Abstract: There is described a method for the preparation of a hyperpolarised target molecule, wherein said molecule comprises at least one —OH, —NH or —SH moiety, via proton exchange from a polarisable molecule, said method comprising the steps of: (i) preparing a fluid containing a transfer catalyst; parahydrogen; and a polarisable molecule containing at least one exchangeable proton, such as, an —OH, —NH or —SH moiety; (ii) applying a magnetic field or radio frequency excitation such that hyperpolarisation is transferred from parahydrogen to the polarisable molecule when bound to the magnetisation transfer catalyst; (iii) separately or simultaneously introducing a target molecule, wherein said target molecule contains at least one —OH, —NH or —SH exchangeable proton, enabling hyperpolarisation transfer via proton exchange with the polarisable molecule.

Abstract: The disclosure relates to the assembly of Virus Like Particles [VLPs] using packaging native and artificial packaging signals and their use in vaccines and immunological compositions and the methods of vaccination or immunisation against human and animal viral pathogens.

Abstract: The disclosure relates to delta (12) and delta (15) desaturases and their use in the modification of oil content in hemp.

Abstract: The present disclosure relates to nucleic acids that encode polypeptides with cytochrome P450 activity involved in the biosynthesis of plant derived diterpenoids or diterpenes.

Abstract: The present disclosure relates to nucleic acids that encode enzyme activities involved in the synthesis of lathyranes, intermediates in the synthesis of lathyranes and also compounds derived from lathyranes such as tiglianes, daphnanes and ingenanes; cells transformed with the nucleic acid molecules and vectors comprising the nucleic acid molecules.

Abstract: The present disclosure relates to nucleic acids that encode polypeptides with cytochrome P450 activity involved in the biosynthesis of plant derived diterpenoids or diterpenes.

Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.

Abstract: The disclosure relates to recombinant protein expression systems comprising genetically modified cells wherein the cells are transformed or transfected with tRNA genes to reduce base mismatch due to genetic degeneracy in the genetic code.

Abstract: There is described a processor for use in the microwave torrefaction of biomass material which comprises, a micronized biomass char material and a method of producing a biomass char material, and a method of producing L-glucosan.

Abstract: There is described a method of transformation of a cellulosic material, such as, lignocellulosic biomass material and/or cellulose, into a directly fermentable saccharide containing mixture wherein said method of transformation comprises the microwave assisted hydrothermal treatment of the cellulosic material.

Abstract: This disclosure relates to the isolation of a nucleic acid molecule[s] that encode a novel cytochrome P450 and an oxidoreductase from a Papaver somniferum [P. somniferum] cultivar, transgenic cells transformed with said nucleic acid molecule and sequence variants thereof; and including methods for the production of intermediates in the production of morphinans.

Abstract: There is described a method of producing (?)-levoglucosenone, said method comprising, heating lignin to a temperature in excess of 150° C. for a time sufficient to convert a proportion of the lignin to (?)-evoglucosenone.

Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.

Abstract: This disclosure relates to the isolation of a nucleic acid molecule[s] that encode a novel cytochrome P450 and an oxidoreductase from a Papaver somniferum [P. somniferum] cultivar, transgenic cells transformed with said nucleic acid molecule and sequence variants thereof; and including methods for the production of intermediates in the production of morphinans.

Abstract: A spin valve element 10 including a spin injector 12 made of a ferromagnetic material, a spin detector 16 made of a ferromagnetic material, and a channel part 14 made of a non-magnetic material. The spin detector 16 is arranged at a position separated from the spin injector 12, the channel part 14 is connected with the spin injector 12 and the spin detector 16 directly or through an insulating layer, and a plurality of spin diffusion portions 30 to 34 with enlarged cross section areas in a direction perpendicular to a spin current is formed in the channel part 14.

Abstract: A spin rotary member includes a substrate, a spin injector made of a ferromagnetic material magnetized in a substrate in-plane direction, and provided on the substrate, a spin rotor made of a ferromagnetic material having a magnetic moment rotatable in the substrate in-plane direction, and provided on the substrate, being separated from the spin injector, a channel part made of a non-magnetic material, arranged between the spin injector and the spin rotor, and bonded with the spin injector and the spin rotor directly or through an insulating layer, and a spin rotation control part configured to control a rotation direction of spin of the channel part.

Abstract: A crystallisation method for an alloy film such as a Co-based ternary Heusler-alloy is described having the steps of: providing a substrate; depositing a layer of the alloy film to be crystallised onto the substrate using a physical vapour deposition process to a depth of up to a few hundred nm; optionally depositing a capping layer thereon; heating the deposited film at an annealing temperature below 300° C. and for example of around 200° C. to 300° C. to effect crystallisation of the alloy film layer. The method is in particular applied to the in the deposition and annealing in situ of an alloy film in or on a semiconductor device for example as a functional film in or on such a device and in particular to the deposition and annealing in situ of a highly-spin-polarised ferromagnetic thin film on a semiconductor or spintronic device.

Abstract: The disclosure relates to delta (12) and delta (15) desaturases and their use in the modification of oil content in hemp.

Abstract: The disclosure relates to anti-viral agents that mimic or inhibit packaging singles of RNA viruses that function in viral capsid formation and their use in the control of viral infection.

Abstract: The present disclosure relates to nucleic acids that encode polypeptides with cytochrome P450 activity involved in the biosynthesis of plant derived diterpenoids or diterpenes.