Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for detecting and treating prostate cancer. In a specific embodiment, a method for identifying a patient as having aggressive prostate cancer comprising the step of detecting overexpression relative to a control of epithelial cell adhesion molecule (EpCAM), H4 clustered histone 5 (H4C5), and tetratricopeptide repeat domain 3 (TTC3) in a urine sample obtained from the patient. In a more specific embodiment, the detecting step comprises detecting protein or ribonucleic acid (RNA) level of EPCAM, H4C5 and TTC3. In another specific embodiment, the method further comprises detecting overexpression relative to a control of one or more of messenger ribonucleic acid (mRNA), circulating RNA (circRNA), extracellular DNA and long non-coding RNA (lncRNA). The method can further comprise detecting metabolites.

Abstract: In an embodiment, the present disclosure pertains to a droplet system, apparatus, or fluid sample testing system to accomplish high-precision and high-efficiency droplet manipulation (e.g., greater than 99% platform operation efficiency). In some embodiments, the droplet system, apparatus, or fluid sample testing system includes at least one microfluidic channel or chamber and at least one interdigitated electrode (IDE) that can create a localized electric field below and/or within at least one fluidic channel or chamber. In some embodiments, this allows size-specific and/or size-dependent droplet manipulation.

Abstract: A method for assessing acute kidney injury of inpatient includes the following steps. An electronic medical record data of an inpatient is captured by a processor, and the electronic medical record data includes a baseline basic serum creatinine concentration data. A target serum creatinine concentration data and a minimum post-admission serum creatinine concentration data of the inpatient are captured by the processor. A dynamic-increasing value of serum creatinine concentration is calculated to obtain by the processor based on the target serum creatinine concentration data, the baseline basic serum creatinine concentration data and the minimum post-admission serum creatinine concentration data. The dynamic-increasing value of serum creatinine concentration is analyzed by the processor to assess whether the inpatient is an inpatient suffering the acute kidney injury or not.

Abstract: Methods are disclosed for generating, manipulating, and controlling non-Gaussian quantum states in continuous variable cluster quantum states usable for quantum computing. Some methods can be used to generate, transport, and enlarge Schrödinger-Cat states embedded in the CV cluster quantum state. Some methods can be used to transform Schrödinger-Cat states embedded in the CV quantum cluster state to grid states (such as Gottesman-Kitaev-Preskill states) and enlarge the grid states. In certain embodiments, some of the methods may be used to generate and control non-Gaussian states in macronode cluster quantum states such as cluster states comprising two-mode macronodes.

Abstract: A polymer separator with improved charge and discharge performance and thermal stability, includes a porous polymer substrate and a coating layer formed on at least one surface of the porous polymer separator. The coating layer includes: functional group bonded to double bond-containing PVDF (DPVDE); and inorganic oxide particles bonded to the functional group.

Abstract: Provided herein is a recombinant AAV (rAAV) comprising an AAV capsid and a vector genome packaged therein, wherein the vector genome comprises an AAV 5? inverted terminal repeat (ITR), an expression cassette comprising an open reading frame (ORF) for a mature human Lamin A (hLaminA) under control of a regulatory sequence which direct expression of mature hLaminA in a target cell, and an AAV 3? ITR. Also provided is a pharmaceutical composition comprising a rAAV as described herein in a formulation buffer, and a method of treatment of idiopathic dilated cardiomyopathy (DCM) or a disease associated with a mutation in a Lamin A (LMNA) gene.

Abstract: Method for nanoparticle-mediated deposition of radiation (NMDR) and targeted radiation therapies using a biodegradable and bioabsorbable iron oxide nanoparticle with a biocompatible coating that is effective to overcome various extra- and intra-cellular barriers and selectively accumulate in solid and metastatic tumors to improve the energy transfer of conventional radiotherapy

Abstract: This disclosure relates to red mud compositions. This disclosure also relates to methods of making red mud compositions. This disclosure additionally relates to methods of using red mud compositions.

Abstract: The present invention relates to: an organ-on-a-chip for mimicking kidney tissue in which renal tubular epithelial cells and renal fibroblasts are co-cultured; a method for manufacturing the organ-on-a-chip; a device for co-culturing three types of cells; and a method for screening for renal fibrosis therapeutic agents by using the organ-on-a-chip. A kidney-on-a-chip according to one embodiment of the present invention has the excellent effects of enabling the time and errors required in screening for renal fibrosis therapeutic agents to be minimized and renal fibrosis therapeutic agents to be more conveniently and simply screened for through an objective evaluation index.

Abstract: Analogs and derivatives of omecamtiv mecarbil (OM), including an 18F-labeled analog, and methods of synthesis thereof. Cardiac myosin targeting vectors comprising a lipid anchoring/solubilizing moiety conjugated to a head made of OM or the OM analog or derivative. Liposomes comprising a cardiac-treating cargo molecule and the cardiac myosin targeting vector. Methods of treating a cardiac condition or disease in a subject by administering to the subject the cardiac-treating cargo molecule and the cardiac myosin targeting vector. Methods of synthesizing an 18F-labeled analog of OM.

Abstract: Disclosed herein is an inline rolling shear alignment (IRSA) coating device and methods of producing a nanostructured film and inorganic nanostructures. The IRSA coating device comprises a coating head for disposing a solvent-containing film having a starting amount of solvent on a substrate; a roller comprising a rigid axle having a pad radially disposed thereon, the pad in contact with the film at a film-roller contact area located a distance from the deposition area; means for causing relative motion between the film and the roller in an operation direction at a film velocity; and a resistance member coupled to the roller, the resistance member configured to apply a rotation-opposing bias to the roller in an amount sufficient to cause the roller to apply a desired amount of shear stress to the film in the film-roller contact area during rotation of the roller.

Abstract: An implantable or injectable scaffold comprising an antigen, a T memory cell inducer, and other optional components is provided for use in enhancing the immune response to the antigen, in particular for subjects who are elderly, immunosenescent and/or immunocompromised, or undergoing cancer therapy. Coronavirus SARS-CoV-2 has caused millions of confirmed cases and hundreds of thousands of deaths. However, there is no effective drug treatment, and vaccine is in great need to control the spread of such highly infectious virus.

Abstract: A system including: a distance sensor system located/oriented/configured to measure a deformation of a geomaterial portion due to compaction of the geomaterial portion; and an electronic processing system configured to: receive signals from the distance sensor system representing the measured deformation, and automatically generate an estimate/measure of a geomaterial layer property of the geomaterial portion based on: the measured deformation; and a pre-defined relationship/model that associates deformation values with geomaterial layer property values (e.g., density values, stiffness values, modulus values, energy values, or layer thicknesses during compaction).

Abstract: A dual screen technique using DEL and 2DCS screens with libraries of synthesized small molecules and synthesized RNA structures (4,096 targets) delivers bona fide ligand-RNA 3D fold target pairs. One of the newly discovered ligands bound a 5?GAG/3?CCC internal loop that is present in pri-miR-27a, the oncogenic precursor of microRNA-27a. The DEL-derived pri-miR-27a ligand is cell-active, potently and selectively inhibits pri-miR-27a processing to reprogram gene expression and halt an otherwise invasive phenotype in triple-negative breast cancer cells.

Abstract: The invention includes systems, compositions, and methods for the making of modular gene editing through reverse transcriptase related processes. Systems and methods that use modified nucleotides and peptides are specifically provided.

Abstract: A computer-implemented method for determining fracture roughness from a core is described. In examples, a drill core is scanned to obtain core images, and natural fractures in the core images are identified using sequential filtering. The identified natural fractures in the core images are digitized and used to obtain a fracture profile comprising a pair of sinusoids corresponding to the top wall and the base wall of the identified natural fractures. A best fitting sinusoid of the fracture profile is determined and used to calculate at least one statistical estimator. The calculated statistical estimator is used to calculate a joint roughness coefficient.

Abstract: Disclosed herein are methods and systems for a training a model for real-time patient diagnosis. A system may include a computer configured to receive audio data and video data of a clinical encounter, the audio data comprising spoken words by an entity and the video data depicting the entity; retrieve clinical data regarding the entity; execute a model using the words of the audio data and the retrieved clinical data regarding the entity as input, the execution causing the model to output a plurality of clinical diagnoses for the entity; concurrently render the corresponding video data and audio data and the plurality of clinical diagnoses via a computing device associated with a user; and store an indication of a selected clinical diagnosis of the plurality of clinical diagnoses responsive to receiving a selection of the clinical diagnosis at the computing device.

Abstract: There is provided a tag device including a first sensor, a second sensor, a pre-processor and a neural network processor. The pre-processor generates first position data of the tag device based on time information sensed by at least one of a third sensor included in each of the one or more anchor devices and the first sensor of the tag device, generates second position data based on first speed data of the tag device sensed by the second sensor and the first position data, and generates an image based on a path of movement of the tag device based on the second position data in an operation period, and the neural network processor classifies the image into one of a plurality of movements by using a trained neural network model.

Abstract: Provided are a drone taxi system based on multi-agent reinforcement learning and a drone taxi operation method using the same. The drone taxi system includes a plurality of drone taxies configured to receive call information including departure point information and destination information from passenger terminals present within a certain range and a control server configured to receive call information of passengers from each drone taxi, select a candidate passenger depending on whether a passenger is present, generate travel route information of each drone taxi from drone state information of the plurality of drone taxies through multi-agent reinforcement learning, and transmit the travel route information to the drone taxi.

Abstract: A method of treating a skin wound in a subject by administering at least one inhibitor of C-C chemokine receptor type-3 (CCR3) and/or at least one inhibitor of a CCR3 ligand, thereby causing increased activity of keratinocytes adjacent the skin wound, wherein epithelialization of the skin wound is promoted, and wherein the increased activity of keratinocytes is at least one of (1) increased proliferation of the keratinocytes and (2) increased migration of the keratinocytes adjacent the skin wound. The skin wound may be a chronic wound or an acute wound for example. The inhibitor may be, for example, an antibody or antibody fragment, a small molecule, or an siRNA able to inhibit expression of CCR3.