Abstract: Provided are methods of forming graphene laminate compositions and architectures. The method comprises: (i) contacting a graphene structure comprising one or more planar graphene sheets with a first interlayer material; (ii) depositing of a conductive material, where in the conductive material is deposited along an edge of the graphene and one end of the first interlayer; and (iii) contacting the graphene structure with a second interlayer material. Also provided are graphene laminates structures comprising doped graphene films having improved mechanical strength, electrical mobility and optical transparency.

Abstract: The disclosure relates to the assembly of Virus Like Particles [VLPs] using packaging native and artificial packaging signals and their use in vaccines and immunological compositions and the methods of vaccination or immunisation against human and animal viral pathogens.

Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.

Abstract: The present disclosure relates to a method for cultivation of insect biomass, for example, larvae and/or eggs using a feed comprising lignocellulose incubated with lignocellulose digesting fungal cells; a feed comprising pre-treated lignocellulose for cultivation of insect biomass; and a livestock feed obtained through the cultivation method of insect biomass.

Abstract: Methods, computing apparatuses, computer readable media and systems are described that are for use with blockchain applications. An authority server may communicate a data package to a mining node. The mining node may receive the data package from the authority server, the data package comprising a plurality of datasets, each dataset comprising signal information. The mining node may analyse the data package to convert the signal information of each dataset to a corresponding data output. The mining node may communicate the plurality of data outputs to an authority server and, upon verification of the plurality of data outputs, the plurality of data outputs may be used in establishing a proof-of-work for appending a block record to a blockchain. Encryption and decryption methods may be used to secure data according to methods described herein. In some examples, the signal information of each dataset relates to a polynucleotide sequence and the corresponding data output relates to a read.

Abstract: This invention provides highly attenuated influenza viruses and vaccines. The attenuated viruses and vaccines proliferate well and have high safety factors. The attenuated viruses providing protective immunity from challenge by virus of the same subtype, as well as cross protection against heterologous viruses.

Abstract: A method of point cloud generation comprises generating, by a processor, a first point cloud comprising a first set of generated data points; calculating, by the processor, a loss function representative of the quality of the first point cloud, the loss function comprising a smoothness term obtained by constructing vectors between neighbouring data points in the point cloud, performing vector multiplication between neighbouring pairs of vectors, and outputting a smoothness term based on the result of the vector multiplication; and generating, by the processor, a second point cloud comprising a second set of generated data points based at least in part on the calculated loss function of the first point cloud.

Abstract: Hybrid nanopores, comprising a protein pore supported within a solid-state membrane, which combine the robust nature of solid-state membranes with the easily tunable and precise engineering of protein nanopores. In an embodiment, a lipid-free hybrid nanopore comprises a water soluble and stable, modified portal protein of the Thermus thermophilus bacteriophage G20c, electrokinetically inserted into a larger nanopore in a solid-state membrane. The hybrid pore is stable and easy to fabricate, and exhibits low peripheral leakage, allowing sensing and discrimination among different types of biomolecules.

Abstract: Certain embodiments of the present invention relate to methods of forming and manipulating bioconjugates. Particularly, but not exclusively certain embodiments relate to methods of reversible carbon-carbon bond bioconjugation using aldol based chemical reactions at physiological conditions.

Abstract: A system for extracting data from a plurality of electromagnetic data signals encoding the data is provided. The system includes a phase modulator which receives an electromagnetic beam, and generates an electromagnetic primary reference beam with a defined phase. The system further includes one or more mixing units, each mixing unit being arranged to receive a respective one of the data signals and a reference beam, and to generate two mixed signals. The one or more mixing units include a first mixing unit for which the reference beam is the primary reference beam. The system also includes a plurality of detection units. Each detection unit is arranged to receive a respective one of the data signals and a respective mixed signal from one of the mixing units, and to obtain a difference measurement indicative of a difference between the respective data signal and the respective mixed signal.

Abstract: The present application relates to nucleic acids encoding polypeptides with ?-etherase activity; polypeptides with ?-etherase activity; vectors comprising said nucleic acids for the production of recombinant ?-etherase; cells, for example microbial cells transformed with nucleic acids encoding ?-etherase activity and vectors, including nucleic acids encoding ?-etherases; a composition comprising ?-etherases suitable for processing lignocellulose and a method that uses ?-etherases or compositions comprising ?-etherases in the processing of lignocellulose and related polysaccharides.

Abstract: A method of analysing an aqueous fluid comprising obtaining a 2D-IR spectrum of a sample of the aqueous fluid using a 2D-IR spectrometer configured to apply a sequence of IR pulses to the sample, wherein the sequence comprises a pump process followed by a probe pulse, where the pump process is a single pump pulse or a sequence of a first pump pulse and a second pump pulse, and a waiting time Tw between applying the single pump pulse or the second pump pulse and applying the probe pulse is from 150 to 350 fs.

Abstract: Described herein are chimeric polypeptides that include one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Additional aspects of the present disclosure provide genetically altered plants having a chimeric polypeptide including one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Further aspects of the present disclosure relate to genetically altered plants having a stabilized polypeptide including two or more RBMs and one or both of an algal Rubisco-binding membrane protein (RBMP) and a Rubisco small subunit (SSU) protein. Other aspects of the present disclosure relate to methods of making such chimeric polypeptides and plants, as well as cultivating these genetically altered plants.

Abstract: Hybrid nanopores, comprising a protein pore supported within a solid-state membrane, which combine the robust nature of solid-state membranes with the easily tunable and precise engineering of protein nanopores. In an embodiment, a lipid-free hybrid nanopore comprises a water soluble and stable, modified portal protein of the Thermus thermophilus bacteriophage G20c, electrokinetically inserted into a larger nanopore in a solid-state membrane. The hybrid pore is stable and easy to fabricate, and exhibits low peripheral leakage, allowing sensing and discrimination among different types of biomolecules.

Abstract: Provided are methods for producing n-doped graphene films. The method comprises contacting a graphene layer with an alkali metal-doped polymer layer. Compositions comprising (i) a substrate, (ii) a doped polymer, and (iii) graphene are also provided. The methods of the invention produce n-doped graphene films that are resistant to degradation, have high electrical conductivity, and low sheet resistance without altering the optical transmission of graphene.

Abstract: The disclosure relates to recombinant protein expression systems comprising genetically modified cells wherein the cells are transformed or transfected with tRNA genes to reduce base mismatch due to genetic degeneracy in the genetic code.

Abstract: Aspects of the present disclosure relate to genetically modified plants and/or algae with increased carbon use efficiency as a result of an increased ability for bicarbonate to cross membranes within plant cells. Other aspects of the present disclosure relate to methods of making such plants and/or algae as well as cultivating these genetically modified plants to increase carbon use efficiency and/or growing these genetically modified algae to increase carbon use efficiency.

Abstract: There is described a method for preparation of an imaging medium via transfer from a hyperpolarised singlet state that is not parahydrogen, said method comprising the steps of: (i) preparing a system containing: parahydrogen; a magnetisation transfer complex, with a molecular symmetry that allows the creation of a singlet state between spin pairs within it, said complex including a reversibly bound small molecule transference substrate; applying a magnetic field such that hyperpolarisation is transferred into the transfer complex, including the reversibly bound small molecule transference substrate; (ii) introducing a recipient complex capable of binding the small molecule transference substrate, said recipient complex including a recipient substrate, such that the recipient complex and recipient substrate, including the bound transference substrate, is hyperpolarised.

Abstract: A plasmonic phase modulator is provided. The modulator has a conductive layer, and a dielectric layer disposed on the conductive layer. A plasmonic layer is disposed on the dielectric layer. A plasmonic layer is disposed on the dielectric layer. The plasmonic layer is conductive to surface plasmon polariton (SPP) waves. The plasmonic layer may be, for example, a graphene sheet. A voltage signal source is operatively connected between the conductive layer and the plasmonic layer for modulating a propagation speed of an SPP wave propagating on the plasmonic layer.

Abstract: There is described a method for the preparation of an aqueous magnetic resonance imaging medium, said method comprising the steps of: •(i) preparing a multiphasic solvent system comprising an aqueous component and a non-aqueous component, said solvent comprising a target substrate and a SABRE hyperpolarisation transfer catalyst; •(ii) adding H2 or parahydrogen gas; •(iii) agitating the solvent system to form an emulsion thereby transferring the spin order from the hyperpolarisation transfer catalyst to the target substrate; •(v) adding a solvent phase-separation promoter; and •(vi) separating the non-aqueous component and the aqueous component wherein the aqueous component contains the hyperpolarised target substrate and provides the aqueous magnetic resonance imaging medium.