Abstract: A system for multi-slice magnetic resonance imaging (MRI) comprises a gradient coil array comprising a plurality of independent coils distributed about an enclosure; and a controller configured to concurrently actuate said plurality of coils so as to generate a spatially-varying magnetic field within said enclosure such that for at least first and second volumetric slices, a magnetic field magnitude associated with at least one location in the first volumetric slice is substantially equal to a magnetic field magnitude associated with a respective location in the second volumetric slice.

Abstract: The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods for their use and compositions containing the same.

Abstract: A method of assessing vulnerability of Integrated Circuit (IC) can include: preparing a list of logic nets of the IC; obtaining rectangular segments from the logic nets; finding a milling exclusion area based on a covering wire; and superimposing the found milling exclusion area onto the rectangular segments of the logic nets. The milling exclusion area is an area that microprobing attack does not succeed without cutting off at least one of the rectangular segments.

Abstract: Synthetic peptides containing chemical modifications having anti-tumor properties are provided. Further provided are pharmaceutical compositions including the peptides and use thereof for treating proliferative and neoplastic diseases such as cancer.

Abstract: An optical probe having a controlled viewing angle lens tip is provided that includes an elastomer lumen, where the elastomer lumen includes internal dividers disposed to separate the elastomer lumen into a plurality of channels, a lens that is sealably attached to a distal end of the elastomer lumen, where each channel is disposed to operate as an independent hydraulic channel, where an angle of the lens relative to a central axis of the elastomer lumen is positioned according to a state of pressure in each independent hydraulic channel, and a hydraulic generator, where the hydraulic generator is disposed to pressurize each hydraulic channel to a defined state as set by a computer input from a to computer.

Abstract: Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to selectively depolarize neurons residing in microcircuits of the pre-frontal cortex to affect one or more social behaviors, communications, and/or conditioned behaviors in the non-human animal.

Abstract: Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. According to an example embodiment of the present invention, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo.

Abstract: Disclosed are compounds that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL. More particularly, compounds of formula II have utility in a variety of therapeutic uses such as treatment of pain, inflammation, neuropathy, or appetite disorder.

Abstract: A device for performing a procedure may include an elongate tube having a proximal end and a distal end and an adapted link having a proximal end and a distal end. The distal end may include a first mating surface, where the proximal end may be configured to attach to the distal end of the elongate tube. The device may also include a rotating link having a second mating surface configured to rotatably interface with the adapted link first mating surface.

Abstract: A computer-implemented method is provided for estimating the remaining life of a structure being monitored by a sensor. The method includes: receiving data from a sensor, where the data is indicative of strain experienced by a structure and is reported as a plurality of cumulative distribution functions; extracting a probability density function from the data received from the sensor; computing a damage index for the structure from parameters of the probability density function, where the damage index is indicative of damage to the structure accumulated over time; and estimating a remaining life of the structure using the damage index.

Abstract: Split-crank pedaling devices and methods of operation support patient use and rehabilitation, particularly for stroke patients. A split-crank pedaling device includes first and second crank assemblies. First and second motors are operably connected to the first and second crank assemblies. A first shaft sensor produces an indication of a position of the shaft of the first crank assembly. A second shaft sensor produces an indication of a position of the shaft of the second crank assembly. A controller is communicatively connected to the first and second motors and the first and second shaft sensors and calculates a phase error between the positions of the first and second shafts and a predetermined phase relationship between the first and second shafts. The controller operates at least one of the first motor or the second motor to provide a supplemental torque to one of the first crank assembly and the second crank assembly.

Abstract: A dual modality probe is disclosed having both a positron emission tomography sensor and a ultrasound sensor. A dual imaging system is provided having the probe and at least one external positron emission tomography detector and a data acquisition computer system for collecting data simultaneously from the positron emission sensor and the ultrasound sensor of the probe and the positron emission tomography detector. A method for evaluating a target organ of a patient utilizing the probe and imaging system, and performing a biopsy of the organ is disclosed.

Abstract: An automatic cell isolation and collection system for sorting out target cells from a sample includes a crush module, a centrifuge module, a transport module, and a control unit. The centrifuge module includes centrifuge tubes and a magnetic mechanism providing a magnetically attractive force to at least one of the centrifuge tubes. The control unit electrically communicates with the crush module, the centrifuge module, and the transport module, and controls operation of the crush module, transport of the sample via the transport module after the sample is crushed by the crush module, centrifugation of the centrifuge module, and operation of the magnetic mechanism for providing the magnetically attractive force.

Abstract: The invention provides the identification of oncogenic pathways activated in cytologically normal airway cells of individuals having or at risk of having lung disease, as well as specific gene expression patterns (biomarkers) associated with pathway activation. These biomarkers and pathways may provide prognostic and/or diagnostic indicators in lung disease, e.g., lung cancer. Additionally, these pathways and biomarkers may provide therapeutic targets for the treatment of lung disease, as well as markers for the assessment of treatment efficacy.

Abstract: The application describes stabilized WRINKLED1 transcription factors, as well as nucleic acids, and expression cassettes that encode and express such stabilized WRINKLED1 transcription factors and that are useful for increasing production of oils in plants and seeds.

Abstract: A multimodal medical device for the diagnosis and/or thermal treatment of a disease includes an instrument for performing thermal therapy; and an imaging system having multiple tomographic imaging modes, including optical coherence tomography (OCT), ultrasound imaging, photoacoustic (PA) imaging, fluorescence imaging and/or thermal imaging to provide guidance for accurate diagnosis and treatment of the disease.

Abstract: A therapeutic combination of drugs for the treatment of a liver cancer includes safranal or a pharmaceutically acceptable pro-drug thereof, and sorafenib. In representative embodiments, the pro-drug is selected from the group of a safranal salt, hydrate, hemiacetal, acetal, thioacetal, silylether, tautomer, isomer, and combinations thereof. The safranal and the sorafenib may be compounded together in a same unitary pharmaceutical composition including both compounds. Alternatively, the safranal and the sorafenib may be provided in the form of separate pharmaceutical compositions.

Abstract: A metallic alloy, more particularly, a high-entropy alloy with a composite structure exhibits high strength and good ductility, and is used as a component material in electromagnetic, chemical, shipbuilding, machinery, and other applications, and in extreme environments, and the like.

Abstract: Methods and oligonucleotide reagents for identification of bacteria by high resolution melting (HRM) analysis are described. In particular, the invention relates to HRM analysis of hypervariable bacterial genomic DNA of the internal transcribed spacer (ITS) region for fingerprinting eubacterial pathogens.

Abstract: The present invention(s) is directed to novel conductive Mn+1Xn(Ts) compositions exhibiting high volumetric capacitances, and methods of making the same. The present invention(s) is also directed to novel conductive Mn+1Xn(Ts) compositions, methods of preparing transparent conductors using these materials, and products derived from these methods.