Patents Assigned to University of Tsukuba
  • Patent number: 11103369
    Abstract: An artificial leg motion assisting apparatus and an artificial leg motion assisting method which are capable of transmitting knee joint motive power to a commercially-available trans-femoral prosthesis without making a wearer feel a sense of discomfort. When the artificial leg motion assisting apparatus is attached to the commercially-available trans-femoral prosthesis, a control unit controls a drive unit by a specified control method on the basis of mechanical impedance adjusted by an impedance adjustment unit and transmits output of the drive unit to a knee joint coupling.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: August 31, 2021
    Assignees: CYBERDYNE INC., UNIVERSITY OF TSUKUBA
    Inventor: Yoshiyuki Sankai
  • Patent number: 11103182
    Abstract: A walking training system and walking training machine capable of remarkably enhancing the effect of improving an independent walking function are proposed. When a subject having a lower limb functional disorder performs walking training, the degree of dependency on upper limbs can be evaluated by enabling the subject to recognize transitional reductions of a load on a holding part(s) by feeding back the transitional reductions of the load as a sense to feel them.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: August 31, 2021
    Assignees: CYBERDYNE INC., UNIVERSITY OF TSUKUBA
    Inventor: Yoshiyuki Sankai
  • Publication number: 20210214228
    Abstract: A carbon nanotube composite is a carbon nanotube composite including one carbon nanotube and an amorphous carbon-containing layer that coats the carbon nanotube, the carbon nanotube having a D/G ratio of 0.1 or less, the D/G ratio being a ratio of a peak intensity of a D band to a peak intensity of a G band in Raman spectroscopic analysis with a wavelength of 532 nm, the carbon nanotube composite being fibrous and having a diameter of 0.1 ?m or more and 50 ?m or less.
    Type: Application
    Filed: August 29, 2019
    Publication date: July 15, 2021
    Applicants: SUMITOMO ELECTRIC INDUSTRIES, LTD., UNIVERSITY OF TSUKUBA
    Inventors: Toshihiko FUJIMORI, Takeshi HIKATA, Soichiro OKUBO, Jun-ichi FUJITA
  • Patent number: 11059888
    Abstract: A regulatory T cell activator including a substance that inhibits the binding between DNAX accessory molecule-1 (DNAM-1) and CD155.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: July 13, 2021
    Assignee: University of Tsukuba
    Inventors: Akira Shibuya, Kazuko Shibuya, Fumie Abe, Rei Hirochika, Genki Okumura
  • Patent number: 11058685
    Abstract: The present invention provides a therapeutic agent and others for various tumors including angioimmunoblastic T-cell lymphoma (AITL), which is an orphan disease. The present invention relates to a therapeutic agent and others for tumors identified by phosphorylation of a proto-oncogene protein belonging to the VAV family, which comprises dasatinib or a prodrug thereof or a pharmacologically acceptable salt thereof or a hydrate or solvate thereof as an active ingredient.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: July 13, 2021
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Shigeru Chiba, Mamiko Yanagimoto
  • Publication number: 20210196134
    Abstract: A physiological state evaluation apparatus contacts an external auditory pore when mounted in a subject's auricle. The evaluation apparatus: collects sound vibrations generated from a larynx and a pharynx via a cartilage region of the external auditory pore; optically detects a pulsatory motion of blood through blood vessels and measures pulse rate and blood oxygen saturation, on the basis of a change in optical intensity caused by the pulsatory motion; detects brain waves and eye movements using a pair of conductive electrodes for detecting electric potentials of right and left external auditory pore surfaces; detects, sound quality, number of times, tidal volume, and rhythm of the subject's breaths on the basis of the acoustic signal; and evaluates a health condition of the subject while sleeping on the basis of the respiratory condition, the pulse rate and the blood oxygen saturation, and the brain waves and the eye movements.
    Type: Application
    Filed: July 5, 2019
    Publication date: July 1, 2021
    Applicants: CYBERDYNE INC., UNIVERSITY OF TSUKUBA
    Inventor: Yoshiyuki SANKAI
  • Publication number: 20210177270
    Abstract: A photoacoustic imaging apparatus comprises: a light emitting unit emitting pulsed light with a wavelength absorbed inside a subject; a thin, flexible film applied to a skin surface of the subject to make the pulsed light transmit it and reflects the light on its outer surface at the same time; a multi-directional light emitting unit emitting a plurality of visible light beams from multi-directions to the outer surface of the thin film; a micro-vibration detection unit detects, on the basis of diffraction and/or interference of a plurality of reflected light obtained from the outer surface of the thin film, a state of causing micro-vibrations of the thin film as the photoacoustic waves generated from the light absorber collide against an inner backside of the thin film; and a shape image transformation unit that produces the images of a shape of the light absorber as detected by the micro-vibration detection unit.
    Type: Application
    Filed: July 24, 2019
    Publication date: June 17, 2021
    Applicants: CYBERDYNE INC., UNIVERSITY OF TSUKUBA
    Inventor: Yoshiyuki SANKAI
  • Publication number: 20210169533
    Abstract: Problem to be Solved A traverse that is percutaneously provided and a surgical instrument for percutaneously providing the transverse are provided. Solution A rod 10 is placed in each of two rod openings 113, 123 and a transverse bar 130 is inserted in two bar holes 111, 121. Set screws 140, 150 are screwed in screw holes 114, 124. The set screws 140, 150 press the transverse bar 130, thereby restraining the transverse bar 130 in the longitudinal direction. Since portions of the bar holes 111, 121 adjoin the rod openings 113, 123, the pressed transverse bar 130 contacts the rods 10 and pushes the rods 10 against the rod openings 113, 123. A protrusion 127 engages with the rods 10 to restrain hooks 110, 120 in the longitudinal direction and circumferential direction of the rods 10.
    Type: Application
    Filed: December 17, 2020
    Publication date: June 10, 2021
    Applicants: ASRO medical, UNIVERSITY OF TSUKUBA
    Inventors: Tetsuya ABE, Masataka SAKANE, Taira TAKATO
  • Patent number: 11020294
    Abstract: Provided are a mobility and a mobility system which enable a person who requires nursing care with a deteriorated bodily function or cognitive function to lead a life with greater independence. The drive and travel of the mobility by the travel drive unit are controlled by adjusting the current travel state of the mobility to an optimal travel state for ensuring safety while reflecting the user's intention based on the current operation instruction detected by the operation unit, the command signal generated by the voluntary control unit, the travel environment sensed by the environment sensing unit, and the respective types of environmental information acquired by the information acquisition unit.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: June 1, 2021
    Assignees: CYBERDYNE INC., UNIVERSITY OF TSUKUBA
    Inventor: Yoshiyuki Sankai
  • Patent number: 11002678
    Abstract: A data creation method includes: an autofluorescence data generation step of placing a focus of light having a predetermined wavelength at one set of coordinates on a predetermined focal plane, irradiating a sample positioned at the set of coordinates with excitation light containing the light to obtain autofluorescence emitted from the sample, and generating autofluorescence data including intensity data and/or spectrum data of the autofluorescence; a reflected light data generation step of irradiating the set of coordinates on the predetermined focal plane with illumination light to obtain reflected light scattered by the sample, and generating intensity data of the reflected light; and a correspondence data creation step of creating correspondence data associating the autofluorescence data and the reflected light data on the set of coordinates on the predetermined focal plane.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: May 11, 2021
    Assignee: University of Tsukuba
    Inventors: Nobuhiko Nomura, Yutaka Yawata, Tatsunori Kiyokawa
  • Publication number: 20210108218
    Abstract: An expression system is provided, including a first nucleic acid fragment containing a long intergenic region (LIR) derived from geminivirus, a small intergenic region (SIR) derived from geminivirus, and an expression cassette of a target protein linked between the LIR and the SIR and a second nucleic acid fragment containing an expression cassette of a Rep/RepA protein derived from geminivirus, in which the expression cassette of the target protein includes a promoter, a nucleic acid fragment encoding the target protein, and two or more linked terminators in this order.
    Type: Application
    Filed: March 6, 2018
    Publication date: April 15, 2021
    Applicant: University of Tsukuba
    Inventors: Kenji MIURA, Hiroshi EZURA, Ken HOSHIKAWA
  • Patent number: 10961160
    Abstract: A fluoride sintered body suitable for a moderator which moderates high-energy neutrons so as to generate neutrons for medical care with which an affected part of the deep part of the body is irradiated to make a tumor extinct comprises MgF2 of a compact polycrystalline structure having a bulk density of 2.90 g/cm3 or more and as regards mechanical strengths, a bending strength of 10 MPa or more and a Vickers hardness of 71 or more.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: March 30, 2021
    Assignees: UNIVERSITY OF TSUKUBA, DAICO MFG CO., LTD.
    Inventors: Hiroaki Kumada, Tetsuyuki Nakamura, Takuji Shigeoka, Takeshi Ikeda
  • Publication number: 20210078955
    Abstract: The present invention aims to provide a novel low-molecular-weight compound showing an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Application
    Filed: December 11, 2018
    Publication date: March 18, 2021
    Applicants: University of Tsukuba, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hiroshi NAGASE, Tsuyoshi SAITOH, Masashi YANAGISAWA, Yoko IRUKAYAMA
  • Publication number: 20210031358
    Abstract: [Problem] Learning of object operation skills robust against variation of conditions is implemented. [Solution] A behavior estimation apparatus 100 includes a collection unit 200 configured to collect skill data obtained when a slave robot is operated under a plurality of different conditions by using a bilateral system capable of operating the slave robot via a master robot through bidirectional control between the master robot and the slave robot. The behavior estimation apparatus 100 further includes a behavior estimation device 300 configured to estimate a command value for causing the slave robot 520 to automatically behave, based on the skill data collected by the collection unit 200 and a response output from the slave robot 520.
    Type: Application
    Filed: March 20, 2019
    Publication date: February 4, 2021
    Applicant: University of Tsukuba
    Inventor: Sho SAKAINO
  • Patent number: 10905473
    Abstract: Problem to be Solved A traverse that is percutaneously provided and a surgical instrument for percutaneously providing the transverse are provided. Solution A rod 10 is placed in each of two rod openings 113, 123 and a transverse bar 130 is inserted in two bar holes 111, 121. Set screws 140, 150 are screwed in screw holes 114, 124. The set screws 140, 150 press the transverse bar 130, thereby restraining the transverse bar 130 in the longitudinal direction. Since portions of the bar holes 111, 121 adjoin the rod openings 113, 123, the pressed transverse bar 130 contacts the rods 10 and pushes the rods 10 against the rod openings 113, 123. A protrusion 127 engages with the rods 10 to restrain hooks 110, 120 in the longitudinal direction and circumferential direction of the rods 10.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: February 2, 2021
    Assignees: ASRO medical, UNIVERSITY OF TSUKUBA
    Inventors: Tetsuya Abe, Masataka Sakane, Taira Takato
  • Publication number: 20200386684
    Abstract: A data creation method includes: an autofluorescence data generation step of placing a focus of light having a predetermined wavelength at one set of coordinates on a predetermined focal plane, irradiating a sample positioned at the set of coordinates with excitation light containing the light to obtain autofluorescence emitted from the sample, and generating autofluorescence data including intensity data and/or spectrum data of the autofluorescence; a reflected light data generation step of irradiating the set of coordinates on the predetermined focal plane with illumination light to obtain reflected light scattered by the sample, and generating intensity data of the reflected light; and a correspondence data creation step of creating correspondence data associating the autofluorescence data and the reflected light data on the set of coordinates on the predetermined focal plane.
    Type: Application
    Filed: December 22, 2017
    Publication date: December 10, 2020
    Applicant: University of Tsukuba
    Inventors: Nobuhiko NOMURA, Yutaka YAWATA, Tatsunori KIYOKAWA
  • Patent number: 10842585
    Abstract: A model of a body part, e.g., liver, of which the internal structure can be observed easily; and others. In a liver model according to the present invention, the liver parenchyma is formed in the form of a frame to make it possible to observe the portal, veins, a tumor and others in the inside of the frame 31a easily. In addition, the liver model can be handled easily by gripping a gripping part provided at the lower end surface of the inferior vena cava, and the tumor is integrated with the liver model by means of a joint part. The liver model can be manufactured from a model material using a 3D printer on the basis of three-dimensional shape data for model manufacturing purposes, which are produced using an information processing device.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: November 24, 2020
    Assignees: UNIVERSITY OF TSUKUBA, DAI NIPPON PRINTING CO., LTD.
    Inventors: Jun Mitani, Nobuhiro Ohkohchi, Yukio Oshiro, Kentaro Ko, Takuji Hayashi
  • Publication number: 20200309789
    Abstract: Biomarkers for detecting cognitive dysfunction diseases and methods for detecting cognitive dysfunction diseases using the biomarkers are provided. A method for detecting cognitive dysfunction diseases comprising measuring one or more biomarkers for detecting cognitive dysfunction diseases selected from the following (a), (b), and (c) in a biological sample simultaneously or separately: (a) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of apolipoprotein A1 comprising the amino acid sequence represented by SEQ ID NO:1 or a partial peptide thereof; (b) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of transthyretin comprising the amino acid sequence represented by SEQ ID NO:2 or a partial peptide thereof; and (c) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of complement C3 comprising the amino acid sequence represented by SEQ ID NO:3 or a partial peptide thereof.
    Type: Application
    Filed: June 2, 2020
    Publication date: October 1, 2020
    Applicants: MCBI INC., UNIVERSITY OF TSUKUBA
    Inventors: Kazuhiko UCHIDA, Kohji MENO, Hideaki SUZUKI, Yoshinori NISHIMURA
  • Patent number: 10781108
    Abstract: A two-dimensional hydrogen boride-containing sheet of the present invention has a two-dimensional network that consists of (HB)n (n?4).
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: September 22, 2020
    Assignees: University of Tsukuba, Tokyo Institute of Technology
    Inventors: Takahiro Kondo, Junji Nakamura, Hiroaki Nishino, Asahi Fujino, Tomohiro Fujimori, Hideo Hosono, Masahiro Miyauchi
  • Publication number: 20200290877
    Abstract: A carbon nanostructure producing method includes a growth step in which a plurality of catalyst particles in close contact with each other are separated in a flow of a carbon-containing gas so as to grow carbon nanotubes between the plurality of catalyst particles, and an elongation step in which the carbon nanotube is elongated by a wind pressure of the carbon-containing gas with at least one of the catalyst particles being retained.
    Type: Application
    Filed: June 29, 2018
    Publication date: September 17, 2020
    Applicants: SUMITOMO ELECTRIC INDUSTRIES, LTD., UNIVERSITY OF TSUKUBA
    Inventors: Takeshi HIKATA, Soichiro OKUBO, Ryusuke NAKAI, Jun-ichi FUJITA