Abstract: A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.

Abstract: Disclosed herein are tricyclic compounds, including pyrimido[4?,5?:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3?,2?:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2?,3?:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3?,2?:4,5]furo[3,2-d]pyrimidin-4-amine, and pyrimido[4?,5?:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: A dual-polarized patch antenna includes a first insulating substrate; conductive connections, each of which passes through the first insulating substrate, and which are arranged to form a resonant cavity and two feeding ports; first and second metal layers respectively disposed on two opposite surfaces of the first insulating substrate, the second metal layer being formed with a cross-shaped slot that corresponds in position to the resonant cavity; a second insulating substrate disposed on the second metal layer; and four radiation patch units disposed on the second insulating substrate, and corresponding in position to four regions that are on the second metal layer and that are spaced apart by the cross-shaped slot.

Abstract: Methods are provided for treatment of cancer cells, in a regimen comprising contacting the cancer cells with an inhibitor on NGly1, optionally in combination with a direct proteasome inhibitor.

Abstract: The present invention relates to a method for preparing a mutant strain having high producibility of phytoene and a mutant strain prepared thereby. More particularly, a Deinococcus radiodurans mutant strain, prepared by the method of the present invention, having high producibility of phytoene, does not retain an artificial antibiotic-resistant gene, although constructed by introducing a metabolism engineering method, and has high producibility of phytoene. Thus, the mutant strain prepared according to the method can find useful applications in the mass production of phytoene.

Abstract: The present invention provides a silicon carbide fiber reinforced silicon carbide composite material, which is a composite material of SiC fibers and SiC ceramics with improved toughness and can be produced with high yield by relatively simple steps without complex steps such as a step of oxidation-resistant coating or an advanced interface control step. The silicon carbide composite material comprises a multiphase matrix and silicon carbide fibers disposed in the matrix, the matrix containing a silicon carbide phase and a phase that includes a substance of low reactivity with respect to silicon carbide. It can be obtained by steps suitable for mass production and ensures greatly improved fracture toughness while maintaining the excellent properties of SiC ceramics.

Abstract: Antibody-drug-conjugates (ADC) are provided having a structure of: wherein L is PR3 ligand. The ADC has n drug moieties bound to the Trastuzumab antibody such that the ADC has a drug-to-antibody ratio (DAR) between 2 and 4 and the drug moieties are bound to the Trastuzumab antibody through cysteine (S) or lystine (Lys) residues. The disclosed ADCs are particularly useful in treating breast cancer.

Abstract: Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free DNA from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced. Respective amounts of a clinically-relevant chromosomal region and of background chromosomal region(s) are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether first chromosomal region exhibits a deletion or an amplification associated with cancer.

Abstract: A fluorescent nanocomposite which includes a thallium doped gadolinium chalcogenide having formula TlxGd1-xY, wherein x is 0.01 to 0.1, and Y is selected from the group consisting of S, Se, or Te, and a benzothiazolium salt bound to a surface of the thallium doped gadolinium chalcogenide. A method of detecting antimony ions in a fluid sample whereby the fluid sample is contacted with the fluorescent nanocomposite to form a mixture, and a fluorescence emission profile of the mixture is measured to determine a presence or absence of antimony ions in the fluid sample, wherein a reduction in intensity of a fluorescence emissions peak associated with the fluorescent nanocomposite indicates the presence of antimony ions in the fluid sample.

Abstract: Systems and methods which provide for interactive haptic proxies for hand-graspable virtual reality (VR) objects using reconfigurable artifacts and facilitated through use of a haptic reconfigurable artifact toolkit are described. Embodiments provide a haptic reconfigurable artifact toolkit including a set of reconfigurable artifacts for use in forming reconfigurable artifact-based haptic proxies, a set of haptic hardware components for use with respect to reconfigurable artifact-based haptic proxies, and a haptic reconfigurable artifact software platform configured to facilitate generation of reconfigurable artifact-based haptic proxies using items of the set of reconfigurable artifacts and the set of haptic hardware components. Reconfigurable artifacts may be shaped to form reconfigurable artifact-based haptic proxies covering a wide range of hand-grasp postures.

Abstract: Disclosed herein are compounds of Formula I, wherein A, R1 to R6, and x to z have the meanings given in the description.

Abstract: Composition and use of macro-minerals to lower postprandial glycemic response and reduce body weight are disclosed herein.

Abstract: The wide application of power electronic components in power systems with renewable energy sources has changed the fault characteristics of conventional power systems, resulting in the performance degradation of conventional protections. To solve these problems, a novel principle of pilot protection based on structural similarity and square error criteria is provided. The structural similarity criterion utilizes the difference of fault characteristics between renewable sources and synchronous generators to identify internal faults, and the square error criterion is used to solve abnormal calculation of the conventional similarity based protection. Compared with conventional differential protections, the disclosed protection shows excellent performance in speed and reliability during various faults.

Abstract: An atmosphere-breathing pulsed plasma thruster includes an inlet, a discharge section with an anode in fluid communication with the inlet, and a nozzle in fluid communication with the discharge section. Electrode assemblies extend radially through the discharge section and include a second electrode in the discharge section and an elongate portion extending outwardly. An electrode control mechanism moves the plurality of electrode assemblies between an inner position nearer to the anode and an outer position farther from the anode. At least one igniter extends between the anode and a cathode. An ignition circuit connects the anode and the cathodes to a first source of electric energy, and connects the igniter to a second source of electric energy through a controllable switch. A processor controls the position of the second electrodes, for example, in response to changes in atmospheric pressure.

Abstract: The present invention relates to OLED devices and stacks for OLED devices that include a symmetric emissive-layer architecture. In one embodiment, the present invention relates to an emissive stack having three layers, wherein the top and bottom layers emit light in the same or similar color region while the middle layer emits light in a different color region than the other two layers. In such an embodiment, the three layers are in contact with each other with no other layers in between. The symmetric emissive-layer architecture of the present invention can be used to improve the color stability of OLED devices.

Abstract: Disclosed is a display apparatus comprising a plurality of pixels and a light emitting device on each of the plurality of pixels. The light emitting device includes a first semiconductor layer, an active layer, and a second semiconductor layer that are sequentially stacked on a bottom surface and a sidewall of the light emitting device. The sidewall of the light emitting device includes a first facet and a second facet adjacent to the first facet. A first angle is made between the bottom surface and the first facet. A second angle is made between the bottom surface and the second facet. The first facet and the second facet meet each other to define an edge. The edge extends from the bottom surface toward a top surface of the light emitting device.

Abstract: This disclosure provides systems, methods, and apparatus related to a vapor phase photo-electrochemical cell. In one aspect, a device includes a photovoltaic cell, a cathode disposed on the photovoltaic cell, an ionomer membrane disposed on the cathode, and an anode disposed on the ionomer membrane. The cathode includes a cathode catalyst. The ionomer membrane is in contact with the cathode catalyst. The anode includes an anode catalyst. The anode catalyst is in contact with the ionomer membrane. The anode, the ionomer membrane, and the cathode are transmissive to the solar radiation spectrum.

Abstract: An efficient engine combustion system with multiple combustion modes, includes a valve actuating mechanism, a pre-combustion chamber, and a main combustion chamber. The valve actuating mechanism is a fully variable valve mechanism; an intake valve and an exhaust valve are driven by high-pressure oil; ignition is implemented by means of an ignition apparatus of the pre-combustion chamber; and a spark plug and a single-hole fuel injector are mounted in the pre-combustion chamber, a bottom end of which is provided with a flame jet hole. The continuous variable of valve timing and real-time adjustment of valve lift are realized by the control of a three-position four-way servo valve, driven by the high-pressure oil and monitored by a displacement sensor. The efficient engine combustion system with multiple combustion modes employs different combustion modes under different engine conditions, so as to ensure optimal thermal efficiency under different operating condition regions.

Abstract: Described herein is a novel, highly efficient system to remove erythrocytes and purify leukocytes would raise the quality of UCB and other transplant grafts, thereby significantly improving patient outcomes.

Abstract: A metal/?-MoC1-x load-type single-atomic dispersion catalyst, a synthesis method therefor, and applications thereof. The catalyst uses ?-MoC1-x as carrier, and has metal that has the mass fraction ranging from 1-100% and that is dispersed on carrier ?-MoC1-x in the single atom form. The catalyst provided in the present application can be adapted to a wide alcohol/water proportion in hydrogen production based on aqueous-phase reforming of alcohols, outstanding hydrogen production performance can be obtained at a variety of proportions, and catalysis performance of the catalyst is much higher than that of metal loaded with an oxide carrier. Especially when the metal is Pt, catalysis performance of the catalyst provided in the present application in the hydrogen production based on aqueous-phase reforming of alcohols is much higher than that of a Pt/?-MoC1-x load-type catalyst on the ?-MoC1-x carrier on which Pt is disposed on a layer form in the prior art.