Abstract: Methods and compositions for modulating transforming growth factor-beta (TGF?) biological activity in a vertebrate subject in need thereof. The methods involve administering to the vertebrate subject an effective amount of a substance capable of modulating activity of LEMD3 in the vertebrate subject to thereby modulate TGF? biological activity in the vertebrate subject.

Abstract: The disclosed embodiments provide systems and methods for predicting presence of one or more neurological deficits. The system may include a microphone, a camera, one or more memory devices storing instructions, and one or more processors configured to execute the instructions to extract audio information including a period density entropy coefficient and a mel frequency cepstral coefficient from an audio feed received from the microphone. Additionally, the instructions may cause the processor to determine position and depth information of eye movement from a video feed received from the camera and detect features of interest including facial landmarks, spatial orientation of limbs, and positional information of limb movements from the video feed. The one or more processors may further extract the features of interest from the video feed and process the extracted features of interest by aligning the extracted features of interest to a common reference.

Abstract: The present disclosure relates to novel and improved methods of analyzing proteins, peptides and polypeptides by mass spectrometry using ion-ion reactions. More specifically the disclosure relates to improved methods for implementing the m/z selective arresting of ion-ion reactions within the ion-ion reaction cell of a mass spectrometer system during a period where ion-ion reactions are performed.

Abstract: Provided are nucleotide sequences encoding polypeptides with ribonuclease III activity, wherein the nucleotide sequences have been modified to reduce their regulation by miRNAs. In some embodiments, the nucleotide sequences are at least 50% and as much as 100% identical to SEQ ID NO: 20 or SEQ ID NO: 22, and/or encode polypeptides that are at least 90% percent identical to SEQ ID NO: 23. Also provided are vectors and host cells that include the nucleotide sequences, methods for expressing the nucleotide sequences in cells, tissues, and organs, which in some embodiments can be in the eye of a subject in need thereof, methods for preventing and/or treating development of diseases or disorders and/or for restoring undesirably low DICER1 expression using the nucleotide sequences, and pharmaceutical compositions that have the presently disclosed nucleotide sequences.

Abstract: Embodiment relate to a system for developing a model to classify continuous glucose monitoring (CGM) data. The system includes a processor and computer memory having instructions stored thereon that when executed will cause the processor to determine whether two CGM profiles match based on a similarity of shapes of the two CGM profiles, each CGM profile including a data set of CGM measurements. The processor designates two matching CGM profiles as a CGM profile pair. The processor transforms the CGM profile pair into a motif. The processor labels the motif as a labelled motif based on a clinical characteristic. The processor recursively repeats the determine, designate and transform steps of a CGM profile pairing process until a finite set of motifs is created, which includes the labelled motif as a classified data point. The processor monitor, analyzes, or influences a concentration of glucose levels in a fluid.

Abstract: A system or method for compressing continuous glucose monitor (CGM) data for a subject and/or a technician, clinician, or for use with an interventional device. The system or method configures the CGM data to allow the subject, technician, clinician, or interventional device to take a physical action in response to receiving a transmission to improve the safety and/or efficacy of therapy for the subject.

Abstract: Compositions that include anti-cancer, anti-tumor, and anti-microbial infection peptides are provided. In some embodiments, the compositions include 1-10 or more synthetic peptides that are between 8 and 50 amino acids long and include an amino acid sequence as disclosed herein.

Abstract: Provided are peptides that based on the amino acid sequences LDPAKDCGDQKYAY (SEQ ID NO: 1) and LDPSKDCGDPKYAY (SEQ ID NO: 2), optionally wherein the peptide includes an N-terminal stearate modification. Also provided are method for using the disclosed peptides for inhibiting neointima formation in mammals, methods for inhibiting division and/or proliferation of vascular smooth muscle cells, and uses of the disclosed peptides for treating cardiovascular diseases and/or disorder associated with undesirable vascular SMC proliferation, which in some embodiments can re-late to inhibiting neointima formation in a mammal.

Abstract: The present disclosure provides azetidine compounds of Formula I and their pharmaceutically acceptable salts, their compositions, and methods for their use in determining azetidine compound binding to proteins. The azetidine compounds are useful as probes, for monitoring diacylglycerol kinase activity, and for identifying druggable targets.

Abstract: Disclosed herein are methods for the preparation of porous metal oxide materials, including metal oxide xerogels and metal oxide aerogels. Methods for preparing porous metal oxide materials can comprise (i) reacting a metal alkoxide with water in the presence of a catalyst system to form a partially hydrolyzed sol, (ii) contacting the partially hydrolyzed sol with a base catalyst and a non-aqueous solvent to form a precursor gel; and (iii) drying the precursor gel to form the porous metal oxide material. The catalyst system employed in step (i) comprises a combination of a weak acid and a strong acid.

Abstract: Methods, computing devices, and magnetic resonance imaging systems that improve image quality in turbo spiral echo (TSE) imaging are disclosed. With this technology, a TSE pulse sequence is generated that includes a series of radio frequency (RF) refocusing pulses to produce a corresponding series of nuclear magnetic resonance (NMR) spin echo signals. A gradient waveform including a plurality of segments is generated. The plurality of segments collectively comprise a spiral ring retraced in-out trajectory. During an interval adjacent to each of the series of RF refocusing pulses, a first gradient pulse is generated according to the gradient waveform. The first gradient pulses encode the NMR spin echo signals. An image is then constructed from digitized samples of the NMR spin echo signals obtained based at least in part on the encoding.

Abstract: Provided are methods for treating diseases, disorders, and conditions associated with undesirable cellular proliferation in subjects in need thereof. In some embodiments, the methods include administering to a subject in need thereof a therapeutically effective amount of a composition comprising, consisting essentially of, or consisting of a chemotherapeutic agent and a short chain ceramide. Also provided are methods for increasing total ceramide levels in cells, for increasing long chain ceramide to a very long chain ceramide ratios in cells, methods for enhancing apoptosis of cells, for prognosing subjects with diseases, disorders, and conditions associated with undesirable cellular proliferation with respect to treatments, for increasing sensitivities of drug-resistant tumor and/or cancer cells to chemotherapeutics, and compositions that have one or more short chain ceramides and one or more chemotherapeutically active agents.

Abstract: Methods, computing devices, and MRI systems that reduce artifacts produced by Maxwell gradient terms in TSE imaging using non-rectilinear trajectories are disclosed. With this technology, a RF excitation pulse is generated to produce transverse magnetization that generates a NMR signal and a series of RF refocusing pulses to produce a corresponding series of NMR spin-echo signals. An original encoding gradient waveform comprising a non-rectilinear trajectory is modified by adjusting a portion of the original encoding gradient waveform or introducing a zero zeroth-moment waveform segment at end(s) of the original encoding gradient waveform. During an interval adjacent to each of the series of RF refocusing pulses a first gradient pulse is generated. At least one of the first gradient pulses is generated according to the modified gradient waveform. An image is constructed from generated digitized samples of the NMR spin-echo signals obtained.

Abstract: Provided are methods for preventing and/or reducing weight gain in subjects. In some embodiments, the methods include administering an effective amount of a composition that includes a long chain fatty acid of at least 22 carbons and/or a derivative thereof to prevent and/or reduce weight gain in the subject. In some embodiments, the long chain fatty acid is a monounsaturated omega 9 fatty acid, which in some embodiments is nervonic acid or a derivative thereof. Also provided are methods for preventing and/or reducing the development of obesity in subjects, for inhibiting reduction of very-long chain sphingolipids in subjects, for increasing content of one or more ceramides while simultaneously decreasing content of one or more C20-C26 ceramides in subjects, and for reducing blood glucose levels resulting from consumption of high fat diets in subjects.

Abstract: A system for classifying cardiac rhythms is disclosed. The system includes one or more processors, one or more computer-readable tangible storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include first program instructions times between heartbeats. The program instructions further comprise second program instructions to segment the time series into a plurality of segments. The program instructions further comprise third program instructions to calculate a plurality of parameters corresponding to each of the 30-second segments. The program instructions further comprise fourth program instructions to analyze the obtained data and the calculated parameters using a plurality of multivariable algorithms for rhythm classification.

Abstract: A method of assisting a heart for the operation of a ventricular assist device comprising the steps of implanting a cannula to the heart and deploying a stent within a left ventricle, a right ventricle, a left atrium, or a right atrium of the heart. The stent may be transferable from a first compact configuration to a second open configuration to facilitate implantation. The stent may also have a flared distal end to assist with alignment, positioning, and prevent outgrowth.

Abstract: A downwind morphing rotor that exhibits bending loads that will be reduced by aligning the rotor blades with the composite forces. This reduces the net loads on the blades which therefore allow for a reduced blade mass for a given maximum stress. The downwind morphing varies the amount of downstream deflection as a function of wind speed, where the rotor blades are generally fully-aligned to non-azimuthal forces for wind speeds between rated and cut-out conditions, while only the outer segments of the blades are generally aligned between cut-in and rated wind speeds. This alignment for large (MW-scale) rated turbines results in much larger downstream deflections of the blades at high wind speeds as compared to that of a conventional rigid single-piece upwind turbine blade.

Abstract: The present invention provides a bioreactor controller with a simple user interface comprising a microcontroller and a linear motor. The bioreactor controller is microcontroller-based, has a greater temporal accuracy, and inexpensive. The microcontroller of the bioreactor controller selects a protocol mode and a setup mode by the user, runs the protocol mode if the setup mode is not selected by the user, stops running the protocol mode for a predetermined time if the protocol mode is selected by the user until the user is completed with calculations and record-keeping, detects movement error of the bioreactor controller, and informs the error to the user.

Abstract: An automated and quantitative facial weakness screening framework that utilizes a Bi-LSTM network to model the temporal dynamics among the shape and appearance features. The technique is beneficial to assist the paramedics or other users to identify the facial weakness in the field or, more importantly, whenever expertise in neurology is not available either for emergency patient triage (e.g., pre-hospital stroke care) or chronic disease management (e.g., Bell's palsy rehabilitation screen), leading to increased coverage and earlier treatment. The technique provides visualizable and interpretable results to increase its transparency and interpretability. The technique provides for inexpensive solutions that can be used in areas underserved by non-neurologists to more readily identify neurological deficits such as facial weakness in the field or other environment.

Abstract: A protective vest device that will adequately secure an infant from the ability to self-dislodge medical life-sustaining supply lines or equipment, while also supporting proper body alignment. The protective device mitigates self-dislodgement while allowing for free movement and proper alignment of infants arms and hands and which are allowed to touch one another, thereby not inhibiting the ability to explore and expand brain development through tactile stimulation and therefore fostering healthy neuronal pathways of the infant. The fostering healthy neuronal pathways is provided by, for example, allowing the hands to touch one another as the infant develops a sense of where it is in space and time as it continues to grow outside of the womb.