Patents Assigned to University of Virginia Patent Foundation
  • MEDICAL DEVICE THAT APPLIES ELECTRICAL STIMULATION TO THE SPINAL CORD FROM INSIDE THE DURA FOR TREATING BACK PAIN AND OTHER CONDITIONS
    Publication number: 20200179684
    Abstract: This invention provides an device for electrical stimulation of the spinal cord. The device has an electrode assembly with a sufficiently thin profile to be implanted between the pial surface of the spinal cord and the dura mater, and secured to the dura. Electrodes on the electrode assembly are directed towards the surface of the spinal cord, and connected through the dura to a signal generator located outside the dura. Following implantation, the subject is treated by transmitting electrical signals from the signal generator through the leads to the electrodes, stimulating the subject's spinal cord.
    Type: Application
    Filed: February 13, 2020
    Publication date: June 11, 2020
    Applicants: Universty of Iowa Research Foundation, University of Virginia Patent Foundation
    Inventors: Matthew A. Howard, Timothy Brennan, Brian Dalm, Marcel Utz, George T. Gillies, Steven Scott, Randall S. Nelson, Robert Shurig
  • METHOD, SYSTEM AND COMPUTER READABLE MEDIUM FOR ASSESSING ACTIONABLE GLYCEMIC RISK
    Publication number: 20200178905
    Abstract: A system, method and non-transient computer readable medium for assessing the opportunity to address either hyperglycemic or hypoglycemic risk (or both) in patients with diabetes based on historical continuous glucose monitoring (CGM) data.
    Type: Application
    Filed: January 23, 2020
    Publication date: June 11, 2020
    Applicant: University of Virginia Patent Foundation
    Inventor: Stephen D. PATEK
  • Subset encoding method: increasing pattern density for finite automata
    Patent number: 10678505
    Abstract: The subset encoding method and related automata designs for improving the space efficiency for many applications on the Automata Processor (AP) are presented. The method is a general method that can take advantage of the character-or ability of STEs (State Transition Elements) on the AP, and can relieve the problems of limited hardware capacity and inefficient routing. Experimental results show that after applying the subset encoding method on Hamming distance automata, up to 3.2× more patterns can be placed on the AP if a sliding window is required. If a sliding window is not required, up to 192× more patterns can be placed on the AP. For a Levenshtein distance, the subset encoding can split the Levenshtein automata into small chunks and make them routable on the AP. The impact of the subset encoding method depends on the character size of the AP.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: June 9, 2020
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventor: Deyuan Guo
  • Memory systems including support for transposition operations and related methods and circuits
    Patent number: 10664241
    Abstract: A method operating a memory system, can be provided by reading a plurality of data words from a memory system, where each of the plurality of data words is stored in the memory system in a first dimension-major order. The plurality of data words can be shifted into a transpose memory system in the first dimension in parallel with one another using first directly time adjacent clock edges to store a plurality of transposed data words in a second dimension-major order in the transpose memory system relative to the memory system. The plurality of transposed data words can be shifted out of the transpose memory system in the second dimension using second directly time adjacent clock edges.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: May 26, 2020
    Assignee: University of Virginia Patent Foundation
    Inventors: Mohamed Ezzat El Hadedy Aly, Kevin Skadron
  • HORNERIN: A NOVEL NON-VEGF MEDIATED ANGIOGENIC PROTEIN EXPRESSED IN BOTH HUMAN AND MOUSE ANGIOGENIC ENDOTHELIAL CELLS AND HUMAN PANCREATIC CANCER CELLS
    Publication number: 20200155594
    Abstract: Provided are compositions and methods for use of hornerin-binding molecules, including peptides and antibodies. In some embodiments, the presently disclosed subject matter provides compositions that include horning-binding molecules, including but not limited to peptides, uses for the disclosed compositions, including in methods for treating tumors, methods for increasing the survival of subject with tumor, methods for suppressing tumor growth in subjects, methods for reducing tumor vascularity in subjects, methods for treating diseases, disorders, and/or conditions associated with undesirable hornerin expression; methods for modulating hornerin biological activities, methods for imaging cells, tissues, and/or organs that expresses hornerin, and methods for delivering active agents to cells, tissues, and/or organ that expresses hornerin.
    Type: Application
    Filed: September 16, 2019
    Publication date: May 21, 2020
    Applicant: University of Virginia Patent Foundation
    Inventor: Kimberly A. Kelly
  • Isolated T cell receptors and methods of use therefor
    Patent number: 10654908
    Abstract: Provided are isolated TCRs, TCR-like molecules, and portions thereof that bind to phosphopeptide-HLA-A2 complexes. The isolated TCRs, TCR-like molecules, or portions are optionally soluble TCRs, TCR-like molecules, or portions. Also provided are isolated nucleic acids encoding the disclosed TCRs, TCR-like molecules, or portions; host cells that contain the disclosed TCRs, TCR-like molecules, or portions; pharmaceutical compositions that include the disclosed TCRs, TCR-like molecules, portions, nucleic acids, and/or T cells; kits; and methods of using the same.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: May 19, 2020
    Assignee: University of Virginia Patent Foundation
    Inventors: Angela Zarling, Victor H. Engelhard, Kara L. Cummings, Rebecca C. Obeng
  • Detection of polymeric analytes
    Patent number: 10656146
    Abstract: The present invention relates to methods for detecting polymeric analytes, especially biopolymers, and sensors for detecting the polymeric analytes. The present invention uses magnetic beads in a rotating magnetic field to provide a visual detection of the presence of a polymeric analyte, such as nucleic acids, lipids, polysaccharides, proteins, etc. When a polymeric analyte binds to the magnetic beads, application of a rotating magnetic field to the beads results in unique pinwheel formations. Without the presence of the polymeric analyte, the movement of the magnetic beads induced by the rotating magnetic field differs significantly from the pinwheel formations. The pinwheel, therefore, is used to detect the presence of polymeric analytes.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: May 19, 2020
    Assignee: University of Virginia Patent Foundation
    Inventors: James P. Landers, Daniel C. Leslie
  • Pegylated Liposomes and Methods of Use
    Publication number: 20200138715
    Abstract: Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.
    Type: Application
    Filed: May 15, 2017
    Publication date: May 7, 2020
    Applicants: Infectious Disease Research Institute, University of Virginia Patent Foundation
    Inventors: Christopher B. Fox, Susan S. Lin, Darrick Carter, Neal Van Hoeven, Mayuresh M. Abhyankar, William A. Petri
  • Feeding nipple systems for cleft palate or lip
    Patent number: 10639240
    Abstract: An apparatus including artificial nipple for feeding a baby who has a cleft in its palate region. The artificial nipple includes a palate region to define a region facing the baby's palate during use, and the nipple having a tongue region to define a region facing the baby's tongue during use. The palate region is less compliant than the tongue region to both mimic the hard palate and reduces unwanted movement of the nipple, making it easier for the infant to use his or her tongue to expel fluid from the nipple. The tongue region includes a feeding slit, which maybe U or V shaped, from which liquid maybe discharged without risking nasal congestion. The tongue region may further include a soft protrusion, that assists the peristaltic like tongue movement helping the baby feed, and may extend laterally to reduce the risk of nasal congestion.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: May 5, 2020
    Assignee: University of Virginia Patent Foundation
    Inventors: Thanh Tran, Marcelle Huizenga, Katrina Shah, Catherine Pelland, Katherine R. Knaus, Kathleen Borowitz, Silvia Blemker
  • Recombinant antibodies that recognize the C-terminal domains of Ebola virus nucleoprotein
    Patent number: 10640549
    Abstract: This disclosure is directed to compositions and methods for utilizing the boundaries of the C-terminal domains of Nucleoprotein from Zaire Ebola virus as highly stable recombinant protein antigens to generate antibodies for diagnosis and treatment of Ebola virus infection.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: May 5, 2020
    Assignees: University of Virginia Patent Foundation, The University of Chicago
    Inventors: Zygmunt S. Derewenda, Daniel A. Engel, Anthony Kossiakoff, Elena K. Davydova, Mateusz Jaskolowski
  • Method, system and computer readable medium for assessing actionable glycemic risk
    Patent number: 10638981
    Abstract: A system, method and non-transient computer readable medium for assessing the opportunity to address either hyperglycemic or hypoglycemic risk (or both) in patients with diabetes based on historical continuous glucose monitoring (CGM) data.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: May 5, 2020
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventor: Stephen D Patek
  • COMPOSITIONS AND RELATED METHODS FOR MODULATING TRANSCRIPTIONAL ACTIVATION BY INCORPORATING GAG MOTIFS UPSTREAM OF CORE PROMOTER ELEMENTS
    Publication number: 20200123211
    Abstract: Compositions and methods for genetically modifying the production levels of nicotine and other alkaloids in plants are provided.
    Type: Application
    Filed: December 23, 2019
    Publication date: April 23, 2020
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Michael Paul TIMKO, Paul J. RUSHTON, Marta Tatiana BOKOWIEC
  • SYSTEMS AND METHODS FOR MOTION-COMPENSATED RECONSTRUCTION OF MAGNETIC RESONANCE IMAGES
    Publication number: 20200116810
    Abstract: Systems and methods for reconstructing a motion-compensated magnetic resonance image are presented. In certain implementations, a computer-implemented method is provided. The method may include a plurality of operations, including receiving a set of k-space data from a magnetic resonance imaging device, dividing the set of k-space data into a plurality of groups, performing a plurality of initialization operations, performing a first iterative process until a first criteria for the first iterative process is achieved for a current scale of motion estimation, performing a second iterative process until a second criteria for the second iterative process is achieved, and outputting a motion-compensated magnetic resonance image reconstructed in accordance with a predetermined scale of motion estimation.
    Type: Application
    Filed: October 11, 2019
    Publication date: April 16, 2020
    Applicant: University of Virginia Patent Foundation
    Inventors: Luonan WANG, Daniel Stuart Weller, John P. Mugler, Craig H. Meyer
  • INTEGRATED PHOTODIODE WITH UNIQUE WAVEGUIDE DRIFT LAYER
    Publication number: 20200116929
    Abstract: A monolithic waveguide-integrated photodiode having a first electroconductive contact layer, a depleted waveguide core layer, an absorption layer, and a second electroconductive contact layer, the refractive index of the first electroconductive contact layer being less than the depleted waveguide core layer, the refractive index of the waveguide core layer being less than the absorption layer, and the refractive index of the second electroconductive contact layer being less than the absorption layer. The waveguide core layer is arranged between the first electroconductive contact layer and the absorption layer and also acts as a depleted carrier drift layer. This arrangement results in greater quantum efficiency and shorter photodiode lengths for a given bandwidth.
    Type: Application
    Filed: April 18, 2018
    Publication date: April 16, 2020
    Applicant: University of Virginia Patent Foundation
    Inventors: Bassem Tossoun, Andreas Beling
  • Serotonin transporter gene and treatment of opioid-related disorders
    Patent number: 10619209
    Abstract: The gene responsible for encoding SERT has a functional polymorphism at the 5?-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3? UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: April 14, 2020
    Assignee: University of Virginia Patent Foundation
    Inventor: Bankole A. Johnson
  • Unified platform for monitoring and control of blood glucose levels in diabetic patients
    Patent number: 10610154
    Abstract: A flexible system capable of utilizing data from different monitoring techniques and capable of providing assistance to patients with diabetes at several scalable levels, ranging from advice about long-term trends and prognosis to real-time automated closed-loop control (artificial pancreas). These scalable monitoring and treatment strategies are delivered by a unified system called the Diabetes Assistant (DiAs) platform. The system provides a foundation for implementation of various monitoring, advisory, and automated diabetes treatment algorithms or methods. The DiAs recommendations are tailored to the specifics of an individual patient, and to the patient risk assessment at any given moment.
    Type: Grant
    Filed: June 23, 2012
    Date of Patent: April 7, 2020
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Boris P. Kovatchev, Patrick T. Keith-Hynes, Marc D. Breton, Stephen D. Patek
  • Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence
    Patent number: 10603307
    Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: March 31, 2020
    Assignee: University of Virginia Patent Foundation
    Inventor: Bankole A. Johnson
  • CORROSION RESISTANT METAL AND METAL ALLOY COATINGS CONTAINING SUPERSATURATED CONCENTRATIONS OF CORROSION INHIBITING ELEMENTS AND METHODS AND SYSTEMS FOR MAKING THE SAME
    Publication number: 20200080199
    Abstract: A method and apparatus for producing a corrosion inhibiting coating for metal and metal alloy substrates. The coating is comprised of a metal or metal alloy that is similar in composition to the substrate to be coated, further combined with a corrosion inhibiting material. The corrosion inhibiting material may be a refractory metal or metalloid. The method and apparatus for producing the coating allows for the corrosion inhibiting coating to have a supersaturated concentration of the corrosion inhibiting material alloyed with another metal or metal alloy. The method and apparatus allow for the selective vaporization of material sources to make the coating vapor, which are then entrained in a high speed gas flow that directs the coating vapor onto the substrate. Optional plasma assistance and application of a voltage to the substrate may be used. The coating may be customized for a variety of applications.
    Type: Application
    Filed: February 20, 2018
    Publication date: March 12, 2020
    Applicants: University of Virginia Patent Foundation, THE GOVERNMENT OF THE UNITED STATES, AS RESPRESENTED BY THE SECRETARY OF THE NAVY
    Inventors: Haydn N. G. Wadley, Arthur H. Heuer, Paul Natishan
  • Analysis of cardiac rhythm using RR interval characterization
    Patent number: 10582873
    Abstract: A method for analysis of cardiac rhythms, based on calculations of entropy and moments of interbeat intervals. An optimal determination of segments of data is provided that demonstrate statistical homogeneity, specifically with regard to moments and entropy. The invention also involves calculating moments and entropy on each segment with the goal of diagnosis of cardiac rhythm. More specifically, an absolute entropy measurement is calculated and provided as a continuous variable, providing dynamical information of fundamental importance in diagnosis and analysis. Through the present invention, standard histograms, thresholds, and categories can be avoided.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: March 10, 2020
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: J. Randall Moorman, Douglas E. Lake
  • Methods, circuits, systems, and articles of manufacture for state machine interconnect architecture using embedded DRAM
    Patent number: 10580481
    Abstract: A finite state machine circuit can include a plurality of rows of gain cell embedded Dynamic Random Access Memory (GC-eDRAM) cells that can be configured to store state information representing all N states expressed by a finite state machine circuit. A number of eDRAM switch cells can be electrically coupled to the plurality of rows of the GC-eDRAM cells, where the number of eDRAM switch cells can be arranged in an M×M cross-bar array where M is less than N, and the number of eDRAM switch cells can be configured to provide interconnect for all transitions between the all N states expressed by the finite state machine circuit.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: March 3, 2020
    Assignee: University of Virginia Patent Foundation
    Inventors: Elaheh Sadredini, Gholamreza Rahimi, Kevin Skadron, Mircea Stan