Patents Assigned to University of York
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Patent number: 11897917Abstract: Certain embodiments of the present invention relate to methods of forming and manipulating bioconjugates. Particularly, but not exclusively certain embodiments relate to methods of reversible carbon-carbon bond bioconjugation using aldol based chemical reactions at physiological conditions.Type: GrantFiled: September 27, 2017Date of Patent: February 13, 2024Assignee: The University of YorkInventors: Martin A. Fascione, Richard J. Spears, Robin Brabham, Darshita Budhadev, Tessa Keenan
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Patent number: 11824589Abstract: A system for extracting data from a plurality of electromagnetic data signals encoding the data is provided. The system includes a phase modulator which receives an electromagnetic beam, and generates an electromagnetic primary reference beam with a defined phase. The system further includes one or more mixing units, each mixing unit being arranged to receive a respective one of the data signals and a reference beam, and to generate two mixed signals. The one or more mixing units include a first mixing unit for which the reference beam is the primary reference beam. The system also includes a plurality of detection units. Each detection unit is arranged to receive a respective one of the data signals and a respective mixed signal from one of the mixing units, and to obtain a difference measurement indicative of a difference between the respective data signal and the respective mixed signal.Type: GrantFiled: March 13, 2020Date of Patent: November 21, 2023Assignee: University of YorkInventors: Rupesh Kumar Parapatil Subramanian, Timothy Paul Spiller
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Publication number: 20230203461Abstract: The present application relates to nucleic acids encoding polypeptides with ?-etherase activity; polypeptides with ?-etherase activity; vectors comprising said nucleic acids for the production of recombinant ?-etherase; cells, for example microbial cells transformed with nucleic acids encoding ?-etherase activity and vectors, including nucleic acids encoding ?-etherases; a composition comprising ?-etherases suitable for processing lignocellulose and a method that uses ?-etherases or compositions comprising ?-etherases in the processing of lignocellulose and related polysaccharides.Type: ApplicationFiled: January 9, 2021Publication date: June 29, 2023Applicants: The University of York, Wisconsin Alumni Research FoundationInventors: Neil Bruce, Nicola Oates, John Ralph
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Patent number: 11598718Abstract: A method of analysing an aqueous fluid comprising obtaining a 2D-IR spectrum of a sample of the aqueous fluid using a 2D-IR spectrometer configured to apply a sequence of IR pulses to the sample, wherein the sequence comprises a pump process followed by a probe pulse, where the pump process is a single pump pulse or a sequence of a first pump pulse and a second pump pulse, and a waiting time Tw between applying the single pump pulse or the second pump pulse and applying the probe pulse is from 150 to 350 fs.Type: GrantFiled: June 7, 2019Date of Patent: March 7, 2023Assignee: The University of YorkInventors: Matthew Baker, Neil T. Hunt, Samantha Rutherford, Gordon Hithell
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Publication number: 20220275390Abstract: Described herein are chimeric polypeptides that include one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Additional aspects of the present disclosure provide genetically altered plants having a chimeric polypeptide including one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Further aspects of the present disclosure relate to genetically altered plants having a stabilized polypeptide including two or more RBMs and one or both of an algal Rubisco-binding membrane protein (RBMP) and a Rubisco small subunit (SSU) protein. Other aspects of the present disclosure relate to methods of making such chimeric polypeptides and plants, as well as cultivating these genetically altered plants.Type: ApplicationFiled: July 30, 2020Publication date: September 1, 2022Applicants: The Trustees of Princeton University, The Board of Trustees of the Leland Stanford Junior University, University of York, Howard Hughes Medical InstituteInventors: Martin C. Jonikas, Moritz Meyer, Shan He, Alan Itakura, Vivian Chen Wong, Luke Colin Martin Mackinder, Zhiheng Yu, Doreen Matthies, Hui-Ting Chou
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Patent number: 11408880Abstract: Hybrid nanopores, comprising a protein pore supported within a solid-state membrane, which combine the robust nature of solid-state membranes with the easily tunable and precise engineering of protein nanopores. In an embodiment, a lipid-free hybrid nanopore comprises a water soluble and stable, modified portal protein of the Thermus thermophilus bacteriophage G20c, electrokinetically inserted into a larger nanopore in a solid-state membrane. The hybrid pore is stable and easy to fabricate, and exhibits low peripheral leakage, allowing sensing and discrimination among different types of biomolecules.Type: GrantFiled: May 17, 2019Date of Patent: August 9, 2022Assignees: Northeastern University, University of YorkInventors: Meni Wanunu, Alfred Antson, Sandra Greive, Benjamin Cressiot
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Patent number: 11268101Abstract: The disclosure relates to recombinant protein expression systems comprising genetically modified cells wherein the cells are transformed or transfected with tRNA genes to reduce base mismatch due to genetic degeneracy in the genetic code.Type: GrantFiled: January 9, 2017Date of Patent: March 8, 2022Assignee: The University of YorkInventor: Robert White
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Publication number: 20220009854Abstract: There is described a method for the preparation of a hyperpolarised agent, wherein said agent comprises at least one —N?, —O? or —S? moiety (optionally protonated) and a secondary binding site; said method comprising: (i) preparing a fluid containing a polarisation transfer precatalyst and parahydrogen; (ii) introducing a co-ligand to interact with the transfer precatalyst to form a polarisation transfer catalyst; (iii) applying a magnetic field or radio frequency excitation to (ii), such that hyperpolarisation is transferred from parahydrogen to a target molecule; (iv) introducing a target molecule containing at least at least one —N?, —O? or —S? moiety, in conjunction with a secondary binding to form a hyperpolarised agent; wherein the co-ligand is selected from the group consisting of one or more of a sulfoxide, a thioester, a phosphine, an amine, CO, an isonitrile and a nitrogen heterocycle.Type: ApplicationFiled: November 6, 2019Publication date: January 13, 2022Applicant: UNIVERSITY OF YORKInventors: Soumya Singha Roy, Wissam Iali, Ben Tickner, Simon Benedict Duckett
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Publication number: 20210238623Abstract: Aspects of the present disclosure relate to genetically modified plants and/or algae with increased carbon use efficiency as a result of an increased ability for bicarbonate to cross membranes within plant cells. Other aspects of the present disclosure relate to methods of making such plants and/or algae as well as cultivating these genetically modified plants to increase carbon use efficiency and/or growing these genetically modified algae to increase carbon use efficiency.Type: ApplicationFiled: July 12, 2019Publication date: August 5, 2021Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of YorkInventors: Ananya MUKHERJEE, James V. MORONEY, Chun Sing LAU, Luke C.M. MACKINDER
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Publication number: 20210154333Abstract: There is described a method for preparation of an imaging medium via transfer from a hyperpolarised singlet state that is not parahydrogen, said method comprising the steps of: (i) preparing a system containing: parahydrogen; a magnetisation transfer complex, with a molecular symmetry that allows the creation of a singlet state between spin pairs within it, said complex including a reversibly bound small molecule transference substrate; applying a magnetic field such that hyperpolarisation is transferred into the transfer complex, including the reversibly bound small molecule transference substrate; (ii) introducing a recipient complex capable of binding the small molecule transference substrate, said recipient complex including a recipient substrate, such that the recipient complex and recipient substrate, including the bound transference substrate, is hyperpolarised.Type: ApplicationFiled: July 3, 2018Publication date: May 27, 2021Applicant: University of YorkInventors: Simon Duckett, Soumya Singha Roy, Kate M. Appleby
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Patent number: 10969505Abstract: A charged particle detector is provided. The charged particle detector includes a flexible semiconductor wafer, the semiconductor wafer being doped to form a p-n junction, and an amplifier coupled to the semiconductor wafer and configured to amplify a current or voltage across the p-n junction.Type: GrantFiled: December 18, 2017Date of Patent: April 6, 2021Assignee: UNIVERSITY OF YORKInventors: David Jenkins, Thomas Krauss, Christian Schuster
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Publication number: 20200397923Abstract: There is described a method for the preparation of an aqueous magnetic resonance imaging medium, said method comprising the steps of: •(i) preparing a multiphasic solvent system comprising an aqueous component and a non-aqueous component, said solvent comprising a target substrate and a SABRE hyperpolarisation transfer catalyst; •(ii) adding H2 or parahydrogen gas; •(iii) agitating the solvent system to form an emulsion thereby transferring the spin order from the hyperpolarisation transfer catalyst to the target substrate; •(v) adding a solvent phase-separation promoter; and •(vi) separating the non-aqueous component and the aqueous component wherein the aqueous component contains the hyperpolarised target substrate and provides the aqueous magnetic resonance imaging medium.Type: ApplicationFiled: March 3, 2018Publication date: December 24, 2020Applicant: University of YorkInventors: Simon Benedict DUCKETT, Wissam IALI, Alexandra Marla OLARU
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Patent number: 10774089Abstract: There is described a method of producing (?)-levoglucosenone, said method comprising, heating lignin to a temperature in excess of 150° C. for a time sufficient to convert a proportion of the lignin to (?)-evoglucosenone.Type: GrantFiled: April 20, 2016Date of Patent: September 15, 2020Assignee: UNIVERSITY OF YORKInventors: James Hanley Clark, Mario De Bruyn, Vitaliy Lvovich Budarin
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Patent number: 10753868Abstract: There is provided a chirped diffractive element (20) in the form of a grating (22) configured for supporting a plurality of guided mode resonances (54), which resonances (54) may be considered to comprise a standing wave. Chirping the grating (22) may allow guided mode resonances (54) to be distinguishable in terms of position within a section (34) the grating (22). An incident electromagnetic field may be coupled into at least one of the sections (34) when the electromagnetic field has a wavelength value within a predetermined wavelength range and a sample has a refractive index value within a predetermined index range. The incident electromagnetic field may be reflected by at least one of the sections (34) of the grating (22) exhibiting a guided mode resonance (54).Type: GrantFiled: June 16, 2017Date of Patent: August 25, 2020Assignee: UNIVERSITY OF YORKInventors: Christopher Reardon, Graham Triggs, Thomas Krauss
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Publication number: 20200246491Abstract: There is described a method for the preparation of a hyperpolarised target molecule, wherein said molecule comprises at least one —OH, —NH or —SH moiety, via proton exchange from a polarisable molecule, said method comprising the steps of: (i) preparing a fluid containing a transfer catalyst; parahydrogen; and a polarisable molecule containing at least one exchangeable proton, such as, an —OH, —NH or —SH moiety; (ii) applying a magnetic field or radio frequency excitation such that hyperpolarisation is transferred from parahydrogen to the polarisable molecule when bound to the magnetisation transfer catalyst; (iii) separately or simultaneously introducing a target molecule, wherein said target molecule contains at least one —OH, —NH or —SH exchangeable proton, enabling hyperpolarisation transfer via proton exchange with the polarisable molecule.Type: ApplicationFiled: July 24, 2018Publication date: August 6, 2020Applicant: University of YorkInventors: Wissam Iali, Peter Rayner, Simon Benedict Duckett
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Publication number: 20200165613Abstract: The disclosure relates to the assembly of Virus Like Particles [VLPs] using packaging native and artificial packaging signals and their use in vaccines and immunological compositions and the methods of vaccination or immunisation against human and animal viral pathogens.Type: ApplicationFiled: May 31, 2018Publication date: May 28, 2020Applicants: The University of Leeds, The University of YorkInventors: German Leonov, Simon White, Peter Stockley, Nikesh Patel, Emma Wroblewski, Dan Maskell, Reidun Twarock, Richard Bingham, Eva Weiss, Eric Dykeman
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Patent number: 10400222Abstract: The disclosure relates to delta (12) and delta (15) desaturases and their use in the modification of oil content in hemp.Type: GrantFiled: December 8, 2014Date of Patent: September 3, 2019Assignee: The University of YorkInventors: Monika Bielecka, Filip Kaminski, Thilo Winzer, Ian Graham
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Publication number: 20190218529Abstract: The present disclosure relates to nucleic acids that encode polypeptides with cytochrome P450 activity involved in the biosynthesis of plant derived diterpenoids or diterpenes.Type: ApplicationFiled: March 28, 2019Publication date: July 18, 2019Applicant: The University of YorkInventors: Andrew King, Ian Graham
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Publication number: 20190106684Abstract: The present disclosure relates to nucleic acids that encode enzyme activities involved in the synthesis of lathyranes, intermediates in the synthesis of lathyranes and also compounds derived from lathyranes such as tiglianes, daphnanes and ingenanes; cells transformed with the nucleic acid molecules and vectors comprising the nucleic acid molecules.Type: ApplicationFiled: March 13, 2017Publication date: April 11, 2019Applicant: The University of YorkInventors: Ian Graham, Andrew King
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Patent number: 10246688Abstract: The present disclosure relates to nucleic acids that encode polypeptides with cytochrome P450 activity involved in the biosynthesis of plant derived diterpenoids or diterpenes.Type: GrantFiled: January 9, 2015Date of Patent: April 2, 2019Assignee: The University of YorkInventors: Andrew King, Ian Graham