Abstract: The present disclosure is directed to antibodies binding to human respiratory syncytial virus F protein, including both neutralizing and non-neutralizing antibodies, and methods for use thereof.

Abstract: Shielding enzymes are made by modifying the enzyme surface with silica precursors and then depositing silica to a desired thickness while retaining biological activity of the enzyme.

Abstract: According to some embodiments of the present invention, a method of producing an organic-inorganic perovskite thin film includes depositing a layer of inorganic material on a substrate to form an inorganic film, and performing an organic vapor treatment of the inorganic film to produce an organic-inorganic perovskite thin film. The layer of inorganic material comprises an inorganic anion layer having a metal-ligand framework, and the organic vapor treatment provides organic cations capable of becoming inserted into the metal-ligand framework of the inorganic anion layer to form a perovskite structure.

Abstract: A palm-type mechanical gripper with variable-position and rotatable fingers and a dual-drive crank-slider parallel mechanism is provided with a crank-slider mechanism on the left side, which is an active driving structure and is driven by two stepping motors to respectively generate angular displacement of cranks and to change lengths of connecting rods, and a crank-slider mechanism on the right side, which is a driven mechanism and is driven at a constant speed by a pair of gears. The mechanical gripper is provided with three plate spring fingers, wherein two fingers are respectively installed on the connecting rods on left and right sides, and under the cooperative effect of the two stepping motors, the eccentricities of the cranks, the positions and angles of the two fingers respectively on the two connecting rods and the position of the other fixed finger can be changed through manual adjustment.

Abstract: A thermal method of forming ferric oxide nano/microparticles with predominant morphology is described using different solvents. Methods of using the Fe3O4 nano/microparticles as catalysts in the reduction of nitro compounds with sodium borohydride to the corresponding amines and decomposition of ammonium salts.

Abstract: Provided is an apparatus for training a facial-locality super resolution deep neural network, the apparatus including a generator configured to receive a low-resolution image and convert the received low-resolution image into a fake high-resolution image similar to an original high-resolution image, a discriminator configured to compare the fake high-resolution image output from the generator with the original high-resolution image to determine authenticity, and a facial-locality loss term configured to calculate a loss that is to be minimized by the generator according to the authenticity output from the discriminator, wherein the generator is an artificial neural network learning model that learns while adjusting a weight to minimize the loss, and the facial-locality loss term calculates the loss of the generator by reflecting pixel information about a feature region of a face.

Abstract: A method for obtaining magnetic resonance imaging (MRI) echo-planar image (EPI) data, including providing a homogeneous, static background field; providing a gradient field to select a slice of an object for imaging; applying Radio-frequency (RF) pulses to excite magnetic resonance in the selected slice; and measuring a radio frequency signal emitted by the selected slice containing image data. The RF pulses are repeatedly applied separated by a time period shorter than a recovery time of static material in the selected slice such that the static material remains in a state of magnetic saturation, while dynamic material arriving within the slice since a previous RF pulse is not magnetically saturated.

Abstract: A method for forming hollow silica spheres by dissolving a hydrolyzable aryl silane in an aqueous solution of water and an acid to form a hydrolyzed silane solution, mixing the hydrolyzed silane solution with a hydroxide base to form a precipitate, and calcining the precipitate in a multi-stage calcination procedure that includes (a) heating to a first temperature of 180 to 240° C. with a first ramp rate of 3 to 10° C./min and holding the first temperature for 2 minutes to 2 hours, then (b) heating to a second temperature of 600 to 740° C. at a second ramp rate of 0.1 to 4° C./min, and holding the second temperature for 2 to 24 hours.

Abstract: Disclosed a method of fabricating a gallium nitride substrate using hydride vapor phase epitaxy (HVPE), including a step of injecting ammonia (NH3) gas to perform first surface treatment on a sapphire substrate; a step of injecting ammonia gas and hydrogen chloride (HCl) gas to form a buffer layer on the sapphire substrate; a step of injecting ammonia gas to perform second surface treatment on the sapphire substrate; and a step of allowing gallium nitride (GaN) to grow on the sapphire substrate while lowering the flow rate ratio of ammonia gas to hydrogen chloride gas stepwise.

Abstract: The present inventors have found microRNAs which are strongly associated with stabilization of NRF2 in tumors, and an object of the present invention is to provide means for utilizing such miRNAs for the diagnosis and treatment of cancer. The inventors conducted screening of 470 microRNAs in a microRNA library by use of HeLa cells. As a result, 8 miRNAs each exhibiting a large decrease in miRNA activity as compared with a control miRNA, and 8 miRNAs each exhibiting a large increase in miRNA activity as compared with a control miRNA, were identified. The inventors have found that the NRF2 activation in the living body, in particular tumor cells, can be detected by use of the thus-identified miRNAs, whereby malignancy of a tumor, or the like can be differentiated. The inventors have also found that a nucleic acid including a miRNA sequence associated with reduction in the aforementioned ARE activity can be used as a cancer therapeutic agent.

Abstract: A system of tracking medication is disclosed such that the system includes a container with at least one compartment operable to contain at least one medication for administering at predetermined times, at least one sensor coupled to the container, the sensor operable to measure changes in an environment of the container, at least one microcontroller coupled to the sensor, the microcontroller operable to capture and store data recorded by the sensor, a cloud computing infrastructure, at least one wireless module coupled to the cloud computing infrastructure and the microcontroller, the wireless module operable to send and retrieve the data to and from the cloud computing infrastructure and the microcontroller, and a computing device coupled to the wireless module, the computing device operable to track the at least one medication by interacting with the data stored in at least one of the microcontroller or the cloud computing infrastructure.

Abstract: A room temperature nitrogen dioxide gas sensor comprising tin(IV) oxide decorated with gold nanoparticles is described. The tin(IV) oxide may have an average layer thickness of 10-1,000 nm, and is topped with dispersed gold nanoparticles having an average longest dimension of 200-650 nm. The room temperature nitrogen dioxide gas sensor may be used to detect and measure levels of nitrogen dioxide gas at room temperature and at concentrations of 100 ppb-1800 ppm, with a high stability. A method of making the room temperature nitrogen dioxide sensor is also described, and involves sputtering to deposit a tin(IV) oxide layer and a gold layer on a substrate, followed by annealing.

Abstract: Various embodiments provide for the implementation of volumetric diffractive optics equivalent functionality via cascaded planar elements. To illustrate the principle, a design 3D diffractive optics and implement a two-layer continuous phase-only design on a single spatial light modulator (SLM) with a folded system. The system provides dynamic and efficient multiplexing capability. Numerical and experimental results show this approach improves system performance such as diffraction efficiency, spatial/spectral selectivity, and number of multiplexing functions relative to 2D devices while providing dynamic large space-bandwidth relative to current static volume diffractive optics. The limitations and capabilities of dynamic 3D diffractive optics are discussed.

Abstract: Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to a target sequence in a retrovirus and a receptor used by a retrovirus for infecting a cell. The CRISPR construct edits, for example, proviral HIV DNA, thereby eliminating the provirus from an infected cell and simultaneously edits a viral receptor, e.g. CCR5 preventing infection and reinfection of the host.

Abstract: Disclosed are an apparatus and a method for gait type classification using a pressure sensor of a smart insole, which are capable of classifying pieces of gait data having various variances using only a pressure sensor. The apparatus for gait type classification includes a gait data measuring part configured to measure pieces of gait data using a pressure sensor, a pre-processor configured to define a section of a unit step in all the pieces of gait data, divide the pieces of gait data for each unit step, and normalize the pieces of divided gait data to equalize lengths of the pieces of divided gait data, and a feature extractor configured to extract features suitable for gait type classification from the pieces of pre-processed gait data, and a gait type classifier configured to receive the extracted features as an input and determine and classify a final gait type.

Abstract: Provided are methods involving combination therapy comprising administering to an individual in need thereof an antibody that preferentially depletes human B10 cells and an immune checkpoint inhibitor. Antibodies for use in the methods are also provided.

Abstract: A molecular kinetics evaluation method is provided which involves: a step for dosing a human or non-human animal with a proteolysis-inducing molecule, which is a conjugate of a proteolysis induction tag, i.e., a molecule which has affinity for protease and which does not inhibit proteolysis by protease, and a specific protein affinity molecule having affinity to a specific protein, and inducing proteolysis of the specific protein in vivo in the human or non-human animal; and a step for evaluating the molecular kinetics of the specific protein affinity molecules or the proteolysis-inducing molecules by detecting proteolysis of the specific proteins in a sample which is at least part of the human or non-human animal.

Abstract: An improved hyperspectral Raman imaging system and device that obtains full scale Raman images from a sample surface in seconds, wherein the dichromic mirror is located between the objective lens and sample surface. The laser is delivered to the sample surface and the Raman image is collected and transmitted through optic fiber to a camera after filtration. By delivering the laser to the sample without going through the objective lens, a high-power laser can safely illuminate the full field of view of the objective lens, allowing for safe Raman imaging within seconds. This fast and safe Raman imaging system can be used for, among other applications, the early detection of dental caries in practical settings.

Abstract: A spa apparatus may comprise a cart, a magnifying lamp, a phototherapy mask, a bed, and a bathtub. A computer, a storage battery, and a communicator are electrically connected and installed inside the cart, and the cart is electrically connected to a power outlet and a display, which enables the cart to be moved and used not limited by the location of power supply. Moreover, the cart has a drawer and a spacing for the storage of beauty products and tools, and through sequentially connecting to a front arm, a rear arm, and a base, the phototherapy mask is configured to be used in different angles and to be held above or in front of a user's in a preferable height.

Abstract: A modular boiler system for implementing fuel combustion is provided. The system includes a first boiler and a second boiler of a plurality of boilers, an oxygen input unit, a fuel input unit, a recycled flue gas input unit, and a flue gas separator. The first boiler receives oxygen from the oxygen input unit, fuel from the fuel input unit, and recycled flue gas from the recycled flue gas input unit. The first boiler outputs intra-system flue gas. The flue gas separator separates the intra-system flue gas into a first and second flue gas stream, transfers the first flue gas stream to the second boiler, and transfers the second flue gas stream to a gas cleaning system. The second boiler receives oxygen from the oxygen input unit, fuel from the fuel input unit, and the first flue gas stream from the flue gas separator.