Abstract: The present disclosure is concerned with benzo annulene compounds that are capable of inhibiting a Mer tyrosine kinase and/or a Tyro3 tyrosine kinase and methods of treating a bacterial infection, a viral infection, and/or a disorder of uncontrolled cellular proliferation such as, for example, a cancer, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Type:
Grant
Filed:
November 17, 2017
Date of Patent:
May 11, 2021
Assignee:
The University of North Carolina at Chapel Hill
Inventors:
Xiaodong Wang, Hongchao Zheng, Jichen Zhao, Weihe Zhang, Stephen V. Frye
Abstract: Provided herein are in silico methods of modeling hepatic inflammation, fibrosis/cirrhosis, and cancer. The models are computer-implemented agent-based models and are useful in determining patient prognoses in hepatic conditions, including viral infections, damage, inflammation, and cancer. The modeling system also is useful in modeling the effects of active agents on normal hepatic tissue or hepatic tissue perturbed by inflammation, infection, damage, fibrosis/cirrhosis, and cancer.
Type:
Grant
Filed:
July 29, 2016
Date of Patent:
May 11, 2021
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Abstract: Provided herein are immunogenic compositions containing recombinant proteins capable of presenting all, or antigenic portions of, the Eimeria maxima, Eimeria tenella, and Eimeria acervulina IMP1 protein in developing active immunity to, and control of, coccidiosis. Also provided are methodologies of using the immunogenic compositions for administration to poultry and other animals in the control of coccidiosis. Nanoparticle-conjugated rIMP1 immunogenic compositions and methods of making and using them are provided.
Type:
Grant
Filed:
January 11, 2019
Date of Patent:
May 11, 2021
Assignees:
The United States of America, as represented by The Secretary of Agriculture, Board of Trustees of Souther Illinois University
Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.
Type:
Grant
Filed:
July 24, 2020
Date of Patent:
May 11, 2021
Assignees:
Thomas Jefferson University, RTM Vital Signs LLC
Inventors:
Jeffrey I Joseph, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
Abstract: Provided herein are artificial lung organoids. The artificial lung organoids may include an epithelial cell layer comprising mammalian lung epithelial cells, a stromal cell layer comprising mammalian lung fibroblast cells and an endothelial cell layer comprising mammalian endothelial cells. The artificial lung organoids may optionally include a porous membrane between said epithelial cell layer and said stromal cell layer and/or between said stromal cell layer and said endothelial lung cell layer.
Abstract: This application is drawn to a method of using an isoform NELL-1 peptide, and compositions thereof for bone formation or for treating, preventing, or ameliorating osteoporosis.
Type:
Grant
Filed:
April 16, 2018
Date of Patent:
May 11, 2021
Assignee:
The Regents of the University of California
Abstract: The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods for their use and compositions containing the same.
Type:
Grant
Filed:
February 20, 2020
Date of Patent:
May 11, 2021
Assignee:
Duke University
Inventors:
Jonathan A. Covel, Mitchell Mutz, Peter J. Webb, Robert Remme Webb, II
Abstract: A warp knitted fabric formed by a warp knitting machine includes a first knitted portion formed using a first knitting sequence in a machine direction and a formed using a second knitted portion formed using a second knitting sequence in the machine direction, the second knitted portion comprising at least two strips extending in the machine direction, the at least two strips being detached from one another along their lengthwise edges. The second knitted portion has the same width as the first knitted portion, and the first knitted portion and the second knitted portion alternate sequentially in the machine direction and are formed of a single set of continuous textile strands.
Type:
Grant
Filed:
June 12, 2017
Date of Patent:
May 11, 2021
Assignees:
Duke University, North Carolina State University
Inventors:
Howard Levinson, James Brian Davis, Don Ward, Jon Rust
Abstract: The present disclosure discloses a thermophilic L-asparaginase mutant and screening and fermentation methods thereof, and belongs to the field of gene engineering, enzyme engineering and fermentation engineering. In Bacillus subtilis 168, a Pyrococcus yayanosii CH1-derived L-asparaginase encoding gene is used as a template, and a mutation library is constructed by an error-prone PCR (epPCR) technology. A mutant strain with improved specific enzyme activity is screened through a high-flux screening method of synchronous cell disruption and enzyme activity measurement. Mutated residues included in a positive mutant are analyzed to construct a composite mutant strain S17G/A90S/R156S/K272A with improved specific enzyme activity and specific enzyme activity of 3108 U/mg. An expression quantity of the composite mutant strain in the Bacillus subtilis 168 is increased through measures of a strong promoter P43 and RBS optimization.
Abstract: A system for producing dry nanoparticles from a liquid includes a closed tubing system which incorporates a mister, heater and an electrostatic collector therein. The system is able to produce dry nanoparticles from liquid-suspensions and from solvent solutions.
Type:
Grant
Filed:
November 4, 2019
Date of Patent:
May 11, 2021
Assignee:
Georgetown University
Inventors:
Edward Van Keuren, Grace Maglieri, Roman Kosarzycki, Leon Der
Abstract: The present invention relates to the field of three-dimensional face modeling, and provides a three-dimensional real face modeling method and a three-dimensional real face camera system. The three-dimensional real face modeling method includes the following steps: 1, projecting structured light to a target face, and taking a photo to acquire facial three-dimensional geometric data; 2, acquiring facial skin chroma data and brightness data; 3, triangulating the facial three-dimensional geometric data; 4, acquiring patch chroma data corresponding to each of triangular patch regions; 5, performing interpolation calculation to acquire patch brightness data corresponding to each of the triangular patch regions; and 6, calculating a reflectivity of a facial skin region corresponding to each of pixel points. The three-dimensional real face camera system includes: a standard light source, a control and calculation module and a three-dimensional portrait acquisition unit.
Abstract: This system and method provides for a plurality of satellite ground stations, distributed across some geographic region, and for these regions in turn to be scalable to cover large regions, including across the Earth or in orbit with planets or other celestial bodies using a combination of low-orbit satellites, terrestrial participant devices, and cloud-based communications. The invention in its simplest form is intended to solve the short temporal window problem inherent to the scenario where a single base or ground station is trying to track and communicate with a low-end OSAT or even a cube-satellite.
Abstract: A fusion bonding process for polymeric components and welding heads for use in the process are described. Methods and devices can be utilized to weld polymer-based structural components to one another by use of an enhanced friction stir welding technology that combines heating, pressure, and polymer agitation to form a highly secure joint between polymeric structural components and a short fiber reinforced thermoplastic connection element.
Abstract: In one embodiment, a personal flotation device that can be worn by a user includes an inflation system including an inflatable bladder, a gas-generating component configured to generate gas using a chemical reaction and inject the generated gas into the bladder to inflate it, and an actuator configured to activate the gas-generating component; a sensor configured to sense one or more physiological parameters of the user; and an inflation control system configured to receive physiological parameter data from the sensor, to determine whether or not the user is experiencing a medical event that places the user at risk of drowning, and, if the user is experiencing such a medical event, to signal the actuator to activate the gas-generating component so as to provide floatation to the user.
Type:
Grant
Filed:
July 24, 2019
Date of Patent:
May 11, 2021
Assignee:
University of South Florida
Inventors:
Aydin Kemal Sunol, Evan James Ticknor, Selina Kyle Guardiano, Timothy Warren Jacobson, Everett David Rogers, Kyle Louis Cogswell, Robert Dana Frisina, Christopher Lawrence Passaglia
Abstract: A distance protection system and method based on a high-frequency fault component is provided for a renewal energy source (RES) system. The voltage drop caused by a fault has a full frequency of components and this can be extracted by a wavelet transform. A frequency selection principle that renders high-frequency impedance models a stable impedance phase angle is determined. On this basis, internal and external faults with respect to a transmission line are determined by comparing the magnitude of a high-frequency operating voltage with the magnitude of a high-frequency voltage at the fault point. This disclosed protection system and method can eliminate the influence of frequency offset and weak feed of the RES system by using high-frequency signals generated by voltage drops at the fault point, and can also tolerate signal noises and fault resistance.
Abstract: An information processor includes: a display configured to display a screen of a game; a storage device configured to store an amount of a gaming medium usable in the game; and a controller programmed to execute the process of: comparing an amount of the gaming medium stored in the storage device with an amount of the gaming medium at login to the game, and displaying a predetermined message on the display when a relation between these amounts becomes equal to a predetermined ratio.
Abstract: A sensing element (10) for an intrinsic gravity gradiometer (IGG) for use in sensing variation in a gravity field at a location. The sensing element (10) is flexible, elongate and has unfixed opposed ends (12, 14) when part of the gravity gradiometer. The sensing element can be a metallic ribbon, and can be mounted by a number e.g. 3 or 5, pivot points or axes 30-40 at each of the opposed sides along the sensing element, with the opposed ends of the sensing element free to move. The pivot points or axes can include pins, preferably cylindrical pins (48) or the sensing element may be etched within the side wall and remain joined to the remainder of the side wall by connections. The sensing element (10) can form part of one or more resonant cavities or wave guide (44, 52-66), such as a side or dividing wall (46) or part thereof. A dual phase bridge (61,612) arrangement can be provided. Electrical current (I) can be injected into the sensing element.
Type:
Grant
Filed:
October 23, 2017
Date of Patent:
May 11, 2021
Assignees:
The University of Western Australia
Inventors:
Alexey Vladimirovich Veryaskin, Jeremy Francis Bourhill, Eugene Nikolay Ivanov, Michael Edmund Tobar
Abstract: A soft structure fiber reinforcement technology is provided. In an example embodiment, the fiber reinforced elastomeric sheet comprises a sheet of elastomeric matrix; and a fiber array comprising a plurality of fibers embedded within the elastomeric matrix. Each fiber of the array of fibers has a tensile modulus that is significantly greater than the tensile modulus of the elastomeric matrix. The fiber reinforced elastomeric sheets may be used in grasping or gripping robots, walking or jumping robots, artificial muscles, compliant prosthetics, impact and/or vibration dampening soft structures, passive soft structure configured to passively restrict deformation in an unwanted direction while allowing deformation in another direction, and/or the like.
Type:
Grant
Filed:
December 14, 2017
Date of Patent:
May 11, 2021
Assignee:
University of Florida Research Foundation, Incorporated