present invention relates to a nalfurafine-containing percutaneous absorption patch having a support, a drug layer and a control layer which are laminated successively, wherein the drug layer contains at least one kind of a drug selected from the group consisting of nalfurafine and a salt thereof, and capable of maintaining a given level of drug skin permeation amount without permeation of an excess amount of the drug through the skin in a short time even when applied to the skin in which the horny cell layer and the like are damaged and the skin barrier is insufficient.

Abstract: From OCT-measured data, only the image data of the choroidal vascular network present in the layer of the choroidal layer is selectively extracted, thereby accurately obtaining the thickness of the choroidal vessels and thickness of the choroidal vascular network from the image data, to allow for quantitative evaluation of the choroidal vascular network. The optical coherence tomography apparatus has an optical coherence tomography device, and a computer that processes the three-dimensional OCT tomographic images obtained based on the OCT-measured data acquired by the optical coherence tomography device. The computer functions as a means for selectively separating out only the images of the choroidal vessels from the three-dimensional OCT tomographic images to acquire image data of the choroidal vessels, and also as a means for obtaining the data to be used in the quantitative evaluation of the shape of the choroidal vessels based on the image data of the choroidal vessels.

Abstract: The purpose of the present invention is to provide a compound useful as a prophylactic or therapeutic agent for various diseases and symptoms related to orexin receptors, and a medical usage of the same. The present invention provides a morphinan derivative represented by the general formula (I) below or a pharmaceutically acceptable acid addition salt thereof, the morphinan derivative having excellent selectivity for and antagonism against orexin receptors and excellent therapeutic and prophylactic effects on drug dependence, and an orexin receptor antagonist and a therapeutic or prophylactic agent for drug dependence each containing it as an active ingredient.

Abstract: Provided is a coating agent which can be stably immobilized on metal surface, and which can give blood compatibility. Provided is a copolymer which is usable as the above-mentioned coating agent that comprises PEG segment and a segment which has a phosphoric acid residue (PO(—OH)2) and a cyclic nitroxideradical randomly as a side chain or a pendant group.

Abstract: A microchannel device includes: an upstream channel portion configured to allow an upstream liquid plug and a gas to flow therethrough; a downstream channel portion configured to allow a downstream liquid plug and a gas to flow therethrough; a liquid holding portion provided between a downstream end portion of the upstream channel portion and an upstream end portion of the downstream channel portion, the liquid holding portion being configured to hold a main liquid plug therein; and a gas bypass channel portion provided so as to bypass the liquid holding portion from the downstream end portion of the upstream channel portion to the upstream end portion of the downstream channel portion, the gas bypass channel portion being configured to allow the gas to flow therethrough in a state in which the liquid holding portion holds the main liquid plug.

Abstract: The present invention is intended to provide an active exercise apparatus for lower limbs that allows a user to perform on a floor lower limb active exercise highly effective in preventing thrombosis.

Abstract: A super-resolution microscope includes an illuminator that irradiates illumination beams of colors of different wavelengths through an objective lens onto a sample while causing the illumination beams to overlap at least spatially and a detector that detects a signal beam generated by the sample through irradiation with the illumination beams. As the illumination beams, the illuminator irradiates first and second illumination beams onto the sample from the same direction. The first illumination beam includes multiple wavelengths or monochromatic light for inducing a nonlinear optical effect in the sample. The second illumination beam has a different wavefront distribution on a converging surface of the objective lens or a different spatial distribution of an electrical field vector than the first illumination beam and suppresses induction of the nonlinear optical effect. The detector detects a signal beam generated by the sample as a result of the nonlinear optical effect.