Abstract: An apparatus method for driving light emitting diodes (LEDs), comprising: receiving an alternating current input; producing a DC current having a voltage with an AC-DC boost power-factor correction stage, having a variable-frequency operation, and a set of switches controlled in dependence on the voltage to limit a peak LED current; and producing an LED drive current with a DC-DC power conversion stage having a set of switches to selectively pulse-width modulate the LEDs to control a brightness, wherein the set of switches in the AC-DC boost power-factor correction stage and the set of switches in the DC-DC power conversion stage are each controlled to switch at zero current.

Abstract: The disclosure provides a short-process separation system for separating ionic liquid from alkylation reaction effluent, comprising an alkylation reactor, an ionic liquid storage tank, a primary coalescence separator, a secondary coalescence separator, a flash tank, a low-temperature fine coalescence separator and a fractionating tower that are linked in order. The inlet of the ionic liquid storage tank communicates with the bottom flow ports of the primary coalescence separator, the secondary coalescence separator and the low-temperature fine coalescence separator through delivery lines, and the outlet of the ionic liquid storage tank communicates with the return port of the alkylation reactor through a delivery pump. The alkylated oil collected from this system has a high degree of cleanliness, and can be used directly as a component for formulating clean gasoline. The ionic liquid catalyst collected therefrom may be directly returned to the alkylation reactor for cycle use.

Abstract: A p53 degradation inducing molecule which can induce degradation of p53 proteins or p53 composites, and a pharmaceutical composition containing said p53 degradation inducing molecule are provided. This p53 degradation inducing molecule is a conjugate of a p53 affinity molecule which has affinity for p53 proteins or p53 composites, and a proteolysis induction tag which has affinity for protease and which does not inhibit proteolysis of proteins by protease.

Abstract: The cis-isomer and trans-isomers of the plant-derived compound gnetin H are shown have anticancer properties, anti-inflammatory properties, and low toxicity. Therapeutic and prophylactic compositions that contain cis-gnetin H, trans-gnetin H, and derivatives thereof, as well as methods of making and using said compositions, are provided. cis-gnetin H and/or trans-gnetin H can be used in purified form or as a plant extract.

Abstract: Disclosed herein are unique single stranded DNA oligonucleotide products identified as binding with high affinity and specificity to ovarian tumor cells that may be used in the delivery of therapy to and diagnosis of ovarian cancer.

Abstract: A method of making a thin film transistor, the method includes: providing a semiconductor layer; arranging a first photoresist layer, a nanowire structure, a second photoresist layer on the semiconductor layer, wherein the nanowire structure includes a single nanowire; forming one opening in the first photoresist layer and the second photoresist layer to form an exposed surface, wherein a part of the nanowire is exposed and suspended in the opening; depositing a conductive film layer on the exposed surface using the nanowire structure as a mask, wherein the conductive film layer defines a nano-scaled channel, and the conductive film layer is divided into two regions, one region is used as a source electrode, and the other region is used as a drain electrode; forming an insulating layer on the semiconductor layer to cover the source electrode and the drain electrode, and locating a gate electrode on the insulating layer.

Abstract: The present disclosure provides methods and kits for treating pain. More particularly, the present disclosure relates to methods of using PD-L1/PD-1-associated compounds to treat pain and/or bone destruction from bone cancer, and associated kits. The present disclosure also provides methods to assess the efficacy of compounds to suppress PD-1-associated nociceptive neuron activity.

Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Abstract: A method of diagnosing the occurrence or non-occurrence of a blood vessel blockage or hemorrhage comprises non-invasively applying ultrasound to a location on a patient's body, where the ultrasound is applied in an alternating and pulsed fashion, administering acoustic amplifiers to the patient, monitoring a feedback acoustic response signal of the acoustic amplifiers triggered by the ultrasound, and determining a diagnosis based at least in part on a relationship between an acoustic response signature of the acoustic response signal and a baseline acoustic response signature.

Abstract: The disclosure provides for single chain variable fragments to oxidized phospholipid epitopes and methods of use thereof, including the production of transgenic animal models and the use of the fragments as therapeutic agents for treating CAS.

Abstract: Systems, methods, and apparatus for meta-materials which are stretchable and tunable using an array of liquid conductor meta-atoms encased in one or more layers of elastomer. Fabrication techniques allow effective manufacture of the metamaterial in a number of form factors for a number of applications, including but not limited to fabrics or wraps around three-dimensional shapes.

Abstract: The present invention discloses a method for analyzing coalbed methane geological selection of a multi-coalbed high ground stress region, including the following steps: defining the concepts of a favorable area, a sweet spot area, and a sweet spot section; carrying out the selection process on the favorable area, the sweet spot area and the sweet spot section in sequence; selecting different indicators for the characteristics of each stage, explicitly presenting key indicators and reference indicators at each stage, and providing an indicator with one-vote veto rights in the key indicators; and carrying out comprehensive analysis to obtain favorable planar areas and vertical intervals of coalbed methane exploration and development in the multi-coalbed high ground stress region. The method of the present invention provides instructions on coalbed methane geological selection of a multi-coalbed high ground stress region, and is of great significance for the development of coalbed methane.

Abstract: The present invention provides halogenated quinoline derivatives, such as compounds of Formula (I) or (I?), and pharmaceutically acceptable salts thereof, and methods of preparing the halogenated quinoline derivatives. The halogenated quinoline derivatives are expected to be antimicrobial agents and may act through an iron(II)-dependent mode of action. The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the halogenated quinoline derivatives and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium), killing a microorganism (e.g., a bacterium), inhibiting the formation and/or growth of a biofilm, reducing or removing a biofilm, and/or disinfecting a surface.

Abstract: A reservoir for containing a fluid includes a cylindrical wall sized to engage a shaft bored into ground, a bottom end cap fixed to a lower end of the cylindrical wall and a top end cap fixed to an upper end of the cylindrical wall. The top end cap is concave such that the top end cap extends below a top end of the cylindrical wall. The bottom end cap, the top end cap, and the cylindrical wall define a subterranean chamber. A plug made of a composite material is on the top end cap, with a lower face disposed on the concave top end cap and a peripheral face engaging the shaft. At least one pressure port extends downwardly into the shaft and through the plug and the top end cap, defining a fluid path to the subterranean chamber.

Abstract: Certain embodiments include a cubic boron nitride (c-BN) device. The c-BN device includes a n/n+ Schottky diode and a n/p/n+ bipolar structure. The n/n+ Schottky diode and the /p/n+ bipolar structure are on a single-crystal diamond platform.

Abstract: A system for measuring a cathode current includes a conducting bar and a current measuring device. The conducting bar has a rectangular plate-like structure, and a first end of the conducting bar is vertically cut to form a plurality of long teeth. The plurality of long teeth are equally spaced at the first end of the conducting bar. The number of the plurality of long teeth is equal to the number of cathodes. The upper surface of each of the long teeth may include a raised conductive contact. Each of the conductive contacts is connected with one cathode of an upstream slot. A second end of the conducting bar is connected with a downstream slot, and the second end of the conducting bar is one end opposite to the first end. The current measuring device is disposed on the conducting bar and used for measuring the current of each cathode.

Abstract: A portable laparoscope is disclosed. In implementations, the portable laparoscope includes a housing and an elongated tube coupled to the housing. A lighting source and a camera are disposed proximate to an end of the elongated tube opposite the housing. The camera is configured to capture an image in a viewing area that is illuminated by light provided by the lighting source. The portable laparoscope includes an image display apparatus configured to display the images acquired by the camera and/or to transmit the images to a remote display device. The housing may be configured to hold and position an insufflator.

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

Abstract: Provided are an engineering plastic composite and a method for producing the same. The engineering plastic composite includes a carbon fiber having a surface modified by a hydrogen plasma and including a functional group and an engineering plastic. The carbon fiber is mixed with the engineering plastic to constitute a composite.

Abstract: Structures and methods of using a microwave pasteurization device, as well as related non-linear waveguides. In some embodiments, an in-shell egg pasteurization device with a non-linear slotted waveguide. In some embodiments the non-linear slotted waveguide comprises shaped waveguide applicators. The shaped waveguide applicators may employ oval, lens, or plum shaped non-linear slots to improve efficiency and efficacy of pasteurizing in-shell eggs, live oysters, tomatoes, or blueberries while maintianly the quality and functional attributes of the raw product.