Abstract: An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.

Abstract: The present technology describes various embodiments of positron emission tomography (PET) systems for use with mammography machines and associated devices and methods. In several embodiments, a PET system includes a tissue platform and one or more PET detection panels removably coupled to the mammography machine. The panels are configured to generally surround the tissue platform and obtain an approximately 360 degree data sample of tissue. The system can further include an output device configured to output the data sample for image reconstruction. In some embodiments, the system is configured to provide high resolution images, quantitative image accuracy, dynamic imaging, and/or biopsy guidance.

Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic that increases proportionally with respect to increasing azimuth angle of the segment.

Abstract: A method for establishing semantic equivalence between a plurality of concepts including: providing an Orthogonal Semantic Equivalence Map in which first, second, and third extensional concept models are related; selecting or de-selecting a concept in the first concept model; selecting or deselecting a (relation, concept) pair representing an intensional relation from a concept in the first concept model to a concept in the second concept model over a concept in the third concept model; determining a subset of intensional relations from the selected concepts in the first concept model to concepts in the second concept model; determining a set of concepts from the first concept model that are related to concepts in the second concept model over the selected (relation, concept) pairs; and determining the narrowest common extension of the set of concepts from the first, second, or third concept models that are related over the selected intensional relations.

Abstract: The invention relates to the field of drilling fluid, and discloses a strong plugging drilling fluid composition and preparation method thereof, and use thereof. The strong plugging drilling fluid composition comprises water, bentonite, Na2CO3, a shale inhibitor, a filtrate reducer, a viscosity reducer, an anti-collapse agent, a nanometer plugging agent, a lubricant and a weighting agent. The shale inhibitor is modified asphalt, the anti-collapse agent is ultra-fine calcium carbonate, and the nanometer plugging agent is polyethylene glycol surface-modified nano-graphene.

Abstract: Disclosed herein are methods for decreasing Ataxin 2 mRNA and protein expression. Such methods are useful to treat, prevent, or ameliorate Ataxin 2 associated diseases, disorders, and conditions. Such Ataxin 2 associated diseases include spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis (ALS), and parkinsonism.

Abstract: The present invention relates to compositions and methods of use thereof for inhibiting mutant HTT mRNA transcription or CAG-expanded HTT protein expression in a cell, comprising contacting the cell with an effective amount of an oligomer targeting a differentiating polymorphism, wherein the differentiating polymorphism is selected from rs72239206, rs363107, rs362313, rs2530595, rs113407847. Specific oligomer sequences are also provided.

Abstract: The present disclosure provides an ion migration tube and a method of operation the same. The ion migration tube includes an interior space and an ion gate disposed within the interior space, the interior space includes an ionization region having an absolute value of potential V1 and a migration region. An ion gate is disposed between the ionization region and the migration region and includes a first ion gate grid having an absolute value of potential V2 and a second ion gate grid having an absolute value of potential V3, the migration region comprises at least a first migration region electrode having an absolute value of potential V4 and a second migration region electrode having an absolute value of potential V5. When the ion gate is opened, a potential well is formed for ionized ions between the first ion gate grid and the first migration region electrode so as to compress an ion group entering the migration region.

Abstract: A robotic device for providing vertical mobility has a payload is disposed inside a central compartment and supported by a skid. The skid can move up and down through latch and hook pairs to keep intimate contact with the surface and cross over bumps. The apparatus uses a flexible seal to create a reliable vacuum chamber. The flexible seal comprises a foam ring inside fabric pocket. A plurality of rod and spring strips are configured to apply a downward force to the flexible seal to conform with surface curvatures. The fabric pocket fills in the gaps or seams to maintain a vacuum. The air flows inside a manifold and passes through a filter to avoid debris from damaging the vacuum motor assembly.

Abstract: A method of growing an AlGaN semiconductor material utilizes an excess of Ga above the stoichiometric amount typically used. The excess Ga results in the formation of band structure potential fluctuations that improve the efficiency of radiative recombination and increase light generation of optoelectronic devices, in particular ultraviolet light emitting diodes, made using the method. Several improvements in UV LED design and performance are also provided for use together with the excess Ga growth method. Devices made with the method can be used for water purification, surface sterilization, communications, and data storage and retrieval.

Abstract: Disclosed herein are optical sensor platform(s) employing hyperbolic metamaterial(s) supporting highly confined bulk plasmon guided modes over broad wavelength range(s) from visible to near-infrared. By exciting these modes using—for example—a two-dimensional (2D) grating-coupling technique, sensors according to the present disclosure advantageously exhibit extreme sensitivity modes up to a maximum of 30,000 nm per refractive index unit and a record figure of merit of 590 thereby permitting detection of ultralow-molecular-weight bio-molecules at picomolar concentrations.

Abstract: A solar chemically recuperated gas turbine system includes an exhaust-gas reformer, a solar reformer and a gas turbine unit with a combustion chamber. The reaction outlet of the exhaust-gas reformer is connected to the inlet of the solar reformer, the flue gas side inlet of the exhaust-gas reformer is connected to the exhaust-gas outlet of the gas turbine. The solar reformer outlet is connected to the combustion chamber inlet. Combustion gas drives the gas turbine after fuel burns in the combustion chamber, and the exhaust gas enters the exhaust-gas reformer. Fuel and steam are mixed and enter the reaction side of the exhaust-gas reformer through a fuel inlet. A reforming reaction between the fuel and steam under heating of the exhaust gas generates syngas. A further reforming reaction occurs by absorbing concentrated solar energy after the syngas enters the solar reformer, and the reactant is provided to combustion chamber.

Abstract: The present disclosure provides antibacterial prodrugs and methods of making and using the same.

Abstract: Herein disclosed is an economical standalone system that replaces conventional monomer purification methods needed to perform chemical reactions that require reactants with a high degree of purity. Chemical reactions, such as anionic polymerization, can produce highly monodisperse homopolymers and block copolymers, however to do so they require very high purity reactants along with a moisture and oxygen free atmosphere. The system and method uses traditional column purification methods, but incorporates them into an economical, standalone, compact, and hazard free system. This method is different in view of safety, cost of cleaning procedure, time commitment, space availability, design and operational ease; helping researchers save time by cutting down the operating commitment by 90% and most importantly making it safer.

Abstract: Universal linear components are provided. In general, a P input and Q output wave combiner is connected to a Q input and R output wave mode synthesizer via Q amplitude and/or phase modulators. The wave combiner and wave mode synthesizer are both linear, reciprocal and lossless. The wave combiner and wave mode synthesizer can be implemented using waveguide technology. This device can provide any desired linear transformation of spatial modes between its inputs and its outputs. This capability can be generalized to any linear transformation by using representation converters to convert other quantities to spatial mode patterns. The wave combiner and wave mode synthesizer are also useful separately, and can enable applications including self-adjusting mode coupling, optimal multi-mode communication, and add-drop capability in a multi-mode system. Control of the wave combiner and wave mode synthesizer can be implemented with single-variable optimizations.

Abstract: In certain embodiments, vision defect information may be generated via a dynamic eye-characteristic-based fixation point. In some embodiments, a first stimulus may be displayed at a first location on a user interface based on a fixation point for a visual test presentation. The fixation point for the visual test presentation may be adjusted during the visual test presentation based on eye characteristic information related to a user. As an example, the eye characteristic information may indicate a characteristic of an eye of the user that occurred during the visual test presentation. A second stimulus may be displayed during the visual test presentation at a second interface location on the user interface based on the adjusted fixation point for the visual test presentation. Vision defect information associated with the user may be generated based on feedback information indicating feedback related to the first stimulus and feedback related to the second stimulus.

Abstract: In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (ADCs) developed from these antibodies for diagnostic and/or therapeutic targeting of CD46-overexpressing tumors.

Abstract: An electrodeless LED display and a method for fabricating the same are disclosed. In the method, an epitaxial layer is provided and a transparent conduction layer is formed on the epitaxial layer to bond a substrate. The epitaxial layer is etched to form dies deposition metal films on the transparent conduction layer. Conduction channels are formed on the substrate, and two ends of each conduction channel are respectively provided two conduction metal blocks. First metal members are formed on the metal film formed on the dies and the conduction metal blocks to connect with the dies on the different conduction channels. Then, second metal members are formed on the first metal members formed on the conduction metal blocks, whereby the second metal members and the first metal members formed on the dies are located on an identical plane.

Abstract: A system includes a transmitter coupled to a vehicle and a client system. The transmitter broadcasts a wireless signal. The client system includes a receiver that receives the wireless signal from the transmitter. The client system determines an identifier within the wireless signal, compares the identifier within the wireless signal to a list of identifiers, and in response to determining that the identifier within the wireless signal matches a particular identifier within the list of identifiers, generates an alert that the vehicle is approaching.

Abstract: A sample holding device and related method designed to facilitate inexpensive and reliable testing of materials or specimens with beam diffraction and scattering techniques. The device features a sample receptacle that is made out of a polymer, cellulose, polymeric material, or cellulosic material. The flexible nature and low melting point of the sample receptacle allows for reliable sealing against the vacuum or gaseous environment used for beam diffraction or scattering analysis. The sample holding device can be considered disposable because of its low cost, eliminating the need for complex or unreliable cleaning procedures.