Abstract: 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD), as well as variants, derivatives, analogs, modifications, and conjugates thereof, are identified as therapeutic agents for treating or preventing human cancers and precancerous conditions. DMDD can be isolated from the root of Averrhoa carambola L., commonly known as starfruit. Pharmaceutical and nutraceutical compositions, as well as dietary supplements, are provided, as are methods of administration and treatment.
Abstract: With regard to image data processing, a method of obtaining a focus term by using periodicity of the focus term is provided. The focus term may be used in a plurality of operation processes for processing image data.
Type:
Grant
Filed:
September 24, 2018
Date of Patent:
May 4, 2021
Assignees:
SAMSUNG ELECTRONICS CO., LTD., University of Seoul Industry Cooperation Foundation
Inventors:
Yongkyu Kim, Kichul Kim, Hojung Kim, Hyunsik Park, Hongseok Lee, Hyunwook Ji
Abstract: An impact detection methodology is disclosed. Systems and methods can be utilized to detect impacts of concern such as collisions, falls, or other incidents. Systems and methods can be utilized to monitor an area and detect falls or collisions of an individual, for instance, as may require intervention to aid the subject. A system can include two or more accelerometers and a controller. The accelerometers can be in communication with the structure (e.g., within or on the walls or floor of a structure) and can monitor the structure for vibrations. The accelerometers can be coupled to a controller that is configured to process data obtained from the accelerometers and provide output with regard to the force and/or location of an impact within the structure.
Abstract: A method of training neural network for obtaining medical sagittal image includes: using a first neural network on a 3-D medical image to generate a prediction sagittal mask; generating a prediction result according to the 3-D medical image and the prediction sagittal mask; generating a ground truth result according to the 3-D medical image and a ground truth sagittal mask; using a second neural network on the prediction result and the ground truth result; generating a loss function data according to an output of the second neural network; and adjusting parameters of the first neural network or the second neural network according to the loss function data.
Abstract: A piezoelectric stack includes a porous resin sheet, and a surface coating layer disposed on an exterior surface of the porous resin sheet, the exterior surface including at least one of a front surface and a back surface of the porous resin sheet, the surface coating layer having a volume resistivity of not less than 1×1013 ?·cm, the porous resin sheet and the surface coating layer having different elastic moduli.
Type:
Grant
Filed:
October 29, 2013
Date of Patent:
May 4, 2021
Assignees:
Valqua, Ltd., A School Corporation Kansai University
Abstract: A cell composition composed of spermatogonial stem cells, Sertoli cells, Leydig cells and optionally peritubular cells, is provided, as is a culture composition, artificial testicular construct, hydrogel composition, and device containing the same. A method for using the device as a physiologically relevant in vitro model of human testicular function to screen compounds for pharmacological or toxicological activity is also provided.
Type:
Grant
Filed:
October 14, 2016
Date of Patent:
May 4, 2021
Assignee:
Wake Forest University Health Sciences
Inventors:
Samuel Pendergraft, Hooman Sadri-Ardekani, Anthony Atala, Colin Bishop
Abstract: An MRI system uses a Cartesian-radial hybrid k-space trajectory to capture three-dimensional k-space data and reconstruct an image of an area of interest of a subject. The MRI system performs a series of k-space acquisitions to collect the data. A first k-space acquisition includes acquiring a two-dimensional EPI projection in a first plane parallel to a frequency-encoding direction and acquiring additional two-dimensional EPI projections in planes that are radially shifted about a center axis parallel to the frequency-encoding direction with respect to the first plane, until a selected number of projections are acquired. Each subsequent k-space acquisition includes acquiring an additional set of two-dimensional EPI projections in all of the planes in which an EPI projection was acquired during the first k-space acquisition, each additional set of EPI projections being shifted along a respective plane in a direction perpendicular to the frequency-encoding direction.
Type:
Grant
Filed:
September 5, 2018
Date of Patent:
May 4, 2021
Assignees:
Siemens Healthcare GmbH, University of Utah Research Foundation
Inventors:
Sunil Goraksha Patil, Henrik Odeen, Dennis L. Parker
Abstract: Described herein is an arm supporting exoskeleton, comprising an arm link mechanism. The arm link mechanism comprises a proximal link, a distal link, an arm coupler, and a variable force generator. The distal link is rotatable relative to the proximal link. The arm coupler is adapted to couple an upper arm of a person to the distal link. The variable force generator comprises a first spring and a second spring, configured to create a torque between the proximal link and the distal link. In the first force mode, the variable force generator exhibits a first stiffness rate defined by the first spring that supports the upper arm of the person against gravity forces and. In the second force mode, the variable force generator exhibits a second stiffness rate defined by the first spring and the second spring that supports the upper arm of the person against the gravity forces.
Type:
Grant
Filed:
August 19, 2020
Date of Patent:
May 4, 2021
Assignee:
The Regents of the University of California
Inventors:
Logan Van Engelhoven, Homayoon Kazerooni
Abstract: A ratio of reversible electroporation and irreversible electroporation may be controlled by selecting a symmetric waveform or asymmetric waveform to either minimize or enhance irreversible effects on cells in the target tissue. Combined reversible and irreversible electroporation includes inserting one or more therapeutic electrodes into a target tissue, introducing an electroporation compound into the target tissue, selecting a pulse waveform that is either 1) asymmetric bipolar that has positive and negative pulses with different durations, or 2) symmetric bipolar that has positive and negative pulses with the same duration, and delivering to the target tissue a series of electrical pulses having the selected pulse waveform.
Type:
Grant
Filed:
February 4, 2020
Date of Patent:
May 4, 2021
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
Type:
Grant
Filed:
April 18, 2019
Date of Patent:
May 4, 2021
Assignees:
Mayo Foundation for Medical Education and Research, The Regents of the University of California
Inventors:
Purna C. Kashyap, Michael Fischbach, Brianna B. Williams
Abstract: Polypeptide compositions comprising a human immunoglobulin constant region with a modified IgG4 hinge region having an N-terminal deletion of 1, 2, 3, 4, 5 amino acids, relative to a native human IgG4 hinge sequence are provided. In some embodiments the hinge sequence further comprises the amino acid substitution S228P (Eu numbering). Polypeptides comprising the modified sequence optionally comprise a binding moiety specific for an epitope that is present on red blood cells; and can provide for reduced agglutination of hematopoietic cells compared to a comparable polypeptide with a native hinge region.
Type:
Grant
Filed:
October 26, 2017
Date of Patent:
May 4, 2021
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Jie Liu, Irving L. Weissman, Ravindra Majeti
Abstract: Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.
Type:
Grant
Filed:
August 20, 2019
Date of Patent:
May 4, 2021
Assignee:
Oregon Health & Science University
Inventors:
Klaus Frueh, Scott G. Hansen, Jay Nelson, Louis Picker, Patrizia Caposio
Abstract: Compositions and methods are disclosed herein to deliver and anchor nanoscale drug carriers into the extracellular matrix (ECM) of tissues, such as degenerating cartilage or tumor margins, and to provide local and sustained release of drugs.
Type:
Grant
Filed:
October 3, 2017
Date of Patent:
May 4, 2021
Assignee:
University of Florida Research Foundation, Inc.
Abstract: Rubber composites with regions doped with conductive material, e.g., carbon nanotubes, and patterned regions doped with both conductive material and semiconductive material, e.g., carbon nanotubes and polcrystalline silicon are created with rubbing-in technology. The composites provide for a deformable and elastic composite which maintains semiconductor operations under stress, and can be used for filtering, determining compressive force, and a variety of other applications.
Type:
Grant
Filed:
September 9, 2020
Date of Patent:
May 4, 2021
Assignee:
King Abdulaziz University
Inventors:
Muhammad Tariq Saeed Chani, Abdullah Mohamed Asiri, Hasan Karimov
Abstract: Provided are: a transformation plasmid for transforming anaerobes and enabling highly efficient and stable secretory expression of a target protein; a gene delivery carrier formed from said anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these. Also provided are: a novel secretory signal; a transformation plasmid including said secretory signal; a gene delivery carrier formed from anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these.
Type:
Grant
Filed:
January 18, 2016
Date of Patent:
May 4, 2021
Assignees:
Shinshu University, Anaeropharma Science, Inc.
Abstract: Disclosed herein are embodiments of composites and compositions that can be used for therapeutic applications in vivo and/or in vitro. The disclosed composites can comprise cores having magnetic nanoparticles, quantum dots, or combinations thereof and zwitterionic polymeric coatings that facilitate solubility and bioconjugation. The compositions disclosed herein can comprise the composites and one or more biomolecules, drugs, or combinations thereof. Also disclosed herein are methods of making the composites, composite components, and methods of making quantum dots for use in the composites.
Type:
Grant
Filed:
January 16, 2018
Date of Patent:
May 4, 2021
Assignee:
Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada, Reno
Abstract: Disclosed is an immunity inducer. The immunity inducer comprises virus like particles; the virus like particles comprise a virus-derived outer coat protein and an antigen-bound protein comprising an exogenous antigen; the outer coat protein constitutes an outer coat of the virus like particles, and the antigen-bound protein is comprised in the outer coat; and the virus like particles induce an immune effect of a living body on the antigen.
Type:
Grant
Filed:
November 29, 2016
Date of Patent:
May 4, 2021
Assignees:
Saitama Medical University, SYSMEX CORPORATION
Abstract: Methods for reducing the concentration of one or more contaminants in water using zero-valent iron media. In the method, a mixed aluminum (III) and iron (II) salt solution is added to water containing one or more contaminants that is in contact with a zero-valent iron media that comprises (a) a reactive solid comprising zero-valent iron and one or more iron oxide minerals in contact therewith and (b) magnetite to provide an aqueous reaction medium. The aqueous reaction medium is contacted with the zero-valent iron media for a period of time sufficient to reduce the concentration of one or more of the contaminants.
Abstract: A Carbon NanoTube (CNT) composite electrode includes a lower electrode having a through-hole formed therein, and configured to be attached to the skin of a subject body to detect a biosignal, an upper electrode provided on one surface of the lower electrode to form an enclosed space between the lower electrode and the upper electrode, and configured to receive the biosignal detected by the lower electrode, and an air discharge portion formed in at least one of the lower electrode and the upper electrode, and discharging air present in the enclosed space and the through-hole externally so as to be configured to allow the upper electrode and the lower electrode to be attached to the skin of the subject body via vacuum suction.
Type:
Grant
Filed:
December 20, 2017
Date of Patent:
May 4, 2021
Assignee:
Industry-Academic Cooperation Foundation, Chosun University
Inventors:
Youn Tae Kim, Jae Hyo Jung, Ji Hoon Lee, Si Ho Shin