Abstract: Various examples related to metaconductor based skins and transmission lines are provided. In one example, a flexible metaconductor skin includes a flexible substrate; at least one layer of non-ferromagnetic metal disposed on the flexible substrate; and a layer of ferromagnetic metal disposed on the at least one layer of non-ferromagnetic metal. The flexible metaconductor skin can be used as a multi-layer coplanar waveguide (CPW) transmission line.

Abstract: A microwave sensor includes a cloud of particles, e.g., Rubidium 87 atoms. A probe laser beam transitions ground-state particles in its path to an excited state. A set of one or more coupling laser beams causes excited particles to transition to a first Rydberg state so that particles in the intersection of the laser beams are in a dark superposition which is transparent to the probe laser beam so that a frequency spectrum of the probe laser beam shows a transmission peak at the laser frequency. A microwave lens focuses a microwave vector (e.g., a microwave signal) within the intersection, causing particles in the first Rydberg state to transition to a second Rydberg state, splitting the transmission peak into a pair of peaks. The intensity of the microwave vector can be calculated based on the frequency difference between the pair of peaks. The direction of the microwave vector can be determined from the location of the laser-beam intersection.

Abstract: Methods and systems are disclosed for performing Transmission Control Protocol (TCP) communications. A TCP packet may be received. An artificial error may be added to the TCP packet to prevent the occurrence of a TCP meltdown.

Abstract: The present invention relates to a method of preparing an MFI zeolite with a microporous and mesoporous hierarchical structure in which a non-benzene-based first structure-directing agent, which provides ordered microporous pore sizes and a framework of MFI zeolite seed crystals, and a second structure-directing agent containing one benzene ring and an ammonium ion, which functions as a mesopore-directing agent without interfering with the function of the first structure-directing agent, are simultaneously used; an MFI zeolite with a microporous and mesoporous hierarchical structure, which is prepared by the method, and a catalyst use thereof for a reaction of converting acetylene into an aromatic compound; and a method of preparing an aromatic compound from acetylene using the catalyst.

Abstract: Hearing protection combined with head motion tracking for magnetic resonance (MR) procedures is provided. Trackable earplugs include an MR-visible sample combined with a passive resonant circuit. The trackable earplugs act as wireless markers for the MR system. A third wireless MR marker can be disposed on the forehead of the subject to facilitate motion tracking in six degrees of freedom (i.e., 3 rotations, 3 translations). Preferably, the coordinate system for motion tracking is rotated relative to standard MR coordinates to ensure distinct tracking peaks from the two trackable earplugs.

Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.

Abstract: A method of modifying a chemical interaction between a functional group of an immobilized amine in a solid sorbent composition and a compound that chemically interacts with the functional group to reduce the heat required to desorb the compound from the solid sorbent. A method of inhibiting degradation of an immobilized amine in an immobilized amine solid sorbent. Compositions and methods of use of a low-cost regenerable immobilized amine solid sorbent resistant to degradation.

Abstract: RNA polymerase I (Pol I) is a dedicated polymerase for the transcription of the 47S ribosomal RNA precursor subsequently processed into the mature 5.8S, 18S and 28S ribosomal RNAs and assembled into ribosomes in the nucleolus. Pol I activity is commonly deregulated in human cancers. Based on the discovery of lead molecule BMH-21, a series of pyridoquinazolinecarboxamides were synthesized as inhibitors of Pol I and activators of the destruction of RPA194, the Pol I large catalytic subunit protein. The present invention identifies a set of bioactive compounds, including purified stereoisomers, that potently cause RPA194 degradation that function in a tightly constrained chemical space. Pharmaceutical compositions comprising these compounds and their uses in cancer and other Pol I related diseases is also provided.

Abstract: The disclosed embodiments generally relate to a method and system to synthesize a target molecule within a droplet. In an exemplary embodiment, a first microfluidic device configured to contact a polynucleotide-containing component from a sample with lysis reagents to form a first droplet. The lysis reagents include an enzyme having protease activity. The first droplet is encapsulated with an immiscible carrier fluid. A collection reservoir is provided to receive and incubate the first droplet for a first duration of time. The first duration of time is sufficient to inactivate the enzyme of the lysis reagent. A second microfluidic device is provided to receive the first droplet and add nucleic acid synthesis reagent to thereby form a second nucleic acid synthesis droplet in the immiscible carrier fluid. Finally, a reaction chamber is provided to synthesize the target polynucleotide within the second nucleic acid synthesis droplet.

Abstract: An image processing apparatus is provided. The image processing apparatus includes a memory configured to store at least one instruction; and a processor configured to read the at least one instruction and configured to, according to the at least one instruction: apply a learning network model to an input image frame and acquire information on an area of interest; and acquire an output image frame by retargeting the input image frame based on the acquired information on the area of interest. The learning network model is a model that is trained to acquire the information on the area of interest in the input image frame.

Abstract: Chimeric antigen receptors for efficient and selective in vitro proliferation and uses thereof. Specifically, the present invention provides a CAR-encoding molecule with specific selectivity in vitro. By introducing a humanized selective domain into the molecule, the CAR-positive cells after being infected can be efficiently sorted via a secondary sorting step. Upon exposure to the selective domain-specific antibody, the CAR-transduced immune cells can be selectively expanded; therefore, the ratio of the CAR-positive target cells in the final product is significantly increased, improving the efficiency of preparing CAR gene-modified immune cell products. The present invention provides a more reliable technical support for further promotion and application of such products in clinical practice.

Abstract: Methods are provided for the preparation of a sample using a digital microfluidic platform and the optional subsequent mass analysis of an extracted analyte. A sample is dried, optionally on a solid phase support, and contacted with digital microfluidic array. An analyte present within the dried sample is extracted into an extraction solvent by electrically addressing the digital microfluidic array to transport a droplet of extraction solvent to the dried sample spot. The extracted sample may be dried and subsequently processed on the digital micro fluidic array for derivatization. The digital microfluidic device may further include an integrated microfluidic channel having an output aperture, and the method may further include contacting a droplet containing extracted analyte with the microfluidic channel and applying a suitable electric field for generating nano-electrospray, thereby enabling the device to be directly interacted with a mass analysis device.

Abstract: Provided are a method of modeling a channel and transmitting molecules for passive transport molecular communication, the method being performed by a first device, that is, a transmission device, and including a molecular transmission step of transmitting molecules which are an information carrier through the channel, an H-diffusion function information reception step of receiving information about an H-diffusion function which is a function associated with a diffusion of the channel, and a molecular transmission property control step of controlling a transmission property that the molecules are transmitted based on the received information about the H-diffusion function, a method of modeling a molecular channel using an H-diffusion function in relation to the diffusion of the channel, and a transmission control method thereof.

Abstract: A method for determining gaze location includes: providing a gaze tracking device including an illumination source to illuminate an eye of an observer at an angle of about 20 degrees to 40 degrees relative to a resting eye position of the eye, a camera or an imager includes at least one focusing lens, the camera or imager to acquire sequences of digital images of the eye, and a processor to run a gaze tracking process; and running the gaze tracking process to locate at least two Purkinje reflections of the illuminating source from the eye in the images. A gaze tracking system and a gaze tracking device are also described.

Abstract: The purpose of the present invention is to provide a novel medicinal use in regeneration medicine, said medicinal use comprising using pluripotent stem cells (Muse cells). Provided is a cell preparation for treating skin ulcer, said cell preparation comprising SSEA-3 positive pluripotent stem cells isolated from a mesenchymal tissue of a living organism or cultured mesenchymal cells. The cell preparation according to the present invention is based on such mechanism of skin tissue regeneration that, when the Muse cells are administered to a skin ulcer site of a subject suffering from the aforesaid disease, the Muse cells differentiate into skin-constituting cells.

Abstract: The present disclosure provides systems and methods for verifying radiation source delivery in brachytherapy by allowing for the radiation source location and dwell time to be determined via real-time measurement. In an embodiment, a radiation detector may be disposed proximate to a radiotherapy target. The radiation detector is configured to provide real-time information indicative of ionizing radiation emitted by a radiation source. A controller may perform operations including receiving, from the radiation detector, real-time information indicative of at least one of: a particle flux rate, an energy fluence, or an absorbed dose of ionizing radiation emitted from the radiation source. The operations may also include determining, based on the received information, at least one of: a location of the radiation source or a dwell time of the radiation source.

Abstract: A magnetic resonance spectrometer and a control apparatus for the magnetic resonance spectrometer based on an FPGA. The control apparatus includes a control unit and a conversion receiving unit. The control unit includes a clock source. A waveform generation unit and a signal receiving unit inside the control apparatus are synchronized by means of the same clock source. The control apparatus includes two working modes: a continuous wave mode and an impulse wave mode. The control apparatus can output a microwave signal which is modulated by any wave and has higher synchronism and time resolution.

Abstract: Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.

Abstract: The present invention provides a method for treating or preventing gout in a subject afflicted therewith comprising administering a compound presented or an ester or salt thereof, so as to thereby treat or prevent the gout in the subject.

Abstract: A new and distinct variety of grapevine plant named ‘Paseante Noir’, particularly selected for its high resistance to Pierce's disease, as well as quality of fruit and wines produced is disclosed.