Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.

Abstract: [Problem] The objectives of the present invention are to provide a method for making an animal that has been stressed, in particular, chronically stressed, affect or develop a specific disease or symptom, and, through elucidating the process from loading stress to affection or onset of the disease or symptom, to provide a useful tool for research and development of preventing or treating methods of the disease or symptom. [Solution] The present invention relates to a method for producing a disease modeling non-human animal having cerebrovascular inflammation, the disease modeling non-human animal, a method for screening a drug using the disease modeling non-human animal, a method for determining the risk of a disease using the presence of cerebrovascular inflammation as an indicator, and a pharmaceutical for preventing and/or treating progressive multiple sclerosis or the like.

Abstract: A switch bootstrap charging circuit suitable for a gate drive circuit of a GaN power device includes a high-voltage MOSFET, a low-voltage MOSFET, a high-voltage MOSFET control module, and a low-voltage MOSFET control module. The low-voltage MOSFET is a PMOS transistor, and the source of the low-voltage MOSFET is connected to the power supply voltage. The drain of the high-voltage MOSFET serves as an output terminal of the switch bootstrap charging circuit. The low-voltage MOSFET control module and the high-voltage MOSFET control module generate a gate drive signal of the low-voltage MOSFET and a gate drive signal of the high-voltage MOSFET according to the gate drive signal of the lower power transistor.

Abstract: A method of reducing the severity of abdominal adhesion due to surgical complications comprising: administering to said patient at least a first dose of trametinib between 0.01 mg to 2.0 mg, and after said surgical procedure, administering to said patient a further dose of trametinib between 0.01 mg to 2.0 mg, daily, for at least seven days post-surgery.

Abstract: Provided is a method for manufacturing an inorganic material having a tensile stress, which includes: forming an inorganic stressor from an inorganic wafer made of an inorganic matter; forming an inorganic layer on the inorganic stressor; and etching a bulk inorganic matter at a lower portion of the inorganic stressor to generate an inorganic material having a tensile stress, wherein the inorganic layer has a tensile stress by etching the bulk inorganic matter to relieve a compressive stress applied to the inorganic stressor when the inorganic stressor is being formed. Therefore, FET and various circuits having higher charge mobility may be realized, and also, since characteristics may be maintained even when being applied to a plastic substrate, high performance flexible electronic device may be manufactured.

Abstract: Duchenne muscular dystrophy (DMD) is an inherited X-linked disease caused by mutations in the gene encoding dystrophin, a protein required for muscle fiber integrity. The disclosure reports CRISPR/Cpf1-mediated gene editing (Myo-editing) is effective at correcting the dystrophin gene mutation in the mdx mice, a model for DMD. Further, the disclosure reports optimization of germline editing of mdx mice by engineering the permanent skipping of mutant exon and extending exon skipping to also correct the disease by post-natal delivery of adeno-associated virus (AAV). AAV-mediated Myo-editing can efficiently rescue the reading frame of dystrophin in mdx mice in vivo. The disclosure reports means of Myo-editing-mediated exon skipping has been successfully advanced from somatic tissues in mice to human DMD patients-derived iPSCs (induced pluripotent stem cells).

Abstract: An organic tellurium compound is disclosed having a versatility that, when used as a living radical polymerization initiator, it is applicable to polymerization of a vinyl monomer in an aqueous vehicle without using any surfactant or dispersant. The organic tellurium compound is represented by a general formula (1), where R1 and R2 each independently represent a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, A represents an alkali metal atom or an alkaline earth metal atom, x=1 when A is monovalent, x=½ when A is divalent, and R3 is represented by a general formula (2), where in the general formula (2) R4 represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, R5 and R6 each independently represent an alkylene group having 2 to 8 carbon atoms, and a represents an integer from 0 to 10.

Abstract: A novel sweat absorbing textile electrode comprises a textile electrode body and an electrical coupling member, the textile electrode body comprising a conductive foam and a conductive fabric wrapped around the conductive foam, the electrical coupling member being fixed on the conductive fabric; wherein a through hole is provided on the conductive fabric on the side in contact with the human skin. The textile electrode has a light weight, small size and soft texture. It fits on the skin, has good air permeability, and is capable to absorb sweat, which can prevent short circuit between electrodes caused by sweat and be used for collecting bioelectrical signal when sweat comes out from human body. It may also be applied in bioelectrical signal monitoring in high temperature, high humidity environment, and during daily exercise.

Abstract: A method of casting an article from a molten metal including: admitting molten metal to a mould formed from a foundry sand comprising a blend of silica sand and a zircon aggregate, the zircon aggregate exhibiting a sharp rise in linear thermal expansion coefficient in a temperature band above 1200° C. and up to 1600° C.; and cooling the mould and molten metal to solidify the molten metal and form a cast article, wherein one or more surfaces of the mould, or of a portion of the mould, in contact with the molten metal are uncoated.

Abstract: A multilayer encapsulation thin-film and a method and apparatus for preparing a multilayer encapsulation thin-film are provided.

Abstract: A line commutated converter (LCC) for a high voltage direct current power converter, the LCC comprising at least one LCC bridge circuit for connection to at least one terminal of a DC system, each bridge circuit comprising a plurality of arms, each associated with a respective phase of an AC system, each arm comprising: an upper thyristor valve or valves, and lower thyristor valve or valves connected in series; an associated branch extending from between the upper and lower thyristors; and at least one thyristor-based capacitor module for each phase, each module comprising a plurality of module thyristors, the or each capacitor module operable to insert a main capacitor into the respective arm of the bridge circuit by firing at least one or more of said module thyristors.

Abstract: A series elastic robotic limb may include an energy generator, an energy storage element, and a link assembly. The link assembly may include a plurality of links coupled, via one or more joints, at one or more pivot locations. The energy generator may output a first force that causes an accumulation of energy in the energy storage element while the link assembly is in a first configuration and transitions the link assembly from the first configuration to a second configuration. The energy storage element may release the energy accumulated in the energy storage element when the link assembly is in the second configuration. The link assembly in the second configuration may trigger a motion of the series elastic robotic limb by at least amplifying the first force output by the energy generator and a second force associated with the energy released from the energy storage element.

Abstract: The invention provides efficient cyclization processes of hydroxyalkenoic acids and products produced therefrom. The following reactions are claimed: Formula (I), (II), (V) and (VI).

Abstract: The present invention addresses the problem of solving problems of the conventional techniques and producing, by an economically advantageous means, fermented milk having hardness to such an extent that the texture of the fermented milk can be kept during distribution. The present invention relates to a method for producing fermented milk, comprising homogenizing a raw material mix under a high pressure to reduce the average particle diameter of a fat and then fermenting the homogenized product. More specifically, the present invention relates to: a method for producing fermented milk using a material that is sterilized at an ultra-high temperature, said method comprising homogenizing a fat in a raw material mix, which contains a material sterilized at an ultra-high temperature, under a high pressure and then fermenting the resultant product; and fermented milk produced by the method.

Abstract: Methods for treating intestinal inflammation and/or colon cancer include administering an amount of a broccoli-derived nanoparticle to a subject in need thereof. Pharmaceutical compositions comprising broccoli-derived nanoparticles are also provided. Further provided are methods for screening for a compound useful for treating a colon cancer that include the steps of contacting a provided intestinal epithelial cell with a test compound and measuring an amount of expression of COP9 signalsome subunit 8 (CSN8) in the intestinal epithelial cell to thereby identify the test compound as useful for treating colon cancer.

Abstract: The present application relates to a terahertz transmitting antenna including a microstrip feed line, a substrate, at least two antenna switches, at least one conducting plate, an insulating layer and at least two antenna patches. The terahertz transmitting antenna is provided with at least two antenna switches and at least two corresponding antenna patches, which substantially increases a transmitting bandwidth and a corresponding transmitting power of the terahertz transmitting antenna. The terahertz transmitting antenna with the increased transmitting bandwidth and the increased transmitting power can be applied to a small sized terahertz spectral detection device to assist the transmitting source to transmit the signal in the terahertz band. The terahertz transmitting antenna adopting the multi-frequency switching technology can reduce an operation time of a spectral fingerprint recognition algorithm to rapid identify specific target substances.

Abstract: Methods are described herein for isolating clonal populations of T cells having a defined genetic modification. The methods are performed, at least in part, in a microfluidic device comprising one or more sequestration pens. The methods include the steps of: maintaining individual T cells (or precursors thereof) that have undergone a genomic editing process in corresponding sequestration pens of a microfluidic device; expanding the T cells into respective clonal populations of T cells; detecting, in one or more T cells of each clonal population, the absence of a cell surface marker that was present in the individual T cells (or precursors thereof); and detecting, in one or more T cells of each clonal population, the presence of a first nucleic acid sequence that is indicative of the presence of an on-target genome edit in the clonal population of T cells. Also described are compositions comprising one or more clonal populations of T cells isolated according to the methods disclosed herein.

Abstract: Provided herein are polypeptides comprising membrane-anchored IL-12. Also provided herein are T cells expressing the membrane-anchored IL-12. Further, methods of treating cancer comprising administering T cells expressing membrane-anchored IL-12 are provided herein. Also provided are combination treatments comprising T cells expressing membrane-anchored IL-12 and T cell chemoattractant-inducing chemokines. In addition, methods are provided for activating T cells to express NKG2D and methods of their use in the treatment of cancer.

Abstract: Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore system to cause the polymer to interact with the nanopore tunnel. The ion current through the nanopore is measured to provide a current pattern reflective of the structure of the portion of the polymer interacting with the nanopore tunnel. This is used as a metric for characterizing the associated protein that does not pass through the nanopore.

Abstract: A scoring method includes steps of: storing a word list in a database of a computer; storing word vector combinations in the database; extracting a keyword from a submitted answer, and looking up, in the word list, a word vector that corresponds to a word which conforms with the keyword; and obtaining, from the database, one of the word vector combinations, and calculating, for each of benchmark nouns of the one of the word vector combinations thus obtained, a semantic distance between the keyword and the benchmark noun based on word vectors respectively corresponding to the keyword and the benchmark noun, and calculating an originality score based on the semantic distances of the respective benchmark nouns thus calculated.