Abstract: A method and device that provides an improved way to treat lymphedema. An ultrasonic fluid pump including speakers attached to a flexible material stocking, combined with a controller, which is adapted to control the operation of the speakers to enable the speakers to cause fluid to flow in a predetermined direction.
Type:
Application
Filed:
December 13, 2022
Publication date:
June 15, 2023
Applicant:
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
Abstract: The present invention discloses a positioning and navigation method for automatic inspection of an unmanned aerial vehicle in a water diversion pipeline of a hydropower station, comprising: using a laser radar carried by an unmanned aerial vehicle (UAV) to scan the inside of a water diversion pipeline to obtain point cloud data; determining the central axis of the cylinder model; determining the foot point of the current position coordinate of the UAV in the central axis in a body coordinate system; calculating the actual speed of the UAV in a central axis coordinate system according to the distance change of central axes of two frames; and adjusting the attitude of the UAV according to the actual speed and the desired speed of the UAV. The present invention can adapt to pipeline environments with different bending degrees.
Abstract: The treatment of various sensitive organs with low energy acoustic shockwaves has been proposed. However, the prior art is lacking in guidance as to what constitutes an efficacious minimum dosage or a safe maximum dosage for various target organs and tissues. Through extensive experimentation with cultured cells, live animals, and animal disease models, the inventors of the present disclosure have determined safe and efficacious shockwave energetic dosage ranges for vital and sensitive organs, including the brain, pancreas, kidneys, liver, and spleen, as well as for skin and subcutaneous tissues, peripheral nerves, and skeletal muscles.
Type:
Application
Filed:
September 17, 2022
Publication date:
June 15, 2023
Applicant:
The Regents of the University of California
Inventors:
Tom Lue, Guiting Lin, Ching-Shwun Lin, HongXiu Ning
Abstract: A bonding method is capable of realizing high bonding strength and connection reliability even at a connection part in a high temperature area by means of simple operation low temperature bonding. The method includes a first step wherein, on at least one of the bonded surfaces of two materials to be bonded having a smooth surface, a thin film of noble metal with a volume diffusion coefficient greater than that of the base metal of the material to be bonded is formed using an atomic layer deposition method at a vacuum of 1.0 Pa or higher, a second step wherein a laminate is formed by overlapping the two materials to be bonded so that the bonded surfaces of the two materials are connected through the thin film, and a third step wherein the two materials to be bonded are bonded by holding the laminate at a predetermined temperature.
Type:
Grant
Filed:
April 3, 2020
Date of Patent:
June 13, 2023
Assignees:
WASEDA UNIVERSITY, HARIMA CHEMICALS, INC.
Abstract: Biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with a biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof.
Type:
Grant
Filed:
March 19, 2019
Date of Patent:
June 13, 2023
Assignee:
The George Washington University
Inventors:
Rohan Fernandes, Elizabeth Sweeney, Juliana Cano-Mejia
Abstract: Methods of vulcanization using a high content sulfur polymer, instead of elemental sulfur, have been developed. These high sulfur content polymers are referred to as Chalcogenide Hybrid Inorganic/Organic Polymers (CHIP) materials and have good polymer compatibility in that they are soluble in a number of polymers. Furthermore, CHIP materials may have weaker bonds than the S—S bonds of elemental sulfur and thus provide for a higher crosslinking efficiency vulcanization.
Type:
Grant
Filed:
June 14, 2018
Date of Patent:
June 13, 2023
Assignee:
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Inventors:
Dong-Chul Pyun, Richard S. Glass, Kyle Carothers, Yueyan Zhang
Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
Type:
Grant
Filed:
July 29, 2020
Date of Patent:
June 13, 2023
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Abstract: The present disclosure provides solid compositions comprising a sorbent and an active composition, as well as delivery devices comprising the solid compositions. The disclosure also provides methods of making the solid compositions, as well as methods of utilizing the solid compositions as a pest repellant and as attractant for targets.
Abstract: Provided herein are devices that facilitate the magnetic separation of an analyte from a sample, and methods of use thereof. In particular embodiments, devices and methods are provided for the trans-interfacial magnetic separation (TIMS) of analytes from a sample.
Type:
Grant
Filed:
June 6, 2018
Date of Patent:
June 13, 2023
Assignee:
Northwestern University
Inventors:
David M. Kelso, Abhishek K. Agarwal, Sally M. McFall, Tom Westberg, Matthew Austin Butzler, Jennifer L. Reed
Abstract: Dural repair devices that are configured to effectively and reliably repair the damage of a dural tear due to incidental durotomies are provided, along with methods of use. The devices and methods enhance the ability of a surgeon to repair a patients dura mater, or dura, during surgery of the central nervous system. The dural repair device has a multi-layer structure configured to exert a pressure or tamponade effect to compress a patient's dura to its state prior to the spinal surgery. Thus, the dural repair devices and methods of use may reduce the patients risk morbidity, further surgery, spinal headaches, or other injuries and discomforts.
Abstract: Structures for response shaping in frequency and time domain, include an optical response shaper and/or a modulator device with multiple injection. The device comprises a resonator having an enclosed geometric structure, for example a ring or racetrack structure, at least two injecting optical waveguides approaching the resonator to define at least two coupling regions between the resonator and the injecting waveguides, and may define at least two Free Spectral Range states. One or both of the coupling regions has a coupling coefficient selected for a predetermined frequency or time response, and the coupling coefficient or other device parameters may be variable, in some case in real time to render the response programmably variable.
Abstract: Compositions and methods disclosed concern an isogenic population of in vitro human embryonic stem cells comprising a disease form of the Huntingtin gene (HTT) at the endogenous HTT gene locus in the genome of the cell; wherein the disease form of the HTT gene comprises a polyQ repeat of at least 40 glutamines at the N-terminus of the Huntingtin protein (HTT). The cell lines of the disclosure comprise genetically-defined alterations made in the endogenous HTT gene that recapitulate Huntington's Disease in humans. Furthermore, the cell lines have isogenic controls that share a similar genetic background. Differentiating cell lines committed to a neuronal fate and fully differentiated cell lines are also provided and they also display phenotypic abnormalities associated with the length of the polyQ repeat of the HTT gene. These cell lines are used as screening tools in drug discovery and development to identify substances that fully or partially revert these phenotype abnormalities.
Type:
Grant
Filed:
February 24, 2017
Date of Patent:
June 13, 2023
Assignee:
The Rockefeller University
Inventors:
Ali Brivanlou, Albert Ruzo, Alessia Deglincerti, Tomomi Haremaki, Fred Etoc
Abstract: A fusion chimeric protein is described herein that can assemble a functional carboxysome core, which is able to fix carbon by taking atmospheric carbon dioxide and converting it into useful carbon-containing compounds such as 3-phosphoglycerate (3-PGA).
Type:
Grant
Filed:
October 31, 2019
Date of Patent:
June 13, 2023
Assignee:
Board of Trustees of Michigan State University
Abstract: A ferroelectric device includes a substrate, a first electrode on the substrate, and a hexagonal ferroelectric material on the first electrode. The first electrode comprises a single crystal epitaxial material. By using a single crystal epitaxial material for an electrode to a hexagonal ferroelectric material, a high-quality material interface may be provided between these layers, thereby improving the performance of the ferroelectric device by allowing for a reduced coercive field.
Abstract: An optical connector ferrule, an optical connector, and a composite fiber connecting assembly are provided. The optical connector ferrule includes a stationary ferrule having a first through-hole, a composite fiber, and a connecting ferrule having a second through-hole. The composite fiber includes a first optical fiber and a signal wire, and is placed in the first through-hole in the stationary ferrule. The connecting ferrule includes a conductive path. The stationary ferrule has a second end face abutting a third end face of the connecting ferrule. The first optical fiber has an end connected to an end of the second through-hole. The signal wire and the conductive path are connected to each other.
Type:
Grant
Filed:
August 30, 2019
Date of Patent:
June 13, 2023
Assignees:
KYOCERA Corporation, TOHOKU UNIVERSITY
Inventors:
Daisuke Komada, Hiroki Tachibana, Ko Matsui, Yuanyuan Guo
Abstract: An operation method of a first receiving node in a distributed communication system may comprise: receiving a signal from a transmitting node; extracting a combined signal vector from a reception signal vector corresponding to a vector of the received signal; obtaining a compressed combined signal vector by extracting a preset number T of combined signal elements from among a plurality of combined signal elements constituting the combined signal vector; quantizing the compressed combined signal vector to obtain a quantized combined signal vector; and transmitting the quantized combined signal vector to a second receiving node included in the distributed communication system.
Type:
Grant
Filed:
September 14, 2021
Date of Patent:
June 13, 2023
Assignees:
Electronics and Telecommunications Research Institute, University of Ulsan Foundation for Industry Cooperation
Abstract: The disclosed subject matter provides systems and methods for spatial and spectral modulation of light. An example system for modulating light can include a substrate and a plurality of meta units, coupled to the substrate and configured to spatially and spectrally modulate the light, wherein the plurality of meta units includes a perturbation and forms a perturbed lattice supporting a quasi-bound state in the continuum.
Type:
Grant
Filed:
December 3, 2020
Date of Patent:
June 13, 2023
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Inventors:
Nanfang Yu, Adam Overvig, Stephanie Malek
Abstract: Implementations of the present disclosure relate to apparatuses, systems, and methods for anastomosing vascular systems in medical procedures. A pair of similar or identical coupling devices may be disposed at the ends of two vessels, either natural or synthetic. The coupling devices may be capable of hermaphroditically connecting to one another to provide a simple and secure connection which promotes growth of the vessels between the bio-absorbable coupling devices.
Type:
Grant
Filed:
April 29, 2020
Date of Patent:
June 13, 2023
Assignee:
UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventors:
Jayant P. Agarwal, Bruce K. Gale, Huizhong Li, Himanshu J. Sant
Abstract: The present invention discloses a mouse-human chimeric antibody preferably recognizes the MUC1 glycopeptide epitope RPAPGS(GalNAc)TAPPAHG (SEQ ID NO.: 34) on the surface of cancer cells, and the encoding sequences, wherein the monoclonal antibody having a light chain and a heavy chain. Moreover, the present invention provides humanized light and heavy chains, and the encoding sequences. The results of paired expression show that humanized antibodies also recognize the MUC1 glycopeptide epitope RPAPGS(GalNAc)TAPPAHG (SEQ ID NO.: 34) on the surface of cancer cells, and show the same specificity as the parental antibody.
Type:
Grant
Filed:
January 18, 2017
Date of Patent:
June 13, 2023
Assignees:
NanoCruise Pharmaceutical Ltd., Board of Regents of The University
of Texas System