Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides. The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.

Abstract: A system and method for measuring a pulmonary performance value of a subject. In one embodiment, a system includes one or more imaging devices, each configured to capture one or more images of a subject inside an interior chamber, such as a plethysmograph chamber. An exemplary system also includes an imaging processor in communication with the one or more imaging devices for estimating a change in volume of the subject from information about the one or more images.

Abstract: A chromatographic system that includes a light source and an imaging and analysis system for detecting particle size and analyzing other characteristics of particles in the effluent of a filtration column while filtration is ongoing. The effluent is directed into a guiding tube having a flow axis. Coherent light from the light source is shone into the guiding tube along the flow axis, thereby illuminating particles in the effluent within the guiding tube. An imaging device is used to capture images of the portion of the light scattered by the particles. The image signals are analyzed and used to provide information regarding particle size and other characteristics of the particles in the effluent scattering the light.

Abstract: A sample slide, launch system, and method for microscopy having two optical fibers positioned proximate a sample slide with optical fiber mounting elements to deliver EMR to a surface of the sample slide at a critical angle for total internal reflection microscopy. In one exemplary embodiment, the EMR from the first optical fiber and the EMR from the second optical fiber may have different polarization states and/or wavelengths.

Abstract: Systems for and methods of assessing urinary flow rate via sound analysis. Embodiments of the uroflow measurement systems include a computer and a telephone or a digital recording mechanism to capture the sound of one or more urination events, which are stored as audio files in a database. The uroflow measurement systems may include sound analysis software for analyzing the strength and duration of each urination event and may include a web-based uroflow software application for viewing the results via the Internet or other network. In one embodiment, the sound analysis software performs the steps of reading in the raw data of a selected audio file, generating a plot of the audio signal amplitude vs.

Abstract: An electrical signal filter for processing a discrete-time real signal having a length N. In one embodiment, the filter comprising a delay line having N taps and a corresponding respective N filter coefficients. Values for the filter coefficients are determined by first shifting an impulse function of length N by a fraction of N so as to obtain a shifted impulse function. An analytic-signal-generating method is then applied to the impulse function so as to output the filter coefficient values. The values are then assigned to the N taps to complete the filter.

Abstract: A biopesticide composition for pest management that includes a sweet whey product and spores mixed with a carrier to form a growing environment in a target region. The growing environment forms a micro-factory that is suitable for spore growth, such that the number of spores substantially increases from a first spore concentration prior to application to the target region to a second spore concentration after a period of time. The biopesticide composition may include other additives that modify the micro-factory in a manner that facilitates spore growth and/or increases the probability that a target pest, e.g., an insect, will come into contact with the spores.

Abstract: The invention relates to methods and products for treatment of a neurological defect such as a subarachnoid hemorrhage or cerebral vasospasm. Specifically, R-type voltage-gated calcium channel inhibitors and related compositions and kits are described.

Abstract: An in-situ monitoring system is engaged with a mechanical system for which it is desired to assess or monitor the in-situ performance of the mechanical system. The in-situ monitoring system includes at least one input sensor and at least one output sensor for collecting data corresponding, respectively, to input into, and output from, the mechanical system. The monitoring system also includes an analyzer that utilizes the input and output data to generate an in-situ response representation of the mechanical system. The in-situ representation may be used to make a decision regarding the status of the mechanical system, e.g., to replace all or part of it, to adjust it or to do nothing. In one embodiment, the analyzer is programmed to adapt to the operating conditions of the mechanical system by automatically selecting which one of a number of target representations should be used to characterize the in-situ representation.

Abstract: The invention is based in part on the discovery that uncoupling proteins (UCPs) are expressed in the plasma membrane of rapidly dividing cells but not of growth arrested, chemotherapy resistant cells. It has also been found according to the invention that UCP is expressed in the lysosomal membrane under certain metabolic conditions. Thus the invention is methods, products, screening assays and kits relating to the manipulation of UCP expression within cellular and intracellular membranes.

Abstract: Systems for and methods of assessing urinary flow rate via sound analysis. Embodiments of the uroflow measurement systems include a computer and a telephone or a digital recording mechanism to capture the sound of one or more urination events, which are stored as audio files in a database The uroflow measurement systems may include sound analysis software for analyzing the strength and duration of each urination event and may include a web-based uroflow software application for viewing the results via the Internet or other network In one embodiment, the sound analysis software performs the steps of reading in the raw data of a selected audio file, generating a plot of the audio signal amplitude vs.

Abstract: A system and method of modeling a circulatory system including a regulatory mechanism parameter. In one embodiment, a regulatory mechanism parameter in a lumped parameter model is represented as a logistic function. In another embodiment, the circulatory system model includes a compliant vessel, the model having a parameter representing a change in pressure due to contraction of smooth muscles of a wall of the vessel.

Abstract: A detection circuit for detecting changes in capacitance. The detection circuit includes a tuned ratio circuit and an alternating current (AC) source AC-coupled to the tuned ratio circuit. The tuned ratio circuit includes first and second tuned circuits that are tuned to, or close, to the frequency of the AC source. Output circuitry is coupled between the two tuned circuits. During use as a transducer, an active capacitive transducer is inductively coupled to the first tuned circuit. Changes in the capacitance of the active capacitive transducer cause changes in the tuning of the first tuned circuit. The output circuitry generates an output signal that is a function of the difference between the tunings of the first and second tuned circuits.

Abstract: A sample slide, launch system, and method for microscopy having two optical fibers positioned proximate a sample slide with optical fiber mounting elements to deliver EMR to a surface of the sample slide at a critical angle for total internal reflection microscopy. In one exemplary embodiment, the EMR from the first optical fiber and the EMR from the second optical fiber may have different polarization states and/or wavelengths.

Abstract: A magnetic on-off robotic attachment device (MOORAD) (100, 300, 400, 624, 624?, 660, 676, 804) is used to make a number of systems, such as a mobile apparatus (608, 644, 668, 700, 700?), a belt mechanism (800) and a sensor device (504, 508, 656). The MOORAD allows the respective system to be removably magnetically attached to a ferromagnetic structure/object (228, 420, 604, 604?, 720A-B, 720A?-B?, 848). Each MOORAD generally includes a dipole magnet (104, 304A-B, 404) movable relative to first and second ferromagnetic portions (112, 116, 316A-D, 408, 412) that are separated by corresponding magnetically insulating portions (120, 320A-C, 416) so as to change that MOORAD between off and on states.

Abstract: The invention provides methods for identifying modulators of yeast phenotypic transitions and methods for treating fungal infections with modulators of phenotypic transitions of yeast cells. These methods include methods for identifying inhibitors of the budded-to-hyphal transition of Candida albicans and methods for treating fungal infections with inhibitors of the budded-to-hyphal transition of Candida albicans.

Abstract: A system and method of identifying relational patterns across a plurality of databases using a data structure and the data structure itself. The data structure including one or more data node branches, each of the one or more data node branches including one or more data nodes, each of the one or more data nodes representing a data item of interest and corresponding data item support values for the data item across the plurality of databases in relation to other data items represented in the data node branch. The data structure can be used to mine one or more relational patterns considering pattern support data across the plurality of databases at the same time.

Abstract: The present invention relates to methods and kits for the detection and diagnosis of cancer or precancerous conditions. Methylation of specific genes has been identified as indicative of cancer and methods of the invention, in part, relate to the detection of methylation levels in cells as a determination of cancer or a precancerous condition in the cell.

Abstract: A prosthetic lung for receipt by a lung space of a patient includes a mass exchange apparatus for use in blood/air mass exchange, an air sac and an air vessel. The mass exchange includes plural blood flow conduits for defining blood flow and a plural air flow conduits for defining air flow. The plural air flow conduits and the plural blood flow conduits at least partially include gas-permeable membrane material and the conduits are arranged relative to each other to enable transfer of oxygen from the air to the blood and transfer of carbon dioxide from the blood to the air. The mass exchange apparatus is provided with at least one first air port and at least one second air port, so that the air flow may be defined therebetween by the plural air flow conduits. The air sac defines an air sac cavity in fluid communication with at least one first air port of the mass exchange apparatus.

Abstract: This application includes, in part, methods of preparing antibodies that specifically bind to tnethylation-controlling J (MCJ) polypeptide. In some aspects, the application also includes, hybridoma cell lines that produce antibodies that specifically MCJ polypeptide; antibodies and antigen-binding fragments thereof produced with the methods of the application,—and methods of using antibodies and antigen-binding fragments that specifically bind MCJ polypeptide for diagnosis and treatment of cancer.