Abstract: The present invention discloses a roller-type omnidirectional physical exercise platform, mainly including a housing, a plurality of groups of alternately-placed spiral rollers disposed inside the housing, a motor configured to drive the spiral rollers. The spiral rollers include clockwise spiral rollers and counterclockwise spiral rollers. Roller bodies of the clockwise spiral rollers are obliquely embedded with rotatable wheels at particular angles. Two ends of the roller are mounted with gears and bearings providing a support function. The counterclockwise spiral roller is mirror-symmetrical with the clockwise spiral roller. The present invention presents an active omnidirectional physical exercise platform.

Abstract: A sensing device including a transistor, at least one response electrode, and a selective membrane is provided. The transistor includes a gate end, a source end, a drain end, and a semiconductor layer, wherein the source end and the drain end are located on the semiconductor layer, and the gate end is located between the source end and the drain end. The at least one response electrode is disposed opposite to the gate end of the transistor and spaced apart from the transistor. The selective membrane is located on the at least one response electrode or on the transistor.

Abstract: A logic-memory cell includes a spin-orbit torque device having first, second and third terminals configured such that current between the second and third terminals is capable of changing a resistance between the first and second terminals. In the cell, a first transistor is connected between a logic connection line and the first terminal of the spin-orbit torque device and a second transistor is connected between the logic connection line and the third terminal of the spin-orbit torque device.

Abstract: An apparatus of adaptive index structures is provided. Four common data attributes, including time, space, keyword, and value, are used. The present invention is a structure adaptively selecting the most efficient combined index by estimating index performance and selectivity rate. The main concept is to set indexes with high selectivity rates at positions having higher priorities for processing query. The intermediate result of query is minimized and the performance is further improved. The present invention uses multiple indexes, where all possible combined-index orders are considered and the best combined index is selected according to different query adaptabilities. As a result, the structure has a high chance of saving query time at a rate of more than 25 times as compared to a structure with indexes of a single attribute sequence. Furthermore, as compared to the traditional relational database PostGIS, the reaction time is also twice faster.

Abstract: A prosthesis, radiation bolus, pre-surgical model, or burn mask formed using a rapid prototyping device, such as a three-dimensional printer. In some exemplary aspects, the prosthesis includes a scaffolding and a coating at least partially covering the scaffolding. Methods and systems for forming the prosthesis, radiation bolus, pre-surgical model, or burn mask are also provided.

Abstract: Aspects and embodiments of the present invention relate to the treatment of neurological disorders such as for example, Alzheimer's disease and Parkinson's disease. Particularly, certain embodiments relate to GIP/GLP-1 co-agonist peptides for use in the treatment of these two neurological disorders. Also included in the present invention are inter alia pharmaceutical compositions comprising the GIP/GLP-1 co-agonist peptides, together with methods of treating such disorders as well as other subject matter.

Abstract: Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.

Abstract: In some embodiments, a method includes a shaft having a side catheter guide attached thereto via a guide coupler into an inferior vena cava and a superior vena cava such that the guide coupler is disposed in a right atrium, and applying a distal force to a proximal portion of the side catheter guide such that a distal end of the side catheter guide deflects laterally about the guide coupler towards a septum. The method further includes extending a side catheter that is disposed within the side catheter guide distally from the side catheter guide towards and into contact with the septum. The method further includes, with the side catheter in contact with the septum, extending a septum penetrator that is slidably disposed within the side catheter distally from the side catheter such that the septum penetrator pierces the septum.

Abstract: The present invention relates to a method of improving fire retardant properties of a substrate, the method comprising providing the substrate with a graphene-based composite, wherein the graphene-based composite comprises graphene-based material intercalated with inorganic metal hydrate.

Abstract: The present invention discloses an adaptive and rapid repairing device for single roller, which includes a working module and a mechanical arm module, which are fixedly connected, where the mechanical arm module is connected with a movable module; the working module includes a supporting frame, symmetrical dovetail grooves are opened in two sides of the supporting frame, the dovetail grooves are movably connected with four sliding supports symmetrically arranged along the supporting frame; a connecting rod support penetrates the two through holes opened in the top of the sliding support, the top end of the connecting rod support is hinged with a long connecting rod; the supporting frame is provided with a worm gear mounting support, the worm gear mounting support is equipped with worm gears and worms through rotating shafts, and the worm is fixedly connected with an output shaft of a worm motor.

Abstract: A low-temperature high-performance thermoelectric material possesses a chemical formula of (AgyCu2?y)1?xTe1?zSez, wherein ?0.025?x?0.075, 0.6?y?1.4, 0<z?0.25, diffraction peaks of a main phase of the thermoelectric material are indexed as a cubic structure at room temperature of 300 K, a highest ZT value between 300 K and 673 K is in range of 0.4 to 1.6, an average ZT value (ZT)avg is in range of 0.2 to 1.4. The highest ZT value of this material at the room temperature is comparable to that of Bi2Te3, which is an excellent complement to existing low-temperature thermoelectric materials. At the same time, the present invention also indicates a new strategy to improve the low-temperature thermoelectric performance of Cu2X-based (here, X is S, Se, Te) materials, and lays a foundation for the application of Cu2X-based materials in the field of low-temperature thermoelectricity.

Abstract: The invention provides novel deoxybenzoin-containing polymers exhibiting branched (including hyperbranched) architectures, and related methods and uses thereof.

Abstract: Adrenergic receptor modulating compounds and methods of using the same are provided. Also provided are methods of treating a subject for a disease or condition associated with an adrenergic receptor including administering a therapeutically effective amount of the subject compound. Aspects of the disclosure include a method of modulating an inflammatory pathway in a cell, such as the production of TNF-alpha in the cell. The method can include contacting a cell with ?1-selective adrenergic receptor modulating compound to selectively activate a cAMP pathway over a beta-arrestin pathway in the cell. Pharmaceutical compositions and kits which include the subject compounds are provided.

Abstract: The present invention provides a spectral imaging device characterized in that N images are captured with ambient light, and spectra can be obtained from the captured N images for spectral analysis. In particular, a filter device is employed to divide a spectral range of the ambient light into N spectral bands, and each capture corresponds to one spectral band.

Abstract: Small molecules comprised of spiroindolinone analogues are provided. Some spiroindolinones are provided with a particular relative stereochemistry in which the indolone carbonyl and all three hydrogens are on the same face of the central pyrrolidine ring. A stereoselective method of synthesis is provided for making some of the spiroindolinones described above. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, fungal infections. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.

Abstract: Provided herein are drug implants comprising a therapeutically active agent for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and a therapeutically active agent disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may comprise bicalutamide, e.g., for use in the treatment of prostate cancer.

Abstract: A lens-free imaging system for generating an image of a scene includes an electromagnetic (EM) radiation sensor; a mask disposed between the EM radiation sensor and the scene; an image processor that obtains signals from the EM radiation sensor while the EM radiation sensor is exposed to the scene; and estimates the image of the scene based on, at least in part, the signals and a transfer function between the scene and the EM radiation sensor.

Abstract: The present invention includes a method for thermodynamic modeling of asphaltene precipitation comprising: calculating the Gibbs free energy for the transition between asphaltene molecules in solution into an imaginary crystalline asphaltene nanoaggregates or asphaltene nanocrystals; calculating the Gibbs free energy for the transition between asphaltene nanoaggregates or nanocrystals redissolving into colloidal asphaltene nanoaggregates using the computer: and predicting asphaltene solubility in a solvent, wherein the predicted asphaltene solubility is used to add a solvent to a liquid, semi-solid, or solid comprising asphaltenes to prevent, e.g., fouling of a wellbore, pipeline, downstream unit operations, to provide flow assurance for crude oil pipeline network, or for petroleum crude blending.

Abstract: Crosslinking compounds for effective and efficient cross-linking and identification of intermolecular and intramolecular interactions of proteins, peptides and nucleic acids.

Abstract: The presently disclosed subject matter relates to torrefied biomass briquettes and methods for producing the same that make use of a mixture of lightly torrefied material (LTM) and highly torrefied material (HTM) and/or make use of torrefied materials that are subjected to a hydrolysis pretreatment prior to being torrefied.