Abstract: A photolithography mask plate, the photolithography mask plate including: a substrate; a carbon nanotube layer on the substrate; a patterned chrome layer on the carbon nanotube layer, wherein the patterned chrome layer and the carbon nanotube layer have the same pattern; a cover layer on the patterned chrome layer.

Abstract: Multifunctional cancer targeting nanoparticles include a magnetic central core including gold coated iron oxide, an outer layer including trimethyl chitosan microspheres and folic acid and a linker between the central core and the outer layer, the linker including cysteamine. An anti-cancer drug can be supported by the outer layer. The multifunctional cancer targeting nanoparticle can provide simultaneous cancer cell diagnosis and therapy. An amount of heat and an amount of the anti-cancer drug released by the nanoparticle can be controlled by application of a magnetic field.

Abstract: Provided herein are compounds of Formula (I), Formula (II), and Formula (III), and compositions comprising the same, as well as methods of use thereof for controlling or inhibiting the formation of calcium oxalate kidney stones, inhibiting the production of glyoxylate and/or oxalate, and/or inhibiting hydroxyproline dehydrogenase (HYPDH).

Abstract: The tactile sensor of the present disclosure is an indirect optical sensor, comprising a frame, a sensing plate, a single beam LED light source, a miniature camera, and a grating plate in the sensing plate and the single light source illuminates the grating plate. Geometric interference fringes caused by the shadows of gratings and gratings, images taken by a miniature camera, through an innovative instantaneous steps phase shifting technique, which eliminates the need for any mechanical phase shifting device to detect the pressure and space. The position is measured and has fast and accurate tactile sensing. The advantage of this method is that directly shooting the moiré image while calculating the spatial position, temperature, and pressure. Instantaneous steps phase shifting technique can solve the problems of traditional mechanical stepping, non-instant and complex operation problems.

Abstract: Disclosed herein are bacterial proteins that increase pancreatic beta (?) cell number and/or proliferation, methods of increasing ? cell number and/or proliferation using such proteins, and methods of treating or inhibiting diabetes in a subject by administering such proteins to the subject. In some embodiments, the protein has at least 80% sequence identity to the amino acid sequence set forth as any one of SEQ ID NOs: 1-7, or fragments thereof. Recombinant vectors including a nucleic acid encoding the protein (such as a nucleic acid encoding a protein with at least 80% sequence identity to any one of SEQ ID NOs: 1-7 or fragments thereof) operably linked to a heterologous promoter are also disclosed. Also disclosed are methods of identifying compounds that increase ? cell number and/or proliferation by determining the effect of test compounds on ? cell number or proliferation in zebrafish pancreas.

Abstract: A method of estimating a battery state includes acquiring one or more parameters for estimating a present state of the battery based on a previous state of the battery; acquiring a present usage environment of the battery; and estimating the present state by applying any one or any combination of any two or more of the previous state, the present usage environment, and the acquired one or more parameters to an electrochemical model that is expressed by simplified parameters simplified by either one or both of parameter grouping and partial non-dimensionalising of an electrochemical reaction governing equation of the battery.

Abstract: Methods are provided for determining whether a cancer patient is likely or not likely to experience HFSR (hand foot skin reaction) from a therapy comprising administration of an effective amount of regorafenib or an equivalent thereof, the methods including screening a biological sample isolated from the patient for the rs2280789 polymorphism, and/or the rs3817655 polymorphism. Methods are further provided for identifying the clinical outcome of cancer patients following a therapy comprising regorafenib or an equivalent thereof, the methods entailing screening a biological sample isolated from the patient for the rs7527092 polymorphism, and/or rs2071559 polymorphism. After determining if a patient is likely to be successfully treated, the disclosure also provides methods for treating the patient.

Abstract: Disclosed is a microbattery having a substrate with a surface that includes an array of posts extending from the surface of the substrate to form a first electrode. An selectively-cured electrolyte forms a conformal coating over the surface of the substrate and the array of posts to provide a coated electrode. A second electrode substantially encases the coated electrode.

Abstract: A method for separating a carbon nanotube array grown on a growth substrate from the growth substrate includes providing a carbon nanotube array grown on the growth substrate. The carbon nanotube array includes a plurality of carbon nanotube, each of the plurality of carbon nanotubes includes a top end and a bottom end, and the bottom end is bonded to the growth substrate. The bottom end is oxidized to form an oxidized carbon nanotube array. And then the oxidized carbon nanotube array or the growth substrate is applied to a force.

Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea, or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer, wherein the soft segment includes a polyisobutylene macrodiol and/or diamine. Additionally disclosed is a method of forming a polyisobutylene-based thermoplastic urethane, comprising the steps of (a) reacting a polyisobutylene macrodiol and/or diamine with a diisocyanate to form a first reaction mixture; (b) combining a metal catalyst and a chain extender with the first reaction mixture to create a second reaction mixture, a molar ratio of the metal catalyst to the diisocyanate being greater than 0.0:1 and less than or equal to 0.4:1; and (c) reacting the second reaction mixture for a period of time sufficient to form the polyisobutylene-based thermoplastic urethane.

Abstract: A vibration-driven energy harvester includes: a fixed electrode; a movable electrode that is disposed so as to face opposite the fixed electrode and is allowed to move relative to the fixed electrode; and an ionic liquid disposed between the fixed electrode and the movable electrode which face opposite each other, wherein: power is generated as an external vibration moves the movable electrode, causing a change in at least one of an area of an electrical double layer formed on two sides of an interface of the fixed electrode and the ionic liquid and an area of an electrical double layer formed on two sides of an interface of the movable electrode and the ionic liquid.

Abstract: The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: The multi-leg fiber reinforced concrete is concrete in which fibers have been embedded to prevent the concrete from being fractured due to cracks developing therein. Each fiber has multiple legs, defining two and three dimensional structures. At least one fiber is embedded in a volume of concrete, where the at least one fiber has at least first and second legs respectively extending along first and second directions. The first and second directions are angularly oriented with respect to one another between 45° and 135°, with each of the first and second legs having a free end and a fixed end. Each free end has a substantially Z-shaped contour. The fixed ends of the first and second legs may be joined together to define a two-dimensional fiber structure. The at least one fiber may be partially coated with a polymeric material, such as polypropylene.

Abstract: The invention provides a method for inducing human primordial germ cell-like (PGC-like) cells from human pluripotent stem cells, with high efficiency and high reproducibility, and a cell surface marker for identifying human PGC-like cells. In particular, the invention provides a method for producing a human PGC-like cell from a human pluripotent stem cell, includes a step of producing a mesoderm-like cell by culturing a human pluripotent stem cell in a culture medium comprising activin A and a GSK3? inhibitor, and a step of culturing the mesoderm-like cell in a culture medium containing BMP. The invention also provides a method for producing an isolated human PGC-like cell, which includes the aforementioned two steps and the additional step of selecting a cell positive to at least one cell surface marker selected from the group consisting of PECAM (CD31), INTEGRIN?6 (CD49f), INTEGRIN?3 (CD61), KIT (CD117), EpCAM, PODOPLANIN and TRA1-81.

Abstract: Described herein is the finding that activators of CXCR3, such as proteins that bind CXCR3 (e.g., IP-9, IP-10 and PF4), enhance the density of goblet cells in the eye. Goblet cells in the conjunctiva are the primary source of tear mucus. Accordingly, the present disclosure describes methods of treating dry eye syndrome by administering an activator of CXCR3. Also described are methods of increasing goblet cells density, such as goblet cell density in the conjunctiva.

Abstract: An MRI pulse sequence is disclosed. The pulse sequence involves a plurality of slice selective pulses (51,55) which each individually have a desired rotation that is less than or equal to the total desired rotation. The slice selective pulses each cause a rotation about respective axes, which may be different to each other. Optionally phase correction (re-phasing) gradients (53, 56) can also be included in the pulse sequence.

Abstract: The present invention involves a test subject performing a sit-to-stand (STS) operation while wearing a device (MD) that contains an acceleration sensor (11) on the front of the chest. The present invention derives a muscular strength index (maximum acceleration value per unit of muscle mass during STS activity) representing the muscular strength of a human body by obtaining maximum acceleration value data from a signal expressing the size of an acceleration vector comprising a tri-axial component in detected acceleration, and using the maximum acceleration value data and the muscle mass or body fat mass of the text subject.

Abstract: Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The methods are useful for treating cancer and viral infection in a subject.

Abstract: Modular lens adapter system are provided for use with a hand held computer device having a camera for mobile ophthalmoscopy. The modular lens adapter systems include an anterior adapter and a posterior adapter configured to removably engage with a hand held computer device. The anterior adapter can include a variable intensity light source, a clamp, and a movable macro lens. The posterior adapter can include a hand held computer device mount, a lens mount, and a telescoping arm with a first end and a second end with the first end configured to removably engage with the mount and the second end configured to contact the lens mount. Methods are also provided for using the systems to obtain an image of an anterior portion of the patient's eye and a posterior portion of the patient's eye.

Abstract: The present invention relates to novel non-ferromagnetic amorphous steel alloys represented by the general formula: Fe—Mn-(Q)-B-M, wherein Q represents one or more elements selected from the group consisting of Sc, Y, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu, and M represents one or more elements selected from the group consisting of Cr, Co, Mo, C and Si. Typically the atomic percentage of the Q constituent is 10 or less. An aspect is to utilize these amorphous steels as coatings, rather than strictly bulk structural applications. In this fashion any structural metal alloy can be coated by various technologies by these alloys for protection from the environment. The resultant structures can utilize surface and bulk properties of the amorphous alloy.