Abstract: Embodiments of the present invention relate generally the use of compositions comprising a glutathione precursor and a selenium source, e.g., compositions which elevate intracellular glutathione, in the prevention and treatment of Zika viral diseases, e.g., Zika fever. Related embodiments are directed to use of such compositions, e.g., compositions comprising a glutathione precursor and a selenium source, in reducing the infectivity of Zika viruses or Zika viral particles.

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein is versatile polyene cyclization strategy that exploits conjugated ?-ionyl derivatives. Photomediated disruption of the extended ?-system within these chromophores unveils a contra-thermodynamic polyene that engages in a Heck-type cyclization to afford [4.4.1]-propellanes. The connectivity of overbred polycycles generated from this process is controlled by the position of the requisite C-Halide bond. Thus, compared to conventional biomimetic polyene cyclization, this approach allows for complete control of regiochemistry and facilitates incorporation of both electron-rich and electron-deficient (hetero)aryl groups. This strategy was successfully applied to the total synthesis of abietanes such as, for example, taxodione and salviasperanol, two isomeric abietane-type diterpenes that previously could not be prepared along the same synthetic pathway.

Abstract: An electrostatic discharge (ESD) protection circuit includes a first pad configured to provide a first voltage, a second pad configured to provide a second voltage, an equalizing circuit including a first inductor, a second inductor, and a third inductor, an input/output pad connected to the equalizing circuit, and a diode circuit including a first diode and a second diode. An end of the first diode is connected to the first pad and another end of the first diode is connected the equalizing circuit. An end of the second diode is connected to the equalizing circuit and the first diode and another end of the second diode is connected to the second pad.

Abstract: Composite materials that include a phosphor and boron nitride particles. The composite materials may be scintillating materials. The boron nitride particles may be 10B enriched particles. Systems that include composite materials and a detector. Methods of detecting or blocking neutrons. Methods of manufacturing composite materials, including large-area composite materials.

Abstract: Disclosed are articles comprising substrate and graphene coating that are configured to support a sample for electron or optical microscopy. Also disclosed are methods of making the same and methods of using the same in imaging technology.

Abstract: Provided is an analog-to-digital converter and a voltage offset correction method thereof. The analog-to-digital converter may include a digital-to-analog converter (DAC) configured to generate a first comparison voltage, a comparison circuit configured to output a first comparison result signal based on a result of comparing the first comparison voltage with a second comparison voltage, and a control circuit configured to control the DAC and output an output signal, wherein the DAC may include a correction circuit configured to generate a correction voltage by selectively switching switches connected to terminals to which a plurality of reference voltages are applied, and correct a voltage offset of the comparison circuit based on the correction voltage.

Abstract: An artificial and/or simulated environment is used to raise a domestic or commercially raised animal to promote a positive health feedback and to minimize stress on the animal. The simulated environment is used to create the façade of a free range or cage free environment, while also minimizing the exposure to inclement weather, potential predators, and other unknown or stress-inducing situations. The results include animals that have higher resistance to diseases and have a lower stress. The artificial environment can be created by projecting or otherwise showing images and/or videos depicting simulation of environments, climate, and/or other unknown situations to normalize the animals to the same.

Abstract: New types of particle feedstocks and heterogeneous grain structures are provided for rare earth permanent magnets (REPMs) and their production in a manner to significantly enhance toughness of the magnet with little or no sacrifice in the hard magnetic properties. The novel tough REPMs made from the feedstock have heterogeneous grain structures, such as bi-modal, tri-modal, multi-modal, laminated, gridded, gradient fine/coarse grain structures, or other microstructural heterogeneity and configurations, without changing the chemical compositions of magnets.

Abstract: A topological spin memory effect, defined as the recovery of magnetic skyrmions or magnetic bubble skyrmions in magnetic thin films after a transition to a dramatically different spin texture, is used for encrypted non-volatile information storage. The storage strategy is based on magnetic skyrmions, that is, topologically protected spin textures comprising chiral domain walls surrounding small (e.g., nanometers to microns in diameter), typically circular, single-domain cores. Systems and methods are described for encrypted non-volatile information storage based on a spin memory effect in magnetic thin films that support skyrmions. Systems and methods encrypt and recover information stored in the form of magnetic skyrmions.

Abstract: Methods, systems, and apparatus for high-resolution patterning of various substrates with functional materials, including nanomaterials. A technique of preparing a patterned substrate in a high-resolution mold for stick and transfer process is disclosed with promotes integrity of the high-resolution pattern onto the substrate. One example of a substrate is an adhesive tape. The transferred pattern(s) are scalable and can be implemented in different fabrication processes. One example is a roll-to-roll processes. In one embodiment, the transferred pattern comprises nanomaterials and the substrate comprises a flexible substrate for use in flexible and conformal assemblies for a wide variety of applications including, but not limited to, electrical-based sensors on non-planar inanimate surfaces, plant body surface, or human or animal skin.

Abstract: Described herein are technologies for concentrating rare-earth elements from a heavy fraction of grit in gangue produced in kaolin mining. In some examples, grit is separated as a non-clay fraction of gangue produced in a kaolin mining operation. The grit is separated into a heavy mineral grit sub-fraction and a light mineral grit sub-fraction. Rare-earth elements, particularly heavy rare-earth elements, are thereafter extracted from the heavy mineral grit sub-fraction using various extraction technologies.

Abstract: Compounds and treatment methods with compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: or a prodrug or pharmaceutically-acceptable salt thereof, where: each X comprises at least one cyclic moiety directly attached to the oxygen or connected via an alkyl linkage, where at least one of the linkage and/or the X moiety comprises a deuterium substitution; and Z is selected from the group consisting of aldehydes and bisulfite salts, or the ester or carbamate prodrugs thereof.

Abstract: Refractory-reinforced multiphase high entropy alloys (RHEAs) advantageously providing high strength and fracture toughness in an as-AM deposited condition and other conditions are described.

Abstract: This disclosure presents systems, devices, and methods that use magnetometers to measure large magnetic moments with strong magnetic anisotropy. A torque magnetometer may include an actuator driven by a motor, a load cell coupled to the actuator, a rotatable spool having a platform configured to hold a sample of a superconductor material, where the rotatable spool is coupled to the load cell by a first line, a pulley, and a second line extending between the rotatable spool and a counterweight, where the second line is positioned on the pulley. Movement of the actuator may cause the rotatable spool to rotate an angle of the platform relative to a magnetic field about the rotatable spool, and the load cell is capable of measuring the tension on the first line.

Abstract: This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.

Abstract: Metal halide perovskite crystals, composite materials that include metal halide perovskite crystals and a polymeric matrix material, devices that include metal halide perovskite crystals, and methods of forming metal halide perovskite crystals, composite materials, and devices. The devices may include optoelectronic devices, such as light-emitting diodes. The light-emitting diodes may emit red light.

Abstract: Disclosed herein are embodiments of methods for encoding, decoding, and matching patterns in collections of signals. These methods use weighting functions to scale the signals. This scaling enables the use of signals of arbitrary duration, wherein the signals may include discrete sequences and spike trains. In the most general case, the signals can be represented using functionals, which extends the expressive power of the methods. Further disclosed herein are embodiments of a system that performs these methods.

Abstract: Embodiments of the present systems and methods may provide improved capability to predict the risk of recurrence of ductal carcinoma in situ (DCIS) conditions using whole slide image analysis based on machine learning techniques. For example, in an embodiment, a computer-implemented method for determining treatment of a patient may comprise receiving an image of living tissue of a patient, annotating the entire image into tissue structures, extracting texture features from the annotated image, determining a distribution of the extracted texture features relative to tissue conditions, classifying the patient into a risk group based on the distribution, and treating the patient accordingly based on the risk group.

Abstract: A technique, and its applications, for high resolution, rapid, and simple nanopatterning. The general method has been demonstrated in several forms and applications. One is patterning nanophotonic structures at an optical fiber tip for refractive index sensing. Another is patterning nanoresonator structures on a sensor substrate for plasmonic effect related detection of VOCs. In the latter example, a graphene oxide coated plasmonic crystal as a gas sensor capable of identifying different gas species using an array of such structures. By coating the surface of multiple identical plasmonic crystals with different thicknesses of Graphene-Oxide (GO) layer, the effective refractive index of the GO layer on each plasmonic crystal is differently modulated when exposed to a specific gas. Identification of various gas species is accomplished using pattern recognition algorithm.

Abstract: Disclosed herein are systems and methods for removing trichloroethane (TCA), trichloroethene (TCE), and 1,4-dioxane (1,4-D) from contaminated liquids. The system and methods rely on catalyst reduction of TCA and TCE, where the reduced products are then degraded by microorganisms The system comprises a first reactor comprising a catalyst film of precious metal nanoparticles deposited on a first nonporous membrane and a second reactor comprising a biofilm of microorganisms that are capable of degrading ethane and 1,4-D deposited on a second nonporous membrane. The first reactor further comprises a hydrogen gas source, wherein the hydrogen gas source delivers hydrogen to the gas-phase side of the first nonporous membrane, and the catalyst film is deposited on the liquid-phase side. The second reactor further comprises an oxygen gas source, wherein the oxygen gas source delivers oxygen to the gas-phase side of the second non-porous membrane, and the biofilm is deposited on the liquid-phase side.