Patents Assigned to University
  • VHH based binding antibodies for anthrax and botulinum toxins and methods of making and using therefor
    Patent number: 11001625
    Abstract: Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent, methods, compositions and kits having a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes at least one or a plurality of disease agents that are toxins, for example at least one of a Botulinum toxin or an Anthrax toxin.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: May 11, 2021
    Assignee: Tufts University
    Inventor: Charles B. Shoemaker
  • Method and system for multiple input, multiple output communications in millimeter wave networks
    Patent number: 11005540
    Abstract: Disclosed herein are methods and systems for processing signals from multiple users at an antenna array, and to provide beamforming for transmitting to those multiple users, and more particularly for channel estimation and wireless signal recovery in wireless networks carrying transmissions in the millimeter wave frequency bands to enable such beamforming. Such methods and systems enable MIMO communications at millimeter wave frequencies for multiple users communicating with a MIMO antenna system, such as a massive MIMO multi-antenna system (multi-antenna arrays that consist of hundreds of antenna elements). Such methods and systems may characterize the communications link (i.e., channel) at that frequency band, and directly provide a precoding matrix for beam steering towards a particular user that is in communication with the antenna system.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: May 11, 2021
    Assignee: Morgan State University
    Inventors: Arlene Cole-Rhodes, Peter Taiwo
  • Multi-hypervisor virtual machines
    Patent number: 11003485
    Abstract: Standard nested virtualization allows a hypervisor to run other hypervisors as guests, i.e. a level-0 (L0) hypervisor can run multiple level-1 (L1) hypervisors, each of which can run multiple level-2 (L2) virtual machines (VMs), with each L2 VM is restricted to run on only one L1 hypervisor. Span provides a Multi-hypervisor VM in which a single VM can simultaneously run on multiple hypervisors, which permits a VM to benefit from different services provided by multiple hypervisors that co-exist on a single physical machine. Span allows (a) the memory footprint of the VM to be shared across two hypervisors, and (b) the responsibility for CPU and I/O scheduling to be distributed among the two hypervisors. Span VMs can achieve performance comparable to traditional (single-hypervisor) nested VMs for common benchmarks.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: May 11, 2021
    Assignee: The Research Foundation for The State University
    Inventors: Yaohui Hu, Kartik Gopalan
  • Nanofiber spinning apparatus and method
    Patent number: 11001943
    Abstract: A simple controllable set-up for drawing single filament nanofibers from polymer solutions or melts using a rotating rod or a set of rods (round brush) is described. The set-up can be assembled in a few minutes and applied to fabricate customized nanofiber scaffolds and meshes for various applications. The resulting fiber diameter is controlled precisely in the range 40 nm to 5 ?m by adjusting the rotational speed and polymer concentration. Owing to the simple design and capability to manipulate single nanofibers, the spinning set-up can be used to wind a single filament into unidirectional, orthogonal or randomly oriented 2D and 3D meshes with controlled density, thickness and combinations of different fibers and materials in the scaffolds. The method is scalable and can be implemented easily for laboratory and industrial manufacturing.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: May 11, 2021
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Alexander Tokarev, Oleksandr Trotsenko, Darya Asheghali, Sergiy Minko
  • Active content playback apparatus and active content creation apparatus
    Patent number: 11003743
    Abstract: An active content playback apparatus according to the present invention includes a storage storing active content including an active content header, embedded content, and an engine code, and a player program for executing the content; a memory temporarily storing data and program; and a central processing unit loading the active content into the memory according to an execution request for the active content and controlling an execution through a process of the player program of the embedded content loaded into the memory by executing the engine code included in the active content.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: May 11, 2021
    Assignee: Sangmyung University Seoul Industry-Academy Cooperation Foundation
    Inventor: Sang-ug Kang
  • Optical control of atomic quantum bits for phase control of operation
    Patent number: 11004009
    Abstract: The disclosure describes various aspects of optical control of atomic quantum bits (qubits) for phase control operations. More specifically, the disclosure describes methods for coherently controlling quantum phases on atomic qubits mediated by optical control fields, applying to quantum logic gates, and generalized interactions between qubits. Various attributes and settings of optical/qubit interactions (e.g., atomic energy structure, laser beam geometry, polarization, spectrum, phase, background magnetic field) are identified for imprinting and storing phase in qubits. The disclosure further describes how these control attributes are best matched in order to control and stabilize qubit interactions and allow extended phase-stable quantum gate sequences.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: May 11, 2021
    Assignee: University of Maryland, College Park
    Inventors: Christopher Monroe, Marko Cetina, Norbert Linke, Shantanu Debnath
  • Blackbody radiation source
    Patent number: 11002608
    Abstract: The present invention relates to a blackbody radiation source. The blackbody radiation source comprises a blackbody radiation cavity, a black lacquer layer and a plurality of carbon nanotubes. The blackbody radiation cavity comprises an inner surface. The black lacquer layer and the plurality of carbon nanotubes are located on the inner surface. Each carbon nanotube comprises a top end and a bottom end. The bottom end of each carbon nanotube is immersed into the black lacquer layer, and the top end of each carbon nanotube is exposed out from the black lacquer layer. An extending direction of each carbon nanotubes is substantially perpendicular to the inner surface.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: May 11, 2021
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Yang Wei, Guang Wang, Shou-Shan Fan
  • Silk-based nanoimprinting
    Patent number: 11001685
    Abstract: Protein-protein imprinting of silk fibroin is introduced as a rapid, high-fidelity, and/or high-throughput method for the fabrication of nanoscale structures in silk films, through controlled manipulation of heat and/or pressure. High resolution imprinting on conformal surfaces is also demonstrated.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: May 11, 2021
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Mark A. Brenckle
  • Synthesis and use of ?-hydroxylated polyunsaturated fatty acids
    Patent number: 11001783
    Abstract: The present invention provides a synthetic chemical method for preparing ?-hydroxylated polyunsaturated fatty acids (PUFAs) including 20-hydroxyeicosatetraenoic acid (20-HETE), 20-hydroxyeicosapentaenoic acid (20-HEPE), and 22-hydroxydocosahexaenoic acid (22-HDoHE) and a method of use thereof for treating cancer and macular degeneration.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: May 11, 2021
    Assignees: The Regents of the University of California, University of Massachusetts
    Inventors: Guodong Zhang, Bruce Hammock, Sung Hee Hwang, Weicang Wang
  • Cellular libraries of peptide sequences (CLiPS) and methods of using the same
    Patent number: 11001832
    Abstract: The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: May 11, 2021
    Assignee: The Regents of the University of California
    Inventors: Patrick Sean Daugherty, Kevin Todd Boulware
  • Systems and methods for semantic segmentation of 3D point clouds
    Patent number: 11004202
    Abstract: Systems and methods for obtaining 3D point-level segmentation of 3D point clouds in accordance with various embodiments of the invention are disclosed. One embodiment includes: at least one processor, and a memory containing a segmentation pipeline application. In addition, the segmentation pipeline application configures the at least one processor to: pre-process a 3D point cloud to group 3D points; provide the groups of 3D points to a 3D neural network to generate initial label predictions for the groups of 3D points; interpolate label predictions for individual 3D points based upon initial label predictions for at least two neighboring groups of 3D points including the group of 3D points to which a given individual 3D point belongs; refine the label predictions using a graph neural network; and output a segmented 3D point cloud.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: May 11, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lyne P. Tchapmi, Christopher B. Choy, Iro Armeni, JunYoung Gwak, Silvio Savarese
  • Fasting mimicking and enhancing diet for treating hypertension and lipid disorders
    Patent number: 11000057
    Abstract: Methods for lowering hypertension, elevated total cholesterol, elevated glucose and insulin, elevated IGF-1, elevated triglyceride levels, and/or elevated CRP levels, and elevated liver fat without negatively affecting or lowering the levels of these markers/factors in subjects with already low levels of these markers are provided. A method for elevating stem cells and regeneration and anti-inflammatory agents is also provided. Finally, a method for treating metabolic syndrome is also provided. A hypocaloric or calorie free diet or a fasting mimicking diet is administered for a first time period to the subject to reduce blood pressure or the levels of the above markers/risk factors for aging and age-related diseases.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: May 11, 2021
    Assignee: University of Southern California
    Inventors: Valter D. Longo, Sebastian Brandhorst, Min Wei
  • Food safety vaccine to control and reduce campylobacter in poultry
    Patent number: 11000583
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: May 11, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Roy Curtiss, III, Soo-Young Wanda
  • Biomedical patches with aligned fibers
    Patent number: 11000358
    Abstract: A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: May 11, 2021
    Assignee: Washington University
    Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
  • ICOS critically regulates the expansion and function of inflammatory human Th17 cells
    Patent number: 11001805
    Abstract: The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: May 11, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James L. Riley, Chrystal Paulos, Carl H. June, Bruce L. Levine
  • Predicting metabolic side effects of transported drugs
    Patent number: 11004539
    Abstract: Provided are drug-transport metabolomics profile assessments and therapies.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: May 11, 2021
    Assignee: The Regents of the University of California
    Inventors: Sanjay K. Nigam, Henry C. Liu
  • Tranceiver circuit and receiver circuit
    Patent number: 11005518
    Abstract: A transceiver circuit may include: a first NMOS transistor suitable for puffing up a transmission line in response to a TX signal in a TX mode and for being turned on or off according to a voltage level of the transmission line in an RX mode; and a first PMOS transistor suitable for pulling down the transmission line in response to the TX signal in the TX mode and for being turned on or off according to the voltage level of the transmission line in the RX mode.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: May 11, 2021
    Assignees: SK hynix Inc., Seoul National University R&DB Foundation
    Inventors: Deog-Kyoon Jeong, Han-Gon Ko
  • Delivery of cargo proteins via ARRDC1-mediated microvesicles (ARMMs)
    Patent number: 11001817
    Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of cargo proteins into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: May 11, 2021
    Assignees: President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Quan Lu, Qiyu Wang, Stanley N. Cohen
  • Trifunctional T cell-antigen coupler and methods and uses thereof
    Patent number: 11001621
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: May 11, 2021
    Assignee: McMaster University
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Anthony Mwawasi
  • Chimeric antigen receptor for efficient selective proliferation in vitro and uses thereof
    Patent number: 11001639
    Abstract: Chimeric antigen receptors for efficient and selective in vitro proliferation and uses thereof. Specifically, the present invention provides a CAR-encoding molecule with specific selectivity in vitro. By introducing a humanized selective domain into the molecule, the CAR-positive cells after being infected can be efficiently sorted via a secondary sorting step. Upon exposure to the selective domain-specific antibody, the CAR-transduced immune cells can be selectively expanded; therefore, the ratio of the CAR-positive target cells in the final product is significantly increased, improving the efficiency of preparing CAR gene-modified immune cell products. The present invention provides a more reliable technical support for further promotion and application of such products in clinical practice.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: May 11, 2021
    Assignee: Xuanwu Hospital Capital Medical University
    Inventors: Zhiguo Chen, Yu Zhao