Abstract: An X-ray grating configured for use in an X-ray imaging apparatus is provided. The X-ray grating has a silicone-based base layer. A plurality of silicon-based ridges is on a surface of the silicon-based base layer, wherein the plurality of silicon-based ridges from a plurality of trenches, where a trench of the plurality of trenches is between two silicon-based ridges of the plurality of silicon-based ridges. A plurality of silicon-based bridges extends between adjacent silicon-based ridges, wherein each silicon-based ridge of the plurality of silicon-based ridges is connected to at least one adjacent silicon-based ridge of the plurality of silicon-based ridges by at least one of a silicon-based bridge of the plurality of silicon-based bridges and wherein at least one of a plurality of four adjacent trenches does not have any silicon-based bridges.

Abstract: An impedance spectroscopy biosensor is provided that is fabricated on a stretchable substrate. The stretchable substrate is integrated with an impedance biosensor that undergoes cyclic strain without cracking. The biosensor is formed by curing an elastomer precursor while on a pre-tensioned membrane that includes a conductive electrode. The resulting elastomeric material is released from the support after curing which releases the pre-tensioned state to produce the biosensor.

Abstract: Provided is a method for estimating optimal efficiency point parameters in an axial-flow PAT power generation mode, including: I1, calculating an axial velocity of an optimal efficiency point; I2, calculating a flow rate of the optimal efficiency point; I3, calculating a theoretical hydraulic head; I4, calculating a frictional hydraulic head loss and a local hydraulic head loss of each segment; I5, calculating an output power of the optimal efficiency point; I6, calculating a hydraulic head of the optimal efficiency point in a power generation mode; and I7, calculating an optimal efficiency. Further provided is a method for estimating a performance curve in an axial-flow PAT power generation mode based on the above method for estimating an optimal efficiency point parameter, including: II1, calculating a normalized flow-hydraulic head curve; II2, calculating a normalized hydraulic head-output power curve; and II3, calculating a hydraulic head-efficiency curve.

Abstract: This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 2-amino-N?-benzylidene-acetohydrazide compound or derivative thereof to a subject in need thereof. In certain embodiments, the 2-amino-N?-benzylidene-acetohydrazide compound is ((E)-N?-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(m-tolylamino)acetohydrazide; or (E)-N?-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(p-tolylamino)acetohydrazide.

Abstract: The disclosed invention relates to the novel composition of matter that allows for the controlled release of highly active compounds to be delivered to a desired site. This novel composition utilizes the immune system to allow for the controlled release of desired compounds. The present invention can utilize a plurality of highly active compounds, with one embodiment being the use of chemotherapeutics for the treatment of cancer.

Abstract: A system and methods for authenticating an electronic signature using a biometric fingerprint includes registering a subscriber to the service. The subscriber asks document signers enter their fingerprint(s) by a fingerprint reader. The fingerprint data is applied to a fingerprint matcher which generates a gallery pair table of fingerprint minutiae for each signer. A secret user ID or operation number is generated. A sharing module splits the fingerprint information into N shares and generates a threshold number S. The secret is applied to the sharing module and N shares of the secret are generated. The N shares of fingerprint data are each combined with one share the secret to form N combined shares. The N combined shares are each stored in different cloud storage locations. Retrieval of the secret to authenticate the signers requires S signers to enter their fingerprints and S combined shares to be downloaded from the clouds.

Abstract: The invention provides systems and methods for tissue-mounted electronics and photonics. Devices of some embodiments of the invention implement high performance, and optionally flexible, device components having miniaturized formats in device architectures that minimize adverse physical effects to tissue and/or reduce interfacial stresses when mounted on tissue surfaces. In some embodiments, the invention provides complementary tissue mounting strategies providing for mechanically robust and/or long term integration of the present devices, for example, via mounting on tissue surfaces that are not subject to rapid growth or exfoliation processes such as the fingernail, toenail, tooth or earlobe. Devices of the invention are versatile and support a broad range of applications for sensing, actuating and communication including applications for near field communication, for example, for password authentication, electronic transactions and biometric sensing.

Abstract: The present disclosure relates generally to compounds comprising oligonucleotides complementary to a cystic fibrosis transmembrane conductance regulator (CFTR) RNA transcript. Certain such compounds are useful for hybridizing to a CFTR RNA transcript, including but not limited to a CFTR RNA transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the CFTR transcript. In certain embodiments, such compounds are used to treat one or more symptoms associated with Cystic Fibrosis.

Abstract: An organic light emitting diode includes a support body, an anode electrode, a hole transport layer, an organic light emitting layer and an electron transport layer stacked on each other in that order. The electron transport layer has a first surface and a second surface opposite to the first surface. The electron transport layer includes a polymer and a plurality of first carbon nanotubes dispersed in the polymer, and partial surface of the plurality of first carbon nanotubes is exposed from the first surface and is in direct contact with the organic light emitting layer.

Abstract: A miniature temperature-controlled triaxial tester for testing unsaturated soil suitable for micro-computer tomography (CT) scanning and a method thereby. The triaxial tester includes a device body, where the bottom of the device body is fixed on a base, and the top of the device body is provided with a strain control device. The device body includes a vertically arranged polymethyl methacrylate shell, a PMMA inner cover is nested inside the PMMA shell, and a vacuum gap is formed between the PMMA shell and the PMMA inner cover; a pressure cell is formed by a space defined by the PMMA inner cover, a sample accommodating area for accommodating a test sample is arranged in the pressure cell, a heating element is arranged below the sample accommodating area and connected to a temperature control device, and a temperature sensor is arranged inside the PMMA inner cover and connected to a receiver.

Abstract: The present invention relates to compositions and methods for the treatment of a canine CD20 positive disease or condition using a canine CD20-specific chimeric antigen receptor. One aspect includes a modified canine T cells and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity in canine.

Abstract: An end cap mounting system for a lens of a lighting fixture includes a lens engagement portion having a proximal end, a distal end, an outer surface and an inner surface. The inner surface defines a cavity extending distally into the lens engagement portion from the proximal end for a cavity depth to a cavity end surface. The cavity has an inner wall with a perimeter corresponding to a first asymmetric shape of an outer profile of a lens. A central protrusion extends proximally from the cavity end surface towards the proximal end. The protrusion has an outer wall with a perimeter that corresponds to a second asymmetric shape of an inner profile of the lens. A gasket-receiving recess is positioned proximate to the cavity end surface between the outer wall of the central protrusion and the inner wall of the cavity to receive a gasket.

Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.

Abstract: A transparent electrode with a transparent substrate and a composite layer disposed thereon, wherein the composite layer includes a graphene layer and a plurality of nanoparticles, wherein the nanoparticles are embedded in the graphene layer and extend through a thickness of the graphene layer, and wherein the plurality of nanoparticles are in direct contact with the transparent substrate and a gap is present between the graphene layer and the transparent substrate.

Abstract: Disclosed herein, inter alia, are pyridopyrazines and methods of using the same.

Abstract: An intravascular cutting device described herein uses high-pressure water, saline, or other fluid to cut tissue and other materials including but not limited to calcified tissue, stents, stent grafts, and other devices. In some embodiments, the cutting device includes a working end that has a nozzle with a hole to allow the release of a high-pressure fluid jet. Opposite of the nozzle is a catch plate or deflector anvil that prevents the fluid jet from cutting healthy tissue. The device user will place the item to be cut between the nozzle and catch plate and then advance the device along the item to be cut as the fluid jet is activated, thus cutting the object as it advances.

Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.

Abstract: A substrate integrated waveguide (SIW) for phase shifter for millimeter wave applications has a waveguide with a plurality of curved sections and which passes through the substrate from a wave entry port to a wave exit port. The plurality of curved sections forms a serpentine path of curves in a first direction followed by curves in a second direction which are opposite the first direction. Phase shifting elements are positioned in the waveguide in each of the curved sections. The phase shifting elements may take the form of PIN diodes or a pattern of liquid metal filled vias in the waveguide.

Abstract: A method of producing a graphene film (22) includes forming a catalyst film (20) on a support (18); forming a graphene film (22) on the catalyst film (20); and electrolytically removing the catalyst film (20) from the support (18). The method may include transferring the graphene film (22) to a substrate (29). A supported graphene film includes a conductive support (18); a catalyst film (20) formed on the conductive support (18) having a thickness in a range of 1 nm to 10 ?m, and a graphene film (22) formed on the catalyst film (20).

Abstract: A memory device having an error correction function includes: a memory element including multiple memory cells, a reconfiguration logic unit configured to group input data according to data retention properties of each memory cell in which each of the input data will be stored or group storage data stored in the memory element according to data retention properties of each memory cell in which each of the storage data is stored and arrange each of the input data or each of the storage data grouped by identical retention properties to be adjacent to each other, an error correction encoder configured to apply an error correction encoding algorithm with a different intensity to the grouped input data in each group, and an error correction decoder configured to apply an error correction decoding algorithm corresponding to an intensity applied by the error correction encoder to the grouped storage data in each group.