Abstract: A bullhead-shaped grooved diversion jet and empennage swing vibration suppression device and method. The device consists of an impeller diversion module and a drainage rotary cover module. The impeller diversion module consists of a center impeller, sleeve bearings, small impellers, and small impeller rotating shafts. The drainage rotary cover module consists of a drainage front cover, a perforated jet rear cover, and empennages. The device is mounted on an outer wall of a riser in a sleeving manner. Under a combined action of drainage and space allocation of horizontal rectangular grooves, flow rate distribution of the center impeller, flow direction adjustment of the small impellers, diversion of lateral diversion holes, jet flows of side rear reducing holes, flowing space division and wake vortex turbulence of rotary swinging empennages, around-flow boundary layers at two sides and a tail of the riser are deeply damaged, which suppresses the formation of large vortexes.

Abstract: Aspects of the present disclosure involve systems, methods, and the like, for a fabrication of a particulate matter (PM) sensor that utilizes a capacitance sensor to detect sub-micrometer and nanoparticles in the respirable range of an environment. In one implementation, the capacitance sensor may comprise interdigitated electrodes between which a capacitance may be measured. PM deposited on the sensor may cause the capacitance between the electrodes to be altered and such a change in capacitance may be measured by the PM sensor. This measurement of the change in capacitance of the interdigitated capacitance sensor may therefore be correlated to the presence of sub-micrometer and nanoparticles in an environment. In one particular implementation, the PM sensor may further include a micro-heater circuit, a readout circuit, and an interface connecting the readout circuit to the micro-heater/capacitance sensor of the PM sensor.

Abstract: Methods of forming graphene may include reacting a dispersed mixture, comprising fly ash, a charged heteroaromatic compound, particularly a pyridinium compound, such as a 1-(4-pyridyl)-pyridinium salt, and a solvent, particularly an alcohol, such as ethanol, with a polymeric oxidizing agent, preferably polymer-supported pyridinium chlorochromate, to form a second mixture; and contacting the second mixture at a temperature of 120 to 180° C. with a gas stream comprising at least 0.1 vol. % CH4 and at least 10 vol. % H2 to form graphene on the fly ash. Methods of managing waste may comprise using fly ash waste to produce graphene. Devices for implementing such methods may involve steel cylindrical reaction vessels including a cover through which a valve-stoppable pipe is fed, which reaction vessel is at least partially surrounded by a heating device, and suitable for handling solvent and fly ash, as well as for receiving gas inflow through the pipe.

Abstract: The present invention is directed to optimized HIV-1 gp41-Binding Molecules having reduced immunogenicity. More specifically, the invention relates to optimized gp41-Binding Molecules that comprise a gp41-binding Variable Light Chain (VL) Domain and/or a gp41-binding Variable Heavy Chain (VH) Domain that has/have been optimized to reduce the immunogenicity of such Domain(s) upon administration to a recipient subject. The invention particularly pertains to gp41-Binding Molecules that are multispecific gp41-Binding Molecules (including bispecific diabodies (including DART® diabodies), BiTE®s, bispecific antibodies, trivalent binding molecules (including TRIDENT™ molecules), etc.) that comprise: (i) such optimized gp41-binding Variable Domain(s) and (ii) a domain capable of binding to an epitope of a molecule present on the surface of an effector cell.

Abstract: Described are methods for preventing or inhibiting genomic instability and in cells affected by diagnostic radiology procedures employing ionizing radiation. Embodiments include methods of preventing or inhibiting genomic instability and in cells affected by computed tomography (CT) radiation. Subjects receiving ionizing radiation may be those persons suspected of having cancer, or cancer patients having received or currently receiving cancer therapy, and or those patients having received previous ionizing radiation, including those who are approaching or have exceeded the recommended total radiation dose for a person.

Abstract: A complex pressure environment test device, comprising a test table and a hydraulic control system. The test table comprises a base for fastening a closure head under test, and an outer cover; the base has water inlets and outlets. The hydraulic control system comprises a watering hydraulic pump, a pressurizing hydraulic pump, and a pilot-operated overflow valve; the watering hydraulic pump is separately connected to a first two-position two-way valve and a second two-position two-way valve; the second two-position two-way valve is connected to a second one-way valve; the second one-way valve is separately connected to a water inlet and a first pilot-operated pressure regulating valve; the first pilot-operated pressure regulating valve is separately connected to a first remote pressure regulating valve and a first one-way valve. There is also a hydraulic circuit is present and used for testing.

Abstract: The present invention provides a method for reconstructing a 3D object based on dynamic graph network, first, obtaining a plurality of feature vectors from 2D image I of an object; then, preparing input data: predefining an initial ellipsoid mesh, obtaining a feature input X by filling initial features and creating a relationship matrix A corresponding to the feature input X; then, inputting the feature input X and corresponding relationship matrix A to a dynamic graph network for integrating and deducing of each vertex's feature, thus new relationship matrix is obtained and used for the later graph convoluting, which improves the initial graph information and makes the initial graph information adapted to the mesh relation of the corresponding object, therefore the accuracy and the effect of 3D object reconstruction have been improved; last, regressing the position, thus the 3D structure of the object is deduced, and the 3D object reconstruction is completed.

Abstract: Described herein are methods and systems for using an alkaloid, such as manzamine A, for anti-proliferative effects at relatively low and non-cytotoxic concentrations (up to 4 ?M) wherein manzamine A blocks cell cycle progression in cervical cancer cell lines and regulates cell cycle-related genes, including restoration of p21 and p53 expression inducing apoptosis.

Abstract: A method of joining a high entropy alloy is provided. The method of joining a high entropy alloy includes the steps of: arranging specimens made of a high entropy alloy to be in contact with each other; and diffusion joining the specimens made of the high entropy alloy by simultaneously applying a compressive stress and a current to a joint of the specimens within a range in which the high entropy alloy does not melt.

Abstract: An isolated expression enhancer active in a plant, portion of a plant or plant cell, the expression enhancer is provided. The isolated expression enhancer may be selected from the group consisting of nbMT78 (SEQ ID NO:1); nbATL75 (SEQ ID NO:2); nbDJ46 (SEQ ID NO:3); nbCHP79 (SEQ ID NO:4); nbEN42 (SEQ ID NO:5); atHSP69 (SEQ ID NO:6); atGRP62 (SEQ ID NO:7); atPK65 (SEQ ID NO:8); atRP46 (SEQ ID NO:9); nb30S72 (SEQ ID NO:10); nbGT61 (SEQ ID NO:11); nbPV55 (SEQ ID NO:12); nbPPI43 (SEQ ID NO:13); nbPM64 (SEQ ID NO:14); and nbH2A86 (SEQ ID NO:15). Methods for using the isolated expression enhancer are also provided.

Abstract: Disclosed are compounds of formula (I) and formula (II): wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.

Abstract: The present invention relates to a thin film composite membrane and a manufacturing method therefor. The thin film composite membrane according to the present invention has superior water flux and excellent salt (NaCl) rejection and/or boron rejection.

Abstract: An apparatus has a device representing an endoscope, the device being either an endoscope or a dummy endoscope having shape and feel resembling an endoscope, and includes a tracker adapted to operate with a three-dimensional tracking system to track location and orientation of the device in three dimensions in a simulated operating-room environment. The apparatus also has a physical head model comprising hard and soft components, the device representing an endoscope configured to be inserted into the physical head model to provide a haptic feedback of endoscopic surgery.

Abstract: The invention relates to IL-21, to antibodies and related fragments thereof for binding to IL-21, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, in particular inflammation, infection and oncology.

Abstract: Diagnostic methods for identifying cancer bearing subjects appropriate for treatment with CPX-351 include genetic and ex vivo testing of cells from a candidate subject. Combination treatment with CPX-351 and FLT-3 inhibitors improve CPX-351 uptake and toxicity.

Abstract: Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and imaged continuously. In a number of embodiments, the microfluidic channel establishes flow that enables individual cells to each be imaged at multiple angles in a short amount of time. A pattern recognition system can analyze the data captured from high-speed images of cells flowing through this system and classify target cells. In this way, the automated platform creates new possibilities for a wide range of research and clinical applications such as (but not limited to) point of care services.

Abstract: Methods and formulations for promoting the healing of fracture nonunion sites under inflammatory conditions. The formulation includes a flexible biodegradable scaffold loaded with therapeutically effective amounts of CXCL12 and SPPI encapsulated in biodegradable microspheres. The method includes applying the formulation directly to a region of a fracture nonunion to effect sustained local release of the therapeutically effective amounts of CXCL12 and SPPI to the fracture nonunion region.

Abstract: A rotationally shift invariant and multi-layered array system for full-field of view and/or photon collection by 4pi steradian field of view. In the system, all of the incoming light (i.e., light from all directions), in a solid angle of 4pi steradians, is focused inside the optics. The optics have a spherically shift invariant structure, providing rotational shift invariance. The system comprises a nontraditional use of the Gabor Superlen and is a configuration of multiple microlens array shell structures with concentrically arranged bulk optical components. Examples of such bulk optical components include Luneburg lenses, micro-structured surfaces, a single lens, a plurality of single lenses, ball lenses, metalenses, diffractive optical elements, and magnetic lenses. In an embodiment, the Gabor Superlens (i.e., microlens array) is planar. In an embodiment, no moving parts are required for the system to achieve truly full-field of view imaging and/or photon collection by 4pi steradian field of view.

Abstract: Provided herein are methods of preparing a template nucleic acid for next-generation sequencing. The methods comprise performing primer extension using c7dGTP instead of dGTP, which then allows for the input nucleic acids to be selectively digested by c7dGTP-resistant restriction enzymes, thereby enriching the template nucleic acid prior to next-generation sequencing library preparation.

Abstract: The present disclosure includes a time-to-digital converter (TDC) based RF-to-digital (RDC) data converter for time domain signal processing polar receivers. Polar data conversion achieves better SNR tolerance owing to its phase convergence near the origin in a polar coordinate. The proposed RDC consists of a TDC for phase detection and an analog-to-digital converter (ADC) for amplitude conversion. Unlike the conversional data converter, the proposed ADC's sampling position is guided by the detected phase result from the TDC's output. This TDC assisted data-converter architecture reduces the number of bits required for the ADC. In addition, oversampling is no longer needed. With precisely controlled tunable delay cells and gain compensator, this hybrid data convertor is capable to directly convert Quadrature Amplitude Modulation (QAM) waveforms and Amplitude Phase Shift Keying (APSK) waveforms directly from the RF signal without down-conversion.