Patents Assigned to University of Vermont and State Agricultural College
  • Methods of treating diseases associated with PPAR?
    Patent number: 9393288
    Abstract: The invention relates to methods for modulating PPAR-? activity using relaxin or agonists thereof. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including small vessel disorders of the brain and those associated with increased blood-brain barrier permeability, cognitive disorders such as Alzheimer's disease, vascular dementia, epilepsy, stroke, CADASIL and migraine.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: July 19, 2016
    Assignee: The University of Vermont and State Agricultural College
    Inventor: Marilyn J. Cipolla
  • Adjustable total internal reflectance microscopy (TIRFM) illuminator apparatus
    Patent number: 9335533
    Abstract: A new apparatus and method of delivering light to the hack aperture of a High Numerical Aperture (NA) Microscopy Objective lens for Total Internal Reflectance Microscopy (TIRFM) is provided. The apparatus and method include pumping light generated by a laser through an optical fiber which is optically coupled to the objective lens by a collimating optical element, such as, for example a lens or prism. The apparatus and method also include providing a fiber axial translator which is mechanically adjustable for focusing the laser light optically coupled to the objective lens. The apparatus also includes a mechanical coupler for mechanically coupling the apparatus to the object lens such that the laser light optically coupled to the objective lens can be adjusted to exceed, or not exceed, a critical angle associated with TIRFM illumination.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: May 10, 2016
    Assignee: The University of Vermont and State Agricultural College
    Inventors: Guy Kennedy, David M. Warshaw
  • Methods of predicting and monitoring labor
    Patent number: 9326722
    Abstract: The invention includes, in part, methods and apparatus for determining the status of labor in a pregnant subject. In some embodiments of the invention, organ-level uterine function is determined as a measure of the status of labor such as non-labor (e.g. false labor), latent phase labor, active phase labor, or post-delivery.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: May 3, 2016
    Assignee: University of Vermont and State Agricultural College
    Inventor: Roger C. Young
  • LEPTIN FOR TREATING SYSTEMIC INFLAMMATORY RESPONSE SYNDROME
    Publication number: 20160058839
    Abstract: Provided are methods and compositions for reducing the severity of systemic inflammatory response syndrome (SIRS). The method comprises administering to an individual who has been diagnosed with SIRS, a composition comprising leptin.
    Type: Application
    Filed: May 2, 2014
    Publication date: March 3, 2016
    Applicant: UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE
    Inventor: Benjamin T. SURATT
  • Method and system for the selective oxidative decarboxylation of fatty acids
    Patent number: 9272275
    Abstract: Selective, radically initiated oxidative decarboxylation may produce low viscosity renewable fuels from biologically derived fats and oils. Fatty acids and triglycerides may be decarboxylated using oxidants at a water/oil interface. The oxidants may be produced using photo-Fenton reagents. The reaction advantageously can be carried out at room temperature and pressure and has fewer unwanted byproducts than traditional decarboxylation techniques.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: March 1, 2016
    Assignee: University of Vermont and State Agricultural College
    Inventors: Bryan J. Holmes, Alexander Wurthmann
  • Peptidic activators of type I cGMP dependent protein kinases and uses thereof
    Patent number: 9260486
    Abstract: The present invention relates to cGMP protein kinase (PKG) and regulatory domains and methods of use thereof. The structural determination of PKG domains is also described. cGMP independent PKG activators and uses thereof are also described.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: February 16, 2016
    Assignee: The University of Vermont and State Agricultural College
    Inventors: Wolfgang Dostmann, Brent W. Osborne, Thomas M. Moon
  • AUGMENTING THE IMMUNE RESPONSE BY PROMOTING CELL DEATH OF IMMUNE CELLS
    Publication number: 20160030538
    Abstract: Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject.
    Type: Application
    Filed: July 22, 2015
    Publication date: February 4, 2016
    Applicant: The University of Vermont and State Agricultural College
    Inventor: Ralph C. Budd
  • METHODS AND COMPOSITIONS FOR EXPRESSING FUNCTIONAL CLASS XIV MYOSIN
    Publication number: 20150329610
    Abstract: The invention, in part, includes methods and compounds useful to prepare and functional class XIV myosin. Functional class XIV myosin prepared using methods of the invention may be useful to screen for and identify compounds that inhibit and treat parasitic infections and contamination.
    Type: Application
    Filed: May 14, 2015
    Publication date: November 19, 2015
    Applicant: University of Vermont and State Agricultural College
    Inventors: Kathleen M. Trybus, Gary E. Ward
  • Apparatus and method for ultrasound treatment for ballast water management
    Patent number: 9174189
    Abstract: The invention provides a method of treating a target area with an ultrasound wave pattern, including: providing an ultrasound apparatus having an ultrasound wave generator operatively attached to a plurality of transducers, coupled to an immersible support and configured to emit an ultrasound wave; immersing the apparatus into a water environment; positioning the apparatus proximate to a target area to treat at least one in situ organism; and emitting a pattern of ultrasound waves from the transducers, the pattern of ultrasound waves additive in effect and emitted onto the target area to threat an in situ underwater organism.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: November 3, 2015
    Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE, MONTCLAIR STATE UNIVERSITY
    Inventors: Mei-Yin Wu, Jun-Ru Wu
  • METHODS AND COMPOUNDS FOR REDUCING THREONYL-tRNA SYNTHETASE ACTIVITY
    Publication number: 20150210997
    Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by elevated threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is elevated as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by elevated TARS activity.
    Type: Application
    Filed: July 24, 2013
    Publication date: July 30, 2015
    Applicant: UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE
    Inventors: Christopher Francklyn, Karen M. Lounsbury, Jason Botten
  • Compact repeaters for wireless sensing
    Patent number: 9093741
    Abstract: In one embodiment, a repeater for wireless sensing includes a base substrate, a front substrate, a rear substrate, a receive antenna formed on the front substrate, a transmit antenna formed on the rear substrate, and a frequency multiplier formed on the base substrate between the antennas.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: July 28, 2015
    Assignees: University of South Florida, University of Vermont and State Agricultural College
    Inventors: Thomas McCrea Weller, Ibrahim Turki Nassar, Jeffrey Frolik
  • METHODS AND COMPOSITIONS FOR METABOLIC REGULATION
    Publication number: 20150202257
    Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
    Type: Application
    Filed: July 10, 2013
    Publication date: July 23, 2015
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Ketki M. Hatle
  • METHODS AND COMPOUNDS FOR INCREASING THREONYL-tRNA SYNTHETASE ACTIVITY
    Publication number: 20150166976
    Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by reduced threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is reduced as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by reduced TARS activity.
    Type: Application
    Filed: July 24, 2013
    Publication date: June 18, 2015
    Applicant: University of Vermont and State Agricultural College
    Inventors: Christopher Francklyn, Karen M. Lounsbury, Jason Botten
  • TREATMENTS OF OXIDATIVE STRESS CONDITIONS
    Publication number: 20150157686
    Abstract: The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.
    Type: Application
    Filed: June 20, 2013
    Publication date: June 11, 2015
    Applicant: The University of Vermont and State Agricultural College
    Inventors: Yvonne M. Janssen-Heininger, Vikas Anathy
  • METHODS AND PRODUCTS RELATING TO GSK3ß REGULATION
    Publication number: 20150150950
    Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.
    Type: Application
    Filed: December 5, 2014
    Publication date: June 4, 2015
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Tina M. Thornton
  • Portable Ultrafine Particle Sizer (PUPS) Apparatus
    Publication number: 20150068282
    Abstract: The Portable Ultrafine Particle Sizer (PUPS) invention is provided. The PUPS is an instrument which can measure particle number concentration for particle sizes under 200 nanometers in-situ. The PUPS is a compact design for quick mounting on vehicles. Size discrimination is accomplished using a compact reverse Differential Mobility Analyzer (rDMA). Particle charging is accomplished using corona ionization. Concentration measurements are completed using a unique flexible printed circuit board electrode which can be removed for cleaning, disposal or chemical analysis of collected particles at the end of its in situ measurement life.
    Type: Application
    Filed: April 20, 2014
    Publication date: March 12, 2015
    Applicant: The University of Vermont and State Agricultural College
    Inventors: Andrew Vize, Matthew Casari, Jeff Frolik, Britt Holmen
  • System and Method for Processing Signals to Enhance Audibility in an MRI Environment
    Publication number: 20150063596
    Abstract: A system for processing signals to enhance patient audibility of a plurality of signals in an MRI environment is provided. The system includes an acoustic measuring device for measuring sound power levels generated by the M RI and a principal frequency component identifier for identifying principal frequencies measured by the acoustic measuring device. The system also includes an audio equalizer for controlling the amplitude and frequency of each of the plurality of signals in accordance with the principal frequencies. Further provided by the system is an attenuator for attenuating an overall sound level of the signals being processed and a dynamic range compression processor.
    Type: Application
    Filed: November 7, 2014
    Publication date: March 5, 2015
    Applicant: The University of Vermont and State Agricultural College
    Inventor: John Mantegna
  • Genipin cross-linked fibrin gels
    Patent number: 8968725
    Abstract: The invention provides a genipin cross-linked fibrin gel. The ratio of genipin to fibrin in the gel ranges from about 0.1:1 to about 10:1 (genipin:fibrin). The gel can be hydrogel. Also provided is method for repairing tissue defects by administering the gel to site of tissue defect.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: March 3, 2015
    Assignee: University of Vermont and State Agricultural College
    Inventors: Rachel Schek, Arthur J. Michalek, James C. Iatridis
  • DETECTION OF GLUTATHIONYLATED PROTEINS
    Publication number: 20150056633
    Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc.
    Type: Application
    Filed: September 18, 2014
    Publication date: February 26, 2015
    Applicants: The University of Vermont and State Agricultural College, Universiteit Maastricht
    Inventors: Yvonne M. Janssen-Heininger, Niki Reynaert
  • CARDIAC PACEMAKER AND USES THEREOF
    Publication number: 20150051660
    Abstract: The invention relates to improved cardiac pacemakers and methods of use thereof. In particular the cardiac pacemakers are useful for normalizing heart rates over resting heart rates in order to condition the heart to improve overall cardiac output.
    Type: Application
    Filed: March 13, 2013
    Publication date: February 19, 2015
    Applicant: The University of Vermont and State Agricultural College
    Inventor: Markus Meyer