Abstract: A compressed gas energy storage system to provide isothermal compression/expansion for energy storage includes a housing defining an envelope including an internal volume; a phase change material (PCM) partially filling the internal volume; a dendritic (hierarchical) gas flow path through the PCM; and a piston driven by a drive mechanism and that moves relative to the PCM within the housing.

Abstract: Aspects of the disclosure relate to manufacturing AAV using a stable cell line that expresses the rep gene by engineering tRNA to suppress a mutation introduced to a rep integrated into the genome of the cell line.

Abstract: A PAM-N receiver capable of adaptively adjusting threshold voltages determining a level of a received signal and a method of adaptively adjusting threshold voltages thereof are disclosed. According to the method of the present invention, the result of comparison between reference data levels and the level of data in the received signal are used to adjust the reference data levels, and the threshold voltages of a PAM-N receiver are adaptively calculated from the adjusted reference data levels, thereby reflecting transmission line conditions and Inter-Symbol Interference.

Abstract: Systems, methods, and apparatuses are provided for permeability prediction. The method acquires data associated with one or more geological formations, calculates, using processing circuitry and a trained Hidden Markov model, log-likelihood values to group the data into a plurality of clusters, and trains an artificial neural network for each of the plurality of clusters when the mode of operation is training mode. Further, the method acquires one or more formation properties corresponding to a geological formation, determines using the trained Hidden Markov model, a log-likelihood score associated with the one or more formation properties, identifies a cluster associated with the one or more formation properties as a function of the log-likelihood score, and predicts a permeability based at least in part on the one or more formation properties and a trained artificial neural network associated with the identified cluster when the mode of operation is forecasting mode.

Abstract: The disclosure provides methods of treating coronavirus infections (e.g., COVID-19) by administering hematopoietic stem cells, with or without an immune checkpoint inhibitor (e.g., PD-1 antagonist). The disclosure also provides methods of treating coronavirus infections (e.g., COVID-19) by adoptive cell transfer of polyclonal T cells and coronavirus-specific T cells (e.g., SARS-CoV-2-specific T cells).

Abstract: The present subject matter relates to techniques for simultaneous blood-brain barrier opening and cavitation imaging. The disclosed system can include a transducer and a processor. The transducer can be configured to generate a plurality of focused transmits and simultaneously obtain a plurality of power cavitation images. The processor can be configured to control a parameter of the focused transmits, acquire the power cavitation images between each focused transmit, and generate a cavitation map based on the power cavitation images.

Abstract: Embodiments of the invention include immunogenic compositions that comprise an attenuated recombinant Francisella tularensis subspecies holarctica Live Vaccine Strain (LVS) having a deletion in a polynucleotide encoding CapB (LVS ?capB), wherein the LVS ?capB expresses one or more antigens present on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Embodiments of the invention also include methods of immunizing a susceptible host against a pathogen comprising administering to the host a vaccine that comprises an attenuated recombinant Live Vaccine Strain lacking a polynucleotide encoding CapB (LVS ?capB), wherein the LVS ?capB expresses one or more antigens expressed by a severe acute respiratory syndrome coronavirus 2 (SAR8-CoV-2) polypeptide.

Abstract: Disclosed herein is a meta-muffler for reducing broadband noise. The meta-muffler includes: a flow pipe through which a fluid flows; an outer barrel disposed outside the flow pipe to be spaced apart from the flow pipe; and multiple metastructures arranged in a flow direction of the fluid and each comprising an opening opened parallel to the flow direction of the fluid, a resonance chamber disposed between the flow pipe and the outer barrel and communicating with the flow pipe through the opening, and a neck adjustment member extending from the outer barrel toward the flow pipe to be spaced apart from the opening in the flow direction of the fluid. The meta-muffler can increase transmission loss of noise flowing through the flow pipe through maximization of energy loss of sound waves entering the resonance chamber of the metastructure and can effectively attenuate noise over a wide band ranging from low frequencies to high frequencies.

Abstract: A tube assembly for a living organism includes a tube and a first ferrule. The tube is partially placeable into a living organism. The tube includes a first end, a second end, a through-hole, and a lens. The through-hole extends in a first direction from the second end to the first end. The first ferrule covers an outer periphery of the tube in the first direction. The lens is located in a portion of the through-hole including at least the first end. The tube and the first ferrule contain a ceramic material.

Abstract: Provided are a composition for regulating stem cell function comprising the genus Lactobacillus bacteria-derived extracellular vesicles as an active ingredient, and a method for regulating a stem cell function using the same, wherein the genus Lactobacillus bacterial-derived extracellular vesicles have the effect of greatly improving the proliferation of stem cells, and the extracellular vesicles are naturally secreted from a symbiotic the genus Lactobacillus strain in human tonsillar tissue and are human-friendly and natural substances, and thus can be used in various research fields by promoting the proliferation of aged stem cells with minimal toxicity and side effects.

Abstract: Provided herein are methods and materials that allow targeting and imaging of interactions between probes and targets. In some embodiments, the probes include nanoscale materials with embedded solutions that can be used to measure physical enhancement by materials under X-ray irradiation. In some embodiments, the methods of the present invention include delivering a probe material to a target that can have a delivered donor material. In some embodiments, methods of the present invention include irradiating the target and determining an optical change in the probe characteristic of a physical enhancement.

Abstract: Various embodiments relate to a computing device for attention-based joint training with a noise suppression model for a sound event detection (SED) technology that is robust against a noise environment and a method thereof, and are intended to improve SED performance that is robust against a noise environment by using a joint model in which a noise suppression model and an SED model have been jointed. According to various embodiments, an attention scheme and a weight freezing scheme are added to the joint model.

Abstract: Isatin derivatives, and methods of using isatin and isatin derivatives as photoinitiators, are described.

Abstract: Provided is a system and method for the distributed networked test of electric vehicles based on a cloud platform, comprising a cloud computing platform and a plurality of remote test benches, wherein the remote test benches, being provided at least two, to form a remote distributed networked structure and transmit test data to the cloud computing platform; the cloud computing platform, being in real-time bidirectional data communication with the remote test bench and configured to receive each test data in real-time, perform a data cleaning, a data classing washing, a data fusion and a data mining, extract useful data information from the test data, build corresponding a data model and a mechanism model on the cloud computing platform according to historical data and a mechanism of control object, control for different test benches, and complete a fault diagnosis and an early warning.

Abstract: Disclosed is a processor for performing a speculative execution for an out-of-order execution. The processor may include: a core; and an L1 cache memory, and the core may include a speculative track buffer (STB) storing speculative track information in order to track the speculative instruction when a speculative instruction is recorded in a reorder buffer (ROB), and a load queue (LQ) transmitting a commit doorbell signal or a restore doorbell signal for a first speculative block to which a first speculative instruction belongs to an L1 cache memory based on first speculative track information of the first speculative instruction when a speculative success or a speculative failure of the first speculative instruction included in the speculative instruction is decided, and the L1 cache memory may include a write buffer.

Abstract: A memory device includes a semiconductor substrate and a memory cell at a memory region of the semiconductor substrate. A memory cell includes a memory portion of the semiconductor substrate, a tunneling layer, a storage layer, a first electrode, and a second electrode. The tunneling layer is over the memory portion of the semiconductor substrate. The storage layer is over and in contact with the tunneling layer. The first electrode is over the storage layer. The second electrode is over and in contact with the tunneling layer but is spaced apart from the storage layer.

Abstract: The current disclosure provides for novel therapeutic methods by identifying cancer patient populations that may be treated effectively by immunotherapies. Accordingly, aspects of the disclosure relate to a method of treating cancer in a subject comprising administering to the subject immune checkpoint blockade (ICB) therapy after the subject has been determined to have increased expression of CXCL13 in a biological sample from the subject.

Abstract: This invention relates to an antidepressant/anxiolytic drug comprising a compound represented by the following formula (I) or (II), wherein R1 is a hydrogen atom, a C1-6-alkyl group, a C1-6-alkoxy group, a C2-6-alkenyloxy group, a halogen atom, a C1-6-haloalkyl group, a C1-6-haloalkoxy group, or a substituted or unsubstituted phenyl group; R2 is a hydrogen atom, a C1-6-alkyl group, a C1-6-alkoxy group, a C2-6-alkenyloxy group, a halogen atom, a C1-6-haloalkyl group, a C1-6-haloalkoxy group, or a substituted or unsubstituted phenyl group; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group; or a salt thereof, or a solvate thereof.

Abstract: The present invention relates to novel fused imidazo pyrazole derivatives of formula (I), and formula (II), and methods for preparation thereof, in the presence of a chitosan-Al2O3 nanocomposite film. The invention also relates to pharmaceutical compositions comprising compounds of the invention as active ingredients as well as the use of compounds of the invention for antimicrobial action.

Abstract: Methods for the rapid elimination of carbon monoxide (CO) from CO-bound hemoglobin, myoglobin and cytochrome c oxidase in subjects with CO poisoning are described. The disclosed therapy involves the use of rationally designed, modified, regulator of CO metabolism (RcoM) proteins and pharmaceutical compositions thereof, which scavenge carbon monoxide from poisoned tissue. The recombinant RcoM compositions are infused into blood, where they rapidly sequester carbon monoxide and limit the toxic effects of carbon monoxide on cellular respiration, oxygen transport and oxygen utilization.