Abstract: Devices (dot blot boxes) for use in immunoblotting are described. The dot blot boxes can include a series of hooks, clips or the like on opposite sides of a container for retaining a test strip there between. The dot blot boxes can be sized to retain a plurality of test strips generally parallel to one another such that they do not contact one another and do not contact the base of the container. A container can hold a fluid, e.g., a blocking buffer solution or antibody solution, and the test strips can be submerged in the fluid while retained in the container.

Abstract: Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol.

Abstract: Among the various aspects of the present disclosure is the provision of a method of detection, treatment, and monitoring of cardiovascular disease or a foot wound by detection of a novel biomarker, Fatty Acid Synthase (FAS). Briefly, therefore, the present disclosure is directed to methods that allow for improved, noninvasive, and reliable diagnosis of these conditions, particularly in subjects suffering from Type 2 Diabetes (T2D).

Abstract: Compositions and methods for modifying the production levels of alkaloids in plants are provided. Alkaloid production can be genetically controlled by modulating the transcriptional activation of PMT genes mediated by members of the ERF family and/or Myc family of transcription factors. Novel nucleotide sequences encoding the Myc family of transcription factors are also provided.

Abstract: A test apparatus used for simulating debonding between a carbon fiber reinforced polymer (CFRP) and concrete in a CFRP-strengthened structure consists of a primary structural block, a secondary structural block, an adjustable hanger, a receiving slot, an attachment mechanism, a pull-off disk, a connecting plate having a plurality of rods. The adjustable hanger and the secondary structural block are slidably positioned into the receiving slot that traverses into a structural body of the primary structural block. The adjustable hanger is mainly used during double-shearing tests and mixed-mode tests, wherein both shearing and peeling is analyzed in mixed-mode tests. The secondary structural block is used in double-shear tests, mixed-mode tests, single-shear tests, tension pull-off tests, and beam-bend tests. The attachment mechanism, which holds the primary structural block, the secondary structural block, and the adjustable hanger together, is also used during single-shear tests and beam-bend tests.

Abstract: The disclosure provides for provides for water-soluble near-infra red (NIR) emissive compounds, processes of making the compounds thereof, and use of the compounds therein.

Abstract: Examples of receivers and receiver techniques are described herein. An example system may include a carrier source that may provide a wireless carrier signal and a wireless communication device, separate from the carrier source. The wireless communication device may provide a wireless communication signal containing data. A receiver may include an antenna positioned to receive the wireless carrier signal and the wireless communication signal, a two-port mixer coupled to the antenna and configured to mix the wireless carrier signal and the wireless communication signal to provide an intermediate frequency signal, and a demodulator configured to extract, at least in part, the data from the intermediate frequency signal.

Abstract: A method of magnetic resonance imaging acquires undersampled MRI data and generates by an adversarially trained generative neural network MRI data having higher quality without using any fully-sampled data as a ground truth. The generative neural network is adversarially trained using a discriminative neural network that distinguishes between undersampled MRI training data and candidate undersampled MRI training data produced by applying an MRI measurement function containing an undersampling mask to generated MRI training data produced by the generative neural network from the undersampled MRI training data.

Abstract: Single-shot, adaptive metrology of rotationally variant optical surfaces, such as toroids, off-axis conies and freeform surfaces. An adaptive interferometric null test uses a high definition liquid crystal phase-only spatial light modulator (SLM) as the reconfigurable null element, on which a simulated nulling phase function is encoded, based on the specifications of the surface under test to generate a null interferogram. The power component of the surface sag is nulled by system design, not the SLM, enabling the SLM to fully compensate the residual departure without the need to tilt the optic or use a custom Offner-null. By wrapping the phase function at multiples of 2*pi radian, the upper limit in sag of the optic under test is theoretically removed.

Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.

Abstract: A hyper-precise positioning and communications (HPPC) system and network are provided. The HPPC system is a next-generation positioning technology that promises a low-cost, high-performance solution to the need for more sophisticated positioning technologies in increasingly cluttered environments. The HPPC system is a joint positioning-communications radio technology that simultaneously performs relative positioning and secure communications. Both of these tasks are performed with a single, co-use waveform, which efficiently utilizes limited resources and supports higher user densities. Aspects of this disclosure include an HPPC system for a network which includes an arbitrary number of network nodes (e.g., radio frequency (RF) devices communicating over a joint positions-communications waveform). As such, networking protocols and design of data link and physical layers are described herein.

Abstract: Methods of inducing bradycardia (slowing a heart rate) in a subject in need thereof, treating a medical condition in which inducing bradycardia (slowing a heart rate) is desirable or beneficial in a subject in need thereof and/or treating a medical condition associated with cardiac arrhythmia, are provided. The methods are effected by blocking SK4 channel in SAN cell of the subject and/or by administering to the subject a therapeutically effective amount of a blocker of an SK4 channel. A method of identifying candidate compounds for treating an arrhythmic cardiac disorder, by identifying compounds that reduce a pacing rate of the SAN cells is also provided.

Abstract: To solve the technical problem of the incapacity to perform a quantitative matching design of residual compressive stress in the process of prior structural cold working-residual compressive stress design, the invention provides a method of structural cold working-residual compressive stress distribution quantitative matching design, characterized by treating the fatigue strength of a mechanical structure and parts as a field, and matching a structural stress field and a fatigue strength field organically, to quantitatively match the residual compressive stress in conjunction with characteristics of the cold working process.

Abstract: Disclosed are compositions and methods relating to prostate cancer. In particular, disclosed are bivalent targeting ligands that specifically bind prostate specific membrane antigen and gastrin-releasing peptide receptor. Bivalent binding agents disclosed herein can be used to image a tissue in a subject in need thereof and to diagnose prostate cancer in a subject in need thereof. Bivalent binding agents disclosed herein can be used to treat prostate cancer in a subject in need thereof.

Abstract: The present invention relates to broadly neutralizing anti-influenza monoclonal antibodies or antigen-binding fragments thereof. The present invention further relates to therapeutic uses of the isolated antibody or the antigen-binding fragment thereof.

Abstract: In response to a detected presence of an intended target appliance within a logical topography of controllable appliances identity information associated with the intended target appliance is used to automatically add to a graphical user interface of a controlling device an icon representative of the intended target appliance and to create at a Universal Control Engine a listing of communication methods for use in controlling corresponding functional operations of the intended target appliance. When the icon is later activated, the controlling device is placed into an operating state appropriate for controlling functional operations of the intended target appliance while the Universal Control Engine uses at least one of the communication methods to transmit at least one command to place the intended target appliance into a predetermined operating state.

Abstract: A method for real-time assessment of image information employing a computer that includes one or more processors includes obtaining, via a scanner, a magnetic resonance (MR) image of a region-of-interest, and providing data corresponding to at least a portion of the MR image to a deep learning model, where the deep learning model is previously trained based on one or more sets of training data. The method further includes assessing the data using the deep learning model and data obtained from an image quality database to obtain an assessed image quality value, and formulating an image quality classification in response to the assessed image quality value. The method additionally includes outputting the image quality classification within a predetermined time period from an initial scan of the region-of-interest.

Abstract: A C—C chemokine receptor 3 (CCR3) peptide analog that exhibits biased antagonism by binding to and inhibiting ligand-mediated signaling and chemotaxis while promoting the internalization and degradation of CCR3 is provided as is a method of using the peptide analog to treat, prevent, or ameliorate one or more symptoms of an eosinophil- or CCR3-mediated disease or condition.

Abstract: A deposition nozzle is provided that includes offset deposition apertures disposed between exhaust apertures on either side of the deposition apertures. The provided nozzle arrangements allow for deposition of material with a deposition profile suitable for use in devices such as OLEDs.

Abstract: A thin-film thermocouple probe includes a columnar substrate, a tungsten-26% rhenium film and an indium oxide (In2O3) film. A side surface of the columnar substrate is provided with a first straight groove and a second straight groove. The tungsten-26% rhenium film is arranged on a front end surface of the columnar substrate and in the first straight groove. The indium oxide film is arranged on the front end surface of the columnar substrate and in the second straight groove. The indium oxide film on the front end surface of the columnar substrate is connected to the tungsten-26% rhenium film on the front end surface of the columnar substrate. A first metal lead wire is connected to the tungsten-26% rhenium film, and a second metal lead wire is connected to the indium oxide film. A method of preparing the thin-film thermocouple probe is provided.