Abstract: This application includes, in part, methods of preparing antibodies that specifically bind to tnethylation-controlling J (MCJ) polypeptide. In some aspects, the application also includes, hybridoma cell lines that produce antibodies that specifically MCJ polypeptide; antibodies and antigen-binding fragments thereof produced with the methods of the application,—and methods of using antibodies and antigen-binding fragments that specifically bind MCJ polypeptide for diagnosis and treatment of cancer.

Abstract: A sample slide, launch system, and method for microscopy having a fiber insertion portal terminating within the sample slide and having a fiber insertion axis such that when an optical fiber is inserted within the fiber insertion portal the optical fiber is positioned so to deliver an EMR to a surface of the sample slide at a desired angle.

Abstract: Vibrational energy harvesting (VEH) structures that include resonant beams each having a fundamental resonance frequency and a parametric mode frequency and including at least one piezoelectric layer for generating electrical charge in response to each of fundamental-resonance excitation and parametric-mode excitation of that beam. Circuitry is provided for harvesting the electrical charge from the resonant beam. In some embodiments, the parametric mode frequency of the beam is tuned to be close to its fundamental resonance frequency so as to increase the effective bandwidth of a VEH structure. The effective bandwidth of a VEH structure can be further increased by tuning ones of multiple parametric-mode-enabled resonant beams to slightly different fundamental resonance frequencies and parametric mode frequencies.

Abstract: A breath biofeedback method and system for encouraging a subject to modify respiration. The system includes a thoracic volume input module measuring thoracic volume data of the subject and a pattern module providing target breathing patterns in communication with a display generator. The display generator producing display information representing a displayable image including a first object having a first position determined as a function of the thoracic volume data and a second object having a second position determined as a function of the target breathing pattern and the thoracic volume data. The displayable image is designed such that when displayed on the display device the displayable image encourages the subject viewing the displayable image to modify respiration.

Abstract: A thermoelectric device (100, 342) that includes at least one thermoelectric couple (118, 304) that contains a thermoelectric junction (156) between two dissimilar materials (P, N) that allow exploitation of either the Seebeck effect or Peltier effect of the junction. The thermoelectric couple includes two thermoelements (120, 124, 324, 326) that extend between the hot side (104) and cold side (108) of the device. Each thermoelement has a thermally insulating region (128, 132) that insulates the hot side from the cold side and an electrical energy storage device (136, 138, 308, 310) that stores electrical energy. When operating in a Seebeck mode, each storage device may be periodically discharged by harvesting circuitry (200, 300) so as to harvest the energy stored therein. When operating in a Peltier mode, each storage device may be periodically charged by charging circuitry (900, 1000) so as to induce a temperature change at the thermoelectric junction.

Abstract: The invention relates, in part, to methods of determining Notch signaling in cells, tissues and/or subjects. The invention additionally relates, in part, to diagnostic assays for cell differentiation-associated diseases or conditions and for screening tools in research and clinical applications.

Abstract: A breath biofeedback method and system for encouraging a subject to modify respiration. The system includes a thoracic volume input module measuring thoracic volume data of the subject and a pattern module providing target breathing patterns in communication with a display generator. The display generator producing display information representing a displayable image including a first object having a first position determined as a function of the thoracic volume data and a second object having a second position determined as a function of the target breathing pattern and the thoracic volume data. The displayable image is designed such that when displayed on the display device the displayable image encourages the subject viewing the displayable image to modify respiration.

Abstract: A launch system and method for microscopy having an optical fiber positioned proximate a sample slide with an optical fiber mounting element so as to deliver an EMR from the optical fiber into a first sample slide and to a surface of a second sample slide at a critical angle for total internal reflection at an interface of the surface of the second sample slide and a sample positioned proximate to the surface of the second sample slide.

Abstract: A sample slide, launch system, and method for microscopy having a fiber insertion portal terminating within the sample slide and having a fiber insertion axis such that when an optical fiber is inserted within the fiber insertion portal the optical fiber is positioned so to deliver an EMR to a surface of the sample slide at a desired angle.

Abstract: A method of preparing mesoporous inorganic oxide spherical particles includes providing a reaction mixture capable of producing mesoporous inorganic oxide spheres; heating the reaction mixture to produce mesostructured inorganic oxide particles and removing organic material from the mesostructured inorganic oxide particles to form the mesoporous inorganic oxide spherical particles. In one embodiment a reaction mixture includes a proton donor, a source of inorganic oxide, and a source of fluoride. In another embodiment a reaction mixture includes a proton donor, a source of inorganic oxide, and an alcohol. Mesoporous inorganic oxide spheres produced by the method of the present invention are also provided.

Abstract: A method of calculating an electron resonance spectra data value for each of one or more chemical constituents. In one embodiment, one or more potential electron capture orbitals is identified for each of the one or more chemical constituents; an electron orbital wavefunction is determined for each of the one or more potential electron capture Orbitals; and a theoretical electron resonance spectra data value is generated for each of the one or more chemical constituents. In another embodiment, a theoretical electron resonance spectra data value may be used to identify an unknown chemical constituent.

Abstract: Self-healing cable apparatus and methods disclosed. The self-healing cable has a central core surrounded by an adaptive cover that can extend over the entire length of the self-healing cable or just one or more portions of the self-healing cable. The adaptive cover includes an axially and/or radially compressible-expandable (C/E) foam layer that maintains its properties over a wide range of environmental conditions. A tape layer surrounds the C/E layer and is applied so that it surrounds and axially and/or radially compresses the C/E layer. When the self-healing cable is subjected to a damaging force that causes a breach in the outer jacket and the tape layer, the corresponding localized axially and/or radially compressed portion of the C/E foam layer expands into the breach to form a corresponding localized self-healed region. The self-healing cable is manufacturable with present-day commercial self-healing cable manufacturing tools.

Abstract: Wood finishes and methods of production and application of wood finishes are provided. The finishes may contain biologically produced components, such as proteins, and specifically may include whey proteins derived from dairy processing. The wood finishes are environmentally friendly as they use reduced levels of solvents and provide a safe and protective coating for wood and wood products.

Abstract: New Gp32F protein for determining, localizing or quantitating single-stranded DNA or RNA molecules comprises a Gp32 protein conjugated at an environment-sensitive amino acid (e.g. cysteine-166) to a fluorescent label.

Abstract: A chromatographic system that includes a light source and an imaging and analysis system for detecting particle size and analyzing other characteristics of particles in the effluent of a filtration column while filtration is ongoing. The effluent is directed into a guiding tube having a flow axis. Coherent light from the light source is shone into the guiding tube along the flow axis, thereby illuminating particles in the effluent within the guiding tube. An imaging device is used to capture images of the portion of the light scattered by the particles. The image signals are analyzed and used to provide information regarding particle size and other characteristics of the particles in the effluent scattering the light.

Abstract: A launch system and method for microscopy having an optical fiber positioned proximate a sample slide with an optical fiber mounting element so as to deliver an EMR from the optical fiber into a first sample slide and to a surface of a second sample slide at a critical angle for total internal reflection at an interface of the surface of the second sample slide and a sample positioned proximate to the surface of the second sample slide.

Abstract: The invention relates to products and methods for determining, localizing, and quantitating single-stranded polynucleotides. The methods of the invention include the use of Gp32F protein and mutant Gp32F protein to monitor polynucleotide reactions such as DNA replication, annealing, and excision and to determine single-stranded polynucleotide structures such as gaps, flaps, and bubbles.

Abstract: A system (100, 200, 300) for damping vibrations of a vibratory structure (104, 308). The damping system includes an active damper (112, 124, 128, 216), a vibration sensor (116, 208, 208A?-C?), and a controller (120, 212) for controlling the active damper in a manner that damps vibration of the vibratory structure. In some embodiments, the active damper comprises an active mass (132, 220, 220A?-C?, 220A?-C?) and an actuator (136) for controlling the movement of the active mass. In other embodiments, the active damper comprises a flexural damper (128).

Abstract: Systems for and methods of assessing lower urinary tract function from urinary flow data via sound analysis and user-provided information regarding the lower urinary tract symptoms (LUTS) of frequency, urgency and urge incontinence. Embodiments of the LUTS assessment systems include a computer and a telephone or a digital recording mechanism to capture the sound of one or more urination events, which are stored as audio files in a database. The LUTS assessment systems may include sound analysis software for analyzing the strength and duration of each urination event and may include a web-based software application for viewing the results via the Internet or other network. The database stores information from multiple urination events, and combined with information regarding the lower urinary tract symptoms, serves as an objective tool to assess bladder function and monitor progression of disease or therapy effectiveness.

Abstract: An in-situ monitoring system is engaged with a mechanical system for which it is desired to assess or monitor the in-situ performance of the mechanical system. The in-situ monitoring system includes at least one input sensor and at least one output sensor for collecting data corresponding, respectively, to input into, and output from, the mechanical system. The monitoring system also includes an analyzer that utilizes the input and output data to generate an in-situ response representation of the mechanical system. The in-situ representation may be used to make a decision regarding the status of the mechanical system, e.g., to replace all or part of it, to adjust it or to do nothing. In one embodiment, the analyzer is programmed to adapt to the operating conditions of the mechanical system by automatically selecting which one of a number of target representations should be used to characterize the in-situ representation.