Abstract: A method of inhibiting the growth or proliferation of ovarian cancer cells is provided. The method comprises contacting the ovarian cancer cells with an effective amount of 8-hydroxynaphthalene-1,3,6-trisulfonic acid (?-Stat), a salt of ?-Stat, a derivative of ?-Stat, or a salt of a derivative of ?-Stat. Also provided is a method of treating an ovarian cancer or inhibiting ovarian cancer cell growth or proliferation in a subject by administering to the subject a therapeutically effective amount of ?-Stat, a salt of ?-Stat, a derivative of ?-Stat, or a salt of a derivative of ?-Stat.

Abstract: The present disclosure provides methods for producing bioengineered tissue along with an apparatus and other relevant compositions employed in generation thereof.

Abstract: The present invention relates to an ultraviolet reflecting agent composition or a water repellent agent composition, which contains at least one compound selected from among 2-pentacosanone, 2-heptacosanone, 2-nonacosanone, tetracosanal, hexacosanal, octacosanal and triacontanal.

Abstract: Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)). Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as cancer). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.

Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.

Abstract: Disclosed is a high-throughput transcriptional assay format in Actinomycete bacteria, and Streptomyces spp. in particular, that leverages eGFP, inserted both at a neutral site and inside the biosynthetic cluster of interest, as a read-out for secondary metabolite synthesis. Using this approach, a silent gene cluster in Streptomyces albus J1074 was induced. The cytotoxins etoposide and ivermectin were revealed as potent inducers, allowing the isolation and structural characterization of nearly 20 novel small molecule products of the chosen cluster. One of these molecules is a novel antifungal, while several others inhibit a cysteine protease implicated in cancer. Studies addressing the mechanism of induction by the two elicitors led to the identification of a pathway-specific transcriptional repressor that silences the gene cluster under normal growth conditions.

Abstract: A method and apparatus for producing a corrosion inhibiting coating for metal and metal alloy substrates. The coating is comprised of a metal or metal alloy that is similar in composition to the substrate to be coated, further combined with a corrosion inhibiting material. The corrosion inhibiting material may be a refractory metal or metalloid. The method and apparatus for producing the coating allows for the corrosion inhibiting coating to have a supersaturated concentration of the corrosion inhibiting material alloyed with another metal or metal alloy. The method and apparatus allow for the selective vaporization of material sources to make the coating vapor, which are then entrained in a high speed gas flow that directs the coating vapor onto the substrate. Optional plasma assistance and application of a voltage to the substrate may be used. The coating may be customized for a variety of applications.

Abstract: A circuit for power transmission through a single conductive element. The circuit includes an oscillator, a single conductive element, and a load. The oscillator is configured to generate a periodic voltage. The single conductive element is connected in series with the oscillator. The load is connected in series with the single conductive element. The load includes a first diode, a first resistor, and a first inductor. The first diode is connected in series with the single conductive element. The first resistor is connected in series with the first diode. The first inductor is connected between the first diode and the single conductive element. The first inductor is connected in series with the first resistor.

Abstract: A novel composition formed of a first compound is disclosed where the first compound is selected from

Abstract: The present invention relates to a use of an agarobiose or agarooligosaccharides having anticariogenic activity. More specifically, a lower concentration of agarobiose or agarooligosaccharides than the concentration of xylitol suppresses the growth of Streptococcus mutans and suppresses acid production, and thus can be used for anti-cariogenic purposes.

Abstract: Devices for controlling movement of aerial buckets via hydraulic systems. Each hydraulic system has valves that control movement of the aerial bucket. A control head of the device has a joystick that is moveable and encoders that detect movement of the joystick. A valve actuator manifold of the device is coupled between the control head and the hydraulic system and supports valve actuators moveably coupled to the valves. Servo drive systems supported by the valve actuator manifold are coupled to the valve actuators and are controllable to move the valve actuators. A processor module of the device is in communication with the encoders and the servo drive systems. The processor module controls the servo drive systems based on input from the encoders such that moving the joystick controls movement of the aerial bucket.

Abstract: An anti-bedsore bed may comprise a bed unit, a first bed body, and a second bed body. The bed unit has a first mattress, and a bottom portion is coupled on a bottom surface thereof. Moreover, the bottom portion comprises a plurality of first supporting units at positions corresponding to a user's upper back, middle portion of back and lower back, and each of the first supporting units has a first sliding block moveably mounted on the bottom portion. Each of the first sliding blocks has a first supporting rod, and an abutting unit is pivotally connected to an upper end of the first supporting rod. Each of first power units secured on a bottom surface of the first sliding block is engaged with the first supporting rod while each of second power units secured on the bottom portion is engaged with the first sliding block.

Abstract: A leakage magnetic field shielding device includes: a leakage magnetic field determining unit for determining phase and magnitude of a leakage magnetic field based on information obtained from a power supply device and a current collector device; a shielding current controller for determining a shielding current based on the phase and magnitude of the leakage magnetic field and supplying the determined shielding current to the leakage magnetic field shielding device; and a shielding unit for shielding the leakage magnetic field by generating a shielding magnetic field in accordance with the supply of the shielding current. The shielding unit has a multiple resonance characteristic depending on an arrangement of capacitors and coils and is disposed to surround the power supply device or the current collector device. The shielding magnetic field has resonance frequencies canceling magnetic fields corresponding to fundamental frequency and multiple frequency of the leakage magnetic field.

Abstract: A model-based control scheme consisting of either a proportional-integral-derivative (IMC-PID) controller or a model predictive controller (MPC), with an insulin feedback (IFB) scheme personalized based on a priori subject characteristics and comprising a lower order control-relevant model to obtain PID or MPC controller for artificial pancreas (AP) applications.

Abstract: The present disclosure relates to a process for acid-catalyzed decomposition of aryl ?-hydroperoxide with a continuous flow tubular reactor. The process is a novel process performed in a tubular reactor, taking the aryl ?-hydroperoxide such as cumene hydroperoxide (CHP) as a raw material and taking acids as a catalyst, performing acid-catalyzed decomposition of the aryl ?-hydroperoxide solution in a short reaction time ranging from tens of seconds to several minutes, thereby obtaining the phenols; wherein an inert component may be filled in the reactor, so that the effects of heat transmission and mass transfer can be enhanced. The aryl ?-hydroperoxide and acid are respectively introduced by a metering pump into a mixing module to be mixed, and then enter the tubular reactor to be reacted so as to produce the products such as phenols.

Abstract: The present invention provides processes for the preparation of diverse heterocyclic scaffolds from alpha-enaminone building bloc of formula (I).

Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with a pain, a depressive disorder, a mood disorder, an anxiety disorder, borderline personality disorder, opioid addiction, or opioid withdrawal symptoms by administering the compound to the subject.

Abstract: A logic element includes a logic block, a supply voltage input, switchable power gates and a gate selector. The logic block implements a logic function on input data to obtain at least one output data signal. The switchable power gates transfer a supply voltage from the supply voltage input to the logic block in accordance with respective gate control signals. At least two of the power gates have different respective electrical properties. The gate selector switches on differing ones of the power gates in accordance with gate selection data.

Abstract: An organic hydride production apparatus includes: an electrolyte membrane having proton conductivity; a cathode, provided on one side of the electrolyte membrane, that contains a cathode catalyst used to hydrogenate a hydrogenation target substance using protons to produce an organic hydride; an anode, provided opposite to the one side of the electrolyte membrane, that contains an anode catalyst used to oxidize water to produce protons; and an anode support, provided opposite to the electrolyte membrane side of the anode, that supports the anode. The anode support is formed of an elastic porous body of which the Young's modulus is greater than 0.1 N/mm2 and less than 43 N/mm2.

Abstract: The present disclosure discloses an anti-reflection coating and a method of forming the same. According to one embodiment of the present disclosure, the anti-reflection coating includes a first layer positioned on a substrate to be spaced apart from the substrate by a first distance and a second layer positioned on the first layer to be spaced apart from the first layer by a second distance. In this case, the first and second layers are a metamaterial forming a structural double layer and are realized as an anomalous dispersive medium that does not absorb incident light. The structural double layer may realize spatiotemporal dispersion that varies depending on an incidence angle using the nonlocality of the electromagnetic wave reaction of incident light.