Abstract: A method and system use mathematical models and available patient information to virtualize a continuous glucose monitoring trace for a period of time. Such a method and system can generate the virtualized trace when episodic patient data is incomplete. Such a method and system can also rely on self-monitored blood glucose measurement information to improve the virtualized continuous glucose monitoring trace.

Abstract: A system-on-a-chip (SoC) comprises a power supply circuit coupled to an energy harvesting transducer and configured to operate using energy from the energy harvesting transducer; a microcontroller coupled to a system bus of the SoC; an interface configured to communicate with the microcontroller via the system bus of the SoC, the interface configured to generate data upon occurrence of an event; and a computation accelerator configured to establish, based on an energy consumption level of the SoC, a data path between the interface and the computation accelerator that at least partially bypasses the system bus such that the data is transmitted to the computation accelerator via the data path.

Abstract: Suppressing artifacts in MRI image acquisition data includes alternatives to phase cycling by using a Convolutional Neural Network to suppress the artifact-generating echos. A U-NET CNN is trained using phase-cycled artifact-free images for ground truth comparison with received displacement encoded stimulated echo (DENSE) images. The DENSE images include data from a single acquisition with both stimulated (STE) and T1-relaxation echoes. The systems and methods of this disclosure are explained as generating artifact-free images in the ultimate output and avoiding the additional data acquisition needed for phase cycling and shortens the scan time in DENSE MRI.

Abstract: A system, method and non-transient computer readable medium for tracking hypoglycemia risk in patients with diabetes exercise. A system may include a digital processor configured to execute instructions to receive an input from each available data source of a plurality of intermittently available data sources; determine a plurality of probability signals for impending hypoglycemia, wherein each probability signal is based on one or more of the inputs from the available data sources or a lack of input from an unavailable data source; wherein a probability signal for each unavailable data source is assigned a value corresponding to a zone of uncertainty; and determine an aggregate risk of hypoglycemia based on the plurality of intermittently data sources by aggregating the plurality of probability signals.

Abstract: Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.

Abstract: In one aspect the disclosed technology relates to embodiments of a method (e.g., for automatic cine DENSE strain analysis) which includes acquiring magnetic resonance data associated with a physiological activity in an area of interest of a subject where the acquired magnetic resonance data includes one or more phase-encoded data sets. The method also includes determining, from at least the one or more phase-encoded data sets, a data set corresponding to the physiological activity in the area of interest where the reconstruction comprises performing phase unwrapping of the phase-encoded data set using region growing along multiple pathways based on phase predictions.

Abstract: A surgical device for retracting tissue of a subject while offering lighting and suction means integrated into the same device. This device is useful in many different surgical procedures, including those requiring precise tissue retraction in small openings of a subject, such as facial orbital fracture repair.

Abstract: A technique for providing biobehavioral rhythm models that generate a series of characteristic features which are further used for measuring stability in biobehavioral rhythms and to predict different outcomes such as health status through a machine learning component. A computational framework is provided for modeling biobehavioral rhythms from mobile and wearable data streams that rigorously processes sensor streams, detects periodicity in data, models rhythms from that data and uses the cyclic model parameters to predict an outcome. The framework can reliably discover various periods of different length in data, extract cyclic biobehavioral characteristics through exhaustive modeling of rhythms for each sensor feature; and provide the ability to use different combination of sensors and data features to predict an outcome.

Abstract: Provided are nucleic acids and vectors that collectively encode various gene products related to converting styrene to polyhydroxybutyrate (PHB). In some embodiments, the nucleic acids and vectors collectively encode a styrene monooxygenase polypeptide, a flavin reductase polypeptide, a styrene-oxide isomerase polypeptide, and a phenylacetaldehyde dehydrogenase polypeptide, an acetyl-CoA C-acetyltransferase polypeptide, a 3-ketoacyl-ACP reductase polypeptide, a class I poly(R)-hydroxyalkanoic acid synthase polypeptide, and optionally an influx porin polypeptide. Also provided are systems and methods for producing PHB from styrene, methods and systems for remediating polystyrene waste. In some embodiments, the systems are in vivo systems.

Abstract: Equivalent insulin pump retrospective virtual basal rates for daily injections are constructed from planned insulin injections according to a virtual basal rate profile developed for a patient, and a database of historical insulin injections, i.e. basal injections actually administered by the patient, providing a unified framework for analysis, design, optimization, and adaptation of MDI (multiple daily injections) and CSII (continuous subcutaneous insulin infusion (i.e. insulin pump)) treatment parameters for patients with diabetes.

Abstract: Provided is a method and system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system. The method and system includes a catheter device with associated lumens having diagnostic agent ports for delivering the diagnostic agent (e.g., infusate) through the lumens and advancing the diagnostic agent so as to exit out from the lumens to at least a portion of the brain site and while sealing a portion of the brain site thereby preventing the exited diagnostic agent from travelling proximally beyond the sealing location, and at the same time imaging at least a portion of the brain site during at least a portion of the sealing duration so that the brain site can be visualized on a medical imaging system. The diagnostic agent (infusate) is able to highlight borders and internal patterns of the deep structures of the brain thereby enabling direct targeting.

Abstract: This invention relates to methods and compositions for treatment of inv(16) leukemia and particularly to treatment of acute myeloid leukemia. Disclosed is a method of treating inv(16) leukemia comprising the step of administering to a subject in need thereof a therapeutically effective combination of a) a compound of the formula (1) and b) a chemotherapeutic agent selected from the group consisting of pirarubicin, aclarubicin, mitoxantrone, doxorubicin, daunorubicin, idarubicin, epirubicin, cytarabine, pharmaceutically acceptable salts and mixtures thereof. The therapeutically effective combination synergistically inhibits proliferation of inv(16) leukemia cells. This invention also relates to pharmaceutical compositions comprising a therapeutically effective combination of the compound of formula (1) and the chemotherapeutic agent and a pharmaceutically acceptable excipient.

Abstract: An electronic system is provided that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, wherein the system includes a subsystem that models dynamic glucose concentration in a T2DM or prediabetic subject, including an electronic module that models endogenous glucose production (EGP(t)), or meal glucose rate of appearance (Ra(t>>, or glucose utilization (U(t)), or renal excretion of glucose (B(t)), a subsystem that models dynamic insulin concentration in said T2DM or prediabetic subject, including an electronic module that models insulin secretion (S(t)), an electronic database containing a population of virtual T2DM or prediabetic subjects, each virtual subject having a plurality of metabolic parameters, and a processing module that calculates an effect of variation of at least one metabolic parameter value on the glucose insulin metabolic system of a virtual subject by inputting the plurality of metabolic parameter values.

Abstract: A chiral molecule can be defined as a molecule that has a non-superimposable mirror image. These mirror images can be referred to as enantiomers. The enantiomers generally have the same set of bond lengths and bond angles in their three-dimensional geometry. Apparatus and techniques described herein can be used to perform analysis of chiral molecules using cavity-enhanced molecular rotational spectroscopy. A sample cell can define a resonant cavity, and a sample introduction port can provide pulse jet injection of an analyte molecule and a chiral tag to allow analysis of a complex comprising the analyte and chiral tag.

Abstract: Provided are methods for treating inflammation in subject in need thereof. In some embodiments, the methods include administering to the subject an effective amount of a Sigma-1 receptor (S1R) activity modulator to thereby treat inflammation in the subject. Also provided are pharmaceutical compositions that include an effective amount of a Sigma-1 receptor (S1R) activity modulator and uses of the pharmaceutical compositions to treat inflammation in a subject in need thereof.

Abstract: Methods and systems are described for producing non-invasive and targeted neuronal lesions using magnetic resonance and acoustic energy. Imaging data corresponding to a region of interest is obtained, the region of interest within an imaging subject. Information indicative of a target region within the region of interest is received from the obtained imaging data. Focused acoustic energy directed to the target region within the region of interest is generated to disrupt a barrier between a therapeutic agent and parenchymal tissue in response to insonification by the focused acoustic energy, the therapeutic agent comprising a neurotoxin and microbubbles.

Abstract: A positron emission tomography (PET) assembly includes an annular housing and an annular scintillator disposed within the annular housing. The annular scintillator includes an annular, substantially continuous crystal scintillator tube configured to absorb ionizing radiation and to emit light energy. A plurality of photo detectors are annularly disposed around the annular scintillator within the annular housing and configured to detect the emitted light energy.

Abstract: A system and method for providing optical multiple input and multiple output data communication using optical signals includes a plurality of light sources, a plurality of photodetectors, and at least one controller. The plurality of light sources are configured to emit optical signals to communicate data. The plurality of photodetectors are configured to sense the optical signals, and are embedded in at least one receiver. At least one of the plurality of photodetectors is configured to receive the optical signals from two or more of the plurality of light sources. The controller is configured to assign a transmit power to at least some of the plurality of light sources based on parameters of the plurality of photodetectors.

Abstract: A microfluidic device for the detection of drugs, explosives, chemical warfare, or other substances which is able to directly accept a swab into the device for testing. This device additionally contains on-board reagents to perform colorimetric testing for threshold determination directly in the device. These features are useful in a wide array of situations, such as at security checkpoints, environmental monitoring, clinical analysis, which require testing completely unknown substances and therefore must test for multiple different substances in one test. This is especially useful for police and other law enforcement officials who often must use field-deployable platforms making accurate field-testing critical for safety.

Abstract: Provided are compositions that include an effective amount of a peptide or polypeptide derived from a Bordetella ACT AC domain, optionally wherein the peptide or polypeptide is 80-100% identical to an amino acid sequence as set forth in SEQ ID NOs: 1-5 and 44-53. Also provided are methods of using the same for preventing and/or treating a diseases, disorders, and conditions associated with the presence and/or development of biofilm; and for reducing the incidence of nosocomial infections; for inhibiting biofilm development and/or for reducing or eliminating biofilm present on medical, dental, and industrial surfaces.