Abstract: The present invention relates to compositions and methods for activating expression from the paternally-inherited allele of UBE3A in human Angelman's Syndrome neurons using viral vector delivery of short hairpin RNAs, ribozymes, and/or microRNAs.

Abstract: A method for differentiable architecture search based on a hierarchical grouping mechanism includes: obtaining a target dataset; selecting a set number of normal cells and two reduction cells; enabling the reduction cells to be located at ? and ? of all cells, respectively, and then concatenating all cells to form an initial search network; training the initial search network to optimize a cost function to complete a one-level search or a two-level search, wherein in the one-level search, control weight parameters are shared by the inter-group operations and are shared by the intra-group operations among the cells; and in the two-level search, the control weight parameters are shared by the inter-group operations and are not shared by the intra-group operations, obtaining normal cells and reduction cells based on the one-level search or the two-level search; and constructing a target network using the normal cells and the reduction cells.

Abstract: Systems and methods provide a novel computational approach to planning the endovascular treatment of cardiovascular diseases. In particular, the invention simulates medical device deployment and hemodynamic outcomes using a virtual patient-specific anatomical model of the area to be treated, high-fidelity finite element medical device models and computational fluid dynamics (CFD). In an embodiment, the described approach investigates the effects of coil packing density, coil shape, aneurysmal neck size and parent vessel flow rate on aneurysmal hemodynamics. A processor may receive patient clinical data used to construct the relevant anatomical structure model. The processor may access medical device models constructed using finite element analysis and three dimensional beam analysis, and simulates the deployment of selected medical devices in the anatomical structure model.

Abstract: Provided is a smart surveillance system that includes one unmanned aerial vehicle (UAV), a plurality of Internet of Things (IoT) terminals distributed in a surveillance area, and a plurality of base stations distributed in the surveillance area, wherein the UAV selects any IoT terminal from among the plurality of IoT terminals using deep learning auction training, receives surveillance data from the selected IoT terminal, and transmits the surveillance data to a data center through the Internet and any one base station among the plurality of base stations.

Abstract: A device and method for enhancing nitrogen and phosphorus removal based on a multistage AO partial denitrification coupled with Anammox process in combination with a sludge hydrolytic acidification mixture belong to the technical field of active sludge method wastewater treatment. A system includes a water tank, a water pump, a biochemical reaction zone, a hydrolytic acidification tank and other devices.

Abstract: Non-human animals and offspring thereof comprising at least one modified chromosomal sequence in a gene encoding a CD163 protein are provided. Animal cells that contain such modified chromosomal sequences are also provided. The animals and cells have increased resistance to pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV). The animals and offspring have chromosomal modifications of a CD163 gene. The invention further relates to methods of breeding to create pathogen-resistant animals and populations of animals made using such methods.

Abstract: Mechanisms for defending a computing system from attack are provided. The mechanisms include: maintaining a round counter that tracks a round number for a local host; determining a location in a graph for each of a plurality of hosts including the local host; determining monitor hosts of the plurality of hosts that are monitoring the local host; determining monitoree hosts of the plurality of hosts that are being monitored by the local host; sending a message to each of the monitor hosts identifying a value of the round counter; forwarding a first set of heartbeat messages from previous monitoree hosts to the monitor hosts; attempting to receive messages from the monitoree hosts; determining whether any messages were not received from the monitoree hosts; and in response to determining that one or more messages were not received from the monitoree hosts, generating an alert.

Abstract: Various implementations include a self-heating device. The device includes an electrically insulative layer, an electrically conductive layer, a first electrode, and a second electrode. The electrically insulative layer has a first surface and a second surface spaced apart from the first surface. The electrically conductive layer has a first surface and a second surface spaced apart from the first surface. The second surface of the conductive layer is coupled to the first surface of the insulative layer. The conductive layer includes a polymer. Conductive nanoparticles are embedded in the polymer. The first electrode and a second electrode are coupled to the conductive layer. The first electrode and the second electrode are spaced apart from each other and in electrical communication with each other through the conductive layer. The conductive layer produces heat through Joule heating when electrical current is passed through the conductive layer.

Abstract: A long-lasting and stable perovskite solar cell utilizes fluorine-containing inorganic ammonium salts to form ion exchange with perovskite to construct a perovskite light-absorbing layer to protect the perovskite, greatly improving stability of the perovskite solar cell. The perovskite solar cell can maintain 94% and 81% of its initial efficiency after being placed in a nitrogen-filled glove box and humid air for 14,016 hours and 2,500 hours, respectively, and can still maintain 83% of its initial efficiency after performed by heat aging at 85° C. for 1,248 hours, reaching a world-class level. A preparation method of the perovskite solar cell is simple, materials used to prepare the perovskite solar cell are inexpensive, and the stability of an obtained device is significantly improved under various conditions.

Abstract: A method for generating a 3D image of a body shape includes obtaining a set of far-field patterns of electromagnetic waves from a given body shape of a human or animal, establishing a one-to-one correspondence between the body shape and the set of far-field patterns of electromagnetic waves, representing the far-field patterns as a shape generating vector, mapping a vector of characteristic parameters to the shape generating vector, producing a body generation model by taking the vector of characteristic parameters and the shape generating vector as input and output data to form a training dataset for machine learning, specifying a characteristic vector of an unknown geometric body shape and obtaining a shape generating vector of the unknown geometric body shape based on the body generation model, and reconstructing the unknown geometric body shape based on the shape generating vector.

Abstract: Non-degradable, non-immunogenic microporous hydrogel compositions are provided. Such hydrogel compositions consist of flowable hydrogel particles comprising a bioinert polymeric backbone, including for example a poly(ethylene glycol)(PEG)-based polymeric backbone, an annealing component comprising a physiologically-stable, radically polymerizable alkene, including for example methacrylamide, and a heparin compound. Methods of treating glottic incompetence and/or providing laryngeal reconstruction are also provided. Such methods consist of providing a subject suffering from glottic incompetence and/or in need of laryngeal reconstruction, and administering a non-degradable, non-immunogenic microporous hydrogel composition disclosed herein.

Abstract: The present invention provides methods of treating Restless Legs Syndrome (RLS) including administering to a subject an effective amount of a dopamine D1 receptor antagonist. Compositions and kits useful for treating RLS are also provided.

Abstract: The present invention has developed methods and compositions utilizing the cell surface CD107a (LAMP-1) as a marker that divides bone-forming and fat-forming progenitor/stem cells within human adipose tissue. The present invention is able to partition stromal progenitors for improved bone and soft tissue engineering and therapies.

Abstract: Provided are compositions and methods for making a diploid yeast having heterozygosity for at least one chromosome. The method includes mating haploid yeast having at least a first modified chromosome comprising a synthetic chromosome suitable for recombination-site-mediated evolution (as a SCRaMbLE-ready modification). The SCRaMbLE-ready modification includes introduced site-specific recombinase recognition sites that can be recognized by a recombinase. Yeast that have at least one SCRaMbLE-ready modification of a chromosome are mated with a haploid yeast devoid of the SCRaMbLE-ready modification to obtain diploid SCRaMbLE-ready yeast. Subsequent to mating the haploid SCRaMbLE-ready yeast to yeast devoid of the SCRaMbLE-ready modification the method includes using the recombinase to recombine the first modified chromosome to obtain heterozygous diploid yeast comprising at least one recombined (SCRaMbLEd) chromosome and a homologous non-SCRaMbLEd chromosome.

Abstract: Self-adaptive systems, uses of the systems, and methods for adapting one or more properties of a material are disclosed.

Abstract: The system is for use with a tissue sample and includes a tray and an apparatus. The tray is for receiving the tissue sample in use and an apparatus. The apparatus includes: a support which receives the tray in use: a probe adapted to transmit waves and identify wave echoes: a tissue marking device; and a transporter adapted to: convey the probe over the tissue sample in use, the probe and the transporter being adapted such that, in use, information about the tissue sample is collected sufficient to permit a radiologist to identify structures which resemble lymph nodes in the tissue sample; and convey the tissue marking device to locations of interest which correspond to the locations of structures which resemble lymph nodes in the tissue sample.

Abstract: Scaffold compounds are used to design small molecule compounds and structure-activity relationship studies identify inhibitors of inflammation. Methods include pharmaceutical compositions of the small molecule compounds to inhibit, prevent and treat diseases and conditions associated with inflammation, including multiple sclerosis, Alzheimer's disease, acute myocardial infarction, traumatic brain injury and autoinflammatory diseases.

Abstract: Provided herein are amino acid compositions useful for increasing the translocation of the cystic fibrosis transmembrane conductance (CFTR) protein from the cytoplasm to the plasma membrane, particularly in epithelial cells. Methods for increasing the concentration of CFTR in the plasma membrane, increasing chloride ion transport, and increasing water transport are also provided. These compositions and methods are useful in treating cystic fibrosis in subjects bearing one or more mutations in the CFTR protein. Use of these compositions for the treatment of cystic fibrosis and in the preparation of a medicament for the treatment of cystic fibrosis are also encompassed herein.

Abstract: Embodiments of the present disclosure provide for methods of making substrates having an (AR) antireflective layer, substrates having an antireflective layer, devices including a substrate having an antireflective layer, and the like. The AR layer can have a total specular reflection of less than 10% at a wavelength of about 400-800 nm, and a height of about 500-1000 nm.

Abstract: The gene responsible for encoding SERT has a functional polymorphism at the 5?-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3? UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.