Abstract: Provided are a method of preparing retinal ganglion cells by differentiation of stem into retinal ganglion cells, retinal ganglion cells differentiated by the method, a method of screening for a death inhibitor or a proliferation promoter of retinal ganglion cells using the retinal ganglion cells differentiated by the method, a kit of screening for the death inhibitor or the proliferation promoter of retinal ganglion cells including the retinal ganglion cells differentiated by the method, a pharmaceutical composition for treating glaucoma or optic neuropathy including the retinal ganglion cells, a method of treating glaucoma or optic neuropathy including the step of administering the retinal ganglion cells to a subject suspected of having glaucoma or optic neuropathy, and a method of preparing a mature retinal ganglion cell line.

Abstract: A photonic crystal device includes a two-dimensional crystal including a gain medium and having a first photonic crystal resonator and a second photonic crystal resonator spaced apart from each other and a graphene layer disposed to cover a portion of the first photonic crystal resonator and not to cover the second photonic crystal resonator.

Abstract: A method for impulse noise detection and removal in color images based on Moran's I statistic using Moran's I vector median filter (MIVMF) which comprises detection and removal components. The detection module determines if a pixel is noise or is noise-free. If it is a noise pixel, the vector median filter (VMF) will be used to remove the noise. This detection capability meets the so-called “switching” mechanism, which only selects noisy pixels for suppression. The inventive filter expedites processing time with the reduced number of vector calculations due to this new detection function, achieved with Moran's I index and the indication of 1-D Laplacian kernels. Compared to other vector-type median filters, the inventive MIVMF was faster in the filtering process and efficient in removing random impulse noise with different noise levels in color images. The MIVMF demonstrated a promising de-noising result based on the criteria of Peak Signal-to-Noise Ratio (PSNR) and Structural Similarity Index Metric (SSIM).

Abstract: Provided are an apparatus and method for classifying home appliances based on power consumption using deep learning, which can efficiently classify home appliances in use by applying deep learning and analyzing power data collected from a house. The apparatus includes a home appliance classification model creation module configured to encode power consumption data collected from a house to learn a home appliance classification model and create an RNN-based home appliance classification model and a home appliance classification module configured to collect and encode data on power consumption currently in use and classify home appliances using the home appliance classification model created by the home appliance classification model creation module.

Abstract: The invention provides a method of automatic speech recognition. The method includes receiving a speech signal, dividing the speech signal into time windows, for each time window determining acoustic parameters of the speech signal within that window, and identifying phonological features from the acoustic parameters, such that a sequence of phonological features are generated for the speech signal, separating the sequence of phonological features into a sequence of zones, and comparing the sequences of zones to a lexical entry comprising a sequence of phonological segments to a stored lexicon to identify one or more words in the speech signal.

Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells, nuclei, whole chromosomes, or other sources of long DNA molecules. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.

Abstract: Method and apparatus to produce a step function with a designed transition (rise and/or fall) time on the order of <10 ns that reaches steady state by implementing a system that sums a number of currents at different rise times (frequencies) to generate the step function. The system also includes a passive output filter, composed of low resistance, inductance and very low capacitance to mitigate overshoot and high frequency noise.

Abstract: Provided herein is a method, a programmed computer and an article of manufacture for predicting a prenatal, neonatal, obstetric or childhood clinical event, disease or disorder, as well as a method for generating in-utero fetal and placental growth curves, using a continuous recursive algorithm housed in a computer and data periodically collected during pregnancy.

Abstract: Improved processes for the extraction of quassinoids such as quassin and neoquassin from natural substances containing these compounds are described. The process uses compounds that are Generally Recognized As Safe by the U.S. Food and Drug Administration. In a first embodiment, the process includes a sonication method using water and no organic solvent. The process is highly efficient and comprises fewer steps than other processes known in the art. In a second embodiment, a method of extracting quassinoids from natural substance comprising bark of a plant of the plant family Simaroubaceae is also disclosed. In a third embodiment, indirect sonication of quassinoids is described using a mixture of polar and non-polar organic solvents.

Abstract: Disclosed are a recombinant Corynebacterium glutamicum (C. glutamicum) for producing fucosyllactose which is transformed to express ?-1,2-fucosyltransferase, GDP-D-mannose-4,6-dehydratase (Gmd), GDP-L-fucose synthase (WcaG) and lactose permease (LacY), wherein the Corynebacterium glutamicum has phosphomannomutase and GTP-mannose-1-phosphate guanylyltransferase, and a method for producing fucosyllactose using the same. According to the recombinant Corynebacterium glutamicum and the method for producing fucosyllactose according to the present invention, with use of a GRAS Corynebacterium glutamicum strain, which is safer than conventional Escherichia coli, 2?-fucosyllactose can be produced at a high concentration while overcoming drawbacks of conventional methods associated with industrial inapplicability resulting from low production concentrations.

Abstract: A mixed reality viewing system includes a viewer configured to be secured to a steady platform and operable by a user to view a theme through the viewer. The viewer includes a display device, a user interface comprising a zoom control, and at least one sensor comprising at least one camera. The mixed reality viewing system also includes a computer graphics generation system communicatively coupled to the viewer. The computer graphics generation system is configured to generate streaming media of a real world environment based on image data captured via the at least one camera of the viewer, generate augmented reality graphics, virtual reality graphics, or both, superimposed on the streaming media of the real world environment, and transmit the streaming media of the real world environment along with the superimposed augmented reality graphics, virtual reality graphics, or both, to be displayed on the display device of the viewer.

Abstract: The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.

Abstract: Disclosed are substituted (4?-hydroxylphenyl)cycloalkane compounds and there use as selective agonists of the estrogen receptor beta isoform (ER?). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases associated with ER activity, such as proliferative diseases and disorders and/or psychiatric diseases or disorders.

Abstract: A system for surface patterning using a three dimensional holographic mask includes a light source configured to emit a light beam toward the holographic mask. The holographic mask can be formed as a topographical pattern on a transparent mask substrate. A semiconductor substrate can be positioned on an opposite site of the holographic mask as the light source and can be spaced apart from the holographic mask. The system can also include a base for supporting the semiconductor substrate.

Abstract: The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using scanning probe microscopy, to detect the analyte. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon.

Abstract: The present disclosure relates to a pre-5th-Generation (5G) or 5G communication system to be provided for supporting higher data rates Beyond 4th-Generation (4G) communication system such as Long Term Evolution (LTE). The present disclosure relates to a pre-5th-generation (5G) or 5G communication system to be provided for supporting higher data rates Beyond 4th-generation (4G) communication system such as long term evolution (LTE). According to various embodiments of the present disclosure, an apparatus in a wireless communication system comprises an antenna array configured to steer a first beam using antenna elements, and a lens including a first focal point and a second focal point. The lens is configured to generate a second beam of a plane wave by compensating for a phase error of the steered first beam passing through at least one of the first focal point or the second focal point.

Abstract: Eyeglasses are disclosed that include eyeglass frames and a pair of ophthalmic lenses mounted in the frames. The lenses include a dot pattern distributed across each lens, the dot pattern including an array of dots spaced apart by a distance of 1 mm or less, each dot having a maximum dimension of 0.3 mm or less, the dot pattern including a clear aperture free of dots having a maximum dimension of more than 1 mm, the clear aperture being aligned with a viewing axis of a wearer of the pair of eyeglasses.

Abstract: In this present disclosure, a computing implemented method is designed for predicting the effluent total nitrogen concentration (TN) in an urban wastewater treatment process (WWTP). The technology of this present disclosure is part of advanced manufacturing technology and belongs to both the field of control engineer and environment engineer. To improve the predicting efficiency, a recurrent self-organizing radial basis function (RBF) neural network (RSORBFNN) can adjust the structure and parameters simultaneously. This RSORBFNN is developed to implement this method, and then the proposed RSORBFNN-based method can predict the effluent TN concentration with acceptable accuracy. Moreover, online information of effluent TN concentration may be predicted by this computing implemented method to enhance the quality monitoring level to alleviate the current situation of wastewater and to strengthen the management of WWTP.

Abstract: The present disclosure discloses a processor security checking method, system and checking device. The processor security checking method includes: acquiring recording information of data read and write operations between a processor and a peripheral device, where the data read and write operation is a data read and write operation initiated by the processor or a data read and write operation initiated by the peripheral; and determining whether the processor is secure according to the recording information of the data read and write operation and an analysis result on the data read and write operation by the checking device. The embodiments of the present disclosure may detect hardware vulnerabilities and improve the security of hardware usage.

Abstract: A method measures a power characteristic at the one or more storage batteries, and controls the one or more batteries to selectively act as a generator to supply power to the power grid or to act as a load to draw power from the power grid in response to a predetermined disturbance in the power characteristic being detected. A system includes a battery charging circuit, a battery to grid circuit and a controller that monitors a power characteristic at the one or more storage batteries, and controls the one or more batteries to selectively act as a generator to supply power to the power grid or to act as a load to draw power from the power grid in response to a predetermined disturbance in the power characteristic being detected.