Abstract: N-substituted hydroxamic acids with carbon-based leaving groups as efficient HNO donors are disclosed. Pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions also are disclosed.

Abstract: A swallow exerciser device that exercises and thereby strengthens the muscles involved in swallowing includes a rigid shell, an adjustable fastener, and an inflatable pad. The rigid shell has a longitudinal dimension such that the shell extends above and below the larynx of the subject when the swallow exerciser device is positioned over the larynx of the subject. The adjustable fastener is dimensioned to secure the shell around a neck of the subject with the shell positioned over the larynx of the subject. The inflatable pad is connected to a proximal surface of the shell. The inflatable pad is dimensioned to apply resistance to force of at least one swallowing muscle of the subject when the shell positioned over the larynx of the subject and when the inflatable pad is in an inflated position. The swallow exerciser device can be used in a method for improving swallowing function in a subject.

Abstract: Bioluminescence resonance energy transfer (BRET) biosensors for assessing the intracellular localization, internalization and trafficking into cellular compartments of proteins such as receptors, and other biomolecules such as second messengers, are disclosed. These biosensors, which are dependent on the concentration/density of the BRET donor and acceptor in cellular compartments rather that specific protein-protein interactions, use a Renilla GFP/Luc BRET pair, which allows the robust and reproducible monitoring of protein trafficking/localization, with a sensitivity compatible with high-throughput screening (HTS). The use of these biosensors for various applications, including assessing/monitoring protein endocytosis, recycling and intracellular trafficking, receptor maturation/rescue by pharmacological chaperones, various endocytosis/exocytosis processes, activation/inhibition, as well as biomolecule concentration/density in different cellular compartments, is also disclosed.

Abstract: A variety of methods, devices, systems and arrangements are implemented for stimulation of the peripheral nervous system. Consistent with one embodiment of the present invention, method is implemented in which light-responsive channels or pumps are engineered in a set of motor units that includes motor units of differing physical volumes. Optical stimuli are also provided to the light-responsive channels or pumps at an optical intensity that is a function of the size of motor units to be recruited. In certain implementations, the intensity of the optical stimuli is increased so as to recruit increasingly larger motor units.

Abstract: The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject.

Abstract: This invention relates to barrier materials comprising reduced graphene oxide, methods of making said materials and their uses. The reduced graphene oxide is preferably formed from the reduction of graphene oxide by HI, HBr or ascorbic acid.

Abstract: Provided herein are methods for multiplexed sample analysis by mass spectrometry. The methods may be performed without the need for chemical tagging. The methods also may include the analogous use of frequency modulation to multiplex mass spectrometric analysis, which may be referred to as frequency-modulated continuous flow analysis electrospray ionization mass spectrometry (FM-CFA-ESI-MS).

Abstract: Described herein are plants that are resistant to herbicides, such as herbicide compositions comprising coronatine, where the herbicide-resistant plants express a modified CORONATINE INSENSITIVE 1 (COI1) protein.

Abstract: A two-chain insulin analogue contains an A chain modified by (i) a monomeric glucose-binding element at or near its N terminus and (ii) a B chain modified by at or near its C terminus by an element that reversibly binds to the monomeric glucose-binding element such that this linkage is displaceable by glucose. The monomeric glucose-binding element may be phenylboronic acid derivative (optionally halogenated). The B chain may be modified by a diol-containing element derived from a monosaccharide, disaccharide or oligosaccharide, a non-saccharide diol-containing moiety or a ?-hydroxycarboxylate-containing moiety. The analogue can be manufactured by trypsin-mediated semi-synthesis. Formulations can be at strengths U-10 to U-1000 in soluble solutions at pH 7.0-8.0 with or without zinc ions at a molar ratio of 0.0-3.0 ions per insulin analogue monomer.

Abstract: Disclosed herein are aerosol particle growth systems including polymer electrolyte membranes and related methods of increasing the size of aerosol particles. In some embodiments, an outer housing contains a reservoir of a working fluid, and a PEM conduit extends through the outer housing, the reservoir, and the working fluid so that the working fluid is in contact with an outer surface of the PEM conduit. The conduit can be generally helical or coiled, for example. In some embodiments, the working fluid is molecularly transported across the PEM and disperses into an aerosol flowing through the PEM conduit. As the aerosol flows through the PEM conduit, the aerosol particles act as nucleation sites for the gaseous working fluid, which condenses on the particles, causing the particles to grow in size and making them easier to detect, collect, measure, count, study, or otherwise investigate.

Abstract: The present invention relates to microemulsions and methods of preparing and using the microemulsions.

Abstract: A tunable electro-optic modulation (EOM) comb generator includes a frequency locking optoelectronic oscillator (OEO) loop including RF electrical components including a phase shifter (PS1), a splitter, and optical components including an intensity modulator (IM) coupled to receive light from a light source and to couple modulated light generated to a frequency locking loop including a frequency shifter, a first phase modulator (PM1), and a periodic optical filter (POF), such as an etalon or resonator. The POF is for optically filtering the OEO loop to generate an optical output and the splitter is for generating RF electrical outputs including at least one RF output coupled to an input of the IM and another RF output coupled to an EO comb including at least a phase modulator. The EO comb combines the optical output and the another RF output to generate a broadband optical frequency comb output.

Abstract: Light emitting devices including sub-pixels having different numbers of emissive layers are provided. At least one sub-pixel of a first color may include a single emissive layer, and at least one sub-pixel of a second color may include multiple emissive layers disposed in a vertical stack. Light emitting devices in which different voltages are applied to each sub-pixel or group of sub-pixels are also provided. In some configurations, the voltage to be applied to a sub-pixel may be selected based upon the number of emissive layers in the sub-pixel.

Abstract: Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to the surface of the nanocarriers. The nanocarriers may comprise a drug and may be administered for localized and sustained delivery of the drug.

Abstract: A method for synthesizing carbon nanocages, including N-doped carbon nanocages, includes a first step of forming a solution including a metal salt and an organic carbon source; a second step of drying the solution to obtain a precursor powder; and a third step of annealing the precursor powder to obtain a nanocage including a metal nanoparticle surrounded by a carbon shell. The metal nanoparticle is then removed from the carbon shell by applying an acid solution.

Abstract: A nucleic acid amplification disk apparatus using a temperature sensitive polymer synthesis and the analysis method using the same, and more specifically, and the nucleic acid amplification device, and the analysis method using the nucleic acid amplification disk unit and the nucleic acid amplification disk for amplifying the Bacterial DNA or RNA, and the driving control section for controlling the nucleic acid amplification disk.

Abstract: The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have numerous uses, such as for treatment of cancer or autoimmue disorders.

Abstract: Described herein are inventions directed to methods of treating a diastolic cardiac dysfunction and the symptoms thereof in a subject that includes administering an amount of a TRPV2 receptor agonist effective to treat the diastolic cardiac dysfunction. The TRPV2 receptor agonist may be administered in at least one of an injection, orally, or transdermally. The amount of TRPV2 receptor agonist is sufficient to result in an improved performance on quantitative diagnostic criteria. In an embodiment, the TRPV2 receptor agonist is administered over a period of about 8 hours to about 24 hours. The TRPV2 receptor agonist may be used for short term treatments, i.e., less than a week, or it may be administered in a long term manner, i.e., over a period of weeks, months, or even years. Exemplary TRPV2 receptor agonists include probenecid, 2-aminoethoxydiphenyl borate, cannabinol, cannabidiol, and combinations thereof.

Abstract: A magnetic device may include a layer stack. The layer stack may include a first ferromagnetic layer; a non-magnetic spacer layer on the first ferromagnetic layer, where the non-magnetic spacer layer comprises at least one of Ru, Ir, Ta, Cr, W, Mo, Re, Hf, Zr, or V; a second ferromagnetic layer on the non-magnetic spacer layer; and an oxide layer on the second ferromagnetic layer. The magnetic device also may include a voltage source configured to apply a bias voltage across the layer stack to cause switching of a magnetic orientation of the second ferromagnetic layer without application of an external magnetic field or a current. A thickness and composition of the non-magnetic spacer layer may be selected to enable a switching direction of the magnetic orientation of the second ferromagnetic layer to be controlled by a sign of the bias voltage.

Abstract: A photodetector focal plane array system having enhanced sensitivity and angle-of-view, including: a substrate including a plurality of photosensitive regions; and a microcomponent disposed adjacent to each of the plurality of photosensitive regions operable for receiving incident radiation from a relatively wider area and directing the incident radiation into a relatively smaller area of the associated photosensitive region by, in part, one or more of waveguiding and scattering; wherein each of the microcomponents is centered with respect to a photodetector mesa of each of the plurality of photosensitive regions. Each of the microcomponents includes one of a microcone, a microcuboid, a micropillar, a core-shell micropillar, a microtubule, a pyramid, an inverted pyramid, and an arbitrary shape microcomponent—with a top surface having a a selected or arbitrary cross-sectional shape and a selected or arbitrary profile.