Abstract: A gradiometer includes a at least one magnet attached to a beam. The magnet moves in response to a magnetic force. A sensing element is configured to measure movement or deflection of the beam or magnet. The gradiometer is configured to determine a gradient of a magnetic field acting on the first magnet based on movement of the magnet. The gradiometer can further measure higher order gradients.

Abstract: A display apparatus includes: a modular display panel including a plurality of display modules; and a timing controller. Each of the plurality of display modules includes: a display panel including a pixel array and subpixel circuits; and a driving unit which drives the subpixel circuits such that inorganic light-emitting elements in the pixel array successively emit light in a first order of multiple row lines or in a second order opposite to the first order. The timing controller provides the driving unit of a first display module with first control signals for causing the inorganic light-emitting elements of the first display module to emit light in the first order, and provides the driving unit of a second display module, which is positioned above or below the first display module, with second control signals for causing the inorganic light-emitting elements of the second display module to emit light in the second order.

Abstract: The present invention discloses a method for realizing uniform stimulation for the oil and gas well by low-cost multi-stage fracturing, comprising the following steps: first calculate and predict the inlet widths of the fracture created in the planned hydraulic fracturing; then design the plugging scheme for blocking the fracture inlet after each fracturing treatment; the selected plugging particles are composed of filling particles and skeleton particles, with designed plugging scheme; after complete the design of plugging scheme, perform the fracturing treatment to create hydraulic fracturing in the reservoir; skeleton particles and filling particles are added into the fractures successively according to plan. The present invention provides a multi-stage single-cluster fracturing method, with the advantages of controllable fracture sizes and low cost. The present invention can realize a good uniformity of stimulation for the oil and gas wells.

Abstract: An object is to provide a peptide gelling agent which gels under physiological conditions and which has a relatively short chain length, and a sustained-release gel based on it. Provided is a hydrogelling self-assembling peptide comprising one or two core peptides consisting of an amino acid sequence represented by the following formula: Xaa-Yaa-Zaa-Yaa-Xaa-Yaa-Zaa-Yaa-Xaa, wherein Xaa is independently Ile or Met, Yaa is independently Asp, Glu, Lys, or Arg, and Zaa is independently Ala or Gly, and wherein the full length of the amino acid sequence constituting said self-assembling peptide is 25 amino acids or less.

Abstract: Described herein is a chimeric antigen receptor (CAR) platform with the ability to (a) serve as an ON/OFF switch (with the ability for tenability/titrability), (b) sense multiple antigens and perform logic computations, and/or (c) independently regulate multiple signaling pathways. The compositions provided herein permit the degree of control and discrimination necessary to optimize CAR T cell therapy. Also described herein are cells comprising such compositions and the use of these compositions and/or cells in the treatment of cancer.

Abstract: A feeder cell for culturing natural killer (NK) cells, genetically engineered to express membrane bound interleukin-18 (mbIL-18), membrane bound interleukin-21 (mbIL-21), and/or OX40L. A method of proliferating NK cells, including: obtaining a blood sample containing a population of NK cells; and contacting at least a part of the population of NK cells with a genetically engineered cell, where the genetically engineered cell is genetically engineered to express mbIL-18, mbIL-21, and/or OX40L.

Abstract: The present application relates to nucleic acids encoding polypeptides with ?-etherase activity; polypeptides with ?-etherase activity; vectors comprising said nucleic acids for the production of recombinant ?-etherase; cells, for example microbial cells transformed with nucleic acids encoding ?-etherase activity and vectors, including nucleic acids encoding ?-etherases; a composition comprising ?-etherases suitable for processing lignocellulose and a method that uses ?-etherases or compositions comprising ?-etherases in the processing of lignocellulose and related polysaccharides.

Abstract: A composite material of polyurethane foam having a layer of reduced graphene oxide and polystyrene is described. This composite material may be made by contacting a polyurethane foam with a suspension of reduced graphene oxide, drying, and then irradiating in the presence of styrene vapor. The composite material has a hydrophobic surface that may be exploited for separating a nonpolar phase, such as oil, from an aqueous solution.

Abstract: Compositions and methods for agrobacterium-mediated chloroplast transgene expression are provided.

Abstract: The current disclosure provides methods for detecting and analyzing KRT4 and KRT17 expression in a sample obtained from a test subject. The current disclosure pertains to methods and kits for identifying a mammalian subject with cervical cancer or non-cancerous lesions of the cervix. The current disclosure further provides methods and kits for determining the likelihood of survival or treatment outcome of a subject having cervical cancer by determining the expression level of KRT17 in a sample.

Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength ?1, to generate a second wavelength ?2 of radiation having a higher energy than the first wavelength ?1.

Abstract: Described herein are methods and compositions for genomic editing. Endonucleases for genomic editing involve inducing breaks in double stranded DNA, for which knock-ins are notoriously inefficient for relying on random integration of homologous DNA sequences into the break site by repair proteins. To address these issues, described herein are novel recombinant fusion proteins that actively recruit linear DNA inserts in closer proximity to the genomic cleavage site, increasing integration efficiency of large DNA fragments into the genome. Such improvements to genomic editing technology allow one to use lower linear DNA concentrations without sacrificing efficiency and can be further combined with other features, such as fluorescent protein reporting systems.

Abstract: The present disclosure discloses a high-precision point cloud completion method based on deep learning and a device thereof, which comprises the following steps: introducing dynamic kernel convolution PAConv into a feature extraction module, learning a weight coefficient according to the positional relationship between each point and its neighboring points, and adaptively constructing the convolution kernel in combination with the weight matrix. A spatial attention mechanism is added to a feature fusion module, which facilitates a decoder to better learn the relationship among various features, and thus better represent the feature information. A discriminator module comprises global and local attention discriminator modules, which use multi-layer full connection to classify and determine whether the generated results conform to the real point cloud distribution globally and locally, respectively, so as to optimize the generated results.

Abstract: The present disclosure is directed to devices, systems and methods that include a stage and an actuator configured to transmit a orthogonal force to the stage, wherein the actuator is configured to receive a plurality of orthogonal acceleration signals, wherein the orthogonal acceleration signals comprise an actuator frequency signal and an actuator magnitude signal.

Abstract: A high-speed 4:1 multiplexer according to an embodiment comprises an input circuit unit including a first circuit that receives a first data as an input signal, and outputs a first output data as an output signal, a second circuit that receives a second data as an input signal, and outputs a second output data as an output signal, a third circuit that receives a third data as an input signal, and outputs a third output data as an output signal, and a fourth circuit that receives a fourth data as an input signal, and outputs a fourth output data as an output signal, a first stage for dividing the output data of the input circuit unit by two and receiving as an input signal, and outputting a first intermediate data and a second intermediate data as an output signal and a second stage of receiving the first intermediate data and the second intermediate data as an input signal and outputting a final data as an output signal.

Abstract: Disclosed are a surface-enhanced Raman scattering-based biosensor for diagnosing prostate cancer with high sensitivity and a method of detecting a prostate-cancer-derived target biomarker using the same.

Abstract: A speech recognition model generating device for generating an E2E speech recognition model using calibration correction comprising an acoustic model including a first artificial neural network module using a speech information as input information and using a first text information corresponding to the speech information as output information, a language model comprising a second artificial neural network module using the first text information as input information and outputting a second text information corresponding to the first text information as output information based on the characteristics of the language model, and a E2E speech model generating unit generating a coupling probability distribution based on a first probability distribution information of the acoustic model output by the acoustic model and a second probability distribution information of the language model output by the language model, and generating a E2E speech model based on the coupling probability distribution, wherein the E2E spe

Abstract: Provided herein are magnetofluidic cartridges of use in a wide variety of sample analysis applications, including nucleic acid amplification assays. The magnetofluidic cartridges include sample inlet wells and sample analysis wells. Temperature sensitive materials are used to separate the sample inlet wells and sample analysis wells from one another prior to performing a given sample analysis application. Related magnetofluidic devices, kits, and methods are also provided.

Abstract: The present invention relates to an artificial bladder system having a double space divided by a partition wall and a wireless, non-powered urine fullness sensor using an RFID technology, which provides an artificial bladder system comprising: an outer wall that forms the outer shape of the artificial bladder, is inserted into the body, and has an inner space; a partition wall, wherein both ends are fixed to the inside of the outer wall, the inner space of the outer wall is divided into a double space of a urine reservoir and a working fluid space, and it is deformable according to amounts of the urine and the working fluid; and a urine fullness sensor installed in the working fluid space and sensing a urine fullness degree based on the deformation of the partition wall.

Abstract: The present invention relates to a gel composition containing at least one selected from the group consisting of an extracellular matrix component and a fragmented extracellular matrix component, and an ion of a metal element.