Patents Assigned to University
  • Small molecule inhibitors of protein tyrosine phosphatases and uses thereof
    Patent number: 10532977
    Abstract: Small molecule compounds derived from ?-sulfophenylacetic amide (SPAA) are provided as novel sulfonic acid based pTyr mimetics. These compounds effectively inhibit a variety of protein tyrosine phosphatases (PTPs), such as mPTPA, mPTPB, LMWPTP, and Laforin. Use of these compounds as pharmaceutical agents for treating diseases associated with abnormal protein tyrosine phosphatase activity is also provided.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: January 14, 2020
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Zhong-Yin Zhang, Rongjun He
  • Recombinant nucleoside-specific ribonuclease and method of producing and using same
    Patent number: 10533163
    Abstract: A recombinant ribonuclease is disclosed. The recombinant ribonuclease is produced by introducing a recombinant DNA sequence into a host; activating expression of the recombinant DNA sequence within the host to produce the recombinant ribonuclease; and isolating the recombinant ribonuclease from the host. Additionally, a method of analyzing an RNA sequence includes digesting the RNA with a first recombinant ribonuclease to give digestion products comprising nucleotides of the RNA sequence; and analyzing the digestion products using an analytical method to provide the identity of at least some of the nucleotides. The recombinant ribonuclease includes at least one of a uridine-specific recombinant RNase MC1 and a cytidine-specific recombinant RNase Cusativin.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: January 14, 2020
    Assignee: University of Cincinnati
    Inventors: Sarah Venus, Balasubrahmanyam Addepalli, Nicholas Paul Lesner, Patrick Alan Limbach
  • Compositions, kits, and methods for identification, assessment, prevention and therapy of breast and ovarian cancer
    Patent number: 10533227
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast or ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast or ovarian cancers are provided.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: January 14, 2020
    Assignees: Millennium Pharmaceuticals, Inc., Board of Regents, University of Texas System
    Inventors: Ole Petter Veiby, Robert C. Bast, Gordon B. Mills, Gabriel N. Hortobagyi
  • Magnetic memory physically unclonable functions
    Patent number: 10536281
    Abstract: A magnetic random access memory (MRAM) physically unclonable function (PUF) device that uses the geometric variations in magnetic memory cells to generate a random PUF response is described herein. Within the MRAM, one or more magnetic memory cells can be used for the PUF. The PUF response is generated by destabilizing the one or more magnetic memory cells and then allowing them to relax. The MRAM PUF has also a relatively small footprint among all other silicon PUFs. Timing and control signals for the MRAM PUF are also described along with power and delay characteristics for use with field and spin transfer torque driven destabilization operations.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: January 14, 2020
    Assignee: University of South Florida
    Inventors: Jayita Das, Kevin P. Scott, Drew H. Burgett, Srinath Rajaram, Sanjukta Bhanja
  • Substituted indole Mcl-1 inhibitors
    Patent number: 10533010
    Abstract: The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: January 14, 2020
    Assignee: Vanderbilt University
    Inventors: Taekyu Lee, Zhiguo Bian, Johannes Belmar, Plamen P. Christov, Nicholas F. Pelz, Subrata Shaw, Kwangho Kim, James C. Tarr, Edward T. Olejniczak, Bin Zhao, Stephen W. Fesik
  • Methods of reducing TDP-43-mediated neuronal cytotoxicity in amyotrophic lateral sclerosis by a UPF1 polypeptide or polynucleotide
    Patent number: 10533038
    Abstract: Nonsense-mediated mRNA decay (NMD) polypeptides, nucleic acids encoding NMD polypeptides, and methods of using such polypeptides and nucleic acids in the treatment of ALS and in screening for agents for the treatment of ALS are described.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: January 14, 2020
    Assignee: Brandeis University
    Inventors: Greg Petsko, Dagmar Ringe, Shulin Ju
  • Peptide-DNA chimeras for treatment of HER overexpressing cancers
    Patent number: 10532109
    Abstract: Provided herein are therapeutic agents having specificity for having inhibitory activity against cancer cells that overexpress human epidermal growth factor receptor (HER) genes, including therapeutic agents comprising one or more HER-targeting peptides, pharmaceutical compositions comprising such therapeutic agents, and methods of using such compositions to treat or prevent a cancer or other disease condition associated with HER overexpression.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: January 14, 2020
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Shengxi Chen, Yanmin Zhang, Sidney Hecht
  • Thixotropic processing of magnesium composites with a nanoparticles-haloed grain structure for biomedical implant applications
    Patent number: 10532134
    Abstract: In described embodiments, the present invention includes a magnesium-based composite material formed from a plurality of ?-phase magnesium grains; and a ?-alloy phase comprising magnesium and nano-diamond and/or and phosphate containing nanoparticles, the ?-alloy phase surrounding each of the plurality of magnesium grains. A method of manufacturing a composite material is also disclosed.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: January 14, 2020
    Assignee: Drexel University
    Inventors: Gongyao Zhou, Haibo Gong, Donggang Yao
  • Biomedical materials
    Patent number: 10532114
    Abstract: A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprises a compound having the general chemical formula: Ca10?yGdy(PO4)6?x(SiO4)x(OH)2?c+y where 0<x<1.3 and 0<y<1.3.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: January 14, 2020
    Assignees: ApaTech Limited, University Court of the University of Aberdeen
    Inventors: Iain Ronald Gibson, Janet Mabel Scott Skakle, Nigel Smith, Thomas Buckland
  • FMRI biomarker of neurodegenerative disease
    Patent number: 10534052
    Abstract: Provided herein are methods related to identifying an early, asymptomatic (prodromal) stage of a neurodegenerative disease or identifying a subject with a symptomatic neurodegenerative disease, including, for example, mild cognitive impairment (MCI), Alzheimer's Disease (AD), or HIV-associated neurocognitive disorder (HAND), using functional MRI data from the subject. Methods are also provided for treating a subject identified with the methods taught herein and for modifying or selecting treatment based on the results of fMRI. Methods are also available for staging neurodegenerative disease and for identifying agents useful in treating them.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 14, 2020
    Assignee: Georgetown University
    Inventors: Xiong Jiang, Maximilian Riesenhuber
  • Reperfusion protection solution and uses thereof
    Patent number: 10531655
    Abstract: In various embodiments a reperfusion protection solution (RPS) is provided along with methods of use thereof. Illustrative reperfusion protection solutions include, but are not limited to a buffer; one or more substrates for the synthesis of adenosine triphosphate (ATP) under anaerobic conditions; citrate-phosphate-dextrose (CPD); and one or more amino acids that stabilize cell membranes. Typically the pH of the organ reperfusion protection solution ranges from about pH 8.1 to about pH 8.4.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: January 14, 2020
    Assignee: The Regents of the University of California
    Inventor: Johnny C. Hong
  • Method and device for transmitting uplink control signal in wireless communication system
    Patent number: 10536256
    Abstract: Disclosed is a 5G or pre-5G communication system for supporting a data transmission rate higher than that of a 4G communication system, such as LTE, and subsequent systems, and a method for transmitting an uplink control signal in a wireless communication system comprises the steps of: transmitting information indicating a first frequency domain to which an uplink control signal is transmitted from a base station, which has determined to perform full-duplex based communication; and performing downlink reception through the remaining frequency domains excluding the first frequency domain.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: January 14, 2020
    Assignees: Samsung Electronics Co., Ltd., Yonsei University-Industry Foundation
    Inventors: Hyoung-Ju Ji, Dae-Sik Hong, Youn-Sun Kim, Jong-Hyun Bang, Hyun-Soo Kim
  • Headlamp for healthcare workers
    Patent number: 10533732
    Abstract: A headlight (1) for a healthcare worker includes: a base part (10), which has a U-shape, is configured to come into abutment, at a center part of the base part (10), with a back side of a head and neck part of a wearer, and includes a right end part (11) and a left end part (11), each of which is configured to be hung on an upper part of an ear so that the base part (10) is retained on a head; a light source device (20), which extends from both or any one of a vicinity of the end parts (11), includes LEDs as light sources, and is configured to illuminate a region in front of the head; and a controller (30) configured to control an illumination state of the light source device (20). The controller (30) is configured to light the light source device (20) when the base part (10) reaches a predetermined depression angle with a standing state of the wearer serving as a reference.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: January 14, 2020
    Assignees: National University Corporation Shimane University, Do Light Co., Ltd.
    Inventors: Morihiko Nakamura, Makie Yano, Hiroyuki Tanaka
  • Methods and compositions for restoration of cone function in BCM
    Patent number: 10533187
    Abstract: Provided are nucleic acid sequences, recombinant adeno-associated viral particles, compositions, and methods related to treating cone monochromacies, such as blue cone monochromacy (BCM). Specifically, the nucleic acid sequences, recombinant adeno-associated viral particles, compositions, and methods involve use of an M-opsin gene operably linked to a cone-specific promoter. Further disclosed is the sequence of a cone-specific PR2.1 promoter.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: January 14, 2020
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: William W. Hauswirth, Ji-Jing Pang
  • Apparatus and method for positioning terminal in wireless communication system
    Patent number: 10536924
    Abstract: The present disclosure relates to a pre-5th-Generation (5G) or 5G communication system to be provided for supporting higher data rates Beyond 4th-Generation (4G) communication system such as Long Term Evolution (LTE). A method for operating of a terminal in a wireless communication system according to an exemplary embodiment includes: receiving signals from other terminals; selecting another terminal which has proximity to the terminal from among the other terminals based on reception powers of the signals and information related to the signals; and determining a location of the terminal based on location information of the other terminals.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: January 14, 2020
    Assignees: Samsung Electronics Co., Ltd., Research & Business Foundation Sungkyunkwan University
    Inventors: Wonjun Hwang, Hyung-Jin Choi, Han Jun Kim, Kyunghoon Lee, Hyunseok Ryu, Min Jang
  • Method of making CoOnanorods for electrocatalytic water splitting
    Patent number: 10533258
    Abstract: A method of making Co3O4 nanorods by thermal decomposition of a cobalt salt is described. A method of using Co3O4 nanorods as an electrocatalyst component to a porous carbon electrode is also described. The carbon electrode may be made of carbonized filter paper. Together, this carbon-supported Co3O4 electrode may be used for water electrolysis.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: January 14, 2020
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Md. Abdul Aziz, Mohammed Ameen Ahmed Qasem
  • Compounds for inhibition of fungal mycotoxin and sporulation
    Patent number: 10531662
    Abstract: Compounds and compositions are described herein that inhibit the biosynthesis of mycotoxins and fungal sporulation. Such compounds and compositions are useful for inhibiting mold. Methods of using such compounds and compositions are also described herein that involve applying the compositions to plants, plant parts, structures, containers, and other surfaces.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: January 14, 2020
    Assignees: Board of Trustees of Michigan State University, Sokoine University of Agriculture
    Inventors: Gale M. Strasburg, Juma A. Mmongoyo, John E. Linz, Felicia Wu, Jovin K. Mugula, Amila A. Dissanayake, Chuan-Rui Zhang, Josephine M. Wee, Muraleedharan G. Nair, Devin M. Day
  • Shape memory polymers and methods of use
    Patent number: 10532125
    Abstract: The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: January 14, 2020
    Assignee: Vanderbilt University
    Inventors: Hak-Joon Sung, Timothy C. Boire, Mukesh K. Gupta, Angela L. Zachman, Sue Hyun-Lee, Colleen M. Brophy
  • Dual catalyst system for propylene production
    Patent number: 10532347
    Abstract: Embodiments of processes for producing propylene utilize a dual catalyst system comprising a mesoporous silica catalyst impregnated with metal oxide and a mordenite framework inverted (MFI) structured silica catalyst downstream of the mesoporous silica catalyst, where the mesoporous silica catalyst includes a pore size distribution of at least 2.5 nm to 40 nm and a total pore volume of at least 0.600 cm3/g, and the MFI structured silica catalyst has a total acidity of 0.001 mmol/g to 0.1 mmol/g. The propylene is produced from the butene stream via metathesis by contacting the mesoporous silica catalyst and subsequent cracking by contacting the MFI structured silica catalyst.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: January 14, 2020
    Assignees: Saudi Arabian Oil Company, King Fahd University of Petroleum & Minerals
    Inventors: Sulaiman Saleh Al-Khattaf, Arudra Palani, Tazul Islam Bhuiyan, Sohel Shaikh, Mohammad Naseem Akhtar, Abdullah M. Aitani, Mohammed A. Al-Yami
  • Dual energy x-ray coronary calcium grading
    Patent number: 10531851
    Abstract: Methods and apparatus for grading coronary calcium, including an example apparatus that includes a set of logics and a memory that stores a set of radiographic images. The set of logics includes an image acquisition logic that acquires a set of radiographic images of a region of tissue, the set of radiographic images including a low-energy reference x-ray image and a higher-energy floating x-ray image, a registration logic that produces a set of registered images from a plurality of members of the set of radiographic images, an enhancement logic that produces a set of calcium-enhanced images from the set of registered images, a post-enhancement logic that produces a bone image from the set of calcium-enhanced images, and a grading logic that computes a coronary heart disease prediction score based, at least in part, on the bone image and a set of features extracted from the bone image.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: January 14, 2020
    Assignee: Case Western Reserve University
    Inventors: David Wilson, Robert Gilkeson, Di Wen