Abstract: The present disclosure provides an anti-immune-checkpoint nanobody that specifically binds to a programmed cell death ligand 1. The present disclosure also provides the nucleic acid sequence of the anti-immune-checkpoint nanobody, use of the anti-immune-checkpoint nanobody for treating cancer and immune-related disorders, and a method for detecting expression levels of PD-L1.

Abstract: A cell or tissue embedding device having an aqueous gel serving as an immunoisolation layer, the aqueous gel containing, as components thereof, a denatured polyvinyl alcohol resin having an activated carbonyl group and a crosslinking agent is highly capable of supplying a physiologically active substance.

Abstract: The disclosure relates to a method and a system for hand pose recognition, a device and a storage medium are disclosed in embodiments of the disclosure. The method includes: capturing a RGB image of a hand from a RGB camera and capturing a depth image of the hand from an active depth camera, so as to obtain a hand pose data set according to the RGB image and the depth image; processing the hand pose data set to obtain a 3D joint position, and taking the 3D joint position as a data set for training a software model; extracting the RGB image by a feature extractor based on a depth neural network to obtain a feature map of a hand pose; and processing the feature map according to an attention mechanism to obtain a global feature map of the hand pose.

Abstract: The present invention relates to an electrode structure for a secondary battery comprising a potential sheath capable of suppressing a side reaction between an electrode and an electrolyte through electric potential control, and a method for manufacturing the same. The electrode structure for the secondary battery according to the present invention uses the electric potential control so that an unstable SEI layer, which causes decrease in cycle characteristic and capacity of an anode material, occurs only on the surface of a potential sheath without occurring on the surface of the anode active material, thereby being capable of completely solving the problems of the existing nanostructured electrode.

Abstract: Disclosed is a dynamic collision avoidance method for an unmanned surface vessel based on route replanning. The method comprises the following steps: acquiring navigation information and pose information of a neighboring ship of an unmanned vessel itself via a vessel-borne sensor; constructing a collision cone between the unmanned vessel and the neighboring ship; introducing a degree of uncertainty with respect to observing movement information of the neighboring ship and applying a layer of soft constraint to the collision cone; applying a speed and a heading limit range of the unmanned vessel; acquiring an ultimate candidate speed set; introducing a cost function to select an optimum collision avoidance speed; and performing an internal recycle of navigation simulation with the optimum collision avoidance speed to obtain a route replanning point for dynamic collision avoidance of the unmanned vessel.

Abstract: The present invention provides a vector library for yeast two-hybrid screening of a deubiquitinating enzyme that binds to a target protein and a method for identifying a deubiquitinating enzyme binding to a target protein using the same. Also, the present invention provides a method for screening an agent having anti-cancer activity targeting the deubiquitinating enzyme USP1, USP7, USP12, or USP49 identified by said identifying method.

Abstract: The present invention relates to the preparation of a membrane for use in the repair of the middle ear including perforations and damage to the tympanic membrane. More particularly, the invention provides for compositions and methods for preparing silk fibroin biocompatible polyurethane membranes using a solvent, which have improved biodegradation, mechanical and vibroacoustic properties.

Abstract: The disclosure provides a Sn—In electroplating bath that is Pb-free, environmentally safe, operates at room temperature, and does not require changes in existing plating assemblies. Room temperature aging and limited thermal cycling tests show that the electroplated Sn—In alloy film on a Cu substrate effectively mitigates whisker growth.

Abstract: The present invention provides a method of treating depression disease in a treatment resistant patient comprising administering to a mucosal membrane of a patient an effective amount of a pharmaceutically acceptable composition comprising an effective amount of ketamine or dextromethorphan, wherein the mucosal administration of the ketamine or dextromethorphan containing composition allows for the mucosal absorption of the composition eliminating the digestive tract of the patient for effecting a rapid acting antidepressant treatment of the treatment resistant patient. This method includes administering the composition to a patient's mucosal membrane of a respiratory tract, a genitourinary tract, an oral tract, or rectal tract of the patient. A pharmaceutically acceptable composition comprising ketamine or dextromethorphan and a vehicle is disclosed. A biomarker for identifying a depressive disease is set forth.

Abstract: The present invention provides a method for producing a manganese-doped nickel molybdate electrode material including mixing a nickel salt solution with a manganese salt solution to form a mixture; adding a molybdate solution into the mixture and being subject to a thermal reaction; and obtaining the manganese-doped nickel molybdate electrode material after washing and drying of the reaction product. The nickel salt includes one or more of nickel nitrate, nickel chloride, and nickel acetate; the manganese salt includes one or more of manganese chloride, manganese nitrate, and manganese sulfate; and the molybdate includes one or more of sodium molybdate or ammonium molybdate. The present method utilizes a single reaction to produce a Mn-doped NiMoO4 electrode material, which does not require using nickel molybdate as an intermediate product. The method simplifies the preparation process and makes it easy to be adjusted, thereby improving the electrochemical properties of the electrode material.

Abstract: Provided herein is a drug delivery device and composition, such as a particle, comprising conditioned medium. Also provided herein is a method of preparing polymeric particles for release of conditioned medium. Further, a tissue growth scaffold comprising particles for release of conditioned medium is provided.

Abstract: A lung function analysis system includes motion sensing devices each including accelerometers, gyros, battery, processor, and ireless transmitter, the processor configured to read motion data from the accelerometers and gyros and transmit the motion data over the wireless transmitter. The system includes a data collection device receiving the motion data and recording the motion data in a database; and a computing device with a lung function data analysis routine adapted to analyze the motion data to provide information useful in treating pulmonary disease. In embodiments, the lung function analysis routine includes a classifier trained on a database of motion data and diagnoses. In embodiments, the accelerometers and gyros are three-axis and/or the devices include electromyographic sensors. In embodiments, the system includes remote sensors such as a stereo camera with or without markers, millimeter-wave radar, or an ultrasonic echolocation device.

Abstract: A source-network coordination type direct-current (DC) circuit breaker based on pre-charged capacitors for an MMC based DC grid is provided. The MMC based DC grid is provided with four converter stations, each having two converters, which are in loop connection through a double-loop DC overhead line. Two ends of each DC line connecting the converters are separately equipped with DC circuit breakers for isolating a fault of the DC line. An MMC active voltage adjusting control strategy is matched with pre-charged capacitor voltage in the self-adaptive mode to provide a beneficial breaking condition for a quick mechanical switch branch, so that the fault line is effectively cut off.

Abstract: The present application relates to a prefabricated concrete beam-column node and a construction method thereof. The construction method of the prefabricated concrete beam-column node includes: assembling node connectors, and mounting studs on each node connector; welding a circumferential reinforcing plate with a groove hole in the center to a middle-rear section of each node connector; mounting a longitudinal rebar on each circumferential reinforcing plate; pouring a concrete beam between two circumferential reinforcing plates; welding a hidden corbel to a side flange of each of structural columns; hoisting the concrete beam, and overlapping each node connector with the corresponding hidden corbel; welding each node connector to the corresponding structural column; and pouring the concrete beam between the circumferential reinforcing plates and the structural columns.

Abstract: Systems and methods for an enhanced ultrasound biofeedback therapy for an improved speech remediation treatment for an individual include transmitting a plurality of ultrasound (US) waves toward a tongue of the individual; receiving a plurality of reflected US waves; converting the plurality of reflected US waves into a plurality of US signals to transmit to an ultrasound machine; and generating one or more enhanced images of the tongue at least partially based on the US signals in real-time, the enhanced images including identified Regions of Interest (ROIs) along tongue sub-parts comprising the tongue root, the tongue dorsum, and the tongue blade and respective ROI points identified therein. An interactive visual story is generated and updated in real-time with a tongue-mapping trajectory of the individual on a display based on the enhanced one or more images to determine a successful or unsuccessful sound production.

Abstract: The basic idea of this invention is to send one or more cubesats into orbit, each equipped with a hardware security module. Users would send their transaction to the cubesats which would collect them into blocks, sign them, and send (bounce) them back to earth (and to one another). Bounce Blockchain provides scalability through sharding (transactions will be partitioned over cubesats). Because modern hardware security modules are tamper-resistant (become inoperable if tampered with) or tamper-responsive (erase their keys if tampered with), take their keys from physical processes, and have been validated, socio-technical protocols can ensure that it is infeasible to forge the identity of a hardware security module in a cubesat with another cubesat. If, however, some cubesats are destroyed, the blockchain will continue to execute correctly though some transactions will be lost. New cubesats can be sent up in short order as they are quite cheap to launch.

Abstract: Disclosed herein are antisense oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA at the 5?-end of UBE3A-AS, which is downstream of SNORD115-45 snoRNA. Also disclosed are pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: An apparatus includes a rotating pole, a first set of photovoltaic modules; and a second set of photovoltaic modules. The second set of photovoltaic modules do not rotate with the rotating pole.

Abstract: A carbonation-resistant cementitious blend containing cement, an expandable agent present, a dispersion agent, a fluid loss additive, a defoamer, and an olive waste. Concrete samples made therefrom and methods of producing such concrete samples are also specified. The addition of olive waste provides enhanced durability (carbonation resistance) and maintains mechanical strength (e.g. compressive strength, tensile strength) after exposure to CO2 and/or brine. The resulting concretes are suitable cementing material for oil and gas wells as well as wellbores for geologic carbon sequestration.

Abstract: Undercooled liquid metallic core-shell particles, whose core is stable against solidification at ambient conditions, i.e. under near ambient temperature and pressure conditions, are used to join or repair metallic non-particulate components. The undercooled-shell particles in the form of nano-size or micro-size particles comprise an undercooled stable liquid metallic core encapsulated inside an outer shell, which can comprise an oxide or other stabilizer shell typically formed in-situ on the undercooled liquid metallic core. The shell is ruptured to release the liquid phase core material to join or repair a component(s).